Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 80, Issue 11
Displaying 1-18 of 18 articles from this issue
  • Nocturnal gastroesophageal motilty in recumbent position
    Tsutomu MATSUZAKI, Tadashi SUGIYAMA, Toshikazu SEKIGUCHI, Toshio NISHI ...
    1983 Volume 80 Issue 11 Pages 2329-2338
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Nocturnal continuous recordings of gastroesophageal intraluminal pressure were obtained in eleven patients with PSS and ten healthy subjects in recumbent position. In the PSS patients, five cases were complicated by reflux esophagitis. The results were compared among the healthy subjects, the PSS patients and the PSS patients with reflux esophagitis.
    A manometric catheter assembly with seven recording side orifices monitored the swallowing action of the pharynx, the esophageal body motor activity, the lower esophageal sphincter pressure (LESP) and the gastric motor activity.
    The amplitude and the duration of esophageal primary peristalsis were significantly reduced in the whole esophageal body of PSS patients comparing with the normal subjects. The velocity of primary peristalsis was also significantly decreased in PSS. Resting LESP increased gradually during the interdigestive state, higher in phase II than in phase I, and the highest in phase III of PSS patients similar to those in the normal subjects. Regarding the comparison of results between PSS patients with and without reflux esophagitis, the amplitude of peristalsis of the former was singnificantly reduced in the lower, middle and upper esophagus. The duration and the velocity of primary peristalsis were more decreased in PSS patients with reflux esophagitis than those without it.
    Resting LESP was also significantly reduced in PSS patients with reflux esophagitis.
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  • The structure of blood vessels in esophageal wall
    Masahiro ARAKAWA, Takemi NODA, Kazunori FUKUDA, Masayoshi KAGE, Toshir ...
    1983 Volume 80 Issue 11 Pages 2339-2346
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Twenty-two autopsy cases with portal hypertension were studied. Micropac added with gelatin was injected into blood vessels and the structure of blood vessels in the esophagus was observed.
    1. From the esophago-gastric junction, small vessels of 2-3cm in length, running in the "bamboo-blind like" pattern, were observed with little anastomosis or weaving.
    2. Most of the vessels in the submucosa and lamina propria were observed running axially, and three to four vessels in the submucosa were weaving and dilated.
    3. At the transitional area among above two vascular structure, specific pattern was observed. It was distinguished 15 of 22 cases on softex photographs with about 1cm length. The largest varicose was seen in this area.
    4. The mucosal protuberance observed at endoscopy consisted of blood vessel running in the submucosa as a "trunk" with many branching smaller vessels arising from its "trunk".
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  • Motonobu MURAKAMI, Takeo MIYAKE, Motoyuki MORIGA, Masahiko SAKAI, Ryoi ...
    1983 Volume 80 Issue 11 Pages 2347-2351
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Impairment of regional gastric mucosal blood flow in chronic gastric ulcer was studied in 20 patients with chronic gastric ulcer and 4 patients with polypectomy-induced ulcers; 19 normal subjects who were confirmed to be free of gastric ulcer by endoscopy were used as a control. Gastric mucosal blood flow was measured using the contact electrode and hydrogen clearance method.
    In the control group, regional gastric mucosal blood flow in the proximal side of the angle was lower than other sites of the stomach. Mucosal blood flow of chronic gastric ulcer of the angle and corpus showed a significant decrease in the active stage of the disease. In contrast, in polypectomy-induced ulcers, there was no decrease in mucosal blood flow during their active stage compared to the surrounding mucosa. These findings suggest the important role of regional gastric mucosal blood flow in the pathogenesis of natural chronic gastric ulcer.
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  • Kyoji OGOSHI, Yasumasa KONDOH, Tomoo TAJIMA, Toshio MITOMI
    1983 Volume 80 Issue 11 Pages 2352-2356
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Serum sialic acid levels were measured in 81 patients with stomach cancer and an attempt was made to define its physiological role in tumor bearing status in relation to cellular immunity and other glycoproteins namely immunosuppressive acidic glycoprotein (IAP), immunosuppressive substance (IS), α1-antichymotripsin (α1-ACT) and acid soluble glycoproteins (ASP).
    Serum sialic acid level was found to increase as the advancement of clinical stages, the histological type with its highest level being well-differentiated tubular adenocarcinoma. Serum levels of sialic acid correlated well either those of IAP, IS and ASP, but not with cellular immunity and α1-ACT. These correlation of sialic acid with cellular immunity and other glycoproteins, however, got lost or even became reversed when they were evaluated in accordance with clinical stages, It is thus suggested that serum sialoglycoprotein levels are under the strong influence of tumor bearing status with the advancement of the disease.
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  • Motomichi SATO, Yoshito KIYASU, Masao LEE, Hitoshi ONO, Toshinobu KUJI ...
    1983 Volume 80 Issue 11 Pages 2357-2362
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Hemostatic function in 58 patients with gastric cancer were investigated. And, Activator (A) and Inhibitor (I) of fibrinolysis of 41 gastric cancer tissues were determined.
