Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 79 , Issue 1
Showing 1-20 articles out of 20 articles from the selected issue
  • II. UDP-galactosyl transferase activity of human gastric mucosa in various gastric diseases
    Shin OKAMOTO
    1982 Volume 79 Issue 1 Pages 1-8
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    UDP-galactosyl transferase activity in biopsy specimens obtained from gastric mucosa (the greater curvature of body, the angle and the greater curvature of antrum) and duodenal mucosa by using endoscope was determined, in various gastric diseases. The biosynthesis of mucosal glycoprotein as a defensive factor was discussed. The level of the enzyme activity was similar (189.7-202.8 U./kg protein) among the three of gastric regions in normal. The enzyme activity was high in the specimen from antrum of gastric ulcer subjects at scarring stage, antrum of erosive gastritis subjects and both antrum and duodenum of duodenal ulcer subjects. The enzyme activity was also high in level in the margin of the gastric ulcer at open stage, while it decreased at scarring stage. It suggested that glycosylation or biosynthesis of the mucosal glycoprotein which was one of the defensive factors was stimulated in these regions. In the atrophic gastritis, the enzyme activity was decreased in the specimen from body and the enzyme activity was increased in the three of gastric regions in gastric carcinoma.
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  • Masayoshi HASHIMOTO
    1982 Volume 79 Issue 1 Pages 9-17
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The relationship between growth potency and alkaline phosphatase activity of intestinal metaplasia of human stomach was studied using enzyme histochemical and autoradiographic technique.
    Both alkaline phosphatase positive and negative glands were seen in the intestinal metaplasia.
    Two types of alkaline phosphatase positive glands were observed, one in which alkaline phosphatase positive cells were distributed from the lower part to the surface of the gland and the other in which alkaline phosphatase positive cells were localized only at the surface of the gland.
    3H-Thymidine labelled cells in the former gland were localized only at the bottom but the labelled cells in the latter were distributed in the lower part of the gland.
    3H-Thymidine labelled cells in alkaline phtsphatase negative gland were distributed from the bottom to middle part of the gland.
    These results imply that the intestinal metaplasia in which cell proliferative zone was localized at the bottom of the gland showed alkaline phosphatase activity just like the activity in the small intestine, however the gland in which the cell proliferative zone was prolonged showed the alkaline phosphatase activity different from the small intestine.
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  • Kimitomo MORISE
    1982 Volume 79 Issue 1 Pages 18-27
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The distribution and localization of immunoglobulin containing cells were studied using immunoglobulin-enzyme bridge method in gastric tissues with intestinal metaplasia and cancer.
    In antral mucosa, most of the immunoglobulin containing cells contained IgA as in other parts of the gastrointestinal tract.
    In the mucosa with intestinal metaplasia, there was a significant decrease in the number of both IgA and IgM containing cells. Also, the number of goblet cells had a negative correlation to that of IgA containgng cells.
    In the cancer tissues, immunoglobulin containing cells of all class decreased in number.
    In the normal mucosa adjacent to the cancer tissue of poorly differentiated type, there was an increased number of IgA containing cells, whereas no change was noted in the comparative site adjacent to that of the well differentiated type. These findings suggest the difference in the mode of local reaction to the cancer erosion in the two different types of cancer.
    In addition, a remarkable increase of IgG containing cells in the cancer tissue in one case of Borrmann IV cancer suggests the presence of an immune reaction directed against cancer.
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  • TOMY WITH PARTICULAR REFERENCE TO INTRALUMINAL PANCREATIC ENZYMES
    Hisashi MATSUMOTO, Osamu MASAMUNE, Yasunori NUNODE, Keiko MASAKI, Juni ...
    1982 Volume 79 Issue 1 Pages 28-37
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    This study was designed to investigate pathogenesis of malabsorption encountered in cases with total gastrectomy from the standpoint of intraluminal pancreatic enzymes. Studies were carried out on 7 controls and 21 cases of total gastrectomy consisting of 16 cases with double tract reconstruction and 5 cases with Roux-en Y reconstruction. Nutritional status was evaluated from the value of RBC, Hb, total protein, albumin, total cholesterol and triglyceride as well as changes of the body weight. BT-PABA test was performed by methods of two different administrations; one was with 5g of D-xylose (method I) and the other with test meal containing 12 g of protein (method II). Urine was collected every one hour for six hours after administration of BT-PABA, and PABA was measured by method of Brotton and Marshall modified by Smith. Daily fecal fat and nitrogen were measured by method of van de Kamer and semimicroKjeldahl, respectively.
    Following results were obtained;
    1) Though loss of the weight was found in most of the cases with total gastrectomy, total protein, albumin and total cholesterol remained normal.
    2) Daily fecal fat and nitrogen were 9.2±1.6g and 2.7±0.3g in double tract reconstruction, 16.7±2.1g and 3.0±0.6g in Roux-en Y reconstruction, respectively. Fecal fat outputs were statistically different between two types of reconstruction.
