Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 78 , Issue 4
Showing 1-23 articles out of 23 articles from the selected issue
  • Shinji CHONO, Hiroaki YAMADA, Tetuo ARAKAWA, Hajime NAKAMURA, [in Japa ...
    1981 Volume 78 Issue 4 Pages 805-811
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In this study using rats, the potency of ulcerogenecity of mefenamic acid was investigated, and the influence of liver damage and stress on mefenamic acid-induced gastric lesions was also investigated.
    Gastric lesions were induced by administration of mefenamic acid in a dose related manner. Mefenamic acid-induced gastric lesions were enhanced in rats with carbon tetrachloride-induced liver damage. Though a low dose of mefenamic acid failed to cause gastric lesions, addition of water-immersion stress, insufficient to cause gastric lesions by itself, induced gastric lesions. Increasing the dose of mefenamic acid resulted in severe antral lesions in contrast with oxyntic lesions, whereas longer duration of water-immersion stress resulted in severe oxyntic lesions in contrast with antral lesions.
    From these findings, it is suggested that gastric lesions induced by mefenamic acid is enhanced by modifying factors such as liver damage and stress.
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  • I. Studies on Assay Method for UDP-Galactosyl Transferase
    Shin OKAMOTO, Terukatsu ARIMA, Itsuo AMIOKA, Hideo NAGASHIMA
    1981 Volume 78 Issue 4 Pages 812-816
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Some characteristics of UDP-galactosyl transferase, which transfers Gal from UDP-Gal to (GlcNAc and GalNAC) n-protein core on the later step of biosynthesis of gastric glycoproteins, were studied in the scraped rat gastric mucosa After scraping of gastric mucosa of Wister rats, it was homogenized, and the homogenate was centrifuged at 500 xg for 10 min. The supernatant was used as enzyme solution and asialo-agalacto-fetuin was used as acceptor protein. In our method UDP-galactosyl transferase activity and protein were able to measure in 1mg wet weight of gastric mucosa. This enzyme activities (U./kg protein) were determined to be less than 10 (n=3) at forstomach, 946±125 (n=5) at fundic gland area, 835±94.9 (n=3) at pyloric gland area. The biopsy specimen could be stored at-70°C for 2 months without loss of UDP-galactosyl transferase activity.
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  • II. Studies on UDP-Galactosyl Transferase Activity in the Rat Gastric Mucosal Damage by Phenylbutazone
    Shin OKAMOTO, Terukatsu ARIMA, Itsuo AMIOKA, Hideo NAGASHIMA
    1981 Volume 78 Issue 4 Pages 817-821
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Effects of phenylbutazone on biosynthesis of gastric glycoproteins were studied. UDPgalactosyl transferase activity in phenylbutazone damaged fundic gland area was not changed when compared with control. The pyloric gland area of the phenylbutazone treated group showed lower UDP-galactosyl transferase activity than the control group. When Proglumide, antiulcerous agent, was administrated to rats with gastric mucosa injured by phenylbutazone, UDP-galactosyl transferase activities in fundic and pyloric gland areas were increased when compared with the group treated only with phenylbutazone. From resalts described above it was indicated that Proglumide had antiulcerous effects by activating biosynthesis of gastric mucosal glycoprotein.
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  • Chiyuki NAKANOMEI, Akira ISHIMORI, Yoshio GOTO, Tadashi YAMAZAKI, Jini ...
    1981 Volume 78 Issue 4 Pages 822-830
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Glucagon provocation test was performed in the patients with hypergastrinemia and petic ulcer to investigate its diagnostic value. A paradoxical response of plasma gastrin level in the Zollinger-Ellison syndrome was demonstrated by glucagon infusion. Glucagon provocation test, therefore, was considered to be of great value in the differentiation of the Zollinger-Ellison syndrome from other diseases with hypergastrinemia and peptic ulcer. Secretin provocation test sometimes caused the false positive results because of a marked increase of pancreatic secretion. Glucagon provocation test, on the other hand, had less possibility to produce the false positive results because glucagon inhibited the pancreatic secretion. Glucagon provocation test was considered to be more useful than secretin provocation test in this respect. Consequently, glucagon provocation test in combination with secretin provocation test is at present the most preferable diagnostic procedure for detecting the Zollinger-Ellison syndrome.
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  • I. Micro-angiological Observation on the Healing Process of the Small Intestinal Ulcer by the Injection Replica Scanning Electron Microscope Method
    Junji YAMADA
    1981 Volume 78 Issue 4 Pages 831-840
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Experimental ulcers were induced in the small intestine of rats by administration of hot water through a canulated tube. Healing process of ulcer was macroscopically divided into acute, healing and scarring stage. Micro-vascular changes were studied by injection replica scanning electron microscope method and injection Indian ink method. Following results were observed.