    The results were as follows: 1) The patients with Stage IV gastric cancer were in the state of chronic DIC. 2) In the non-recurrent group, the values of hemostatic function were almost normal and didn't change postoperatively. On the other hand, in the recurrent group, the values of PT, ATIII and α2PI decreased in almost all cases and an increase in α1AT were observed only in the patients with poor prognosis, postoperatively. 3) Furthermore, an increase in Fbg and decrease in Plg were observed in those who died of cancer. 4) There were I activity in the tissues of gastric cancer which were scarcely detected in the normal gastric mucosa. 5) There were correlation between A/I ratio and histological differentiative degrees of the cancer tissues. So A/I ratio seems to be useful to evaluate the biological potential of malignancy in the gastric cancer.
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  • Kiyotaka FUJISE, Seishi NAGAMORI, Satoshi HASUMURA, Sadamu HOMMA, Haji ...
    1983 Volume 80 Issue 11 Pages 2363-2368
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Heterogeneity of alpha-fetoprotein (AFP) in serum and ascites from the patients of liver carcinomas and hepatic cirrhosis was investigated by an affinity chromatography of the Concanavalin A (Con-A) Sepharose. For this study, we prepared each four cases of hepatocellular carcinoma, metastatic carcinoma to the liver and hepatic cirrhosis. The Con-A affinity chromatography resolved each AFP into Con-A non-reactive, Con-A weak reactive and Con-A reactive forms. The AFP in Con-A reactive form was eluted by the addition of α-Methyl-D-glucoside to the starting buffer. The fractionated patterns of AFP in the serum by affinity chromatography came out as differences among the hepatocellular carcinomas, the metastatic carcinomas and the hepatic cirrhosis. Futhermore, the AFP derived from serum and ascites of the same patients with the hepatocellular carcinoma showed also differences of distribution of the Con-A reactive forms, respectively.
    These results suggest that the investigation of the heterogenous AFP using Con-A Sepharose chromatography may be useful in evaluating the clinical diagnosis of the liver diseases, especially, hepatocellular carcinoma, metastatic liver carcinoma and hepatic cirrhosis.
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  • Retrospective study of patients with the history of blood transfusion
    Masaji NAMBU, Hiroshi UEYAMA, Yasumitsu IMAI, Ryuichi SAKITA, Seiichi ...
    1983 Volume 80 Issue 11 Pages 2369-2374
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    A retrospective study of 51 blood-transfused patients with chronic liver diseases was carried out. All patients were followed up for long-term and diagnosis was made histologically. Of 51 patients, 14 (27.4%) were chronic persistent hepatitis (CPH), 21 (41.2%) were chronic active hepatis (CAH), 12 (23.5%) were liver cirrhosis (LC), 3 (5.9%) were hepatocellular carcinoma (HCC) and one (2.0%) was the other. In three cases with HCC, both HBs antigen and anti-HBs were negative. Peroid until the diagnosis was made after transfusion was 10.5±7.8 years (mean±SD) in CPH, 16.4±10.1 years in CAH, 18.8± 6.8 years in LC and 28.7 ± 1.5 years in HCC. In relation to these periods there were significant differences between CAH and CPH (p<0.05), LC and CPH (p<0.001) and HCC and CPH (p<0.001). Further more, there was significant difference (p<0.001) between that of LC and HCC. From these results it was suspected that the prognosis of transfused patients correlated with interval from blood transfusion.
    Histological findings showed no significant difference between patients with and without the history of post-transfusion liver injury (PTLI). Volume of transfusion also showed no correlation with occurrence of PTLI and with the prognosis of patients.
    These data indicate that blood-transfusion relates with progress to chronic hepatitis, however that other factors are required for development of chronic hepatitis into LC and HCC.
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  • Hisafumi YAMAMOTO
    1983 Volume 80 Issue 11 Pages 2375-2383
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Chronological changes in the T and B cells and liver tissue of mice by prolonged alcohol administration were observed to clarify the immune response in the early stage of the alcoholic liver disease.
    Fatty changes of a slight degree appeared 3 weeks after alcohol administration and persisted throughout the following experimental period. Focal necrosis of hepatocytes with polymorphonuclear cell infiltration was rarely seen but alcoholic hyalin body, mononuclear cell infiltration or fibrosis were not observed.
    B cells were increased 15 weeks and T cells were reduced 27 weeks after alcohol administration.
    It is suggested that the humoral immune response involving the progress of alcohol-induced liver disease would have occured at the earliest stage prior to onset of alcoholic hepatitis.
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  • Shuichi MATSUO
    1983 Volume 80 Issue 11 Pages 2384-2395
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Seventeen patients with chronic non-A, non-B hepatitis (NANB) were the subjects (control groups; acute hepatitis A: 1, acute hepatitis B: 1, chronic hepatitis B: 1, alcoholic hepatitis: 2, fatty liver: 3) of an ultrastructural study to assess virus-like particles and of the clinical study on the relation between the ultrastructural changes and laboratory findings.
