Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 78 , Issue 1
Showing 1-20 articles out of 20 articles from the selected issue
  • Yozo WATANABE, Keiichiro KONDO, Hiroshi KANAZAWA, Atsuo WAKABAYASHI, H ...
    1981 Volume 78 Issue 1 Pages 1-8
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The relationship among the anaphylactoid skin reaction after intradermal administration of secretin (40 unit of Eisaisecretin in 0.1ml of 0.9%NaCl), and exo-and endocrine system or serum IgE level for duodenal ulcer patients (24 cases), gastric ulcer patients (20 cases), postoperative peptic ulcer patients (4 cases) and controls (8 cases) has been investigated. Seventeen out of 24 duodenal ulcer patients, 6 out of 20 gastric ulcer patients, 2 out of 4 posto perative peptic ulcer, and 1 out of 8 controls showed an anaphylactoid skin recation (urticaria and erythema) to intradermal secretin. From these data it may be suggested that there is enhanced inactivation of endogenous secretin in duodenal ulcer patients, and secretin inactivation might involve an immunological mechanism. In the patients responded locally to intradermal secretin (positive skin reaction group) integrated gastrin response to meatextract stimulation (T-IGR), basal acid output and maximal acid output was higher levels than those levels of negative skin reaction group. This observation suggests that impaired release of endogenous secretin causes the failure of long feedback mechanism of secretin for gastrin release.
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  • Eiji ONOYAMA
    1981 Volume 78 Issue 1 Pages 9-19
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The effects of experimental ulcer upon electrical and mechanical activities of the stomach were examined by 24 hr polygraphic recording under unanesthetized and unrestrained state of mongrel dogs. Gastric ulcers were gotten sight of in the angular and/or prepyloric region where the deformation of contraction activity had been previously noticed. Diurnal patterns of the gastric contraction curve in the fasted state after ulceration were classified into 3. In Type I, the contraction and uncontraction periods recurred alternately as same as in control. In Type II, two subtypes were differentiated one from another according to the difference of larger or smaller amplitude in the contraction waves during the contraction period. In Type III, the uncontraction period disappeared and the fasted state consisted of waxing and waning small contraction waves. After ulceration, diurnal rhythm of the BER (basic electric rhythm) intervals turned into stable one. A decrease of the BER propagation velocity was considered to be one cause of delay in gastric emptying accompanied by ulcer. Based on changes in configuration of the BER recorded near by ulcer involving invasion of the muscle layer, those BERs were suspected of abnormal excitation of the longitudinal muscles at there.
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  • (3rd report)Effect of mild acid
    Tetsuo ARAKAWA, Hajime NAKAMURA, Shinji CHONO, Hiroaki YAMADA, Kenzo K ...
    1981 Volume 78 Issue 1 Pages 20-23
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Effect of mild acid on the prostaglandin E2 levels in rat gastric mucosa was investigated. Rats were given 0.25 N HCl intragastrically 15min prior to sacrifice. Intramucosal prostaglandin E2 was extracted, purified and determined according to the previous report.
    The levels of prostaglandin E2 in gastric mucosa were increased both in fundus and antrum in 0.25 N HCl-treated rats (2.16±0.66μg/g and 4.19±0.84μg/g, respectively) compared with controls (1.18±0.16μg/g and 2.20±0.28μg/g, respectively). Furthermore, the development of 0.6N HCl-induced gastric mucosal lesions was inhibited in 0.25N HCltreated rats (ulcer index was 22.0±4.2) compared with controls (ulcer index was 65.4± 14.4).
    In these results, it is suggested that mild irritation of HCl stimulates gastric mucosal barrier through the increase of the prostaglandin E2 levels in gastric mucosa, this may be resulted in inhibition of the development of 0.6N HCl-induced gastric mucosal lesions.
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  • Akira TERADA, Kouichi HIRAMATSU, Takenobu KAMADA, Hiroshi ABE
    1981 Volume 78 Issue 1 Pages 24-30
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Histochemically, it was confirmed that the carbonic anhydrase which catalysed both phases of the reversible reaction, H2CO3_??_CO2+H2O, was recognized in the gastric surface epithelium of the human and dog by the Hannson's cobalt-phosphate method.
    In the human and dog, the intracellular localization of the carbonic anhydrase was mainly at the luminal side in the gastric surface epithelium, and the activity of this enzyme in the gastric surface epithelium was histochemically much almost the same as that in the gastric parietal cell.
