Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 80, Issue 8
Displaying 1-22 of 22 articles from this issue
  • Masuki FUKUDA, Sunao KAWANO, Nobuhiro SATO, Hu QUAN Li, Hideyuki FUSAM ...
    1983 Volume 80 Issue 8 Pages 1569-1574
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The gastric mucosal blood volume and gastric secretion in patients with gastric ulcer were studied with respect to in the healing of gastric ulcer. These patients were divided into two groups; one was the intractable ulcer group which consisted of patients who failed to heal after 3 months therapy; the other was the tractable ulcer group which consisted of patients who healed with medical therapy within 3 months. The mucosal blood volume at 20 regions in the stomach and 4 regions around ulcer margin were measured by a reflectance spectrophotometry during endoscopy and were compared between these two groups.
    The mucosal blood volume at all regions in the stomach except aruond gastric ulcer were almost equal in these two groups. However, the mucosal blood volume around ulcer margin increased maximally at H2 stage in the tractable ulcer group and, thereafter, it decreased and returned to the similar level to that of the surrounding mucosa of gastric ulcer. On the other hand, in the intactable ulcer group, the mucosal blood volume around the ulcer margin did not increase and remained to be the similar level to that of the surrounding mucosa.
    Acid output was significantly higher in the intractable ulcer group than in the tractable ulcer group. Simultaneous study on mucosal blood volume at ulcer margin and acid secretion revealed that most of patients with tractable ulcer had a high mucosal blood volume at ulcer margin and a low acid output in the healing stage. By contrast, those with intractable ulcer had a low mucosal blood volume at the ulcer margin and a high acid output in the healing stage.
    It was concluded that gastric mucosal hemodynamics and acid output at the healing stage of gastric ulcer have a significant role in the healing of gastric ulcer.
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  • Jun TOMINAGA, Saburo NAKAZAWA
    1983 Volume 80 Issue 8 Pages 1575-1580
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    We measured macromolecular glycoproteins in the gastric mucosa and studied its location to search for a role of defensive factors in the mechanisms of peptic ulcer formation. The glandular stomach tissues in rats were seperated into three groups; glandular stomach, separated proper mucosal layer and the remaining tissue of the gastric wall. After lyophilizaton, each of the three groups was examined in two ways with and without delipidization respectively. The glycoproteins were extracted with Tris-HCl buffer containing 2% Triton X-100 and a part of the extract was fractionated on Bio-Gel 1.5m column chromatography. The hexoses of all fractions were analyzed by phenol sulphric acid method using galactose as a standard. Macromolecular peak appeared in the proper mucosal layer but disappeared in the other gastric layer after delipidization. The measurement of the quantitative and qualitative changes in the mucus macromolecular glycoproteins has been very troublesome because of difficulties in its procedure. However, this method of applying delipidization made it possible to estimate its contents in the glandular stomach tissues as an index of defensive factor of the stomach. This study will devote to the research of gastric mucus which may play an important role in the mechanisms of gastric ulcer formation.
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  • Correlation Between Endoscopic and Histologic Findings
    Masahiro TANAKA, Ken KIMURA, Ken SAITO
    1983 Volume 80 Issue 8 Pages 1581-1589
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Endoscopic examination of the stomach and duodenum was carried out in 12 consecutive cases of Crohn's disease which had already involved the small and/or large intestine.
    The minute lesions of the stomach and duodenum were endoscopically discovered in 7 cases (58%) and 5 cases (42%), respectively.
    The characteristic endoscopic features were summarized in 5 patterns as follows:(1) E; patchy erythema, (2) A; aphthoid erosion, (3) V; verrucous lesion, (4) R; radial linear redness and (5) C; cobble stone lesion.
    Through the endoscopic follow up, it could be understood that these lesions were qualitatively and quantatively changed with progressive growth.
    It was, of importance, interested that the transformation from E to V via A and quantative increase of V were observed.
    110 biopsy specimens composed of 89 gastric and 21 duodenal biopsies were histologically investigated on the identification of the epithelioid cell granuloma including both mucosal inflammation and lymphangiectasia.
    The epithelioid cell granuloma was found with the frequency of 63% in "E", 33% in "A", 68% in "V", only 8% in "C" and 18% even in normal appearing mucosa.