    1) Acute stage: The villous capillary vessels were markedly dilated in the marginal zone, while vascular regeneration was rarely observed.
    2) Healing stage: Various types of regenerating vessels were formed. Radial vessels were growing from serosa, and sprout like streight vessels were growing from submucosa. Regenerating capillary networks of villi and crypts were formed in the marginal zone of mucosa.
    3) Scarring stage: The regenerating villous vessels were irregularly arranged and vascular networks were reduced.
    4) Ulcer with prolonged healing: The regenerating vessels formed poor anastomosis, growing sparsely from serosa and submucosa.
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  • Masahiro TADA, Ken KATAKE, Fumio MISAKI, Keiichi KAWAI
    1981 Volume 78 Issue 4 Pages 841-845
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Tissue fibrinolytic activity of the rectal mucosa of 10 cases of ulcerative colitis and 48 normal subjects was examined by the fibrin plate method reported by Astrup and Kondo. Rectal mucosa taken by the biopsy forceps was rinsed in the saline water for a while. After weighing, mucosal particle was put on the fibrin plate. Then diameter of transparent area showing the fibrinolytic activity was measured after the 24 hours incubation at 37°C.
    In the acute phase of ulcerative colitis, tissue fibrinolytic activity increased (59.70±7.12mm2/mg, m±SD) more than that of the normal subjects (31.14±4.11mm2/mg). However, in the chronic-active phase and quiescent phase, tissue fibrinolytic activity decreased (31.24±2.99mm2/mg, 33.79±4.59mm2/mg) as much as that of normal subjects. Therefore, tissue fibrinolytic activity increased only during the early stage after the onset, and soon decreased in the chronic phase.
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  • Hiroshi SHIGEMATSU, Yoshiaki HORIE, Masanori SATO, Yukihisa MIYAZAWA, ...
    1981 Volume 78 Issue 4 Pages 846-855
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Intramural blood flow and flow distribution in the canine intestine were investigated by hydrogen clearance method. A double tipped Platinum electrode with 200 u in diameter was inserted into submucosal and muscular layers, separately. The interference between both electrodes was not noted. The hydrogen disapearance curve showed abrupt cessation during arterial occlusion, and it was confirmed that removal of hydrogen was dependent on blood flow. Total tissue blood flow was measured simultaneously by the hydrogen clearence method and by the direct venous outflow method. The correlation between both methods was significantly high. The mean perfusion rate of the intestine was 1.29-1.31ml/min/g in the submucosa and 0.81-0.92ml/min/g in the muscularis, respectively. There was little difference of perfusion rates between the small and the large intestine.
    This method is repeatedly apPlicable for flow measurement in various organs simultaneously, and so offer the great advantage to investigate the pathophisiology in the sPlanchnic circulation and in the correlation between organs.
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  • Akira TAKADA, Hiromichi NAKAYA, Shujiro TAKASE, Jinichi NET, Yoshiro M ...
    1981 Volume 78 Issue 4 Pages 856-863
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    During 5 months form April to August in 1976, 20 cases of acute viral hepatitis mostly after abdominal or cardiovascular surgery were observed in Kanazawa Medical University Hospital. The incidence of postoperative hepatitis in this period was 2.21% for all operation and 13.7% for open abdominal or cardiovascular surgeries, which were 4 times higher than that in the other period. In 3 out of 20 cases, HBs-antigen was detected, and one case showed anti HA antibody of IgM type. Remained 16 cases was thought to be non-A, non-B hepatitis. Three out of 16 cases did not received blood trasfusion. Other virological studies have shown that cytomegalovirus, herpes simplex virus, and Epstein-Barr virus were not contributable to postoperative hepatitis in this study. From September of 1976 to March of 1978, 18 cases of postoperative hepatitis of non-A, non-B type were sporadically observed. The difference between two groups (epidemic and sporadic) was compared.
    Incubation periods of the epidemic group were less than 4 weeks in 14 of 16 case, while the periods were longer than 5 weeks in 10 of 18 cases of the sporadic group. On the liver biopsy, all cases of the epidemic group revealed zonal or submassive necrosis, while 80% of the sporadic group showed spotty necrosis. Two cases of the epidemic group died with acute illness but none in the sporadic group. Serum transaminase levels and icters index were higher in the epidemic group than those of the sporadic group. About 40 to 50% of the cases took protracted course in both groups. Most cases of the epidemic group resolved within 1 to 2 years course. Finally, unresolved cases were 2 out of 12 cases in the epidemic group, and 5 out of 14 cases in the sporadic group. Clinical features of the epidemic group were short incubation period, severe acute illness and relatively good long-term prognosis. These results suggested a possibility that an outbreak of postoperative hepatitis was caused by a special type of virus.
