Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 79 , Issue 7
Showing 1-19 articles out of 19 articles from the selected issue
  • Hideaki TSUKADA, Takeo MIYAKE, Shungi UEDA, Hitohi SHIRAHASE, Takashi ...
    1982 Volume 79 Issue 7 Pages 1391-1399
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The activity and isozyme patterns of glucosaminidase were studied on human gastric biopsy materials obtained at gastroendoscopic examination, and histochemically glucosaminidase activity was demonstrated.
    In normal gastric mucosa, glucosaminidase activity was higher in antrum than in body. In comparsion with normal mucosa, gastric carcinoma shows high activity, but gastric ulcer and gastritis show low activities. These activities correlated with the differencies in the mucosal structure and the mucus metabolism.
    High glucosaminidase activity was present in the gastric mucosa that secretes mucus actively.
    Gastric ulcer and carcinoma showed a high activity ratio of isozyme B to A (B/A>20%) as compared with the ratio in normal gastric mucosa (B/A<20%).
    Though the endoscopic biopsy materials are small amount and measurement of the enzymatic activity in gastric mucosa requires the confirmation of histological background by microscopic observation, our method may be thought as the most effective procedure because of a fresh material compared with operated or autoptic one.
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  • Akiyoshi DAN
    1982 Volume 79 Issue 7 Pages 1400-1404
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Antral mucosal immunoreactive gastrin and somatostatin concentrations in the same biopsy specimens of peptic ulcer patients were determined by radioimmunoassay. Antral mucosal immunoreactive gastrin concentrations were significantly higher in duodenal ulcer than in gastic ulcer and tended to be higher in duodenal ulcer than in control. Antral mucosal immunoreactive somatostatin concentrations were significantly higher in duodenal ulcer than in control and gastric ulcer. In duodenal ulcer, positive correlation was observed between antral mucosal immunoreactive gastrin and somatostatin, but no correlation was observed in control or gastic ulcer.
    These results suggest that somatostatin may be produced as a result of hyperactivity of the G-cells in duodenal ulcer.
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  • Kenichi HASAMA
    1982 Volume 79 Issue 7 Pages 1405-1411
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We have attempted an electron microscopic analysis of the process of chylomicron synthesis in the epithelial cells of small intestine of 8 normal subjects during lipid absorption. This study has demonstrated a close parallel between enlargement of endoplasmic reticulum which synthesize chylomicron, and enlargement of Golgi apparatus which secrete chylomicron in normal subjects after triolein administration. These phenomena are thought to show the mechanism of normal lipid absorption in man. The serum chylomicron-triglyceride measured at the same time showed increases for 4 hours, indicating that the administered triolein was absorbed
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  • Akira SUGITA, Tsuneo FUKUSHIMA, Hiroshi TAKEMURA, Shuji TSUCHIYA
    1982 Volume 79 Issue 7 Pages 1412-1417
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Hyperamylasemia was observed in 17 out of 95 cases of ulcerative colitis followed at Yokohama City University Hospital. Seven out of 17 cases revealed persisting hyperamylasemia. Hyperamylasemia was seen more frequently in patients with total colitis, but not related to severity of the disease and the previous history of operation to colitis. In cases with persisting hyperamylasemia, both serum pancreatic and salivary amylase isozymes were elevated but amylase creatinine clearance ratio was almost normal. Acute pancreatitis, hepatobiliary diseases, disease of salivary gland and macroamylasemia were neglected from clinical and other laboratory findings. The cause of hyperamylasmia in ulcerative colitis was unknown, but several factors were speculated such as sulphasalazine and steroid therapy, production of amylase by intestinal bacteria and intestinal epithelial cells.
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  • Mamoru WATANABE, Sadakazu AISO, Toshifumi HIBI, Takeshi YOSHIDA, Kensu ...
