Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 77 , Issue 5
Showing 1-20 articles out of 20 articles from the selected issue
  • Mutsuo UECHI, Katashi MATSUNO, Atsushi MAEDA, Akira AKAGAMI, Katsuko Y ...
    1980 Volume 77 Issue 5 Pages 691-697
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Cell-mediated Immunity of the aging and immune response in the family of gastric cancer have been investigated and the following results were obtained.
    Immune response particularly of cell-mediated immunity was found decreased in parallel with aging; decreases in peripheral lymphocyte and T-cell counts, rate of ConA and PHA induced blastoid transformation, and the tendency of increase in suppresser T-cell were noted. Investigations on the immune response in the family of gastric cancer revealed that cellmediated immune response was decreased in them compared to age-matched healthy volunteers. These findings suggest that latent immunological failure may exist in the above family.
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  • Keiji OHE, Toshio SHIRAKAWA, Hitoshi YOKOYA, Masaki ONDA, Akio NOGUCHI ...
    1980 Volume 77 Issue 5 Pages 698-707
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to investigate the possible relation of hydrogen ion back diffusion to theformation of gastric ulcers, the net flux of sodium ions into the luminal test solution (Na+net flux) and the back diffusion of luminal hydrogen ions (H+BD) were comparatively studied amoung 11 normal subjects and 153 patients with various gastric disorders. The results obtained were as follows. (1) Na+ net flux was significantly increased in patients with all kinds of gastric disorders in comparison with normal subjects. However, a significant increase in H+BD was found only in atrophic gastritis, gastric erosion and open gastric ulcer. (2) The patients with gastric ulcer were classified on the basis of the degree of accompanied atrophic gastritis, and compared with normal subjects and the patients with the same degree of atrophic gastritis without ulcer in terms of Na+ net flux and H+BD. No specific increase of H+BD was seen for the presence of gastric ulcer whereas in both groups with severe atrophic gastritis with and without gastric ulcer H+BD was significantly larger than in normal subjects. (3) When the patients with atrophic gastritis and gastric ulcer were classified by the presence or absence of accompanied gastric erosion, a significantly larger H+BD was observed in those patients with erosion than in normal subjects whereas in the patients without erosion no significant increase was seen. From the above findings, it has been concluded that the back diffusion of luminal hydrogen ions into the mucosa is closely related to the presence of gastric erosion which probably constitutes a part of the background of ulcer formation.
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  • Kazumasa MIKI, Oichiro KOBORI, Hiroshi SUZUKI, Hirohumi NIWA, Shiro II ...
    1980 Volume 77 Issue 5 Pages 708-715
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Experimental gastric carcinoma was developed on inbred Wistar strain rats by oral adoministration of N-methyl-N'-nitro-N-nitrosoguanidine, and resulting tumor was trans-planted successfully into subcutane of the same strain rat. Alkaline phosphatase (ALP) isozyme was determined in 14th, 15th and 16th generation of these transplantable tumor tissues, and its enzymological and immunological characteristics were analysed. Its specific ALP activity, sensitivity to amino acids, heat-stability, neuraminidase sensitivity, electro-phoretic mobility, zymogram and sensitivity to anti-rat intestinal ALP antibody did not differed significantly in the different generations, and were also almost the same with those of primary tumors as previously reported on out-bred rats. Therefore, abnormal gene expression in ALP production, especially in intestinal ALP, was seemed to be indifferent to the strain of rats and inherit in transplantable tumor.
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  • Masaru KAWAMOTO, Tsuneo FUKUSHIMA, Naoki ISHIGURO, Akira KUBO, Shuji T ...
    1980 Volume 77 Issue 5 Pages 716-721
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Enteric bacteria and short chain fatty acid (SCFA) in the enteric fluid of 19 non-strangulated intestinal obstruction were investigated. In 12 out of 19 cases, culture of enteric fluid revealed 107-11/ml of SCFA producing enteric bacteria, such as E. coli, Klebsiella and Bacteroides. Thirty five to 905mg/L of SCFA was detected in all the specimen. Acetic acid, propionic acid and lactic acid were prominent. Concentration of SCFA was reached the peak at the time of operation and then gradually decreased in most of operated cases. I t was also gradually decreased with the clinical improvement in conservative cases.
    Ileal obstruction revealed higher concentration of SCFA and increased number of enteric bacteria compared to jejunal obstruction. Increased SCFA in the obstructed enteric fluid would be one of the factors facilitating the bowel distention and increasing peristalsis by either direct or its osmolar action.