    Aggregates of intranuclear particles measuring 20-27nm in diameter were observed in a patient with chronic hepatitis B and in 12 patients (NANB) consisting of three with post transfusion hepatitis and nine with sporadic hepatitis. The incidence of intranuclear particles observed in 12 (NANB) was about 3.4% of hepatocellular nuclei investigated. The incidence of those paticles was 5-15% in four of 12 (NANB). These four patients were revealed intermittent elevation in the levels of s-GPT together with γ-GTP. All of the 10 specimens (seven patients) obtained at the levels more than 100IU/L of γ-GTP showed the intranuclear particles. Various types of nuclear bodies were found in the nuclei of hepatocytes.
    In the specimens showing type IV nuclear bodies, intranuclear particles were frequently found.
    These results suggest that the appearance of intranuclear particles in NANB is closely related to the rise of γ-GTP levels.
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  • Takatsune NAKAYAMA, Yoshiaki HIYAMA, Masayuki SAITOH, Hitoshi HATANO, ...
    1983 Volume 80 Issue 11 Pages 2396-2403
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Sixty-one patients, 41 with hepatocellular carcinoma and 20 with liver cirrhosis, were examined by dynamic computed tomography (CT) and all but one with hepatocellular carcinoma were examined by celiac angiography. Dynamic CT disclosed arterioportal shunting in eleven cases of hepatocellular carcinima and in one of cirrhotics. All of them were confirmed by angiography except one case in which angiography could not be performed. In ten of these eleven cases arterioportal shunt was adjacent to a mass lesion on dynamic CT, suggesting tumor invasion into the portal branch. In one with hepatocellular carcinoma, the shunt was remote from the mass. In one with cirrhosis, there was no mass. In these last two cases, the shunt might have been caused by prior percutaneus needle puncture. In another case of hepatocellular carcinoma, celiac angiography but not CT demonstrated an arterioportal shunt. Thus dynamic CT was nearly as diagnostic as celiac arterigraphy for the demonstration of arterioportal shunt due to portal invasion of hepatocellular carcinoma and percutaneus needle puncture.
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  • Yoshihiro IKEMOTO, Yasuhiro MIZOGUCHI, Hiroko SAWAI, Hiroko TSUTSUI, S ...
    1983 Volume 80 Issue 11 Pages 2404-2413
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    When human peripheral blood mononuclear cells were stimulated with pokeweed mitogen in vitro, anti-TNP-SRBC antibody forming cells were induced. This antibody response was enhanced significantly by adding the estrogen simultaneously with pokeweed mitogen. However, the stimulatory effect of estrogen on the antibody response was inhibited by testosterone. These were also the cases in sex hormone effects on the PWM-induced lymphocyte proliferation. Furthermore, the antibody response and DNA synthesis induced in PWM-stimulated cultures of human blood lymphocytes were increased by culture supernatant prepared from peritoneal macrophages after incubating with estrogen.
    These results suggested that antibody responses were modulated by sex hormones and this was exhibited via modulation of macrophages function at least partially.
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  • Nobuyuki MIZUMACHI
    1983 Volume 80 Issue 11 Pages 2414-2422
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    For the purpose of studying the relationship between the duodenal papilla and pancreatitis, the papillae of dogs were fixed with osmium tetroxide and the minor pancreatic ducts were ligated. Morphological changes in the main pancreatic duct and the pancreatic tissue were observed over one year period. The results were that the dogs histologically developed acute pancreatitis followed by pancreatic ductitis and chronic pancreatitis. During this period hyperamylasemia recurred. This pattern represents a course of chronic relapsing pancreatitis.
    The mechanism involved in the development of chronic pancreatitis suggests stenosis at the terminal portion of the main pancreatic duct.
    Under a scanning electron micrograph, the epithelium of the main pancreatic duct was damaged by an attack of acute pancreatitis and subsequently recovered. But the recurrent attacks of pancreatitis caused the epithelium to develop tall columnar cell metaplasia. This hyperplasia gradually developed in a straight line. This change ran parallel with the longer axis of the main pancreatic duct at the stenotic segment and coincided at right angles with it at the adjacent dilated segment.
    A pancreatograph revealed stenosis of the terminal portion of the main pancreatic duct with the foregoing dilatation. Four months after the operation, the stenotic segment gradually extended to the tail.
    Morphological changes observed around the terminal portion of the main pancreatic duct were gradually extended to the tail with the stenotic segment.
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  • Kazutomo SUZUKI, Hitoshi KUWANA, Norihiko KUDO, Ariyoshi IWASAKI, Taka ...
    1983 Volume 80 Issue 11 Pages 2423-2427
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hideyuki OTSUKA, Nobuharu ISHIGAMI, Shintaro TSUKASA, Shuji HASHIMOTO, ...
    1983 Volume 80 Issue 11 Pages 2428-2432
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hiroshi SHIGEMATSU, Hisaaki SHIMAZU, Yasuhiko MORIOKA, Tetsuya SATO, K ...
    1983 Volume 80 Issue 11 Pages 2433-2437
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Masao KAKEI, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1983 Volume 80 Issue 11 Pages 2438
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Muneharu KOMORI, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1983 Volume 80 Issue 11 Pages 2439
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • 1. Application of PNA substrate
    Tsutomu KUROSAWA, [in Japanese], [in Japanese]
    1983 Volume 80 Issue 11 Pages 2440
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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