Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 78 , Issue 8
Showing 1-20 articles out of 20 articles from the selected issue
  • Katsutoshi OBARA
    1981 Volume 78 Issue 8 Pages 1555-1567
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Six hundred and forty specimens of the resected stomach of patients with gastric disorders were examined histologically for lymphoid hyperplasia (LH). The LH was observed in 91 specimens, in which a spread pattern of LH outside the lesion (so-called RLH) was found in 20 cases, whereas an overlap pattern of LH on the lesions of ulcer or cancer, which was looked just like a reaction to the lesion, was found in 71 cases (45 in ulcer and 26 in cancer).
    In ulcer with LH, LH was present in the bottom of the ulcer or in the muscularis mucosa and showed a close relation to the hardness of ulcer-healing. In cancer with LH, LH was present only in the depressed type of cancer and showed characteristic patterns in the macroscopic and histologic findings of the lesion and also in the mode of submucosal infiltration.
    From these observations, the lesion of both ulcer and cancer associated with such reactive LH was considered as one of special types of ulcer and cancer in the stomach.
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  • Atsuo WAKABAYASHI
    1981 Volume 78 Issue 8 Pages 1568-1576
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The author studied the mechanism of gastrin release during insulin-induced hypoglycemia by 5 series of experiments using dogs; (1) control group, (2) truncal vagotomized group, (3) surgical sympathectomized group, (4) truncal vagotomized with surgical sympathectomized group, (5) bilateral adrenalectomized group. Each group consisted of 5 dogseach. And the highest adrenal eqinephrine secretion rate under insulin hypoglycemia was analyzed in 5 control dogs.
    Serum gastrin and plasma catecholamines were measured periodically before and after insulin. administration. There was a strong correlation between serum gastrin and plasma epinehrine responses except bilateral darenalectomized group. In that group, both serum gastrin and plasma epinephrine responses were significantly suppressed.
    In the other experiments, epinephrine was infused intravenously in amounts of the highest adrenal epinephrine secretion rate. There was a significant correlation between serum gastrin response and plasma epinephrine concentration. Propranolol eliminated the gastrin response to epinephrine, and POB caused no alteration.
    Thus, the author concluded that the release of gastrin during insulin-induced hypoglycemia is mainly intermediated by epinephrine secreted from the adrenal glands.
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  • Akira TERANO, Kazunori MATSUMOTO, Tatsuya MOTOKI, Satoru MURAO, Kazuo ...
    1981 Volume 78 Issue 8 Pages 1577-1584
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Effects of 16-16-dimethyl-prostaglandin E2 (PGE2), cimetidine (CIM) and geranyl-geranylacetone (GGA) on acetyl salicylic acid (ASA) or taurocholic acid (TCA) induced-gastric mucosal damage were investigated in the rat gastric chamber. PGE2, CIM and GGA significantly inhibited the decrease of potential difference of gastric mucosa caused by ASA or TCA. They also depressed the increase of ion flux of H + and Na + in ASA or TCA-induced gastric mucosal damage. Electron microscopic study revealed that PGE2 CIM and GGA reduced the changes of junctional complexes of gastric surface mucous cells induced by ASA or TCA. Results of these experiments indicate that PGE2, CIM and GGA protect the rat gastric mucosa from the damage caused by ASA or TCA and that their influences on the junctional complexes of gastric surface mucous cells might contribute to these protective effects.
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  • A Double Blind And Grossover Clinical Trial
    Sunao HAMABE, Yasuhisa SHINOMURA, Shuichi TAKAHASHI, Masanori KUROKAWA ...