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  • Tadashi TANAKA
    1980 Volume 77 Issue 5 Pages 722-731
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To assess cell-mediated immunity in chronic inflammatory bowel disease, lymphocyte proliferative response to phytohaemagglutinin (PHA) and lipopolysaccharides (LPS) extracted from E. coli 014, 026, 0111 and Vibrio cholerae were measured by lymphocyte transformation test. Lymphocyte proliferative response to PHA in patients with ulcerative colitis did not differ significantly from that in the controls. However, it was significantly depressed in patients with Crohn's disease. This depression disappeared and the response returned to normal level after resection of the involved bowel. Lymphocytes from patients with active ulcerative colitis showed obvious proliferative response to E. coli 014 LPS which is known to contain enterobacterial common antigen (ECA) and to have cross-reactivity to colon antigen, but not to LPS from E. coli 026, 0111, or V. cholerae. In contrast, lymphocytes from patients with Crohn's disease as well as those from healthy controls did not show any proliferative response to all the LPS preparations tested. The proliferative response to 014 LPS seen in lymphocytes of active ulcerative colitis patients was demonstrated to be the response of T lymphocytes. These results suggest that T lymphocytes sensitized to ECA may play an essential role in the pathogenesis of ulcerative colitis.
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  • Takeshi YAMAZAKI
    1980 Volume 77 Issue 5 Pages 732-743
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Hemodynamics in portal hypertension was studied from the standpoint of correlation between retrograde flow of contrast medium into the celiac arterial areas during superior mesenteric angiography and pressure gradient between the aorta and celiac axis.
    Retrograde filling phenomenon was observed in 43 out of 260 patients (16.5%) of various diseases, mainly in 15 cases of stenosis of the celiac axis or it's vicinity, 8 out of 22 cases (36.4%) of Banti syndrome, 7 out of 18 cases (38.9%) of hepatoma and 6 out of 42 cases (14.3%) of liver cirrhosis. The arterial pressure in the celiac axis was reduced in some cases of above-mentioned 4 kinds of diseases.
    It came to the conclusion that retrograde filling phenomenon occured as a effect of not only decreased but increased or accelerated inflow of celiac artety. However, in a few cases of unaltered celiac inflow, congenital or acquired dilated anastomosis was responsible for this phenomenon.
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  • Kazuo TARAO, Yutaro TAKAMURA
    1980 Volume 77 Issue 5 Pages 744-749
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    It is disputed whether retention of bile acids in cholestasis results from impaired secretion from the hepatocyte into the canaliculus, or from back diffusion from the canaliculus across "leaky" tight junctions. We therefore studied the selective effects of cholestasis on bile acid efflux from suspensions of isolated hepatocytes, in which absence of tight junctions precluded the latter mechanism. Cholestasis was produced in male Sprague-Dawley rats, 250-350g, by bile duct ligation (BDL) for 48hr or by s.c. injection of ethinyl estradiol (EE), 5mg/kg daily for 7 days. Isolated hepatocytes were then prepared by hepatic perfusion with collagenase in calcium-free medium, followed by differential centrifugation. Cells were pre-equilibrated with 3H-cholate for 45min. The preloaded cells were resuspended at 37° in buffer free of Cholate to determine bile acid efflux. At t=O and 3.5min, bile acid in cell pellet and media were extracted with NH3-ethanol; and 3H in cholate, glycocholate, taurocholate and total bile acid were determined after separation by thin layer chromatography. Both BDL and EE signifigantly impaired secretion of total and conjugated bile acids without affecting efflux of C. Since only conjugated bile acids are secreted actively by the hepatocyte into the bile canaliculus, the selectively impaired efflux of conjugates suggests that cholestasis impairs canalicular bile acid secretion.
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  • Kazuki URABE
    1980 Volume 77 Issue 5 Pages 750-757
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Studies on gastric acid and pepsin secretion, fasting serum gastrin and secretin concentration had been carried out in 30 patients with liver cirrhosis. Higher levels of gastric acid and pepsin output, increment of gastric acid output and tetragastrin-stimulated volume rate were ob erved in liver cirrhosis with gastric ulcer than in those without gastric ulcer.
    Significantly higher ratio of gastric acid output to pepsin output was also obtained in liver cirrhosis, especially in those with gastric ulcer, than in gastric ulcer without liver disease. In conclusion it was suggested that gastric acid and pepsin might play an important role in gastric ulcer formation in liver cirrhosis, and that the manner of gastric secretion and mechanism of ulcer formation in gastric ulcer without liver disease might be different from those of liver cirrhosis with gastric ulcer.
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  • Masatoshi OKAZAKI, Noriyuki MORIYAMA, Tatsuya YAMADA
    1980 Volume 77 Issue 5 Pages 758-767
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Angiographic findings in 50 cases of hepatocellular carcinoma (HCC), 27 of these received hepatectomy, were analyzed in an attempt to obtain the relation between the portal vein findings, operability and prognosis. The portal vein findings of HCC were devided into two groups; normal and abnormal groups.
