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With Special Reference to the Distribution in Normal Controls and the Patients with Peptic Ulcer
Kazumasa MIKI, Masao ICHINOSE, Chie FURIHATA, Takashi KAGEYAMA, Hirofu ...
1982 Volume 79 Issue 9 Pages
1685-1693
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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Group II pepsinogen (PG II) levels in human serum were evaluated by human PG II radioimmunoassay system as previously reported, and analysed by decades. The cases were diagnosed endoscopically and included 265 normal controls, 259 patients with peptic ulcers (138 duodenal ulcers, 88 gastric ulcers and 33 gastroduodenal ulcers), and 106 other various disorders. Normal PG II level (mean+S.D.) was 14.1±11.1 (μg/l) without sex difference. It got higher gradually until the 6th decade (22.1±13.5), and declined thereafter until the 8th decade (8.6+7.5). The PG II levels of the patients with gastric ulcer and duodenal ulcer were 19.8±29.1 and 17.8±10.4, respectively, and they were significantly higher than those of normal controls in each decade except for 6th decade. The PG II levels of the patients with chronic renal failure showed significantly higher values (49.5±39.5) than those of normal controls and unchanged by the hemodialysis.
From these results, each PG II level should be evaluated with reference to the age of the subject, and it was suggested that the possibility of the serological screening of the high-risk group in the patients with peptic ulcer.
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Mamoru TATSUMI, Yoshio ISHIKAWA, Nobuyoshi ITO
1982 Volume 79 Issue 9 Pages
1694-1700
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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The effect of biliary diversion on the inhibition of gastric secretion by fat in dogs with Heidenhain pouch and Mann-Bollman's duodenal fistula was studied. Biliary diversion was created by the operative procedure; that was ligation, division of the distal common bile duct and construction of Roux-en Y cholecystojejunostomy.
Amogastrin-stimulated acid secretion of Heidenhain pouch was significantly reduced by the intraduodenal corn oil infusion in control dogs. But, in dogs with biliary diversion, this acid secretion was not reduced. However, with the intraduodenal infusion of mixture of corn oil and bile in dogs with biliary diversion similar inhibition of gastric acid secretion was observed as was seen with the intraduodenal infusion of corn oil alone in control dogs.
These results suggested that the inhibitory effect of the intraduodenal infusion of fat on gastric acid secretion was significant, but this effect was not seen in the absence of bile, and that the gastric acid hypersecretion induced by biliary diversion might be due to the inaction of the inhibitory mechanisms of gastric secretion by fat.
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Changes on Blood Flow Influence of HCl Intraduodenal Administration
Koai INOUE, Kazushige SEKINE, Yoshikatsu OKABE, Kazuyuki MIYAMOTO, Nao ...
1982 Volume 79 Issue 9 Pages
1701-1706
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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In order to research on the responce of duodenum to acid, we observed the changes of duodenal blood flow by HCl intraduodenal continuous administration. Body weight 10-20kg dogs were fasted for 24 hours prior to surgery, but water was provided. Under pentobarbital anesthesia set the probe of electromagnetic flow meter (or doppler flow meter) on the duodenal branch of the Arteria pancreatico-duodenalis. Intraduodenal administration of HCl (10ml/min, ) was performed by stomach tube. By pH 1.0 HCl intraduodenal administration, duodenal blood flow was increased. And submucosal blood flow of duodenum, measured by 133Xe-clearance method, was also increased. But, inspite of continuous pH 1.0 HCl intraduodenal pouring, an increase of duodenal blood flow was not continuous. The duration was about 25 minutes. An increase of duodenal blood flow was more predominantly by pH 1.0 HCl than pH 3.0 HCl intraduodenal pouring. But, an increase of blood flow by pH 1.0 HCl following pH 3.0 HCl was not significant. So we thought that an increase of the duodenal blood flow by HCl was caused not only acidity of HCl, but also difference of acidity.