    1982 Volume 79 Issue 7 Pages 1418-1423
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    T cell subsets of peripheral blood lymphocytes were assessed in 27 patients with ulcerative colitis by a fluorescence activated cell sorter, using monoclonal antibodies to the surface antigens of suppressor/cytotoxic (Anti-Leu-2a) and helper/inducer (Anti-Leu-3a) T cells. The population of suppressor T cells was decreased in the the lymphocyte from patients with active ulcerative colitis (8.2±3.6%, p<0.01), compared with those from normal controls (24.6±3.6%). Furthermore, the binding capacity of each lymphocytes from patients with ulcerative colitis to Anti-Leu-2a was decreased.
    The relationship between lymphocytophilic antibodies found in patients with ulcerative colitis and T cell subsets was examined by cell sorting on a fluorescence activated cell sorter. The lymphocytophilic antibodies were demonstrated to be mainly reactive with suppressor T cells, but also reactive with non-suppressor, non-helper T cell subsets and some populations of helper T cells. These results suggest that some other factors except lymphocytophilic antibodies may influence the decrease in suppressor T cells in patients with ulcerative colitis.
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  • Clinical Study Avout Effect of Bile Acid on Endotoxin
    Masataka IWASAKI
    1982 Volume 79 Issue 7 Pages 1424-1434
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Correlation between endotoxemia and serum bile acid concentration in cases with severe liver disaases was investigated in this study. The Limulus Amoebocyte Lysate Test (Limulus Test) was perfoumed simultaneously with the measurement of bile acid concentration in serum or ascites.
    Limulus Test was detected (±), (+) or (++) in 15.6% of acute hepatitis (7 of 45 samples, 32 cases), 17.1% of chronic hepatitis (6 of 35 samples, 25 cases), 32.3% of fulminant hepatitis (10 of 31 samples, 14 cases), 25.2% of liver cirrhosis (56 of 222 samplses, 113cases), 29, 1% of hepatoma (32 of 110 samples, 61 cases), and 28.3% of obstructive jaundice (15 of 53 samples, 37 cases). There was no correlation between incidence of endotoxemia and mean values of serum bile acid concentration levels. However, it is noted that among Limulus Test (±) (+) (++) cases, very few cases were found at the high concentration levels of serum bile acid (80-119.9, umol/l) for acute hepatitis, chronic hepatitis, fulminant hepatitis, and liver cirrhosis. In cases with liver cirrhosis and hepatoma, Limulus Test was detected (±), (+) or (++) more often in ascites than in serum, and, bile acid concentration levels in ascites showed lower values than in serum.
    Limulus Test was performed after mixing endotoxin solution with bile acid (Deoxycholic Acid) to demonstrate that activity of endotoxin decreases with increase in bile acid concentration. Deoxycholic Acid inhibits Pregel coagulation of Limulus Test at the concentration of 20 to 200μmol/l.
    The results of this study suggest that elevation of bile acid concentration in serum plays a role in inactivating endotoxin from the intestinal flora.
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  • Michio KIMURA, Masao OHTO, Yukihiro TSUCHIYA, Hiromitsu SAISHO, Kunio ...
    1982 Volume 79 Issue 7 Pages 1435-1442
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Using the puncture transducer of a linear electronic real-time ultrasound scanner, aspiration and needle biopsy were performed in the diagnosis of focal lesions of the liver.
    Carcinoma cells were demonstrated by aspiration biopsy in 57 of 68 patients with hepatocellular carcinoma and 30 of 32 patients with metastatic carcinoma of the liver. There was no false positive cytological diagnosis of carcinoma cells in patients with benign lesions such as hemangioma and hematoma.
    Carcinoma cells were shown by aspiration biopsy in 9 of 10 patients with small hepatocellular carcinoma, less than 3cm in size.
    A final diagnosis was histologically made by the Silverman needle biopsy in all 3 patients with hepatocellular carcinoma and all 5 patients with focal lesions of the liver who were negative for cytology by aspiration biopsy. Needle biopsy was carried out in combination with a preventive measure for bleeding.
    Pus was obtaind by the aspiration in all 23 patients with hepatic abscesses. The abscesses disappeared only by aspiration or drainage, and the disease cured without surgical operation.
