Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 79 , Issue 10
Showing 1-20 articles out of 20 articles from the selected issue
  • The Possiblity of Application of Nffedipine to Achalasia
    Michio HONGO, Michio HONGO
    1982 Volume 79 Issue 10 Pages 1883-1891
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Calcium-antagonists causes smooth muscle relaxation by the prevention of intra-cellular influx of calcium ions. In this study, the effects of calcium-antagonists on lower esophageal sphincter pressure(LESP)were investigated both basically and clinically. In the study of basic investigation using anesthetized dogs, nifedipine, verapamil and diltiazem decreased resting LESP and inhibited the rise ofLESPby tetragastrin or bethanechol. In the clinical experiment, author intended to apply the depressant effect of calcium-antagonists to LESP-increased state, achalasia, nifedipine which is able to administer sublingually was investigated in achalasia patients. By the administration of nifedpine, LESPof achalasia patients were decreased and the symptoms were relieved. Therefore, nifedipinewill be a possible aid of medical treatment of achalasia.
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  • Miyako BABA, Makoto ICHII, Masaharu TATSUTA, Shigeru OKUDA, Tadao ITOH ...
    1982 Volume 79 Issue 10 Pages 1892-1897
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Relation of serum catecholamines and gastrin secretion was investigated in 6 patients with pheochromocytoma. Serum catecholamines were measured with a high performance liquidchromatography developed in our clinic.
    Results indicate that serum gastrin levels in the basal state and in response to a liquid test meal were significantly higher in patients with pheochromocytoma secreting adrenaline as well as noradrenaline, than in those with a tumor secreting noradrenaline alone. In patients with a tumor secreting adrenaline as well as noradrenaline, the surgical removal of a tumor resulted in a significant decrease in serum catecholamines and serum gastrin levels in the basal state and in response to a test meal.
    Experimental results of rats also indicate that adrenaline-stimulated gastrin secretion in the basal state and in response to a test meal was completely suppressed by propranolol, a betaadrenergic receptor blocking agent.
    It is concluded that beta-adrenergic mechanism are involved for the rise in serum gastrin in the basal state and in response to a test meal.
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  • (6th Report) Effect of Gefarnate on Mucosal Prostaglandins
    Tetsuo ARAKAWA, Hajime NAKAMURA, Hiroshi SATOH, Shinji CHONO, Hiroaki ...
    1982 Volume 79 Issue 10 Pages 1898-1903
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Prostaglandins (PGs) represent an important part on the gastric mucosal protection. We investigated whether an antiulcer agent, gefarnate, stimulate endogenous PGs in rat gastric mucosa. In water-immersion rats, gefarnate (100mg/kg/day, s.c.×7) increased the mucosal PGE2, PGI2 and PGF2α levels compared with controls. The agent also increased hexosamine in the mucosal tissues. These results suggest that stimulation of mucosal PGs, particularly E2 and I2 type, and the ensuing gastric protection are the major action of this agent.
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  • Analysis of Patients by Reflectance Spectrophotometry
    Masuki FUKUDA, Sunao KAWANO, Nobuhiro SATO, Hideyuki FUSAMOTO, Takenob ...
    1982 Volume 79 Issue 10 Pages 1904-1910
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Gastric mucosal hemodynamics and oxygen sufficiency were studied by reflectance spectrophotometry during gastrofiberscopy. The spectra were taken from the gastric mucosa at 20 regions of 42 patients with gastric ulcer and of 51 patients with no gastric lesion. The mucosal blood volume and oxygen saturation of hemoglobin were estimated from the spectra. In patients who had active gastric ulcer, the mucosal blood volume decreased significantly at almost all regions in the stomach. With healing of the gastric ulcer, the mucosal blood volume increased to the same level as that of the control. At the margin of ulcer, the mucosal blood volume increased significantly during the healing stage, and returned to the level as that of the control at the scarring stage.