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  • Yoshitaka HISHITANI, Toshiji MOZAI, Tadashi KANOH
    1981 Volume 78 Issue 1 Pages 31-38
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Studies on abberations of complement system in 111 patients with chronic liver disease were performed. It was demonstrated that the following two mechanisms accounted for the lowering serum complement level in chronic liver disease; (1) decreased synthesis of complement component due to damage of the liver and (2) hypercatabolism of complement such as activation and consumption of complement by circulating immunecomplexes. The dissociation between plasma and serum complement level, especially seen in patients with chronic liver disease, was caused by the mechanism (2), which was mediated by cryoglobulin. When cryoglobulin obtained from serum showing dissociation of complement level, was added to normal human serum and incubated at 0°C for 1 hour, remarkable reduction of CH 50 was found. On the other hand, cryoglobulin obtained from serum showing no dissociation, had no effect on the level of CH 50. In fact, IgM+IgG mixed cryoglobulin which was considered as immune complex, was demonstrated in 11 among 12 cases showing dissociation between plasma and serum complement level. The difference in activation of complement by mixed cryoglobulin may be related to the conformatical difference of IgM molecule (antibody).
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  • Yasunori AOKI, Takashi ANDO, Mitsuru SEISHIMA, Kazuo OGISO, Tsuyoshi S ...
    1981 Volume 78 Issue 1 Pages 39-46
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The First Department of Internal Medicine, Gifu University School of Medicine (Gifu) To elucidate the underlying mechanisms of appearance of abnormal lipoproteins in cholestasis, studies were conducted to investigate the molecular species of lipoprotein-X.
    Plasma low density lipoprotein (LDL) fraction, obtained from the patients with cholestasis, was further separated by zonal ultracentrifugation into 3 subfractions: Peak 1 (density ca. 1.04), Peak 2 (density ca. 1.07) and Peak 3 (density ca. 1.08).
    Since both peak 1 and 2 migrated toward the cathode by electrophoresis on Bacto agar, these fractions were proved to be molecular species of Lp-X(Lp-X1 and Lp-X2).
    A distinct peak of Lp-X1 and Lp-X2 was clearly observed at the advanced stage of extrahepatic cholestasis. But at the early stage of it only a small peak of Lp-X2 was detected.
    In the two cases of intrahepatic cholestasis, the amount of Lp-X2 was more dominant than that of extrahepatic cholestasis. On the other hand, Lp-X-like lipoproteins such as Lp-Xs formed by in vitro incubation according to the method of Manzato and Lp-Xi obtained from cirrhotic patients who received Intralipid infusion were both eluted at the position consistent with Lp-X1 peak of cholestasis.
    These findings strongly suggest that Lp-X1 is produced exclusively either in vitro or intravascularly, and Lp-X2 is formed through the hepatocyte during regurgitation of the bile components into the circulation.
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  • The clinical Study of 10 cases
    Yoshitane KOSAKA, Yukihiko TAMEDA, Masayoshi HAGIWARA, Kojiro TAKASE, ...
    1981 Volume 78 Issue 1 Pages 47-55
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The clinical and laboratory details of ten patients are described who had acute hepatic failure following halothane anesthesia. Five were males and remaining five were females, with ages ranging from 22 to 65, and six patients died. The administration of halothane was once in three cases, while seven patients had repeated exposure (twice in six and three times in one). The interval between first and second or third exposure was in a range of 9 to 68 days. The patients who had hepatic failure after a single administration developed pyrexia, more than 38°C on the 9th to 12th, and jaundice on the 14th to 16th postoperative day. By contrast, in cases with repeated exposure, the clinical onset was much earlier. Pyrexia developed within 2 days and they became juandiced within 10 days after the last administration. Obesity more than 20% of ideal body weight was observed in 8 out of ten patients. Histologically, fatal cases showed submassive to massive hepatie necrosis, while recovered cases had focal to zonal necrosis.
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  • Yoshio KINAMI, Itsuo MIYAZAKI, Mamoru SUGII, Toshinari MURA
    1981 Volume 78 Issue 1 Pages 56-64
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    This experimental study was carried out to clarify the change of pancreatic endocrine function in acute pancreatitis. Male Donryu rats used in the studies were divided into 2 groups, consisting of a group of rats with acute pancreatitis that was induced by Block's method, and a group of rats with simple laparotomy that served as control. And both groups were studied on insulin and glucagon levels in pancreas tissue, protein synthesis, that was examined by the uptake of labeled amino acid, of isolated islets of Langerhans obtained by the collagenase digestion method, and release of insulin and glucagon from isolated islets.
    Insulin and glucagon levels of the pancreas tissue in the rats with acute pancreatitis were significantly lower than that in the control rats. The uptake of labeled amino acid in isolated islets decreased gradually in the rats with acute pancreatitis. And the release of insulin from isolated islets reduced at the 72th hr after acute pancreatitis started. On the other hand, the release of glucagon from isolated islets reduced at the 6th hr.
    These findings, that were observed in the rats with acute pancreatitis, showed that there was . a reduction of synthesis and secretion function in endocrine cells of the pancreas, and suggested that the damage of A cells occurred more rapidly than that of B cells.
