Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 80 , Issue 12
Showing 1-22 articles out of 22 articles from the selected issue
  • Masahiro ARAKAWA, Kazunori FUKUDA, Takemi NODA, Masayoshi KAGE, Toshir ...
    1983 Volume 80 Issue 12 Pages 2485-2492
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    A pathological study on stomach and esophageal wall was carried on 11 autopsy cases after endoscopical sclerotherapy. The following conclusion was obtained.
    1. The most of the cases have severe histological damage on esophageal wall, characterized by deep and wide ulceration, necrosis, hemorrhage, extensive inflammatory cell infiltrate to adventitia associated with an occasional mediastinitis. These changes were more striking in the cases with the sclerotherapy by Paoscle.
    2. Thrombogenesis in varices was observed in a wide range. This was considered to be related to the degree of the histological damage rather than the amount of the injected sclerosant. In some cases thrombosis was sufficiently formed by less amount of the sclerosant.
    3. Further studies on the more cases with sclerotherapy including long-term survival cases will reveal the exact application for sclerotherapy.
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  • Takashi NAKAMURA, Takao KAMAKAMI, Atushi OHKUNI, Sen KO, Yoshimichi IT ...
    1983 Volume 80 Issue 12 Pages 2493-2503
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Even today, there are many uncertain problems concerning the handling of favorite foods in the treatment of peptic ulcer, and also there are very few studies of their effects on the course of peptic ulcer. Therefore, the authors studied the effects of smoking, alcohol and coffee drinking on the recurrence and healing of peptic ulcer.
    Subjects of the study were 591 cases of peptic ulcer, which were followed endoscopically for 5 years and 11 months on the average.
    The results were as follows; 1. Smoking raised recurrence rate of peptic ulcer significantly, and also depressed its healing rate moderately. This habbit seems to affect adversely on the course of peptic ulcer. 2. Alcohol and coffee drinking did not inflict clearly on the recurrence and healing rates of peptic ulcer.
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  • Fumio MISAKI, Kyohei HAYASHI, Yoshiyuki WATANABE, Keiichi KAWAI
    1983 Volume 80 Issue 12 Pages 2504-2511
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To investigate the relation between the consumption of cigarette or dietary factors (alcohol, spice, coffee, black tea and milk) and the onset or relapse of peptic ulcer, we performed a questionnaire to all the patients who were introduced to upper gastrointestinal endoscopy during June, July and August, 1982. The quenstionnaire was filled out in the waiting room right before the examination. This questionnaire has a feature that a patient must write down the consumption of cigarette or dietary factors both before and after occurrence of symptoms. We obtained the sufficient answers from 590 patients including 172 gastric ulcer, 48 gastroduodenal ulcer, 98 duodenal ulcer, 119 normal or atrophic gastritis and 153 miscellaneous diseases.
    Concerning the consumption of these factors before occurrence of symptoms, we compared male patients with gastric ulcer (136 cases), those with gastroduodenal ulcer (38 cases) and those with duodenal ulcer (84 cases), with 65 controls diagnosed endoscopically as normal or atrophic gastritis. As a result of it, by all the epidemiological analyses used, that is, a simple comparion of all ulcer cases with controls, a comparison in the combination of two of the factors and the standardized relative risk, cigarette proved to be a significant risk factor to all sorts of peptic ulcer. Spice and coffee may be risk factors to gastric and duodenal ulcer respectively. On the other hand, neither alcohol, black tea nor milk showed any significant difference in consumption between patients with peptic ulcer and the controls.
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  • Transplantability and tumor doubling time of 100 cases human gastric carcinomas into nude mice
    Nobuyuki MIYAGI, Katsunori NAKATANI, Tomomichi EZAKI, Kazunori SAKAMOT ...
    1983 Volume 80 Issue 12 Pages 2512-2519
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The aim of the present study was to analyse the biological behavior of advanced human gastric carcinoma by transplanting tissues from 100 cases, including all common types classified histologically according to the General Rules for the Gastric Cancer Study in Surgery and Pathology.
    The average transplantability was 51%. The transplantabilities of each histological type was 8 of 14 (57%) cases in papillary adenocarcinoma (pap), 16 of 27 (59%) in tubular adenocarcinoam (tub), 19 to 47 (40%) in poorly differentiated adenocarcinoma (por), 6 of 7 (86%) in mucinous adenocarcinoma (muc), and 2 of 5 (40%) in signet-ring cell carcinoma (sig).
    The average doubling times were 7.9±2.5 days in pap, 16.8±6.6 days in tub, 14.0±3.3 days in por, 13.9±2.8 days in muc, and 12.8 days in sig.
    Age, Sex, Borrmann's and histological types did not influence statistically the transplantability and doubling time judged by multivariant analysis.
    These results suggest that biological behavior differes for individual advanced human gastric carcinomas, and that none of the factors examined per se controls the cancers.
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  • Motonobu MURAKAMI, Makoto SEKI, Hiroshi SAIDA, Masami INADA, Takeo MIY ...
    1983 Volume 80 Issue 12 Pages 2520-2524
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Deep body temperature, gastric mucosal blood flow and blood viscosity were studied in rats under water-immersion stress After stress loading, body temperature was lowered to 23°C in one hour.