    On the other hand, the estimated oxygen saturation of Hb was not changed in the presenceof gastric ulcer.
    From these results, it is suggested that the presence of gastric ulcer effects on the gastricmucosal hemodynamics and this hemodynamic changes may also effect on the cell functions.
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  • III. Histological and Histochemical Studies on Transplantable Human Signetring Cell Carcinoma in Nude Mice
    Nobuyuki MIYAGA, Yoichi KONISHI, Katsunori NAKATANI, Tomomichi EZAKI, ...
    1982 Volume 79 Issue 10 Pages 1911-1917
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Histological and histochemical studies were made on human signet-ring cell carcinomas transplanted serially into BALB/cAJcl-nu male nude mice. The transplantability was 100% and the serial transplantation is now the 19th passage. The tumor growth became rapid by serial transplantation and the doubling time was 16.8±7.7 days at the fist passage and it became shorter as 8.1±1.4 days. The histology of signet-ring cell carcinoma was retained in nude mice. The signet-ring cell carcinoma secretes mainly non-sulfated acid mucin and little sulfated acid mucin. The secreting function of the acid mucin by the signet-ring cell carcinoma has been maintained in nude mice.
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  • Chiyuki NAKANOME, Hiroaki AKAI, Takayoshi TOYOTA, Yoshio GOTO, Kanji K ...
    1982 Volume 79 Issue 10 Pages 1918-1923
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Motilin has been investigated in relation to gut motility, however, the effect of gut hormones on the release of motilin has not been fully elucidated: We have, therefore, investigated the effect of glucagon on the release of motilin in normal subjects and the patients with peptic ulcer. Intravenous administration of glucagon caused a decrease of plasma motilin concentrations dosedependently. In addition, glucagon inhibited the release of motilin induced by test meal ingestion or intraduodenal acidification in normal subjects. In patients with gastric ulcer or duodenal ulcer, a decrease of plasma motilin concentrations by glucagan infusion was observed, on the contrary, a marked increase of plasma motilin concentrations, "paradoxical response", by glucagon infusion was found in the patients with Zollinger-Ellison syndrome.
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  • Especially, Emphasis on Sequential Observations by Endoscopy and X-ray
    Takashi OIDA, Saburo NAKAZAWA
    1982 Volume 79 Issue 10 Pages 1924-1934
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Chemical carcinogen, DMH was administered subcutaneously in rats to investigate the incidence and the pattern of development of colonic cancers. The changes of cancers were observed by successive endoscopic and X-ray examinations. The incidence and the development of cancers depended on the period of DMH administration. In the rats administered for 28 weeks, lymphatic metastasis, peritoneal dissemination and liver metastasis were recognized. Sequential endoscopic examinations revealed that the forms of colonic tumors changed from small elevation to flat elevatipn, dome shape, and elevatipn with central depression fainally. As tumors grew, such changes as redness, erosion and hemorrage were frequently found on their surface. The X-ray examination was not so usefull for observation of sequential changes, but relativelly usefull to diagnose extraluminal tumor. It may be concluded that the present study disclosed the incidence and the process of DMH induced colonic cancers.
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  • Its Significance in Increased Serum γGTP Activity After Ethanol Feeding
    Yoko EBIHARA
    1982 Volume 79 Issue 10 Pages 1935-1943
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Serum γGTP activity is known as a sensitive marker for the detection of alcoholism, but the mechanism of its elevation remains to be elucidated. Since intestinal tissue contains considerable amount of γGTP, we wondered if intestinal γGTP activity is affected by ethanol, contributing to the elevation of serum γGTP activity. To that effect, male rats were pair-fed by nutritionally adequate liquid diet containing either ethanol (36% of cal.) or isocaloric carbohydrate (controls.) After 6 weeks ethanol feeding, serum γGTP activity was moderately increased. Moreover, intestinal γGTP activity was enhanced by 46% expressed per gram of intestinal mucosa. After ethanol, increased γGTP activity was found histochemically in brush-border and submucosal lymphatics. Furthermore, electronmicroscopic observation revealed that intestinal γGTP was localized in plasma membrane and endoplasmic reticulum. To further analyse possible contribution of intestinal γGTP to serum enzyme activity, we introduced cannula into intestinal lymphatic channel near cisterna chyli and lymph was collected continuously for up to 4 hours. In ethanol-fed rats, intestinal lymph γGTP concentration increased by 83% and this was more than doubled when expressed as output per hour. Moreover, diversion of intestinal lymph resulted in a significant decrease in serum γGTP activity. These results suggest that enhanced intestinal γGTP activity contributes, at least partly, to the elevated serum enzyme activity after ethanol.