    Furthermore, the abnormal portal vein findings were classified into 5 groups; regurgitation, collateral vein, thread and streaks, filling defect and not opacified main portal vein branch.
    The abnormal portal vein findings in HCC were considered to be due to tumor thrombus in portal vein and observed in 36 cases (74%).
    In 20 of these 36 cases, the histological examinations of portal vein were carried out, and tumor thrombus in portal vein was found to be present in all these cases.
    In 36 cases of HCC with abnormal portal vein findings, 19 cases were inoperable because of intrahepatic metastasis or big tumor, but superselective hepatic angiography did not always reveal intrahepatic metastasis in these cases.
    In 14 of 36 cases, hepatectomy was done in HCC with the abnormal portal vein findings, but recurrence was high and the prognosis was poor.
    In contrast, 13 cases of HCC who had the good opacification of main portal vein branch (normal portal vein findings) were received operation with good prognosis.
    These data indicate that angiographic portal vein findings by portal vein angiography are very important to decide the operability in patients with HCC, in addition to the observation obtained by hepatic angiography.
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  • Masakuni ONDA, Takashi MIYAZAKI
    1980 Volume 77 Issue 5 Pages 768-778
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The human gallbladder has independent but mutually related two functions, namely, absorption of water and electrolytes by the mucous membrane of the gallbladder and contraction of the smooth muscle. In reference to the muscular structure and innervation particularly intrinsic cases which are closely related to the motility and absorption of the biliary duct system, we investigated the adrenergic and cholinergic innervation by means of the fluorescence histochemical method developed by Falck and Hillarp and the histochemical method of Karnovsky. We also determined the level of catecholamine in the tissue of the biliary duct system in order to clarify the intrinsic autonomic nerve in the cat. The results are as follows.
    1) According to our findings by the fluorescence method, the adrenergic fibres in the gallbladder wall rose from the serous membrane, formed an adventitial plexus around the blood vessel. And the adrenergic fibres were found abundantly in the smooth muscle layer to form muscular plexus and were partially innervated to the mucous layer. But patterns of the adrenergic fibres reaching the surface of the mucous layer were not observed.
    2) As for cholinergic fibres, both the true ChE activity and pseudo ChE activity, were observed in various layers of the biliary duct system, but there was no localized difference between the two.
    3) Adrenergic fibres of the common bile duct were clearly observed. The more abundantly they were distributed to the terminal parts of the common bile duct.
    4) Biogenic monoamines other than adrenaline and noradrenaline were not detected.
    5) The nerve cells observed in the gallbladder and common bile duct were accounted for mostly by Dogiel 11 type.
    6) Digestive tract hormones were not detected in the biliary duct system in the cat, but studies by means of the immunofluorescence method are under way.
    7) Proliferation of adrenergic fibres and a decrease in cholinergic fibres were observed in the truncal vagotomy group.
    8) According to determination of noradrenaline content in the biliary duct system, noradrenaline was found to be in the greatest amounts in the cystic duct and the smallest in the common bile duct. The vagotomy group showed a higher content of noradrenaline compared with the untreated group.
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  • Akira YAMADA, Tatsuya KITAMURA, Haruki MORI, Yutaka MATSUO, Kinori KOS ...
    1980 Volume 77 Issue 5 Pages 779-783
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kikuo NAKANO, Masahiro FUJITA, Hideo SHIGETA, Norimasa KURATA, Noboru ...
    1980 Volume 77 Issue 5 Pages 784-788
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yoshitaka HISHITANI, Yukie NAKAMURA, Masaichi INUI, KOICHI KAKEHI, Tos ...
    1980 Volume 77 Issue 5 Pages 789-793
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Shinichiro YAMAMOTO, Yoshinobu TAKKEMOTO, Sachiko YAMASHITA, Katsuhiko ...
    1980 Volume 77 Issue 5 Pages 794-797
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasuyo NAKASHIMA, Akihiro FUNAKOSHI, Toshinari KIMURA, Hideyuki WAKASU ...
    1980 Volume 77 Issue 5 Pages 798-802
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Masao INADA, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1980 Volume 77 Issue 5 Pages 803
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Shinjiro YOSHIMOTO, Keiichi KAWAI
    1980 Volume 77 Issue 5 Pages 804
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kenichi TAKAYASU, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1980 Volume 77 Issue 5 Pages 805
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takao TSUJI, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1980 Volume 77 Issue 5 Pages 806
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasuhiro MIZOGUCHI, [in Japanese], [in Japanese], [in Japanese], [in J ...
    1980 Volume 77 Issue 5 Pages 807
    Published: May 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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