Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 79 , Issue 5
Showing 1-17 articles out of 17 articles from the selected issue
  • Seiji NOMIYAMA, Bunzo NISHIOKA, Takashi ISHII, Kenji NAKAMURA, [in Jap ...
    1982 Volume 79 Issue 5 Pages 1073-1083
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to investigate the effects of vagotomy on gastrin (G) and somatostatin (D) cell population of a stomach and proliferation kinetics of G-cell, a quantitative analysis of G- and D- cell on truncal vagotomized rats was performed in comparison with that of control rats, by mean of immunoperoxidase identification technique combined with 3H-thymidine autoradiography. A radioimmunoassay was also performed to estimate the serum gastrin concentration both in the vagotomized rats and control rats. The results obtained as follows:
    1) The basal serum gastrin values were significantly higher in vagotomized rats than control rats.
    2) The total number of G-cells in a vagotomized stomach was more than in a control stomach, because the concentration of G-cell per unit mucosal surface did not become higher, but the extent of antral mucosal area became larger after the vagotomy.
    3) The total number of D-cell both in corpus and antrum of a vagotomized stomach was significantly more than that of a control stomach.
    4) It was suggested that a few percent of G-cells have a self-replicating activity and this activity was increased after the vagotomy, from the results that the laveling indices of 3Hthymidine flash lavel were 0.50-0.53% in control rats, 0.87-1.4% in the vagotomized rats.
    5) It was thought that G-cell reproduction from immature gererative cells in the crypt was increased after a vagotomy from the results of 3H-thymidine cummurative autoradiographic studies.
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  • Iwao SASAKI, Jinichi KAMEYAMA, Mikio IMAMURA, Toshio SATO
    1982 Volume 79 Issue 5 Pages 1084-1089
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In two dogs provided with Heidenhain pouch, we studied the effect of antrectomy and ingestion of H2-receptor antagonist on acid secretion, serum secretin levels and serum gastrin levels after a test meal with a simultaneous ligation of the bile and pancreatic ducts.
    Gastric hypersecretion was observed in antrectomised dogs after the ligation and abolished by ingestion of H2-receptor antagonist. Serum secretin levels elevated after the ligation and returned to the control levels by ingestion of H2-receptor antagonist. Serum gastrin levels were kept under 20pg/ml in these experiments. These results suggest that gastric hypersecretion induced by a simultaneous ligation of the bile and pancreatic ducts is not simply due to release of antral gastrin and hypersecretinemia may be secondary to gastric hypersecretion.
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  • Takahiko SATOMI
    1982 Volume 79 Issue 5 Pages 1090-1097
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The concentration of bile acids in the stomachs of patients with peptic ulcers were determined, and the results were assessed in comparison with 1) the degree of deformity of the duodenal bulb and/or the pyloric ring (hereafter to be abbreviated as the bulb and the pylorus, respectively) 2) the extent of gastric erosion observed by endoscopy, and 3) the progress of chronic gastritis found histologically in the resected stomach. Bile acid concentrations were higher in many patients with peptic ulcers than those found in normal subjects, and the difference was significant (23 patients out of the total 43, p<0.01).
    It was also observed that the greater the deformity of the bulb and/or the pylorus in the cases of duodenal ulcer and of coexisting gastric and duodenal ulcers, the higher the levels of bile acid concentrations in many cases, and also the more severe the general chronic gastritis observed. The incidence of erosion was higher in cases of duodenal ulcer, and it was observed to correlate strongly with maximum gastric acid output.
    From these results it was suggested that deformity of the bulb and the pylorus is associated with breakdown of the protective mechanism against regurgitation, and that the increase in the reflux of bile acids into the stomach is one of the factors contributing to chronic gastritis.
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  • Masao ICHINOSE, Kazumasa MIKI, Chie FURIHATA, Takashi KAGEYAMA, Hirohu ...