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  • -Falsepositive Reaction Due to Non-hemoglobin Proteins in the Tests with An Anti-crude Hemoglobin Antibody
    Hiroshi SAITO, Shigeki TSUCHIDA, Hiroshi FUJITA, Sinsaku FUKUDA, Tadas ...
    1982 Volume 79 Issue 10 Pages 1944-1949
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To develop an immunological test for fecal occult blood, we studied the specificities of rabbit antibodies against crude hemoglobin preparation by Drabkin's method, against purified HbAo preparation by Williams' method, and Hemoccult test.
    The antibody against crude hemoglobin (anti-cHb) reacted with erythrocytic non-hemoglobin proteins (NHP) as well as hemoglobin. The antibody against purified hemoglobin (anti-HbAo) did not react with NHP, bovine, chicken, nor with sheep blood in double immunodiffusion. To gain higher sensitivity to detect hemoglobin in stools, we employed counter immunoelectrophoresis (CIEP). Anti-HbAo also did not react with NHP, nor with these animal blood in this method.
    We examined the specificity of CIEP with anti-HbAo in stools from two groups. One is 11 patients with no gastrointestinal bleeding diagnosed by roentgenologic and endoscopic examinations (Group 1), and the other in 24 healthy asymptomatic adults younger than 30 years old (Group 2). Group 2 had 6 positives in Ouchterlony method with anti-cHb. By Hemoccult test, 1 and 2 positives in Group 1 and 2, respectively. By CIEP with anti-HbAo, there was no positive reaction in 2 groups. The positive reactions in Ouchterlony method with anti-cHb were shown to be derived from contaminating substances in stool, which were antigenically identical with NHP. This shows that specific antibody against purified hemoglobin must be used for immunological occult blood test.
    CIEP is rapid and easy to test, which is expected to be useful in screening for colorectal cancer.
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  • Factors Affecting the Clinical Assessment of Alkaline Phosphatase Isozymes
    Takashi KANNO, Mitsuhisa MANABE, Kayoko SUDO
    1982 Volume 79 Issue 10 Pages 1950-1954
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The kinetic properties of four alkaline phosphatase (ALP) isozymes were investigated in order to clarify the causes of the apparent variability of the serum ALP activities as determined with five conventional methods. Liver, intestine and placental ALP which had been purified 150-300 fold from human tissues and a diluted serum with elevated bone ALP were used in this study. All four ALPs showed simillar v/Vmax. ratios in the same assay system despite of the slight variation between the methods. On the other hand, the apparent substrate specificities of these enzymes, especially intestinal ALP were significantly different. The relative hydrolysis rate of intestinal ALP for p-nitrophenylphosphate was less than 30% as compared with liver or bone ALP which proved the same activities as intestinal one in Kind-King method. These results indicated that the elevation of the serum intestinal ALP in the pathological states could not be detected sensitively enough by the methods using p-nitrophenylphosphate as substrate, i.e., SSCC and GSCC recommendation methods, etc. We conclude that the substrate for the standard method in clinical field must be established on the basis of the clinical and biological aspects of these isozymes.
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  • Kazuichi OKAZAKI, Fuminori MORIYASU, Yuzo KANEMATSU, Satoru MATSUSUE, ...
