Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 78, Issue 12
Displaying 1-25 of 25 articles from this issue
  • Sadakatsu TAJIKA
    1981 Volume 78 Issue 12 Pages 2253-2263
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The effects of parenteral nutrients with glucose, amino acids and fat on gastric secretion and the inhibitory mechanism to the gastric secretion of these nutrients in 4 healty subjects and 7 mongrel dogs with Heidenhain pouch were studied.
    The results showed that, in healthy subjects, tetragastrin-induced gastric acid secretion was significantly reduced by intravenous 20% glucouse and 12% amino acids. And in mongrel dogs, tetragastrin-induced acid secretion of Heidenhain Pouch was similarly reduced by intravenous 50% glucose, while less effect by intravenous 12% amino acids was noted, however no reduced was observed with 10% fat.
    According our experiments, it might be suggested that the inhibitory effects of intravenous glucose infusion on gastric acid secretion was possibly through the sympathetic nerve.
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  • In Relation to Plasma Free Fatty Acids
    Hideki NODA
    1981 Volume 78 Issue 12 Pages 2264-2274
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    It is well known that in the inter-digestive state, cyclic motor activity, so-called "inter-digestive caudad-migrating myoelectric complex (I. M. M. C.)" occurs in the alimentary canal and is synchronized with elevations of plasma motilin.Gastric motor activity was correlated with plasma free fatty acids (F.F.A.) levels, falling rapidly after meals and rising gradually as time passes.
    Plasma F.F.A.levels were low after intra-venous hyperalimentation and high during fasting.
    During fasting, powerful contractions continued throughout the observation period and the plasma motilin levels were high.Conversely, after intra-venous hyperalimentation, gastric motor activity was quiescent and the plasma motilin levels were low.
    It is sugested that I.M.M.C. with high levels of plasma motilin occurs only when plasma F.F.A. levels are high, and a state of starvation is important for the appearance of I.M.M.C. and the secretion of motilin.
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  • Masao ICHINOSE, Kazumasa MIKI, Chie FURIHATA, Takashi KAGEYAMA, Hirofu ...
    1981 Volume 78 Issue 12 Pages 2275-2284
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    A new method of radioimmunoassay using double antibody method for human group II pepsinogen (PG II) in serum was developed. 1) In this system, optimal antibody concentration is 2, 000 times dilution of original antiserum. sensitivity of the assay is in the order of 1 ng.per ml of serum and optimal assay range is 10 to 50 ng per ml. Enzymatic activity of 1 ng human PG II is 19.6 units under the condition of pH 2.0 as determined by the method of Anson with a slight modification. 2) No effect of interference of human serum is detected in this system and B/T value of 500 ng per ml of purified human PG I is almost equal to that of 1 ng per ml of purified human PG II. With these results, it is quite permissible to say that only the substances in serum which are immunochemically analogous to human PG II are detected by the system. 3) satisfactory results were obtained as for both intra and between assay reproducibility (coefficient of variation was 3.9% and 3.7-15.3% respectively). 4) The mean (±s. E. ) serum PG II levels in healthy donars were 16.0±0.8 ng/ml for males and 12.4±1.4 ng/ml for females. The difference between males and females was statistically significant (P<0.05). 5) The mean (±s. E. ) serum PG II level of 4 patients with total gastrectomy was 1.1±0.07 ng/ml. These results suggest that most of PG II in human serum is derived from gastroduodenal system.
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  • Especially, the Effect of Cigarette Smoking on the Healing Course of Acetic Acid Ulcer in Rats
    Chiyuki CHUJOH, Saburo NAKAZAWA
    1981 Volume 78 Issue 12 Pages 2285-2294
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    In order to elucidate the effect of cigarette smoking on the gastric mucosa, load with smoking or nicotine administration was given to rats bearing experimental acetic acid ulcer of stomach. The microangiography was performed to measure the diameter of the gastric mucosal vessels. In all groups which were loaded with cigarette smoking, the healing course of acetic acid ulcer was prolonged. Similar result was shown in the groups which were igven subcutaneous injection of nicotine (250μg/kg or 500μg/kg).