    1982 Volume 79 Issue 5 Pages 1098-1105
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    A radioimmunoassay for human Group I pepsinogens (PG I) in serum was developed, using PG I purified from gastric mucosa. 1) Sensitivity of the assay was in the order of 0.7ng per ml of serum and optimal assay range was 2.5 to 50ng per ml. 2) The mean±S.D, of serum PG I levels in normal controls was 43.9±24.9ng/ml. There was no statistically significant difference between normal controls and patients with gastric erosions. 3) Patients with peptic ulcer had increased levels of serum PG I. The gradient for serum PG I levels among peptic ulcer patients was gastric ulcer, gastroduodenal ulcer and duodenal ulcer in the order of increasing magnitude. The latter two had significantly high levels (p<0.001), although the diagnostic ability of serum PG I for the existence of an ulcer was not so good as those reported by others, because of the large overlap with normal controls. 4) Patients with gastric polyp had significantly low serum PG I levels and overlap with normal controls was not large. Serum PG I levels seem to be of value in the diagnosis of gastric atrophy or intestinal metaplasia.
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  • Nobuo HIWATASHI, Hikaru WATANABE
    1982 Volume 79 Issue 5 Pages 1106-1114
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The fine structure of the mucosal true capillaries in ulcerative colitis (U.C.) was studied by electron microscopy and compared with the appearance of the capillaries in other colonic disorders, mainly morphometrically.
    In active U.C., most of endothelial cells showed marked swelling and ballooning, and erythrocytes were seldom found in capillary lumen. These changes suggest increased capillary resistence and decreased vascular flow, and this condition may be involved in microvascular insufficiency of the mucosa. Decrease of numbers of endothelial pinocytic vesicle per unit endothelial cytoplasmic membrane may show hypofunction state of the endothelial cell and replication of the basement membrane around capillaries is indicative of repeated cycles of degeneration and regeneration of endothelial cells.
    In remission of U.C., the almost changes mentioned above were between changes of active U. C. and them of irritable bowel syndrome.
    Consequently, microvascular insufficiency of the mucosa and the hypofunction state of the endothelial cells may be, at least in part, causes of continuous symptoms and tendency to relapses in U.C..
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  • Shujiro TAKASE
    1982 Volume 79 Issue 5 Pages 1115-1122
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    It has been well known that indocyanine green (ICG) is mainly bound to plasma lipoproteins and albumin. It has also been suggested that the binding pattern of ICG to plasma proteins might change according to the types of liver diseases.
    In the present study, plasma HDL, LDL and non-lipoprotein were fractionated by polyanion precipitation method and the distribution ratios of ICG bound to each protein fraction were calculated.
    HDL binding ICG showed, in various liver diseases, some characteristic changes, which suggested that estimation of HDL binding ICG would be very useful for the etiological diagnosis of fatty liver and the evaluation of both severity and prognosis of acute hepatitis and liver cirrhosis. It was also supposed that the changes in HDL binding ICG were not only quantitative changes of plasma HDL but also some qualitative, namely changes of the relative amount of apolipoprotein A-I, in HDL.
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  • Kazuo NAGOSHI, Akira NAKAHARA, Kazuo ORII, Takao OKAMURA, Toshiaki OSU ...
    1982 Volume 79 Issue 5 Pages 1123-1128
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Diagnostic accuracy of various kinds of hepatic angiography was analyzed in the resected 10 cases (15 nodules) of the primary carcinoma of the liver. By the celiac angiography, only 7 (4 cases ) out of 15 nodules (10 cases) were, detected and remaining 8 nodules were not detected. The sizes of these 8 nodules were less than 3cm in diameter and were located near the top of the liver near right diaphragm. These nodules were detected by the super selective hepatic angio graphy; proper hepatic, right hepatic, proper hepatic pharmacoangiography and proper hepatic slow infusion angiography. To detect all of the hepatoma nodules in the liver, proper hepatic or right hepatic and left hepatic angiography are principal.