    1982 Volume 79 Issue 10 Pages 1955-1961
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yashushi OHTSUYAMA
    1982 Volume 79 Issue 10 Pages 1962-1969
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Serial serum AFP changes were studied in 42 patients with chronic hepatitis and in 77 patients with liver cirrhosis in whom hepatocellular carcinoma was detected in 21 cases during the follow-up course. Observation periods were one to six years long, and serum AFP determinations were carried out at intervals from two to four weeks. The change of AFP were classified into 4 patterns. The elevation of the AFP correlated with the rise of serum aminotransferase, and regeneration of liver cells following liver damage was the most causative factor of the elavation of serum AFP in chronic hepatitis. Interpretation of AFP change in liver cirrhosis was more complex; it seemed that the deteriorated clearance of serum AFP was another mechanism besides liver cell regeneration. The rate of development to hepatocellular carcinoma in liver cirrhosis was highest in group with "spiky elevations in low level fluctuation", however, it was noteworthy that highest numbers were found in group with "changes within normal range".
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  • Jinichi Nei
    1982 Volume 79 Issue 10 Pages 1970-1976
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Fifteen heavy drinkers with histological features of chronic hepatitis were studied. Chronic hepatitis observed in heavy drinkers can be divided into 2 subgroups of improved and unimproved cases according to the changes of serum GOT and γ-GTP activities. Clear decreases of both enzyme activities were observed in 9 cases of the improved group, but not in the 6 cases of the unimproved group. The improved group revealed clear improvement of other clinical features following abstinence as well as significantly high GOT/GPT ratios and high glutamate dehydrogenase activities on admission. Leucocyte migration inhibition test by ethanol was more frequently positive in the improved group of chronic hepatitis than in the other types of alcoholic liver injury. Histological characteristics of the liver in the improved group included the coexistence of features of both chronic hepatitis and alcoholic fibrosis. Three out of 4 cases of the improved group developed cirrhosis or precirrhosis during the follow up period. These results suggest that the improved group of chronic hepatitis in alcoholics is one type of alcoholic liver diseases with immunopathological etiology. It is a step toward the development of liver cirrhosis.
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  • Keisho KATAOKA, Kei KASHIMA, Yuji HORII, Katsuhiko KINUGASA, Yasuaki I ...
    1982 Volume 79 Issue 10 Pages 1977-1985
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to evaluate ultrasonographic changes of the pancreas with aging, the size, the parenchymal echo and the duct of the pancreas were investigated in 526 subjects free of pancreatic diseases.
    The maximal anterior-posterior diameter of the pancreas was measured respectively at head, body and tail under real-time observation using the linear electronic scanner. The sizes of three parts of the pancreas significantly decreased with aging.
    The parenchymal echo of the pancreas showed a homogeneous and obviously higher echogenecity compared with one of the liver in elders, and the increased parenchymal echogenecity was seen more frequently with aging.
    The ultrasonographic ability of visualization of the pancreatic duct significantly decreased with aging, however, any significant change was not found in the diameter or the margin of the pancreatic duct.
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  • Report of a case successfully resected
    Shigeru TANAKA, Eizo OKAMOTO, Keiji KUWATA, Akihiro TOYOSAKA, Shuichi ...
    1982 Volume 79 Issue 10 Pages 1986-1990
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Akira SAKAGUCHI, Toichi TAJIRI, Yoshiki SHIMA, Shohei NISHI, Shingo NI ...
    1982 Volume 79 Issue 10 Pages 1991-1994
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kiyoshi WATNABE, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1982 Volume 79 Issue 10 Pages 1995
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hajime NAKAMURA, [in Japanese], [in Japanese]
    1982 Volume 79 Issue 10 Pages 1996
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Norio TANI, [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1982 Volume 79 Issue 10 Pages 1997
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasuyuki ARAKAWA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1982 Volume 79 Issue 10 Pages 1998
    Published: October 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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