    The results of microangiographic study disclosed that the diameter of metarteriole, precapillary and capillary blood vessels decreased after cigarette smoking as well as nicotine administration, and this contraction persisted for sixty minutes.
    It is concluded that cigarette smoking.exerts ill influence upon the healing course of the gastric ulcer, and this effect is hypothesized to be due to the reduction of the gastric mucosal blood flow.
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  • Comparison of Aspirin and Indomethacin
    Shinji CHONO, Hiroaki YAMADA, Tetsuo ARAKAWA, Hajime NAKAMURA, Kenzo K ...
    1981 Volume 78 Issue 12 Pages 2295-2301
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    In view of the fact that exogenous prostaglandins (PGs) inhibit drug-induced gastrointestinal lesions, attention has been drawn to the role that endogenous PG depletion may play in the pathogenesis of these lesions. In this work using rats, the effect of indomethacin and aspirin, representative antiinflammatory agents, on the stomach and small intestine was studied by determining the gastric mucosal level of PGE2 and ascertaining the degree of injury. Both drugs significantly reduced the gastric mucosal level of PGE2 prior to the development of gastric lesions. However, the reduction of the PGE2 level in the gastric mucosa began to be noticed earlier after aspirin administration than after indomethacin administration. Indomethacin lowered the PGE2 level in the small intestinal mucosa prior to the development of lesions in that mucosa. Though aspirin neither decreased the PGE2 level in the same mucosa nor injured it. From these findings, it may be surmised that the decrease of endogenous PGs is one of the causative factors responsible for the formation of druginduced gastrointestinal lesions.
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  • (III) The Hemoperfusion and Oxygen Insufficiency in the Gastric Mucosa after Head-or Thermal-injury Analyzed by Reflectance Spectrophotometry
    Takenobu KAMADA, Nobuhiro SATO, Sunao KAWANO, Akifumi NAKAGAWA, Masuki ...
    1981 Volume 78 Issue 12 Pages 2302-2307
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    To investigate the mechanism of acute gastric mucosal lesions, the reflectance spectrophotometer system has been applied to the human gastric mucosa during gastrofiberscopy by using flexible coaxial fiber optic bundles and a computer-equipped spectrophotometer.
    The spectra were taken from corpus andd antral mucosa of 15 patients with thermal- or headinjury and compared with those from 7 healthy volunteers. In all patients, mucosal blood volume decreased to various degrees after thermal- or head-injury. In seven cases in which mucosal blood volume decreased to about 30% of the level of healthy volunteers, the acute gastric mucosal lesions appeared mainly in the corpus mucosa in three days after the measurement of mucosal blood volume. Although the blood volume in the antral mucosa also decreased to the almost same level as that of the corpus mucosa, the lesions did not appear in the antral mucosa.
    In conclusion, analysis of mucosal blood flow after thermal-or head-injury by reflectance spectrophotometry revealed that ischemia in the gastric mucosa is the main cause of the acute gastric mucosal lesions in the patients with thermal-or head-injury.
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  • Yoshitake IKEDA, Masaki KITAJIMA, Mitsuhisa UEDA, Satoru SOHMA
    1981 Volume 78 Issue 12 Pages 2308-2315
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The pathogenesis of cysteamine-HCl induced duodenal ulcers has not been clearly described. In the present study, we have investigated the relationship between the destruction of the duodenal mucosa and the impairment of the local duodenal blood flow in cysteamine-induced rat models.
    Wistar rats weighing 250-350 grm were anesthetized and a dose of 350mg/Kg of cysteamine was injected into the subcutaneous tissues. The mucosal tissues were investigated at times varing from 30 minutes to 24 hours after injection and were studied with a three dimensional microscope and scanning electron microscope. In order to see the pharmacological effect on the mucosal injury, 10μ/Kg of secretin, 10mg/Kg of cetraxate, and 500 mg/Kg of proglumide were individually administered 30 minutes before the injection. The blood flow was measured using the H+-clearrance technique, and at times varing from 3 to 24 hours. In addition, it was also performed in early hours of 30 minutes and 60 minutes.