    3) In BT-PABA test done by method I, no differences were found in the total urinary PABA excretion between controls and total gastrectomy, though the patterns of hourly urinary PABA excretion were different. While, urinary PABA excretion significantly reduced in the cases with total gastrectomy in BT-PABA test done by method II because of the reduction in the urine collected at 1 and 2 hr after administration of BT-PABA. The grade of reduction was more remarkable in the cases of total gastrectomy of Roux-en Y reconstruction. This indicated that deficiency of intraluminal pancreatic enzymes occurred especially in total gastrectomy of Roux-en Y reconstruction.
    4) Fecal fat was compared to BT-PABA test done by method II. In 3 cases who excreted normal fecal fat, total urinary PABA excretion was also normal. While, among 18 cases whose fecal fat excretion increased, 13 cases exhibited low value of total urinary PABA excretion.
    This results indicated that fat malabsorption was mainly caused by deficiency of intraluminal pancreatic enzymes. However, the remaining 5 cases showed normal urinary PABA excretion. Therefore, this also means that many factors more than deficient pancreatic enzymes should be considered as pathogenesis of malabsorption encountered in total gastrectomy.
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  • Nobuyoshi OKUMURA, Tesuo HAYAKAWA, Aiji NODA, Takaharu KONDO, Akira SA ...
    1982 Volume 79 Issue 1 Pages 38-45
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Pancreatic endocrine function was studied in 25 patients with liver cirrhosis, 20 with chronic hepatitis and 12 healthy controls. The responses of plasma insulin (IRI) and C-peptide (CPR) to 50g oral glucose (GTT) were significantly increased in the liver diseases, when compared with those in healthy controls. In the liver diseases, degree of IRI response was greater than that of CPR.
    In the fasting state, plasma pancreatic glucagon (IRG) of the patients with liver diseases was correlated with BSP retension rate, and inversely with ICG disappearance rate. After GTT, the levels of IRG were significantly suppressed from basal level in chrosic liver diseases as well as in healthy controls. In the liver diseases, degree of IRG suppression was correlated with fasting levels of IRG.
    Hyperfunction of pancreatic β cell to oral glucose load is observed in chronic liver diseases. However, hyperinsulinemia in chronic liver diseases results probably from both pancreatic β cell hyperfunction and decreased degradation of insulin. Hyperglucagonemia in chronic liver diseases is related to liver dysfunction, but the sensitivity of pancreatic α cell to glucose is preserved.
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  • Kendo KIYOSAWA, Yoshihiro AKAHANE, Yuriko KOIKE, Nobuyoshi YAMAMURA, T ...
    1982 Volume 79 Issue 1 Pages 46-54
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Seventy patients of non-A, non-B post-transfusion hepatitis (NANB-PTH) were prospectively followed to clarify the prognosis of them, and also 406 patients of non-A, non-B chronic liver diseases (NANB-CLD) were analysed retrospectively in order to know the implication of blood transfusion in these diseases.
    Out of 70 NANB-PTH patients, 45 cases (64.3%) showed abnormal transaminase levels over 6 months from the onset. In 15 cases among these with prolonged clinical course, liver biopsies were performed repeatedly. Five cases revealed a progression to chronic active hepatitis, 5 cases to chronic persistent hepatitis and the other cases showed unresolved hepatitis or nonspecific reaction.
    In a retrospective study of NANB-CLD, 121(42.8%) of 283 with chronic hepatitis (CH), 26(37.1%) of 70 with liver cirrhosis(LC) and 7(13.2%) of 53 with hepatocellular carci-noma(HCC) had a history of blood-transfusion. The mean intervals from blood-transfusion to entablishment of the diagnosis of NANB-CH, NANB-LC and NANB-HCC were 13.6±8.1, 17.8±10.3 and 23. 7±7.0 years, respectively.
    A representative case with NANB-PTH who developed HCC through CH and LC for 19 years was reported.
    These data indicate that blood-transfusion plays one of the main factors in NANB-CLD, especially in CH and LC.
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  • Akira IWATA
    1982 Volume 79 Issue 1 Pages 55-63
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To clarify the etiologic relationship between hepatitis and cytomegaloviral (CMV) infection, the titers of CMV-complement-fixation (CF) antibody, IgG antibody for late antigen (LA), IgG antibody for early antigen (EA) and IgM antibody for membrane antigen (MA) were measured in the sera from 69 patients with acute hepatitis, 43 patients with chronic active hepatitis, 33 patients with liver cirrhosis and 36 normal subjects.
    High titers of CMV-CF, LA and EA antibodies were more common in the patients with viral hepatitis than in healthy subjects. In comparing the HBsAg negative group with the positive group in acute hepatitis, EA antibody was detected more often in the HBsAg negative group than in the positive group. From these results it is suggested that some cases of viral hepatitis, especially those of acute hepatitis without HBsAg, may be related to CMV infection.
