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Volume 80, Issue 7
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[in Japanese]1983 Volume 80 Issue 7 Pages 1395-1409
Published: 1983
Released on J-STAGE: December 26, 2007
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A Chronological StudyHiroshi FURUKAWA, Takeshi IWANAGA, Takeru ICHIKAWA, [in Japanese], [in ...1983 Volume 80 Issue 7 Pages 1410-1414
Published: 1983
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSExperimental MNNG (N-methyl-N'-nitro-N-nitrosoguanidine) carcinogenesis was studied, chronologically, on the glandular stomach of Wistar rats. In male rats, the hypertrophy of lamina muscularis mucosae (l.m.m.) was frequently observed at the 4th month of the experiment when cancer and mucosal atypia were found less frequently. And the incidence of the hypertrophy of l.m.m. decreased with time after the MNNG treatment, while the incidence of cancer and mucosal atypia increased. In female rats, the hypertrophy of l.m.m., cancer and mucosal atypia were very low in their incidence throughout the observation period (4 to 12 months). When estradiol was injected to male rats, the incidence of gastric cancer became lower than that of intact males. When castration was performed on male and female rats, the incidence of gastric cancer of castrated male rats became markedly lower than that of non-castrated males, while gastric cancers were scarcely observed either in castrated females or in non-castrated females.
These findings, therefore, suggest that female sex hormones exert a suppressive action on carcinogenesis, while male sex hormones facilitate carcinogenesis.View full abstractDownload PDF (619K) -
Yuichi MATSUNAGA, Tomoaki URAKAWA1983 Volume 80 Issue 7 Pages 1415-1423
Published: 1983
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn order to elucidate the therapeutic effects of cimetidine administration and surgical vagotomy on stress ulcers, bound rats were subjected to forced immersion in water to induce acute ulcerous lesions and then therapy with either cimetidine or surgical vagotomy was initiated and therapeutic effects of these two treatments were studied and compared. Intragastric pH, blood flow in the gastric wall, gastric mucosal amine levels, gastric mucosal glycoprotein and mucopolysaccharides levels were periodically determined and based on these determinations studies were made in regard to the mechanisms of action of vagotomy and cimetidine administration in promoting the healing of stress ulcers and the following conclusions were obtained. Almost no therapeutic effects were observed following surgical vagotomy but cimetidine therapy demonstrated clear therapeutic effects. Administration of cimetidine by promoting a recovery of the blood flow in the gastric wall brought about an increase in the levels of both amines and mucopolysaccharides etc, in the gastric mucosa but during surgical vagotomy only a rise in the intragastric pH level was observed but no recovery was occasioned in any of the other monitored parameters.View full abstractDownload PDF (1302K) -
An Experimental StudyChung-Yuan Shy1983 Volume 80 Issue 7 Pages 1424-1431
Published: 1983
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSExperiments were desinged to study the effects of electric stimulation of vagus nerve, atropine, neostigmine in release of endogenous motilin. Five dogs were prepared with chronically implanted bipolar electrodoes on the antrum, duodenum, jejunum and ileum. Recording of electrical activity were obtained in the fasted condition and following intravenous administration of atropine or neostigmine. Meanwhile, blood samples were taken periodically for determination of motilin level. Another fifteen dogs were anesthesized with pentobarbital and then electric stimulation of right cervical vagus nerve were performed. In each of experiment, blood samples were withdrawn from portal vein, hepatic vein and femoral artery. Motilin concentrations were assayed with two-antibody method.
Plasma motilin levels of portal vein and hepatic vein significantly rose during electric stimulation of right vagus nerve. The mean plasma concentration of phase I, II, III, IV were 153.6±13.6pg/ml, 182.7 ±21.6pg/ml, 234.6±18.8mg/ml and 226.8±16.4pg/ml repectively. Cyclic increase of plasma motilin occurred in phase III of electrical activity; activity front, was noted. This cyclic increase could be suppressed by intravenous administration of artopine. The plasma motilin concentration significantly rose following intravenous administration of neostigmine, suggesting that the cholinergic nervous fiber may have some important role in the release of endogenous motilin.View full abstractDownload PDF (939K) -
Yuichi YAMASHITA, Michio MIYATA, Kogoro KASAHARA, Kyotara KANAZAWA, To ...1983 Volume 80 Issue 7 Pages 1432-1439
Published: 1983
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIntravenous bolus injection of pGRP in anesthetized dogs at a dose of 60pmol/kg through the cephalic vein caused significant rise in the concentration of serum immunoreactive gastrin. Simultaneous elevation of both gut-glucagon like immunoreactivity and immunoreactive insulin. On the other hand, the release of immunoreactive secretin, VIP and pancreatic glucagon was not stimulated under the same condition.