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Muneaki KISO, Sachio OTSUKA
1982 Volume 79 Issue 9 Pages
1707-1718
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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5-Fluorouracil (5-FU), 25mg/kg/day, was intraperitoneally administered to male DONRYU rats for up to 5 consecutive days. Histochemical and histological changes in the small intestine (especially the jejunum) were investigated by using electron microscopy to elucidate the mechanism of 5-FU-induced increase in the leakage of macromolecule into the intestinal lumen. The fibrinolysis of the intestinal tissue was also investigated. Acid and alkaline phosphatase activities were markedly decreased after the three doses of 5-FU and could scarcely be traced after the five doses. Horseradish peroxidase (Hrp)-positive granule cells tended to be increased after the two doses of 5-FU, reached the peak after the three doses and became undemonstrable after the five doses. Tissue plasminogen activator activity was markedly increased after the one dose of 5-FU, tended to be decreased after the three doses and became lower than the control value after the five doses. Tissue injury was still slight after the therr doses of 5-FU and did not become marked until the five doses. Trans-4-aminomethyl-cyclohexan carboxylic acid could not prevent 5-FU-induced tissue injury and increase in the leakage of macromolecules into the jejunal lumen. [dl]-α-Tocopherol nicotinate almost completely inhibited 5-FU-induced histochemical changes and increase in the leakage of macromolecules into the jejunal lumen without changing the cellular metabolism-blocking effect of 5-FU. Our study suggested that 5-FU-induced tissue injury and increase in the leakage of exogenous macromolecules into the jejunal lumen might be associated with the release of enzymes present in the lysosome of the jejunal lamina propria.
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Comparison of a Heavily HB-Virus-infected Area and a Non-infected Area
Makoto KASAIIMA
1982 Volume 79 Issue 9 Pages
1719-1723
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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The HBsAg-positive rate in Kahoku-Lake area was clearly higher than that in non-Kahoku Lake area. To clarify the reason, epidemiological studies of the transmission mode of HB virusin the f amilially clustered H BsAg carriers were carried out both in Kahoku Lake area and in nonKahoku Lake area. The incidence of clustered families of H BsAg carriers was found to be higher in Kahoku-Lake area than in non-Kahoku Lake area. The incidence of families having maternal transmission was found to be lower and families with a combination of vertical and horizontal transmission were more frequently found in Kahoku-Lake area. In the families with non-maternal transmission, the rate becoming to be HBsAg carrier tended to be higher in Kahoku-Lake area.
These factors were thought to be one of the reasons for the high positive rate of H BsAg in Kahoku-Lake area.
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SYMPATHETIC DISORDER AND MICROCIRCULATORY FAILURE
Kohdoh ISHII, Akitaka SHIBUYA, Nobuo YAMADA, Hisao SHIBATA, Haruya OKA ...
1982 Volume 79 Issue 9 Pages
1724-1729
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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Plasma concentrations of catecholamine were studied in 56 patients with liver cirrhosis. Epinephrine concentrations remained within normal range in all subjects examined, whereas norepinephrine levels (NE) were normal in 23 patients (41%) and were elevated in 33 (59%). Oral glucose tolerance tests disclosed "borderline" type in the normal NE group (I) and "diabetic" type in the elevated NE group (II). The typical picture of the group I showed neither pleural effusion nor liver atrophy with peripheral platelet count of more than 100, 000/cmm. Peptic ulcer and/or erosions as well as liver atrophy were significantly higher in the subjects with group II than in those with group I, and the platelet count was usually below 100, 000/cmm in group II. On the other hand, the levels of NE had correlations with clinical feature, such as peptic ulcer and/or erosions, ascites and/or pleural effusions, liver atrophy and peripheral platelet count with a statistically significant p value <0.05, <0.02, <0.02 and <0.05, respectively. The results indicate that the sympathetic nervous system is highly disordered in liver cirrhosis, which may lead to the derangement of the systemic microcirculatory system and hepatic failure.
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The Significance of Calcium and Magnesium in Various Effector Cells
Y. MUNAKATA, M. ODA, T. WATANABE, R. BABA, K. FUNATSU, Y. MIZUNO, Y. K ...
1982 Volume 79 Issue 9 Pages
1730-1740
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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Three types of the human lymphocytic cytotoxicities [NK: natural killing, ADCC: antibody dependent cell-mediated cytotoxicity, CMC: cytotoxic T lymphocyte (CTL)-mediated cytotoxicity] against Chang liver cells and the human hepatoma cell line (HCC-M) were done in vitro culture. X-ray energy dispersive microanalysis was performed in various effector cells (NK cells, K cells and CTL). At the early stage of the cytotoxicities (after the 3-hour mixed culture), the number of CTL showing a peak of calcium, and K cells showing a peak of magnesium was increased more than that of the others. It was considered that calcium played an important role in CMC, and that magnesium in ADCC at the early stage of the cytotoxicities.