    1981 Volume 78 Issue 8 Pages 1585-1592
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Two kinds of duuble blind and crossover clinical trials were performed in order to determine the usefulness of glucagon for upper gastrointestinal radiography. 9 healthy volunteers received inactiveplacebo and 1 mg of glucagon intramuscularly preceding the radiographic examination of the upper gastrointestinal tract. Glucagon showed a significantly inhibitory effect on the motility of the gastrointestinal tract. Subsequently, 28 aged subjects ranging from 64 to 90 years (average: 77 years) were alternately given 1 mg of glucagon and 20 mg of butylscopolamine bromide intramuscularly prior to the upper gastrointestinal radiography. When glucagon was given, there was a marked inhibitory effect on the motility of the gastrointestinal tract equivalent to butylscopolamine bromide, yet with fewer side effects. It is concluded that the use of glucagon provides a safer premedication in the examination of the upper gastrorintestinal tract than butylscopolamine bromide in the aged.
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  • Yasunori NUNODE, Osamu MASAMUNE, Hisashi MATSUMOTO, Saburo OHSHIBA
    1981 Volume 78 Issue 8 Pages 1593-1598
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The purpose of this study is to evaluate the fecal fat determination newly deviced. The content of fat in the feces is usally expressed as grams per day. In order to obtain the representative daily output of fat, collection must be complete and must be made over a considerable period of time. In order to reduce the necessity for complete collections, we used continuous fecal markng with radioopaque pellet (ROP) or polyethylene glycol (PEG). These substances were given after each meals and the fat of a single stool sample was corrected from the number of ROP or the value of PEG in the stool to express the daily fecal fat. There was colse correlation between the fat of a single stool sample corrected by ROP or PEG and that obtained from a full 4-day balance study. Therefore, we assessed the reliability of estimating fecal fat output on a single stool by correction by ROP or PEG.
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  • Nobuyuki HAYASHI, Kimitomo MORISE, Shunji OHDATE, Hisakazu NISHIKAWA, ...
    1981 Volume 78 Issue 8 Pages 1599-1605
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Complications of inflammatory bowel disease were studied in 35 patients with ulcerative colitis and 10 patients with Crohn's disease.
    Bowel complications included massive hemorrhage, toxic megacolon, perforation, precancerous lesion, fistula formation, stenosis and anal lesions.
    Extra-intestinal complications included skin and mouth lesions, joint disorders, liver disease, anemis and hypoproteinemia.
    In ulcerative colitis, complications were more frequent with increasing severity and extent of disease.
    In Crohn's disease, hypoproteinemia was more frequent in patients with small bowel disease, while anal lesions were more frequent in patients with colonic involvement.
    Ulcerative colitis and Crohn's disease had most complications (intestinal or extra-intestinal) in common.
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  • Ko TANAKA, Hiroshi KAWAMURA, Noriaki TOHGI, Moriyasu TSUJI, Naoki HIRA ...
    1981 Volume 78 Issue 8 Pages 1606-1612
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In previous reports, we indicated that the high levels of Ascaris suum specific protein (ASP) were obtained in sera from approximately 40% of patients with ulcerative colitis. To investigate the possibility of the presence of immunologically ASP like substance in the colon, we measured the distribution of cross-reacting substance with ASP in rat organs using radioimmunoassay for ASP. The dilution curves of the cytosol extracts obtained from rat colon, small intestine and stomach mucosa, liver, kidney, lung and heart were all parallel to the standard curve of ASP, and it may suggest that the immunologically similar substance with ASP is present in these organs. The concentration of ASP like substance per gram tissue in colon mucosa was higher than that in other organs. The cytosol extract from rat colon mucosa was applied to Sephadex G-100 and ASP like immunoactivities were observed in the fractions identical with 125I-ASP. Polyacrylamide gel electrophoresis of these fractions demonstrated identical with ASP in terms of molecular weight and net charge.
    In conclusion, we demonstrated presence of ASP like substance in the rat colon and discussed the possibility that the immunologically similar substance with ASP might be released from inflammatory colon mucosa to blood stream in patients with ulcerative colitis.
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  • Takakatsu MATSUMURA, Nobuhiro SATO, Hideyuki FUSAMOTO, Sunao KAWANO, Y ...