Removal of the N-terminal thirteen, seventeen of eighteen amino acid residues did not affect the response of serum immunoreactive gastrin to pGRP during the infusion. However, the prolonged effect of pGRP was almost completely abolished by this peptide chain shortening. Removal of the nineteen amino acid residues from the N-terinus caused significant decrease of gastrin releasing activity and the removal of next 20th amino acid residue caused disappearance of this activity. Since the pGRP (20-27) was concluded to be the vital active core of pGRP molecule for gastrin releasing activity.
pGRP (1-13) itself was inactive upon the gastrin releasing activity, but it seemed to be important for the full biological activity of pGRP.View full abstractDownload PDF (934K) -
The Usefulness of Polyacrylamide Slab Gel ElectrophoresisAtsushi TAKAHASHI, Chihiro SEKIYA, Yasuyuki YAZAKI, Masayoahi NAMIKI1983 Volume 80 Issue 7 Pages 1440-1449
Published: 1983
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe studied the isozymes of serum cholinesterase (herein after referred to as ChE) in 15 normal subjects and 187 patients with liver diseases by polyacrylamide slab gel electrophoresis. The polyacrylamide slab gel electrophoresis was very useful for the separation of ChE isozymes and bands 5 and over were clearly distinguished by this method. In acute hepatitis, ChE activities of each band decreased at the acute phase and recovered to the normal level at the convalescent phase. In fatty liver, ChE activities of each band increased before diet therapy and recovered to the normal level after diet therapy. As liver disease progressed, ChE activities of Band 1 (the fast moving band) to 4 tended to decrease as compared with Band 5 and over. Especially in liver cirrhosis, those decreases were marked. We concluded that this result could not be solely due to the decrease in total ChE activity.View full abstractDownload PDF (1572K) -
Mitsujiro FUKUI, Shoich KUSANO, Sumio MATAMA, Koichiro MURATA, Hisao S ...1983 Volume 80 Issue 7 Pages 1450-1460
Published: 1983
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSBetween July, 1972 and May, 1982, we treated 151 patients with hepatocellular carcinoma (HCC) using various treatments at Kitasato University Hospital. Of this series, all had undergone angiography before initial treatment and then their cilinical follow-up studies were made sufficiently. Angiographically, the presence of HCC was delineated in all patients. The methods of treatment were divided into the following four groups: (1) conservative measure including systemic chemotherapy, (2) intraarterial injection chemotherapy, (3) transcatheter arterial embolization and (4) surgical treatment. Among these groups, comparison was made justifiably using a staging system proposed by us, which consists of both morphological and functional classifications. The results of each treatment and the prognosis for HCC following treatment were reviewed and discussed in order to accurately predict the effect of treatment and to properly choose the methods of treatment at the time of patients selection for the management of HCC.
The conclusions were as follows: (1) In the absence of coexisting liver cirrhosis, patients with HCC classified into Type A morphologically should be initially treated surgically because complete cure can be only expected with hepatic resection at the present time. (2) In the presence of coexisting liver cirrhosis, on the other hand, it is recommended that patients with HCC classified into Type A and B morphologically should be treated with transcatheter arterial embolization instead of surgical treatment because the survival rate of the former is superior to that of the latter and a surgical mortality rate in 20 resected cases of this series remains as high as 20%.View full abstractDownload PDF (1276K) -
Tetsuo OHSHIMA, Masayuki ARASHI, Haruyasu YOSHIZAKI, Takashi ABE, Yosh ...1983 Volume 80 Issue 7 Pages 1461-1467
Published: 1983
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe molecular form of IgA in bile specimens from five patients received percutaneous transhepatic cholangial drainage was analysed by high speed liquid chromatography and solid phase radioimmunoassay in order to investigate a transport mechanism of IgA from serum into bile.
IgA was found to be a predominant immunoglobulin in bile, consisting of approximately 50% in bile immunoglobulins. The molecular form of IgA in bile showed mainly dimeric in contrast to that of serum IgA, which showed predominantly monomeric. When calculating the selectivity index of each immunoglobulin in bile, the high index was observed in dimeric IgA and IgM, whereas monomeric IgA showed the low index similar to that of bile IgG. In addition, nearly half of the dimeric IgA in bile had secretory component in its molecule, indicating secretory IgA.