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Comparison with Portographic Findings of the Pars Umbilicus of the Portal Vein
Kenichi TAKAYASU, Noriyuki MORIYAMA, Masao SUZUKI, Tatsuya YAMADA, Tos ...
1982 Volume 79 Issue 9 Pages
1741-1746
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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99mTc-phytate liver scan and percutaneous transhepatic portography (PTP) were performed in 33 patients with portal hypertension due to various hepatic diseases. A defect or space occupying lesion in the left lobe on the scan in these patients was analysed with reference to portographic changes of the pars umbilicus of the left portal vein and the following results were obtained.
1) A false-positive defect on the scintigram was found in 6 (18.2%) of 33 patients, and portal vein pressure (PVP) was above 200mm H2O in all 6 which constituted 21.4% of 28 with PVP above 200mm H
2O.
2) In five out of 6 patients with false-positive scan findings, the pars umbilicus was dilated to more than 25×15mm in size, and it was huge and tortuous in 3 of them.
3) The mean PVP in the group with a false-positive scan tended to be higher than that in patients with no abnormalities on the scintigram.
It was concluded that in reading of liver scintigrams in patients with portal hypertension, a dilated pars umbilicus and huge para-umbilical vein should be considered.
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Haruhide SHINZAWA
1982 Volume 79 Issue 9 Pages
1747-1756
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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For the purpose of detection and analysis of the distribution of α
1-antitrypsin (α
1 AT) in the hepatic tissues, 39 cases with malignant hepatoma and 58 cases with other liver diseases were studied using immunocytochemical tissue method (Peroxidase antiperoxidase method). Immunoreactive α
1 AT deposits were stained in 28 cases out of 34 hepatocellular carcinoma cases (82%) and in one hepatoblastoma case as well as in one case out of 4 cholangiocellular carcinoma cases (25%). Thus, the positive rate of α
1 AT was higher in the tumor tissues of the hepatocellular carcinoma than that in the cholangiocellul ar carcinoma. In the hepatocellular carcinoma, the α
1 AT positive rate had a reciprocal relationship with the grade of the histological differentiation of the tumors. Namely, the more differentiated, the less positive in the α
1 AT positive rate. α
1 AT in tumor Cells mainly revealed three patterns, which were fine granular, coarse granular and inclusion types. In tumor cases with well differentiated type, fine granular α
1 AT type was seen exclusively in high rate. On the other hand, in cases with poorly differentiated type, coarse granular and/or inclusion types of α
1 AT were more frequently observed in tumor cells. Fine granular α
1 AT was also seen in a part of benign cells such as atypical or regenerative hepatocytes, or regenerative bile duct epithelial cells. There was no case who was suggested as a case with immunohistologically α
1 AT deficiency of Z gene variants.
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COMPOSITION AND CT ATTENUATION VALUE
Shuji ISAJI, Takashi NOGUCHI, Ryuji MIZUMOTO
1982 Volume 79 Issue 9 Pages
1757-1765
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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In 272 cases with gallstone disease, the relationship between the gross appearance of gallstones or the stone composition analyzed by infrared spectroscopy and the CT appearance or the CT attenuation value of stones was studied to evaluate a clinical usefulness of computed tomography on the diagnosis of gallstones.
23% of gallbladder stones, 6% of common bile duct stones, none of intrahepatic stones, and as a whole 15.5% of all gallstones were radiopaque on the abdominal plain X-ray films. When compared with the main composition of stones analyzed by infrared spectroscopy, the CT attenuation value was lower than 60 Hounsfiled Units (H. U.) in cholesterol, 60 to 140 H.U. in calcium bilirubinate and it was higher than 140 H.U. in calcium carbonate.
Therefore, CT scan was very useful not only on the diagnosis of gallstone disease, but also to evaluate the main composition of stones, the mechanism of stone formation and the indication for medical treatment.