    The severity of the mucosal injury was higher in the animals studied at 12 and 24 hours compared to the 3 hours (P<0.01). Rats treated with secretin, cetraxate, and proglumide revealed minimal injury of the mucosa after 12 hours of injection. The mucosal blood flow of control group was 1.28ml/grm./min. and the groups investigated at 30 minutes and 60 minutes were 0.68ml/grm. /min. (P<0.05) and 1.10ml/grm. /min.. (N.S. )
    We have investigated the fine microvascular structure of the duodenum. The microvascular structure is tight near the pyloric ring as far as 5mm, however anal side out of it becomes markedly loose and the ulcer is usually seen in this specific region. Therefore we have emphasized the importance of the defence mechanism of duodenal mucosa as a cause of cysteamine-induced ulcer formation.
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  • Akiyoshi DAN
    1981 Volume 78 Issue 12 Pages 2316-2322
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Method of determination for gastric mucosal gastrin and somatostatin concentrations in the same sample was studied. From 100 pg to 100 ng per tube of somatostatin could be determined by a RIA-double antibody method. A commercial RIA kit (Dainabot) was used for gastrin determination. Extraction study of gastric mucosal gastrin and somatostatin using exogenous 125I-gastrin and 125I-Tyr1-somatostatin showed that water (90.3%) extracted more gastrin than 2N CH3COOH (57.7%), while the latter (85.0%) did more somatostatin than the former (56.0%). Finally, the gastric mucosa was homogenized after boiling in the water and divided into three portion. The one portion was subjected to water extraction for the gastrin determination. The other one was used for 2N CH3COOH extraction of the gastrin determination and the rest was subjected for the protein determination.
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  • A study of antilymphocyte antibodies in ulcerative colitis using fluorescence activated cell sorter
    Keizo KITSUKAWA, Takashi IDE, Masuho HARAGUCHI, Muneharu KOMORI, Norih ...
    1981 Volume 78 Issue 12 Pages 2323-2329
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The relationship between the severity of the disease and the anti-lymphocyte antibody was studied in 23 patients with ulcerative colitis. There were 14 males and 9 females in the study group, and 18 persons in the control group.
    Anti-lymphocyte antibodies were demonstrated in 13 of 23 patients with ulcerative colitis. The stage of the disease was moderate to severe in 11 patients, and improving or mild in 2 patients, using the classification criteria of Takemoto et al. Eighty-one series of sera were studied in 23 patients who were colonoscopied around the day of serum examination. Measurement of the antibodies revealed that the level correlated well with the activity of the disease. The sera of 8 of the 13 patients were examined in various stages of the disease. In this study, the level of anti-lymphocyte antibody correlated well with severity of the illness.
    This study does not demonstrate whether the mechanism of anti-lymphocyte antibody production is a result or a cause of the disease, however, production of anti-lymphocyte antibodies does correlate with the severity of the disease process.
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  • Role of ADCC mechanism
    Sadakazu AISO
    1981 Volume 78 Issue 12 Pages 2330-2336
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Lymphocyte cytotoxicity against rat colon epithelial cells which share the antigen-specificity with the human colon was examined in 30 cases of ulcerative colitis, using the 51Cr-release cytotoxicity assay. Lymphocyte cytotoxicity against rat colon cells was observed in the cases of ulcerative colitis, esp, in the active stage. This cytotoxicity was revealed to be mainly mediated by non-T cells. Antibody dependent cell-mediated cytotoxicity against the colon cells was seen, using the sera of the patients and lymphocytes from healthy individual in the assay. The presence of anti-colon antibodies in these sera was demonstrated by analysis of the colon cells treated with the sera on a fluorescence activated cell sorter. All these results suggest that the mechanism of ADCC should play an important role in the destruction of the colonic cells in ulcerative colitis patients.