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  • The Clinicopathological Study of 39 Cases
    Yoshitane KOSAKA, Yukihiko TAMEDA, Rikiya KAWARADA, Kojiro TAKASE, Aki ...
    1981 Volume 78 Issue 4 Pages 864-873
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The clinical and laboratory details of renal complication were studied in 39 patients with fulminant hepatitis. The diagnosis of renal failure was made when the levels of BUN and/or serum creatinine were more than 35 mg/dl and 2.5 mg/dl respectively. The overall incidence of renal failure was 46.2% (18 cases). In most of cases, the etiology of renal failure could not be documented and there was no patient who developed the previous episode of hypotension, systolic blood pressure below 80 mmHg.
    At the onset of renal failure, the disturbances of electrolyte and acid-base metabolism were often encountered in renal failure group. The subsequent hospital course of renal failure group was not different from non-renal failure group regarding to the clinical and laboratory findings, and the incidence of DIC.
    The pathological examination of kidney revealed the findings consistent with that of acute tubular necrosis in most of renal failure patients.
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  • Yasuni NAKANUMA, Goroku OHTA, Takukazu NAGAKAWA, Fujitsugu MATSUBARA
    1981 Volume 78 Issue 4 Pages 874-882
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Histologic changes of the bile ducts at a site of intrahepatic gallstones could be classified into 3 types: proliferative, suppurative and granulomatous cholangitis. Proliferative type, showing proliferation of the periductal glands and their conduits, was a most frequent and common change of the affected bile ducts. Actively secreted mucinous material both from hyperplastic lining epithelium and proliferating, in a variable degree, periductal glands in the stone-containing ducts were found, and may be important as a accelerating factor to lead to growth and further formation of the intrahepatic gallstones. Subcapsular and peripheral hepatic tissue far from location of the stones revealed hepatic fibrosis, ring-shaped periductal fibrosis, stenosis and sclerosis of the portal vein branches, atrophy of the hepatic lobe and lobules. Most of them seemed to develop after the formation of stones. There were no findings suggestive of the presence of congenital anomalies in the livers and kidneys of our cases, as seen in congenital hepatic fibrosis, infantile polycystic disease and Caroli's disease.
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  • Investigation by a New Method Using ADCC System
    Masahiko ADACHI, Masaju SANO, Hiroo IMURA, Kenichi ITO
    1981 Volume 78 Issue 4 Pages 883-889
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    A new method using antibody-dependent cell-mediated cytotoxicity (ACDD) system was developed for studying the frequency and significance of the autoantibody to human liverspecific membrane lipoprotein (LSP). 51Cr-labeled chicken erythrocytes as the target cells, lymphocytes from peripheral venous blood of a normal adult as the aggressors, and sera of patients with chronic liver diseases were used in the system. The autoantibody was found in 100% of 10 patients with lupoid hepatitis, 48% of 21 patients with chronic active hepatitis, and 20% of 10 patients with chronic inactive hepatitis. The frequency of the autoantibody in chronic active liver diseases using this new method was higher than those obtained by the technique of membrane immunofluorescence using rat hepatocytes. We suggest that the mechanism of ADCC may be operable in vivo, being the main pathway of liver cell destruction in chronic active liver diseases.
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  • Part 2. Clinical Evaluation
    Shinichiro KAWAGUCHI
    1981 Volume 78 Issue 4 Pages 890-901
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Recently developed 5 bifunctional chelating agents for the hepatobiliary scanning, 99mTc-HIDA, EHIDA, PIPIDA, BIDA and PI were clinically evaluated. Results were as follows: 1) EHIDA was suitable for the diagnosis of cases with normal or slightly injured hepatic function and BIDA was for those with severe hepatic dysfunction. 2) HIDA & PI when used sequentially served for the differential diagnosis of some constitutional jaundice cases. 3) Color functional image was introduced to display the several indices of the total liver function for 60 min in a singgle fiure.
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  • Kazumoto SASAKI, Masataka KATADA, Hideaki KAWAGUCHI, Hiroshi KOBAYASHI ...
    1981 Volume 78 Issue 4 Pages 902-908
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The cystic duct of 104 gallbladder stone cases and 38 common bile duct stone cases among cholesterol stone cases, whose radiological appearance were visible clearly on PTC pictures, were analysed on their morphological changes, modes of union to common bile duct and pathological findings.
    The dilatation of cystic duct, especially totale extension form was observed as many in common bile duct stones compared with gall bladder stones.
    As concerning the modes of union to common bile duct, the spiral form was few in common bile duct stones.
    The pathological findings of cystic duct in common bile duct stones were erosions, flatten and destruction of villi.