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Morimasa MIURA, Katsuhiro ENDO, Masaru KOIZUMI
1982 Volume 79 Issue 9 Pages
1766-1770
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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The fistulas of the stomach and the pancreas were made in seven mongrel dogs according to the method of Thomas. For the present study the dogs were used under non-anesthesized condition. In these dogs, lower duodenum was perfused through the duodenal cannula for 5 minutes with physiological solution of sodium chloride (50ml), with acid solution (50m1 of 0.1N HCl), with butter emulsion (2g/kg/40ml water) and with acidified emulsive butter (2g/kg/40ml 0. 1N HCl). Blood samples were obtained from the cubital vein and plasma pancreatic polypeptide (PP) was measured by the method of double antibody system of radioimmunoassay. Saline did not make the change of plasma PP, but acid solution significantly increased plasmaPPfrom 54. 0±14.lpg/ml (Mean±S.E.M.) to 216.7±52.0pg/ml (p<0.02), butter emulsion from 105.8±19.9pg/ml to 294.8±50.1pg/ml (p<0.02) and acidified emulsive butter from 63.6±14.1pg/ml to 114.1±16. 6pg/ml (p<0.02). These findings suggest that postprandialPPrelease may, in part, be mediated by the intestinal factors.
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Osamu ISHIKAWA, Akira WADA, Ichiro FUKUDA, Yukio MATSUI, Takeshi IWANA ...
1982 Volume 79 Issue 9 Pages
1771-1777
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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Chemical carcinogen, N-Nitrosobis (2-hydroxypropyl) amine (BHP) was administered subcutaneusly into Syrian Golden hamster to investigate the histogenesis of experimetally-induced pancreatic carcinoma. The induced dysplastic and cancerous lesions were studied not only by microscopical observation but also by
3H-thymidine autoradiography. By examining whether these lesions consisted of goblet cells or not, they were classified into two major groups. One was poorly differentiated adenocarcinoma without goblet cell. This type seemed to have been originated from the precancerous dysplasia occured in intralobular small duct. Another was well differentiated (mainly papillary) adenocarcinoma being composed from goblet cells. This type seemed to have been originated from dysplastic lesion with goblet cells occured in interlobular large duct. Autoradiographical observation showed that
3H-thymidine uptakes increased progressively with the degree of dysplasia. Once the dysplastic lesion, especially in goblet cellpositive type, had become multilayered, 3H-thymidin uptake increased remarkably. This suggests that goblet cell might compose dysplastic lesion afterwards. Comparing with human pancreatic carcinoma, we discussed the histogenesis of the pancreatic carcinoma in this experimental study.
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Katsuhiro ENDO, Noriyuki MIURA, Tsuneaki SATD, Akira UNOURA, Takashi O ...
1982 Volume 79 Issue 9 Pages
1778-1782
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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Mitsuaki YOSHIOKA, Masahiro TSUTSUI, Kenichi IMAMURA, Isao MAKINO, Kaz ...
1982 Volume 79 Issue 9 Pages
1783-1787
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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Hiromasa KASHIMURA, Akira NAKAHARA, Isao KAWAKITA, [in Japanese], [in ...
1982 Volume 79 Issue 9 Pages
1788-1793
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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Computed tomographic demonstration of pseudoaneurysm in a pancreatic pseudocyst
Makoto YAMAMOTO, Hiroaki FUJITA, Kaname ODAKE, Tomoo TOKUDA, Fukui Koz ...
1982 Volume 79 Issue 9 Pages
1794-1797
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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Tetsuo SASANAMI, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
1982 Volume 79 Issue 9 Pages
1798
Published: September 05, 1982
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T. SETOGUCHI, [in Japanese], [in Japanese]
1982 Volume 79 Issue 9 Pages
1799
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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Takafumi ICHIDA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
1982 Volume 79 Issue 9 Pages
1800
Published: September 05, 1982
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T. OHUMI, [in Japanese], [in Japanese], [in Japanese], [in Japanese], ...
1982 Volume 79 Issue 9 Pages
1801
Published: September 05, 1982
Released on J-STAGE: December 26, 2007
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