    1981 Volume 78 Issue 8 Pages 1613-1617
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Using the TBA (thiobarbituric acid) test, the lipoperoxide levels were measured in needle biopsy specimens of human liver of patients with chronic liver diseases, and compared with the lipoperoxide levels in serum obtained on the day of biopsy.
    The levels of serum lipoperoxide were correlated with the levels of liver lipoperoxide in patients with normal liver, alcoholic fatty liver, chronic inactive hepatitis and liver cirrhosis with normoalbuminemia. This finding suggests that hepatic lipoperoxide is secreted into blood. However, in patients with chronic active hepatitis, and liver cirrhosis with hypoalbuminemia the values of serum lipoperoxide were not related to the values of liver lipoperoxide. The patients with alcoholic fatty liver showed remarkably high levels of liver lipoperoxide, which indicates the involvement of lipid peroxidation in the pathogenesis of alcoholic liver damage in men.
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  • Yasuni NAKANUMA, Yoshinori TANAKA, Goroku OHTA, Kenji DOISHITA
    1981 Volume 78 Issue 8 Pages 1619-1627
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    a-fetoprotein (AFP), al-antitrypin (AAT), ferritin and secretory component (SC) were examined in carcicnoma tissue of hepatocellular carcinoma (HCC) and cholangicocellular carcinoma (CCC) by peroxidase anti-peroxidase methok. AFP was demonstrated in 35.7% of HCC as either granular or inclusion form, but absent in CCC. AAT was more frequent in HCC (92.3%) than in CCC (33.3%), and a variety of the intra-and extracytoplasmic apperarance, such as granular, inclusion, luminal surface and intraluminal secretion form were found in HCC, but only the latter two in CCC. Ferritin was demonstrated as granular form in HCC (57.3%) as well as CCC (33.3%). SC was also found in HCC (57.3%) as well as CCC (83.3%). But, cytoplasmic and inclusion foums were frequent in CCC compared with HCC, in which secretion form was predominant. Sizes and degrees of defferentiation of HCC were not correlated with frequency of above mentioned 4 antigens in carcinoma tissues.
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  • Yasuhiro MIZOGUCHI, Yoshihide SAKAGAMI, Takashi SHIBA, Toshihiro HIGAS ...
    1981 Volume 78 Issue 8 Pages 1628-1634
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To elucidate the immunopathogenesis of intrahepatic cholestasis in acute viral hepatitis, the authors investigated the possible participation of cholestatic factor. The peripheral lymphocytes from patients with acute viral cholestatic hepatitis were stimulated with either HBs antigen or liver specific lipoprotein in vitro and the culture supernatant was fractionated by gel filtration using a Sephadex G-75 column. When a definitive fraction (fraction 4) was injected into the mesenteric vein of rats, a marked reduction of bile flow was observed.
    Similar results were obtained when blood serum of patients was fractionated in a identical manner and the same fraction was injected to rats via mesenteric vein.
    A dilated bile canaliculus with the diminution of microvilli and increased vesicles around the dilated canaliculi were observed in liver tissues by electron microscopy three hours after injection of the active fraction into rats.
    These results strongly suggest that not only the sensitized lymphocytes produce the cholestatic factor(s) which caused the intrahepatic cholestasis by specific stimulation, but also this factor involves significantly in the pathogenesis of intrahepatic cholestasis which observes in the patients with acute viral hepatitis.
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  • With Special Reference to ultrastructural Findings of the Liver
    Yoshitane KOSAKA, Masayoshi HAGIWARA, Shozo AKEDA, Yukihiko TAMEDA, Et ...
    1981 Volume 78 Issue 8 Pages 1635-1643
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Clinical features and histological studies of the liver were described in 6 patients with porphyria cutanea tarda. Patients were all men, age ranging from 41 to 61 years old. All patients had significant alchohol beverage, more than 80g per day for 15 to 35 years.