    It is considered that cholesterol gall stones are produced in gall bladder, therefore the cystic duct changes of common bile duct stone cases are closely related with the stone passage through cystic duct.
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  • Koichi NISHIDA, Keiji FUKUMOTO, Shuhei TAKEMURA, Toshikazu YOSHIKAWA, ...
    1981 Volume 78 Issue 4 Pages 909-913
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The First Department of Internal Medicine, Kyoto Prefectural University of Medicine For the quantitative measurement of pancreatic oncofetal antigen (POA), an enzyme immunoassay for POA based on the sandwich method has been developed. Using IgG fraction of anti-POA serum, antibody coupled beads and enzyme (peroxidase) labeled antibody were prepared. The dilution of fetal pancreas homogenate was defined as standard POA, and standard curve was made for the estimation of POA level in each sample. The enzyme immunoassay employed for POA showed satisfactory results in clinical application. And significantly elevated serum POA levels were found in patients with pancreatic cancer, compared with those in other miscellaneous diseases or in normal subjects, suggesting that the measurement of POA in serum may be useful in the diagnosis of pancreatic cancer. Serum POA level has changed being accompanied with the progress and the removal of the cancer of the pancreas, and therefore the assay of serum POA may be also useful in monitoring the course of the disease.
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  • Kazuhito ITO, Tetsuo HAYAKAWA
    1981 Volume 78 Issue 4 Pages 914-922
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To study mechanism on stone formation in the pancreatic ducts in chronic pancreatitis, lactoferrin of the duodenal juice obtained during pancreozymin secretin test was determined by radioimmunoassay in the following three groups: normal exocrine function (n=65), chronic noncalcifying pancreatitis (16) and chronic calcifying pancreatitis (22).
    Lactoferrin concentration of the duodenal juice was significantly higher in chronic pancreatitis than in normal, about three times higher in noncalcifying pancreatitis and five times in calcifying pancreatitis. Amylase concentration, on the other hand, decreased in chronic pancreatitis, half of that of the normal for noncalcifying and one third for calcifying pancreatitis. Difference of lactoferrin between normal and chronic pancreatitis became much greater when expressed in a ratio of lactoferrin/amylase, 14 times greater in noncalcifying and 20 times greater in calcifying pancreatitis.
    Results thus obtained suggest that lactoferrin plays an important role in pancreatic stone formation in chronic pancreatitis.
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  • Izumi SHIBATA
    1981 Volume 78 Issue 4 Pages 923-931
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Recently, ACCR has been widely used for diagnosis of acute pancreatitis. In this report, fundamental studies were performed to evaluate clinical significance of ACCR.
    Since blue starch method gave falsely lower values than the actual ones of urinary amylase, accurate value of ACCR can be obtained by the addition of albumin to urine in order to increase the protein concentration. ACCR can be calculated by simple method instead of one hour clearance method.
    Although ACCR was presented as the method by which influence of impaired renal function on amylase clearance could be eliminated, increased ACCR were observed in patients with renal insufficiency having under Ccr 60 mi/min.
    In patients with acute pancreatitis, diurnal variance of ACCR is not large while daily variance of its is remarkable. Frequent measurement of ACCR is required, because each patient shows different curve. Most elevated values of ACCR were seen in patients with pancreatic diseases, especially acute pancreatitis. ACCR is sometimes within normal range in patients with pancreatitis. However, increased ACCR suggests high possibility of acute pancreatitis.
    Increased ACCR cannot be seen in cases of hyperamylasemia induced by liver diseases, salivary gland disease, or unknown etiology.
    These results suggest that the ACCR is useful for the differential diagnosis of hyperamylasemia and for acute pancreatitis, and ACCR is valuable as well as clinical symptoms, serum amylase level, and urinary amylase output when diagnosing acute pancreatitis.
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  • Yasuhiko NAGASAKI, Yukihiko KAWASAKI, Shohei NISHI, Hirohiko YAMAMOTO, ...
    1981 Volume 78 Issue 4 Pages 932-936
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Joji ISEKI, Shunji FUTAGAWA, Toru ITO, Nobuo MURATA, Tomoe BEPPU, Taka ...
    1981 Volume 78 Issue 4 Pages 937-942
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Keizo KIKKAWA, [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1981 Volume 78 Issue 4 Pages 943
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hiroshi TAKAHASHI, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1981 Volume 78 Issue 4 Pages 944
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yoshifumi KODAMA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1981 Volume 78 Issue 4 Pages 945
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kohzo OHYAMA, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1981 Volume 78 Issue 4 Pages 946
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Insu LIM, [in Japanese], [in Japanese], [in Japanese], [in Japanese], ...
    1981 Volume 78 Issue 4 Pages 947
    Published: April 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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