    The incidence of granuloma in "V" (68%) and "E" (63%) was higher than those of normal appearing mucosa (18%).
    The severity of mucosal inflammation was put in order of "C", "V", "E", "A" and normal appearing mucosa.
    Lymphangiectasia was observed in every specimen from "C" and in about falf of those from "V", "E" and "A".
    These results suggest that distal stomach and proximal duodenum would be fairly involved in Crohn's disease, and further more patchy erythema would be the early manifestation of Crohn's disease.
    Endoscopic detection and follow up of the early lesion would be extremely significant for morphologic understanding of developmental process of the disease.
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  • Michio KOGURE, Toshikazu SEKIGUCHI, Toshio NISHIOKA
    1983 Volume 80 Issue 8 Pages 1590-1598
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    It is well known that alimentary tract of the PSS patients is disordered in motor activity and many reports review the dysfunction in esophageal motility, although few focus on that of duodenum. In this study, duodenal motility was examined in 27 PSS patients and compared with that of 19 normal subjects, in the view points of interdigestive migrating motor complex (IMMC) and secretin-induced IMMC-like motor complex (SI-IMMC).
    Duodenal manometric recordings were obtained by an infused catheter method, using an Arndorfer's system. A polyvinyl sensor catheter was inserted to a part of jejunum through nasal canal. After the appearance of spontaneous IMMCs, secretin of 2U/kg was administered intravenously.
    PSS patients showed less IMMCs than the normal group, but there was no difference in the reaction to secretin administration. The component values of contractions of IMMC were compared between the two groups. The values of amplitude, frequency and conduction velocity were significantly reduced in the PSS group. SI-IMMCs also had the same tendency but the values had no significant differences between the groups. The PSS patients with the history less than ten years had amplitudes of IMMCs which tended to reduce by degrees with years, and the cases with esophageal complaints or abnormal x-ray changes in esophagus or duodenum showed significantly lower amplitudes.
    It is concluded that duodenal motility is significantly reduced in the PSS patients and it correlated with their courses or clinical findings. Alterations in the characteristics of IMMCs and the reaction to secretin administration similar to the normal group suggest that the motor disorders of duodenum in the PSS patient may be due to the changes in the duodenal wall and its smooth muscle layer.
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  • Fumio KONISHI
    1983 Volume 80 Issue 8 Pages 1599-1609
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Total cutting up of tumors was done in 118 resected cases of colorectal carcinoma. For all the blocks, both hematoxyline. eosin (H•E) and elastica van Gieson (E.v.G.) staining were performed in serial sections. Comparing those two stainings, it was turned out to be clear that E.v.G. staining was essential for the histological examination of venous invasion.
    In most of the advanced carcinomas defect of tissue due to carcinomatous ulceration was seen in the submucosa. Because of this reason it was considered to be unreasonable to compare venous invasion in the submucosa with that in the extramural tissue relating to liver and lung metastasis.
    Recurrence rate of liver and lung metastasis was not necessarily dependent on the extent of venous invasion in the extramural tissue. Other factors seemed to be involved in the pathologenesis of liver and lung metastasis.
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  • Comparison between two different pancreatic glucagon-specific antisera, 30K and OAL-123, in radioimmunoassay of plasma glucagon level, and effect of bile acids on those two assay systems
    Hirohito TSUBOUCHI, Atsuyuki KAMIBEPPU, Kunio FUJISAKI, Harumi OKA, Hi ...