    The urinary and fecal excretions of porphyrins were increased in all cases. The peritoneoscopic findings revealed that on the liver surface there were blue spots at the site corresponding to the acinaous marking. Furthermore, typical red fluorescence was observed in liver specimen in all cases. Histologically, there were needle-like inclusion bodies present in the cytoplasma, which were recognized as the third type by electron microscopy. Smooth endoplasmic reticulum appeared hypertrophied and proliferated. Mitochondria were deformed and swollen. The most conspicuous and consistent finding was the presence of paracrystalline inclusion bodies and large electron-dense granules located in the mitochondria.
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  • Itsuo TAKAHASHI, Sinjin TAKEUCHI, Mitsuo NAKAYA, Takeshi NEGISHI, Zen ...
    1981 Volume 78 Issue 8 Pages 1644-1649
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Interdigestive contractile activity of the gallbladder, stomach and duodenum was measured by means of chronically implanted force transducers in 5 conscious dogs. During the interdigestive state, contractions of the gallbladder identified to be closely associated with the initial period of phase II of the interdigestive migrating contractions (IMC) in the duodemum. The contractile force of the gallbladder during this phase was 6.5±0.77 g, which corresponded to approximately 80% of the force of the postprandial contractions. Intravenous infusion of synthetic motilin induced IMC in the stomach and duodenum and during the initial period of motor response of the duodenum reproduced contractions in the gallbladder which were identical to the natural contractions as to their period and pattern.
    The present study clearly indicates that the gallbladder contracts even interdigestive state and the contractions are associated with the phase II contractions in the duodemum.
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  • DEFICIENT AND LOW PROTEIN DIET
    Kazuyuki NAGATA, Wataru YAMAMOTO, Yoshihisa WATANABE, Joichi ADACHI, M ...
    1981 Volume 78 Issue 8 Pages 1650-1657
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The authors made efforts to produce a new experimental pancreatitis in rats by DL-ethionine fed with a choline-deficient and low protein diet.
    1) A dose of 100mg/100g B. W. of ethionine was injected intrapertioneally twice a day at a 12-hour interval to rats raised on a choline-deficient 5% protein feed. Acute hemorrhagic-necrotic pancreatitis was presenting in the histological picture.
    2) A dose of 60mg/100g B. W. of ethionine was injected intraperitoneally to rats raised on a cholie-deficient 15% protein feed twice a day at a 12-hour interval and twice a week for 6 weeks. Histologically, the pancras was presenting a picture of mild chronic pancreatitis.
    3) Various types of pancreatitis ranging from mild to severe were induced by changing the protein content in the feed, the doses of ethionine injection and the administration period. The production of experimental pancreatitis in this time was more definitely and uniformly as compared with pancreatitis induced by ethionine only.
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  • Takeshi KURIHARA, Eiji KITAZAWA, Izumi SHIBATA, Sumie FUJIWARA, Yoshio ...
    1981 Volume 78 Issue 8 Pages 1658-1662
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Shigekazu HAYASHI, Ukio EMA, Kazuo ICHIKAWA, Eiji KOBAYASHI, Mitsumasa ...
    1981 Volume 78 Issue 8 Pages 1663-1667
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • T. KONNO, A. TAMAKI, A. KAKITA, [in Japanese], M. KANBAYASHI, N. SATO, ...
    1981 Volume 78 Issue 8 Pages 1668-1672
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Katsunori NAKATANI, [in Japanese], [in Japanese], [in Japanese], [in J ...
    1981 Volume 78 Issue 8 Pages 1673
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kanji MIENO, [in Japanese], [in Japanese]
    1981 Volume 78 Issue 8 Pages 1674
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yoshitane KOSAKA, [in Japanese], [in Japanese], [in Japanese]
    1981 Volume 78 Issue 8 Pages 1675
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Muneaki ABE, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1981 Volume 78 Issue 8 Pages 1676
    Published: August 05, 1981
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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