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  • Hiromichi NAKAYA
    1981 Volume 78 Issue 12 Pages 2337-2341
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    In 177 patients of chronic liver diseases, most of the cases showing discrepancy between the values of indocyanine green maximum removal rate (ICG Rmax) and hepaplastintest (Hp-T) were normal in Hp-T but abnormal in ICG Rmax. Examining the pathophysiological status of the liver of the cases showing clear discrepancy between these tests, we found that the total number of hepatocytes decreased, while the capacity of protein synthesis of each hepatocyte was well preserved. This characteristic pathophysiological condition was frequently observed in cases of advanced alcoholic fibrosis, abstinent alcoholic cirrhosis, inactive chronic hepatitis in precirrhotic stage, stational liver cirrhosis and solid type hepatocellular carcinoma. These results suggest that different liver function tests reflecting the changes in total functioning hepatic cell mass have different meanings depending on the test and a combined analysis with at least two qualitatively different tests discloses more clearly the underlying pathophysiological status of various liver diseases.
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  • Koichi HARADA
    1981 Volume 78 Issue 12 Pages 2342-2350
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The relationship between alcoholic fatty liver and lipid peroxide was investigated in rats fed an alcohol liquid diet for six weeks. The following results were observed. First, prolonged ethanol feeding increased concentrations of both hepatic tissue triglyceride (T. G.) and hepatic microsomal lipid peroxide. Second, intraperitoneal administration of α-tocopherol (α-toco.) inhibited hepatic microsomal lipid peroxide induced by ethanol. Third, intraperitoneal administration of clofibrate (CPIB) produced a marked increase in hepatic tissue catalase activity associated with an increase of hepatocytic peroxisomes and also inhibited the induction of both hepatic tissue T.G. and hepatic microsomal lipid peroxide at the time of ethanol feeding. These results suggest that the increase in lipid peroxide may be a causal factor in the development of alcoholic fatty liver.
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  • Eiichi ASANO, Takukazu NAGAKAWA, Itsuo MIYAZAKI
    1981 Volume 78 Issue 12 Pages 2351-2356
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Indocyanine green (ICG) plasma transfer rates (a-value:transfer rates between the plasma and the liver, h-value:transfer rates between the liver and the bile, b-value:transfer rates between the liver and the plasma) were determined in patients with obstructive jaundice, and they were evaluated from the effect of biliary diversion and the influence of biliary infection.
    Results obtained are as follows.
    1) Non-effective group, in which jaundice was prolonged, revealed lower b-value before and after biliary diversion, and lower h-value after biliary diversion compared with effective group in which jaundice was well reduced. All ICG plasma transfer rates correlated significantly with the level of serum total bilirubin in non-effective group.
    2) Infectious group (biliary infection group) revealed lower a-and b-value compared with non-infectious group.Especially decrease of the b-value in infectious group was distinctive.These results agreed with our experimental study which had been reported in 1978.
    It is concluded that ICG plasma transfer rates reflect the hepatic disturbance in obstructive jaundice.Decrease of the b-value in ICG plasma transfer rates is presumed to be an indicator to show poor prognosis of obstructive jaundice.
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  • Hisashi MATSUMOTO
    1981 Volume 78 Issue 12 Pages 2357-2366
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Automated frequency analysis of electroencephalogram (EEG) with simultaneous estimation of clinical laboratory tests including plasma amino acids was performed in 29 cases of acute or fulminant hepatitis and 19 cases with cirrhosis of the liver.
    Higher incidence of slow waves was observed as the severity of hepatic encephalopathy progressed up to the grade III.In acute hepatitis, incidence of slow waves was more significantly related to aromatic amino acids (AAA) level and methionine than branched chain amino acids (BCCA) level.On the contrary, in cirrhosis of the liver, it was more significantly related to BCAA than AAA and methionine.Incidence of slow waves was weakly significantly related to the ratio of BCAA over AAA in acute hepatitis, whereas, in cirrhosis of the liver this correlation was much significant.
    These results suggest that automated frequency analysis of EEG can be utilized as useful tool in assessing the severity of hepatic encephalopathy.Among the disturbances of amino acid patterns in hepatic encephalopathy, lower BCAA/AAA ratio may indicate the reduction of functional liver mass in cases of acute hepatitis.By contrast, in cirrhosis of the liver this lower ratio appears to play a role in part in the pathogenesis of encephalopathy.
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  • Takashi KUMADA, Satoshi NAKANO, Hirosato OHTA, Kimio KITAMURA, Hajime ...