    Gastric mucosal blood flow also decreased simultaneously and blood viscosity inversely increased with the decrease of blood (body) temperature. These result strongly suggests that mucosal blood flow is affected by the increase of blood viscosity which is due to decrease of blood (body) temperature in water-immersion restraint stress.
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  • Hajime KUWAYAMA, Yoshinori TASHIRO, Yuko IKEDA, Katsuhiro TAKEUCHI, Yo ...
    1983 Volume 80 Issue 12 Pages 2525-2532
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Despite the fact that nonsteroidal antiinflammatory agents typically damage the mucosa of the upper gastrointestinal tract, little is known about its chronic effects. In order to determine whether chronic indomethacin ingestion (3mg/kg/day, for 4 weeks) affects epithelial proliferation, this study was performed by means of 3H-thymidine autoradiography. The results indicate that indomethacin stimulates epithelial proliferation in rat gastric fundus at doses which cause no detectable injury, indicating an adaptive response. The failure of indomethacin to stimulate epithelial proliferation in antrum or duodenum may account for in part for ulcerogenic action of the drug.
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  • Atsunobu TASHIRO
    1983 Volume 80 Issue 12 Pages 2533-2541
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Serum ferritin levels were determined in 487 cases of various liver diseases. Follow up study of ferritin for more than 6 months in 195 cases showed that there were 5 types in its change: type I was that fluctuated within normal range, type II changed from normal to the levels less than 1000ng/ml, type III changed from normal to more than 1000ng/ml, type IV was always in abnormal high levels and type V gradually increased to abnormal levels.
    Almost all patients in chronic inactive hepatitis belonged to type I, while chronic active hepatitis to type II to IV. Four of 6 patients of type IV progressed to liver cirrhosis. Serum ferritin levels in decompensated liver cirrhosis more fluctuated than those in compensated cases. Hepatic failure occured frequently in cases whose ferritin remained high levels. These results suggested that continuously high levels of ferritin reflected progressive hepatic cell damages and prognostic evaluation could be obtained from the follow up of ferritin. On the other hand, most patients with liver cirrhosis who transformed to hepatocellular carcinoma (HCC) belonged to type I. Moreover, serum ferritin increased after resection of the tumor or injections of anticancer agents to the tumor and returned to normal levels with relatively long period. Thus, measurements of serum ferritin were less valuable in detecting or monitoring HCC when compared with assay of α-fetoprotein.
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  • Yasuhiro MIZOGUCHI, Hiroko SAWAI, Michiru FUKUI, Hiroko TSUTSUI, Takay ...
    1983 Volume 80 Issue 12 Pages 2542-2546
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The effects of sex hormones on the macrophage-mediated hepatocytotoxicity were investigated by determining the protein biosynthesis in isolated hepatocytes after incubation of hepatocytes with culture fluid prepared from sex hormone-treated macrophages. Estrogen-treated macrophages were shown to produce a factor (or factors) which caused the decrease in the protein synthesis. However, this estrogen effect was inhibited by simultaneous addition with testosterone to macrophages. Furthermore, although a higher concentration of estrogen did not show any stimulatory action on macrophages, simultaneous addition of low dosis of testosterone was shown to induce hepatocytotoxicity.
    These results suggested that sex hormones might modulate the macrophage function to induce a cytotoxic activity
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  • Akira ICHINOHE
    1983 Volume 80 Issue 12 Pages 2547-2555
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Serial liver biopsies were performed on 62 alcoholics to clarify the course of development of cirrhosis. Twenty-five of them were abstained. Histological improvements were confirmed by the follow-up biopsies of these 25 patients. The remaining 37 patients continued drinking and recieved serial biopsies at the intervals of more than a year. Eighteen patients of them revealed cirrhosis at the first biopsy. In these cirrhotic patients, the septa tend to be widened histologically. Out of these 19 patients with non-cirrhotic changes, 11 progressed to cirrhosis 1 to 7 years after the first biopsy.
    The first biopsy specimens taken from these 11 patients, showed porto-central bridging fibrosis in 8 patients (72.7%) and disclosed pericellular fibrosis in 6 patients (54.5%), respectively. In 9 out of these 11 patients, alcoholic hepatitis was histologically observed in the course of development of cirrhosis. It was suggested that alcoholic hepatitis plays an important role in the development of cirrhosis. It appeared that alcoholics whose liver specimens showed porto-central bridging fibrosis had a tendency to progress to cirrhosis after continued drinking.
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  • Yoshio KAMEDA
    1983 Volume 80 Issue 12 Pages 2556-2563
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The purpose of this study is to find a novel diagnostic marker of hepatocellular carcinoma (HCC).
    The hepatic tissue zinc content, the serum zinc concentration and the urinary zinc excretion in patients with HCC, with metastatic cancer of the liver and with chronic liver diseases were investigated by atomic absorption spectroscopy. Histochemical and analytical electron microscopical analyses were also made.