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  • Shotaro SAKISAKA
    1982 Volume 79 Issue 1 Pages 64-71
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Rat liver hepatocytes isolated by perfusion with collagenase were divided into two groups light hepatocytes (LH) and heavy hepatocytes (HH).
    The following parameters were measured: mean density-LH 1.10, HH 1.13, mean cell volume (MCV) -LH 3550μm3, HH 3250μm3, G-6-Pase peak-HH higher than LH.
    The electron microscopic morphometry revealed higher volume density of mitochondria in HH. The electron microscopic morphometry also revealed higher volume density of SER in LH.
    Allyl alcohol, known to produce cellular necrosis primarily of periportal hepatocytes, markedly reduced the viability of cultured HH, while the effect on cultured LH was less marked.
    These results suggest that LH are derived primarily from pericentral-vein hepatocytes and HH from periportal hepatocytes.
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  • Makoto KASAJIMA
    1982 Volume 79 Issue 1 Pages 72-82
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Epidemiological studies of HB virus infection, (serum HBsAg and anti-HBsAb detection) were carried out on 15, 600 patients at the Kanazawa Medical University who came from two different areas, Kahoku Lake area and non-Kahoku Lake area in Ishikawa prefecture. The study showed that HBsAg positive rate in Kahoku Lake area was clearly higher than that in non-Kahoku Lake area. Especially the positive rate in the older area of Uchinada-machi which is the main part of Kahoku Lake area was very high (7.3%). Anti-HBsAb positive rate and HB virus infection rate in the older area of Uchinada-machi were 22.2% and 29.5%, respectively. These values were significantly higher than those in the newly developed area of Uchinadamachi not included in Kahoku Lake area and those in the other parts of Ishikawa prefecture.
    These results suggest that the older area of Uchinada-machi is one of the most heavily HB virus infected areas in Japan. And high positive rate of HBsAg in this area may result in an increase of liability to HB virus infection and to becoming HBsAg carriers.
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  • Tomohiko TANI, Takashi SUZUKI, Takayoshi TOBE
    1982 Volume 79 Issue 1 Pages 83-92
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Preoperative angiograms of 144 patients with pancreatic carcinoma and 70 patients with hepatocellular carcinoma were analyzed in relation to mode of tumor growth and clinical course.
    Pancreatic carcinoma was classified as the expansive or the infiltrative group on the basis of changes in the wall of the pancreatic arteries seen on the angiograms. Hepatocellular carcinoma was also classified as the expansive, the infiltrative or the mixed group on the basis of displacement of the arteries around the lesion and distribution of tumor vessels.
    The tumor growth seen in laparotomy was closely correlated with the patterns of the preoperative angiograms. Pancreatic carcinomas of the expansive group proved to be larger than those of the infiltrative group, but less invasive to the surrounding tissues. The tumors in the expansive group were liable to extend as the from of liver metastases, while those in the infiltrative group often showed peritoneal dissemination. Of the hepatocellular carcinomas, most of those in the expansive group had a coronary lucent rim showing encapsulation of the tumor. An A-P shunt was less commonly seen in the expansive group than in the infiltrative and the mixed groups.
    Resectability and prognosis were better in the expansive group of pancreatic and hepatocellular carcinoma than in the infiltrative group.
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  • Akihiro MIZUGUCHI, Mamoru FUJII, Takero NAKAGOMI, Kazuhiko OKABE, Hiro ...
    1982 Volume 79 Issue 1 Pages 93-96
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tsutomu MATSUZAKI, Ryuji AKIYAMA, Masashi SUGIYAMA, Motoyasu KUSANO, R ...
    1982 Volume 79 Issue 1 Pages 97-101
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kenji TAKAHASHI, Masahiro ASAKA, Kiyoshi NAGASE, Masao SAITO, Tamotsu ...
    1982 Volume 79 Issue 1 Pages 102-106
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 79 Issue 1 Pages 107-111
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Akira UEDA, Osamu MIYANAGA, Hiromi ISHIBASHI, Hideo OKUBO
    1982 Volume 79 Issue 1 Pages 112-116
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tadao TAGUCHI, Takashi SHINAGAWA, Kazuo ISHIHARA, Akio KONNO, Kunio OK ...
    1982 Volume 79 Issue 1 Pages 117-120
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yuichi FURUTA, [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 79 Issue 1 Pages 121
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Akiyoshi DAN, [in Japanese], [in Japanese]
    1982 Volume 79 Issue 1 Pages 122
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • H. TSUBOUCHI, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1982 Volume 79 Issue 1 Pages 123
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], Kazuhiko O ...
    1982 Volume 79 Issue 1 Pages 124
    Published: January 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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