    1981 Volume 78 Issue 12 Pages 2367-2375
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Serum ferritin and AFP concentration in 75 patients with hepatocellular carcinoma (HCC) and 150 patients with liver cirrhosis (LC) were measured by radioimmunoassay (RIA). Clinical significance of the elevated serum ferritin was evaluated comparing with serum AFP as follows.
    1) Mean values with standard errors of serum ferritin in HCC and LC were 378±82 ng/ml and 168±67ng/ml respectively and the difference was not significant. The ratio of serum ferritin to serum iron and s-GOT were, on the other hand, significantly higher in HCC than in LC. (P<0.05)
    2) The high values of serum ferritin over 300ng/ml were obtained in 19 of 26 patients with HCC (73.1 %) whose AFP levels were less than 200ng/ml and in 21 cases of 150 patients with LC (14.0%) respectively.
    3) In the 38 cases with HCC, histological classification was carried out according to Edmondson and Steiners' classification. In the majority of patients, the serum ferritin levels showed less than 300ng/ml in the grade II or grade III group and more than 300ng/ml in the grade I or grade IV group respectively.
    4) Thirteen patients with LC who transformed to HCC were classified into 4 types according to changes of serum ferritin and AFP levels. In the first type, neither serum ferritin nor AFP showed abnormal values through the clinical course. Only one patient showed this type. In the second type, AFP increased remarkably leaving ferritin level low. Eight patients (61.5%) were included in this type. In the third type, serum ferritin increased remarkably leaving AFP level low. In the last type, both serum ferritin and AFP increased remarkably. Two patients were included in the both third and fourth groups respectively.
    In summary, it is indispensable to measure the serum ferritin level for diagnosing AFP-negative HCC.
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  • Tatsuo MUNEHISA, Keisuke NAKATA, Aiko FUKAHORI, Toyokichi MURO, Kenji ...
    1981 Volume 78 Issue 12 Pages 2376-2383
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The clinicopathological studies were done in 15 cases of minute hepatocellular carcinoma. The results obtained are summarized as follows: (1) Eleven of 15 cases (73.3%) were found positive by AFP test. (2) No subjective symptoms were felt by 12 cases. (3) Of 13 cases tested, HBs antigen was positive in 7 (53.8%), and HBs antibody was detected in 3 (23.1 %). (4) Determinations of serum levels of LDH, ALP, LAP, γ-GTP, TC and GOT/GPT ratio tended to be useful for diagnosing carcinoma. (5) Scintigraphy by 99mTc-phytate was diagnostic in only 2 of 15 cases (13.3%), while angiography (13/14, 92.9%), ultrasonography (4/4, 100%) and CT scan (8/8, 100%) provided highly positive evidence for diagnosis. Peritoneoscopic examination and tumor biopsy were useful for detecting the tumor located on the liver surface. Tumor scintigram by 131I labeled anti-AFP antibody seems to be diagnostic (3/4, 75.0%). (6) All 15 cases had cirrhosis and 11 of them were operated. A smallest tumor was 1.6×1.5×1.2 cm in size. Their histological findings were of trabecular pattern. Six of 11 operated cases was found alive after 3 months of follow-up study. One of them was diagnosed as minute hepatocellular carcinoma 82 months after the first operation, but the operation was again performed successfully.
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  • Investigation of 6 Cases and Review of Literature
    Hideshi KOMORI, Masatoshi KUDO, Katsuhiko FUJIMI, Shusuke TOMITA, Yosh ...
    1981 Volume 78 Issue 12 Pages 2384-2394
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    In 4 of 6 patients survived from acute hepatic failure showed histological findings similar to chronic hepatitis. One of these 4 patients was considered to be acute hepatic failure based on chronic hepatitis.
    The re-rise of transminase activities was recognized on recovering stage in the remaining 3 cases. These 3 patients were supposedly developed post transfusion hepatitis following blood exchange transfusion for the treatment of acute hepatic failure.
    According to the survey of literature in the last five years, 44% of 76 patients survived from acute hepatic failure showed histological findings of portal inflammation and 51% of the cases revealed re-rise of serum tranSaminase during the long term follow up studies.