    The hepatic tissue zinc contents in noncancerous portion of the liver in chronic hepatitis with HCC (412.4±155.1μg/gm. d.w.) was significantly (p<0.005) higher than those in chronic hepatitis without HCC (160.9±36.7μg/gm. d.w.). The hepatic tissue zinc contents in noncancerous portion of the liver in liver cirrhosis with HCC (255.8±145.9μg/gm. d.w.) was also significantly (p<0.05) higher than those in liver cirrhosis without HCC (157.0±49.2μg/gm. d.w.).
    The hepatic tissue zinc contents in various noncancerous portion of the liver with HCC were homogenously increased.
    Histochemically, stainable zinc were usually found in periportal area of noncancerous portion of the liver.
    According to this study, the measurement of the hepatic tissue zinc may be of value in the diagnosis of the presence of HCC in the hepatic tissue with chronic hepatitis or with liver cirrhosis, also in four of six cases, the presence of low AFP producing HCC.
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  • Yuji TSUJI, Shunichi KOGA, Hiroshi IBAYASHI
    1983 Volume 80 Issue 12 Pages 2564-2573
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Etiologies and clinical features of 270 cases with liver cirrhosis who admitted to our institution during the years from 1971 to 1980 were analysed. The cases were classified into five groups according to their suspected etiology, i.e. alcoholic (incidence; 24.1%), viral (33.7%), alcohol/viral (8.9%), cryptogenic (30.7%) and a group of specific etiologies (2.6%). Incidence of alcoholic cirrhosis increased by 10% compared with the previous study which carried out fifteen years ago at the same institution.
    On physical examination, vascular spider and splenomegaly were more frequent in alcoholic group than in viral group. On liver function tests, viral group showed that mean GOT and TTT were higher than those in alcoholic group. GOT/GPT ratio was lower in viral group than that in alcholoic group.
    Occurrence of hepatocellular carcinoma was obscured in 18.5% of alcoholic cirrhosis, 35.2% of cirrhosis with viral etiology, 45.8% of alcoholic/viral cases and 21.7% of cryptogenic cirrhosis. In HBsAg positive male cases, occurrence of hepatocellular carcinoma was further facilitated by consumption of a large amount of alcohol.
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  • Toshio KABAYASHI, Masao OHTO, Masatoshi SUMIDA, Takashi SHINAGAWA, Shi ...
    1983 Volume 80 Issue 12 Pages 2574-2583
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Twenty-six patients with hepatocellular carcinoma (HCC) smaller than 5cm in diameter were subjected to transcatheter arterial embolization (TAE) therapy, and 10 patients with small HCC were followed up with no therapy as the control. The therapeutic effects were investigated by comparison of clinical findings and prognosis between the groups receiving TAE and no treatment. They were also evaluated based on histopathological findings of the tissues obtained by surgical resection or autopsy in 5 patients with TAE, 5 with both TAE and MMC intraarterial one shot injection (MMC), 4 with MMC and 16 with no therapy.
    Short term clinical effects of TAE therapy were judged from the findings in ultrasonograms and computed tomograms, and changes in serum AFP levels 1.5 months after the performance. The rate of effectiveness was as high as 92.3%. One year survival rate was 70% in the TAE and 87.5% in the no therapy. There was no difference between the two groups. This means that the effects of TAE therapy in small HCC mostly associated with liver cirrhosis should be evaluated in consideration not only of anticancer effects but also damage to liver function concomitantly incurred. From the histopathological findings, the rate of tumor occupation within the capsule as an indication of therapeutic efficacy was much more decreased following TAE than after MMC or no therapy, but extra capsular tumor tissue was not damaged by TAE.
    TAE is clinically effective for small HCCs as a short term treatment, but has some certain limitations in improving long term survival
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  • Toshikazu TAMURA, Mikiya KAWAHITO, Daisuke WADA, Hideki KOREMATSU, Kuz ...
    1983 Volume 80 Issue 12 Pages 2584-2587
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Motoyuki OHIRA, Shinichi OZAWA, Eiki KUBO, Miki YAMANO, Ikuo NAKAZAWA, ...
    1983 Volume 80 Issue 12 Pages 2588-2591
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Mikio TANINO, Tomio KAMETANI
    1983 Volume 80 Issue 12 Pages 2592-2595
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Akemi OZAWA, Hiroshi OGASAWARA, Makoto ONUKI, Hirofumi SAITOH, Yoshio ...
    1983 Volume 80 Issue 12 Pages 2596-2600
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takashi FUKUDA, [in Japanese], [in Japanese], [in Japanese], [in Japan ...
    1983 Volume 80 Issue 12 Pages 2601
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tatsuo TOZAWA, [in Japanese], [in Japanese], [in Japanese]
    1983 Volume 80 Issue 12 Pages 2602
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • A. Sakamoto, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1983 Volume 80 Issue 12 Pages 2603
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Toshikazu TAMURA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1983 Volume 80 Issue 12 Pages 2604
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • A case of early cancer of the gallbladder
    Sei TOMATSU, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1983 Volume 80 Issue 12 Pages 2605
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Akihiro FUNAKOSHI, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1983 Volume 80 Issue 12 Pages 2606
    Published: 1983
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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