    By the superior mesenteric arterial portography, abnormal portogram (Filling defect and stretching) were recognized in the big hepatoma which sizes were greater than 3cm in diameter. Superior mesenteric arterial portography is effective to detect the portal infiltration of the hepatoma.
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  • Yasuhiko SAMESHIMA, Yoshihiro MUTO, Masayuki UCHIMURA, Shinji WAKI, Te ...
    1982 Volume 79 Issue 5 Pages 1129-1136
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Department of Surgery, Hamamatsu Medical Center, Hamamatsu, Japan Thirty-seven cases of biliary anomalies (36 cases of congenital dilatation of the bile ducts with or without anomalous arrangement of the pancreatico-bile duct, 3 cases of anomalous arrangement of the pancreatico-bile duct without dilated bile duct) were treated for the past eight years.
    Among these cases, four cases were associated with gall bladder cancer and four, with bile duct cancer.
    This clinical evidence suggests that gall bladder cancer may also occur in high incidence (10%) as bile duct cancer (10%) in patients with these anomalies. On histological examination of these gall bladder with cancer, marked mucosal metaplasia (mucous gland and goblet cell metaplasia) was observed, and then this histologic study made us to suspect correlation of mucosal metaplasia and development of carcinoma. Therefore 19 cases of congenital dilatation of the bile ducts and 317 control cases were histological studied to investigate the incidence of mucosal metaplasia of the gall bladder.
    On the histological observation, the gall bladder in congenital dilatation of the bile ducts had marked mucosal metaplasia and the results indicated its high incidence in statistcs. And it seemed that mucosal metaplasia in the gall bladder of congenital dilatation of the bile ducts was influenced by existence of anomalous arrangement of the pancreatico-bile duct.
    Based on our clinical and histological study, it is suggested that close relationship may be present between mucosal metaplasia and development of carcinoma, that could be secondary to reflux of pancreatic juice in patients with anomalous arrangement of the pancreatico-bile duct.
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  • Misako YAMAMURO
    1982 Volume 79 Issue 5 Pages 1137-1146
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The enteral hyperalimentation with elemental diet (ED) is now very useful method in the treatment of malnutrition especially before or after surgery.
    The effects of ED on pancreatic and biliary secretion were studied in rats without anesthesia or any stimulants. Conventional intragastric administration of ED markedly stimulated pancreatic exocrine secretion, but intrajejunal ED didn't show any significant effects. There was no different effect on biliary secretion between intragastric and intrajejunal administration. Intrajejunal glucose and amino acid solution depressed pancreatic secretion, but no changes were found with fat emulsion. No significant differences were found in the balance studies of water, nitrogen and electrolytes between the control group and the experimental group with bile or pacreatic fistula during the administration of ED for ten days.
    We conclused that ED would be very useful in the nutritional management of surgical patients with pancreatic or biliary drainage or, so called, high output fistula.
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  • Masahiro MATSUMOTO
    1982 Volume 79 Issue 5 Pages 1147-1155
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In 33 patients with chronic pancreatitis (29 males, 4 females), basal levels of serum vitamin E were significantly reduced as compared with control subjects. The increments of serum vitamin E levels in the patients were significantly less than those in control subjects after oral administration of dl-alpha-tocopherol acetate (600mg). It is of further interest that a positive correlation between serum vitamin E level and exocrine pancreatic function was observed in the patients with chronic pancreatitis. Vitamin E absorption test by vitamin E administration into rat duodenum showed that the increments of serum vitamin E levels were slight in ligation of bile and/or pancreatic duct. On the other hand, serum lipid peroxide levels in patients with chronic pancreatitis showed a significant increase, and a significant negative correlation between serum vitamin E concentrations and lipid peroxide levels was demonstrated. Further, serum glutathione peroxidase (GSHPx) activities decreased in patients with chronic pancreatitis as well as in rats fed with the vitamin E deficient diet for a long period of time.