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  • Kozo KAWAI, Terukatsu ARIMA, Kinichiro SUWAKI, Hideo NAGASHIMA, Rokuro ...
    1981 Volume 78 Issue 1 Pages 65-70
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Protein, bicarbonate, amylase, ribonuclease and immunoreactive trypsin (IRT) in pure pancreatic juice of a patient with normal pancreas and a patient with hypofunctional pancreas were measured. Pancreatic juice was obtained via an external pancreatic fistula in response to graded doses of secretin and pancreozymin-secretin test. The external fistulae were made after partial (1/3) pancreactectomy of the pancreatic head.
    Concentrations of protein and three enzymes mentioned above were reduced in the hypofunctional pancreas. Outputs of bicarbonate and these enzymes of the hypofunctional pancreas were slightly increased in response to high doses of secretin, nevertheless these levels were lower than the normal one. In both of these patients a slight parallelism was observed among protein, amylase and IRT but not among the rest.
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  • Yasuaki INADA, Kei KASHIMA, Katsuhiko KINUGASA, Yuji HORII, Osamu MORI ...
    1981 Volume 78 Issue 1 Pages 71-80
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    It has been noted that PFD, an oral exocrine pancreatic function test, is valuable in clinical practice. The 6hr-urirany excretion of PABA was reduced in 24 percent of patients with some diseases except pancreatic disease. Particulary, it was significantly reduced in the patients with renal and liver diseases comparing with normal subjects, and even in normal subjects it was also reduced in the elderly (over 70 years old).
    We tried to increase the diagnostic ability of PFD as exocrine pancreatic function test by means of PABA absorption test. PABA absorption test was carried out in the same as PFD by oral administration of PABA instead of BTPABA. The ratio of 6hr-urinary excretion of PABA in the PFD and PABA absorption test (PFD/PABA) was significantly reduced in the patients with pancreatic insufficiency, but was not in other diseases. Furthermore, it was constant at all age groups in normal subjects.
    These data indicate that PABA absorption test can exclude the interrupting factors to PFD and that the combination of PFD and PABA absorption test can improve the diagnostic value of PFD by increasing the specificity as an exocrine pancreatic function test.
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  • Yoshio KANEKO
    1981 Volume 78 Issue 1 Pages 81-90
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The experimental acute pancreatitis was treated by various intravenous alimentation and the results were following;
    1) In the group of low calorie insusion (LCI), control of serum glucose was difficult; NEFA increased remarkably, GOT increased, and the level of serum protein decreased. But in the group of intravenous hyperalimentation with fat emulsion (IVHF), control of serum glucose was easy, NEFA did not increase, the level of phospholipid and serum protein increased. So, IVHF therapy was very effective.
    2) In the group of LCI, serum gastrin secretion and trypsin activity were not inhibited, but in the group of IVHF they were inhibited. In the group of LCI with trasylol, the activity of serum trypsin was not inhibited.
    3) Direct IVHF infusion to the pancreatic artery was carried out safely and without difficulty. Serum glucose and insulin level was well controlled, and gastrin secretion was inhibited.
    Thus we conclude that IVHF is very effective treatment for experimental acute pancreatitis, and presume that clinicaly IVHF is useful for acute pancreatitis especially in the severe cases.
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  • Kimitomo MORISE, Shunji ODATE, Nobuyuki HAYASHI, Hisakazu NISHIKAWA, Y ...
    1981 Volume 78 Issue 1 Pages 91-95
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yutaka MOTOHASHI, Akio TAKEI, Shoji YAMADA, Masahito INAZAWA, Toshio N ...
    1981 Volume 78 Issue 1 Pages 96-100
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Ikuto ORYOGI, Kimihiro AKAGI, Koichiro MURAI, Tadahiko FUCHIGAMI, Teru ...
    1981 Volume 78 Issue 1 Pages 101-105
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Toshinari KIMURA, Wontae LEE, Kohichiroh IMAMURA, Shuichi MISHIMA, Hid ...
    1981 Volume 78 Issue 1 Pages 106-111
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tanoshi YATAGAI, Jiro OOSAWA, Yoshiro TAKI, Ryo HOSOTANI, Gakuji OOSHI ...
    1981 Volume 78 Issue 1 Pages 112-115
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takaharu KONDO, Tetsuo HAYAKAWA, Aiji NODA, Yukio IINUMA, Nobuyoshi OK ...
    1981 Volume 78 Issue 1 Pages 116-120
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Y. Kuyama, [in Japanese], [in Japanese], [in Japanese], [in Japanese], ...
    1981 Volume 78 Issue 1 Pages 121
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Shinichiro Yamamoto, [in Japanese], [in Japanese], [in Japanese], [in ...
    1981 Volume 78 Issue 1 Pages 122
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kazuo OGISO, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1981 Volume 78 Issue 1 Pages 123
    Published: January 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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