    There were no serious complications during and after puncture.
    Thus, needle biopsy by real-time ultrasound guidance proved to be simple and reliable in the diagnosis of focal hepatic lesions.
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  • Hisao SHIBAYA, Hirofumi OKAMURA, Shigehiro KOKUBU, Kyutaro TOYAMA, Ats ...
    1982 Volume 79 Issue 7 Pages 1443-1451
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The efficacy of UDCA to cholesterol gallstone has been established. However only a few studies were preformed with regard to the course of dissolution and recurrence. In this study, to analyze the course of dissolution, the size of gallstones expressed as volume index, calculated in the following manner, diameter a×diameter b×a+b/2, was plotted on the semilogarithmic graphpaper and the half life period was determind. It was found that small stones disappeared rapidly and exponentially, but large one having over 1cm of diameter decreased in volume index in two exponential curves. After disappearance of gallstones, recurrence was surveyed. Of 21 patients one pregnant patient had recurrence after delivery.
    From these results it is concluded that 1) in the treatment of cholesterol gallstone with UDCA, even though the effect is not noticeable during the first six months it should be continued. 2) after disapperance of gallstones, preventive administration is not required.
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  • Katsuhiko KINUGASA, Osamu MORINAGA, Yuji HORII, Yasuaki INADA, Keisho ...
    1982 Volume 79 Issue 7 Pages 1452-1459
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to evaluate the bile acid and biliary lipid metabolism, bile acid, cholesterol and phospholipid were assessed in duodenal aspirates obtained at the pancreozymin-secretin test (PS test) in 114 patients. There was no significant correlation between bile acid metabolism and exocrine pancreatic function, because any of total bile acid output, maximal bile acid concentration or G/T ratio of P1 fraction did not show clear correlation with 3 factors of P-S test. However, lithogenic index calculated by the equation of Thomas significantly increased with age and reached a peak at the age of 50-59 years old, and there was a significant positive correlation between lithogenic index versus obesity (% of ideal body weight) (p<0.05). Bile acid output was significantly lower in the patients with gallstone and in those with cholecystopathy (both, p<0.01) and G/T ratio was significantly higher in the patients with gallstone (p<0.05) than in the normal subjects, while these showed no significant change in any patients with liver cirrhosis, diabetes mellitus, diarrhea or chronic pancreatitis. Any significant change in lithogenic index was not noted in all disease groups.
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  • Yoshiki HAMADA, Koichi SUZUKI, Tetsuji KITAHORA, Akira YOKOTA, Hisashi ...
    1982 Volume 79 Issue 7 Pages 1460-1463
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Masahiro TANAKA, Sadao NAGASAWA, Hideaki SAKAI, Norio UENO, Chiaki KAW ...
    1982 Volume 79 Issue 7 Pages 1464-1468
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hitoshi YOSHIDA, Yoshiaki KATO, Yoshio HASEGAWA, Shyunji OHDATE, Nobuy ...
    1982 Volume 79 Issue 7 Pages 1469-1473
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Shigekazu HAYASHI, Tatsunari SATAKE
    1982 Volume 79 Issue 7 Pages 1474-1477
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Akira YAMAZAKI, Satoshi MORIOKA, Yasunori TAKEHIRA, Katsutoshi TAMAKOS ...
    1982 Volume 79 Issue 7 Pages 1478-1482
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hidemasa OKUMURA, Takumi ARAMAKI, Tatsuya SEKIYAMA, Yasumi KATSUTA, Ka ...
    1982 Volume 79 Issue 7 Pages 1483-1487
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasushi MATSUZAKI, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1982 Volume 79 Issue 7 Pages 1488
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasuhiko HIRATA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1982 Volume 79 Issue 7 Pages 1489
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Nobuyuki ADACHI, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1982 Volume 79 Issue 7 Pages 1490
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Morikazu ONJI, [in Japanese], [in Japanese], [in Japanese]
    1982 Volume 79 Issue 7 Pages 1491
    Published: July 05, 1982
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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