    In conclusion, malabsorption of vitamin E in patients with chronic pancreatitis was demonstrated. Less antioxidative activities due to the deficiency of vitamin E was assumed to be responsible for elevated lipid peroxidation. It was suggested that low activities of GSHPx, resolving lipid peroxide, were associated with vitamin E depletion.
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  • Shinji SAITOH, Yoshinobu TAKEDA, Masahiko SAEKI, Takashi AMATSU, Kenji ...
    1982 Volume 79 Issue 5 Pages 1156-1163
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan In order to evaluate the pathophysiology of pancreatic enzymes released into the serum, pancreozymin-secretin test combined by provocative test with determination of isoamylase was performed. Subjects selected for this study consisted of 238 cases with pancreatic and nonpancreatic diseases. The abnormal pancreatic exocrine function by stimulation with pancreozymin-secretin was found in 112 cases, which contained 75 cases with hypersecretion, 21 with hyposecretion of mild degree and 16 with hyposecretion of severe degree. Provocative test was positive in 38.7% and 28.8% in pancreatic and non-pancreatic diseases, respectively. Positive provocative test was most frequently found in the stage following acute pancreatitis followed by pancreatic cyst, pancreatic cancer and suspected chronic pancreatitis in the pancreatic diseases. While, the frequency of positive provocative test was high in cases of liver cirrhosis, biliary diseases and peptic ulcer in the non-pancreatic diseases. Positive provocative test was often found in the cases which showed hypersecretion by stimulation with pancreozymin-secretin. The frequency.was 51.9% and 39.6% in pancreatic and non-pancreatic diseases, respectively. From these results it was shown that the hypersecretive status of pancreas was important for the occurrence of positive provocative test. Furthermore, it was demonstrated that there was close relationship between the pancreatic enzymes released into the serum and pancreatic exocrine function from the long-term follow-up study of both pancreatic and non-pancreatic diseases.
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  • Hideaki OBATA, Akitoshi KOGA, Saburo NISHIURA, Makoto YOSHIDA, Fumio N ...
    1982 Volume 79 Issue 5 Pages 1164-1172
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Our experience with pancreatic cysts was reviewed. There were 24 patients (15 male and 9 female) during the period of 1965 to 1980. Eighteen patients with pancreatic cysts were treated operatively, and three patients were treated conservetively. In the other three patients, only the operations for concomitant lesions were performed, and pancreatic cysts were left.
    Fifteen cysts were verified by the histological examination. These were 11 pseudocysts, 3 retention cysts, and one cystadenocarcinoma. Alcoholism, biliary disease and abdominal trauma were the most common antecedent conditions of the patients with pseudocysts and retention cysts.
    The image diagnosis of pancreas such as retrograde pancreatography, and ultrasonnic scanning was valuable for the diagnosis of these lesions. Operative procedures for pancreatic cysts included internal drainage in 14, complete resection in three, and external drainage in one. The follow up data were collected from 6 months to 15 years after the time of surgery. Five patients died 6 months to 2 years after the operation. Two of the five patients had benign cysts, nevertheless they died of some pancreatic disorders.
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  • Shunji KAISE, Tomoe NISHIMAKI, Takao MORITO, Hiroshi YOSHIDA, Reiji KA ...
    1982 Volume 79 Issue 5 Pages 1173-1177
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Toshiyuki KATO, Masayuki NIWA, Yukifumi SAITO, Kazuei OGOSHI
    1982 Volume 79 Issue 5 Pages 1178-1182
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • K. KIKUCHI, [in Japanese], [in Japanese]
    1982 Volume 79 Issue 5 Pages 1183
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kyosuke USHIO, [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 79 Issue 5 Pages 1184
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hiroyuki ODA, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1982 Volume 79 Issue 5 Pages 1185
    Published: May 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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