These results suggest that dimeric IgA and IgM could be selectively transported from serum into bile by binding to secretory component in the mucosa of the bile duct. However, the presence of dimeric IgA without secretory component was also indicated in bile, and further investigations will be needed.View full abstractDownload PDF (770K) -
(II) Role of the Cephalic PhaseTamotsu KAWANO, Kazutomo INOUE, Koichi SHIMA, Shuhei HASHIDA, Takashi ...1983 Volume 80 Issue 7 Pages 1468-1474
Published: 1983
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe role of the cephalic phase with regards to pancreatic blood flow was observed by the heated thermocouple method using conscious dogs in which a tiny atraumatic element had been implanted in the pancreas. The animals were prepared for external esophagostomy in order that food should not enter their stomachs.
In these animals, a pancreatic blood flow increment (maximum, 89%) occured immediately after meat meal ingestion, but this response was observed by visual and olfactorystimuli only. Therfore, it is thought that the initial blood flow increment observed in the usual food intake was included by the so-called cephalic phase. This initial response did not disappear after truncal vagotomy, suggesting that the pancreatic blood flow response provoked by the cephalic phase was not mediated through the vagal nerve only. In another experimental group, the pancreatic blood flow decreased markedly when the dogs were excited (sympathetic excitation).View full abstractDownload PDF (933K) -
Keiko SHIRATORI, Shin-ichiro WATANABE, Tadashi TAKEUCHI1983 Volume 80 Issue 7 Pages 1475-1479
Published: 1983
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSA sensitive, specific and reproducible radioimmunoassay (RIA) of secretin has been developed in our laboratory. Plasma secretin was purified and concentrated by ethanol extraction according to Chey's method. Recently, sensitivity of the assay increased markedly by using highly specific antiserum. The detection limit was 2pg/ml.
The mean plasma secretin concentration of 53 normal healthy subjects was 4.2±0.3 (M±SE) pg/ml. Ingestion of a test meal resulted in significant increase (7.9±1.0pg/ml) in the plasma secretin concentrations (p<0.001).
In addition, the sensitivity of our RIA method of secretin in human was assesed by measuring plasma secretin concentrations during constant intrajejunal infusion of HCl, or intravenous infusion of secretin. Our RIA system could detect statistically significant increases in the plasma secretin concentrations when 0.05N HCl was infused intrajejunally at a rate of 1.1 and 2.2ml/min, and could detect increments of plasma secretin in respose to intravenous infusion of exogenous secretin (GIH secretin) at a low dose of 0.05 and 0.1CU/kg/hr.
With this sensitive and accurate RIA of secretin, it is now possible to further investigate the physiology and pathophysiology of secretin.View full abstractDownload PDF (564K) -
special reference to the heterogeneity of gastrin in serum and gastrinomaAkiyoshi DAN, Terukatsu ARIMA, Ryoji FUJIWARA, Itsuo AMIOKA, Kozo KAWA ...1983 Volume 80 Issue 7 Pages 1480-1484
Published: 1983
Released on J-STAGE: December 26, 2007
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endoscopic follow-up studyTadashi KODAMA, Shinichiro FUKUDA, Kenji TSUJI, Eiji NAITO, Yoshinobu ...1983 Volume 80 Issue 7 Pages 1485-1489
Published: 1983
Released on J-STAGE: December 26, 2007
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therapeutic trial of endoscopic papillotomySadao NAGASAWA, Masahiro TANAKA, Hideichi SEKI, Machio KUMAGAI, Hideak ...1983 Volume 80 Issue 7 Pages 1490-1495
Published: 1983
Released on J-STAGE: December 26, 2007
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Mitsuyo HASHIMOTO, Naoyuki YAMADA, Sotaro FUKUCHI, Yoshimasa ONO, Masa ...1983 Volume 80 Issue 7 Pages 1496-1500
Published: 1983
Released on J-STAGE: December 26, 2007
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Toshio KADOTA, [in Japanese], [in Japanese], [in Japanese], [in Japane ...1983 Volume 80 Issue 7 Pages 1501
Published: 1983
Released on J-STAGE: December 26, 2007
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Toshio MURAKI, [in Japanese], [in Japanese], [in Japanese], [in Japane ...1983 Volume 80 Issue 7 Pages 1502
Published: 1983
Released on J-STAGE: December 26, 2007
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Kazuichi OKAZAKI, [in Japanese], [in Japanese], [in Japanese], [in Jap ...1983 Volume 80 Issue 7 Pages 1503
Published: 1983
Released on J-STAGE: December 26, 2007
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A case of liver hemangiomaAtsushi OKU, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...1983 Volume 80 Issue 7 Pages 1504
Published: 1983
Released on J-STAGE: December 26, 2007
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