    When histological findings similar to chronic hepatitis are seen in the case recovering from acute hepatic failure, we must take into consideration of possibilities that acute hepatic failure based on chronic hepatitis, post transfusion hepatitis following blood exchange transfusion for the treatment of acute hepatic failure or residual histological reaction in recovering stage of acute hepatic failure.
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  • SHOHEI MATSUZAKI, Masaru ITAKURA, Kenichiro IWAMURA, Hiroshi KAMIGUCHI
    1981 Volume 78 Issue 12 Pages 2395-2401
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Serum sialic acid levels were determined in acute and chronic hepatitis (13 and 20 cases respectively), fatty liver (19 cases), compensated and decompensated cirrhosis (52 and 22 cases respectively), hepatoma (20 cases) and metastatic liver cancer (20 cases). The level in compensated cirrhosis was significantly lower than in control normal subjects (1.18±0.18 mM vs. 1.51±0.12 respectively, p<0.001), and it was further reduced in decompensated ones, whereas the levels in acute and chronic hepatitis and fatty liver appeared to be similar to control. The level in hepatoma was found to be elevated in spite of the association of advanced cirrhosis with them except for two cases (1.82±0.57 in all and 1.70±0.44 in cases with cirrhosis). This level was significantly higher than the levels in cirrhosis (p<0.01). In 60% of the cases with metastatic liver cancer, the level was much higher than the upper range of the normal, and the average was significantly higher than control (2.25±0.64, p<0.001).
    The mean of sialic acid content in hepatoma tissues studied in three cases was 40μg per mg protein of crude preparation of hepatocyte membrane, that was greater than in noncancerous part of the liver (14μg per mg protein). The result indicated the related increase of sialic acid in serum and the tissue at least in hepatoma.
    The measurement of serum sialic acid can be clinically useful for the diagnosis of cirrhosis and liver cancers.
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  • Correlation of Echograms and Histopathological Findings
    Takashi SHINAGAWA, Masao OHTO, Kunio KIMURA, Shoichi MATSUTANI, Michio ...
    1981 Volume 78 Issue 12 Pages 2402-2411
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Real-time ultrasonographic study was performed in 79 patients with hepatocellular carcinoma (HCC) and 48 patients with metastatic liver carcinoma.
    We classified echograms of carcinoma of the liver into 3 types, nodular, massive and diffuse, according to the shape, and into 4 echo patterns, low, low periphery, high and mixed.
    HCC showed different echo patterns depending upon the size. In general, carcinomas smaller than 3 cm in diameter showed the low echo pattern and ones larger than 5 cm the high echo pattern. When compared with histopathological findings, echo patterns of liver carcinomas were significantly related to the degree of necrosis.
    Small HCC usually showed nodular type echograms of the low or low periphery echo pattern.
    Echograms of encapsulated HCC showed acoustic shadows on the lateral side of the tumor in 53.3% of the cases. The capsule of the tumor was seen as a low echo zone at the periphery.
    Differentiation of HCC from metastatic liver carcinoma was possible with an overall accuracy of 83.9% by the blind evaluation method.
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  • Kenichi TAKAYASU, Yasuo SHIMA, Chizuko KOBAYASHI, Jiro KATO, Junichi T ...
    1981 Volume 78 Issue 12 Pages 2412-2416
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Yatsugi NODA, Takashi OKAI, Nobuyoshi TANAKA, Keigo NISHIMURA, Yasuhir ...
    1981 Volume 78 Issue 12 Pages 2417-2420
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Takao TSUJI
    1981 Volume 78 Issue 12 Pages 2421
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Shogo IWABUCHI, [in Japanese], [in Japanese], [in Japanese]
    1981 Volume 78 Issue 12 Pages 2422
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Takatsune NAKAYAMA, [in Japanese], [in Japanese], [in Japanese], [in J ...
    1981 Volume 78 Issue 12 Pages 2423
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Masaya HISAMURA, [in Japanese], [in Japanese], [in Japanese]
    1981 Volume 78 Issue 12 Pages 2424
    Published: December 05, 1981
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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