    1983 Volume 80 Issue 8 Pages 1610-1616
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Plasma pancreatic glucagon concentrations were measured in patients with chronic liver diseases by radioimmunoassay using two different specific antisera, 30K and OAL-123 and the relationship between values obtained by the two assay systems was studied. The concentrations of immunoreactive glucagon (IRG) in plasma from healthy subjects were found to be 99±15 and 111±10pg/ml, measured with the 30K and OAL assay systems, respectively. These IRG levels were significantly rose to about 3 times of the controls in cirrhotic patients, those values were 288±42 and 297±41pg/ml, with the 30K and OAL assay systems, respectively. Significantly correlations were observed between IRG concentrations in patients with chronic hepatitis and liver cirrhosis, which we measured with the 30K and the OAL assay systems. However, there was remarkable difference between the values in 30K-IRG and OAL-IRG in the plasma from some patients with cirrhosis and almost patients with hepatic encephalopathy; the former was much higher than the latter. Since it has been reported that bile acids strongly influence to the value by radioimmunoassay of IRG, we next examined the effect of addition of bile acids to the two assay systems. With the 30K assay system, IRG value remarkably increased by addition of bile acids, especially glycocholic acid and glycodeoxycholic acid. On the other hand, IRG value was hardly influenced by bile acids with the OAL assay system. In cases whose value of 30K-IRG was higher than that of OAL-IRG, the serum concentration of total bile acids was found to be high compared with cases whose value of 30K-IRG was equal or less than that of OAL-IRG.
    These results suggest that the increase in serum bile acids caused the discrepancy between 30K-IRG and OAL-IRG in cirrhotic patient; 30K-IRG shows higher value than OAL-IRG. Thus, it can be concluded that in cases with high concentration of serum bile acids such as hepatic encephalopathy, 30K-IRG does not show true IRG value but OAL-IRG does.
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  • Hiroko SAWAI, Yasuhiro MIZOGUCHI, Hiroko TSUTSUI, Yoshiharu MIYAZIMA, ...
    1983 Volume 80 Issue 8 Pages 1617-1622
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    A significant liver cell damage was induced when the isolated liver cells coated with specific antibody against the liver cell membrane were cocultured with the peripheral blood mononuclear cells and their culture fluids were added to the isolated liver cell suspensions. These hepatocytotoxic effects were demonstrated by measuring the reduction of protein synthesis in liver cells. The pretreatment of mononuclear cells with estrogen was shown to potentiate the hepatocyte injury by ADCC reaction, and this enhancing effect of estrogen was blocked by stimultaneous addition of testosterone. These were also the case when mononuclear cells were pretreated with the culture supernatant from estrogen-treated macrophages. The simultaneous addition of testosterone to macrophages was also shown to block the estrogen effect.
    These results suggest the possibility that sex hormones may modulate the ADCC reaction by affecting on the effector cells and this may due to the effect on the monocyte-macrophage system.
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  • With special reference to the patients of short survival
    Sumio TAKASHIMA, Haruki NAKATSUKA, Kenji NAKAMURA, Nobuyuki KOBAYASHI, ...
    1983 Volume 80 Issue 8 Pages 1623-1630
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Eighty patients with unresectable hepatoma were treated with transcatheter arterial embolization, and 17 died within 3 months postoperatively. Of the 7 cases who died within 1 month, 4 died of hepatic failure and 3 died of renal failure. All of the 4 patients who died of hepatic failure showed obstruction of the portal trunk on arterial portogram. The three patients who died of renal failure complained of severe pain after embolization which was followed by anuria.
    Out of the 10 cases who died between 1 and 3 months after embolization, 5 died of hepatic failure, 2 intraperitoneal bleeding, 1 gastrointestinal bleeding, 1 sepsis and 1 brain metastasis. All of the 5 patients who died of hepatic failure had a large tumor which grew rapidly and showed early regrowth after a temporary reduction in size. The death of the other 5 patients was thought to be unrelated to their embolization.
    From the above mentioned results, embolization can be performed safely with careful technique and postoperative management apart from those in which the portal trunk are obstructed.
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  • Takafumi ICHIDA, Hiroshi NANASAWA, Shuji INATSUCHI, Shinjiro MATSUI, T ...
    1983 Volume 80 Issue 8 Pages 1631-1635
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Masahiro TADA, Yoshinori TANAKA, Yoshikazu SUYAMA, Shinji NISHIMURA, T ...
    1983 Volume 80 Issue 8 Pages 1636-1640
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Takayoshi NOGUCHI, Tetsuo MORIMOTO, Taeko MIYAHARA, Yohei FUKUMOTO, Ta ...
    1983 Volume 80 Issue 8 Pages 1641-1645
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Yoshiharu MOTOO, Takashi OKAI, Masashi UNOURA, Yasuhiro KATO, Norio SA ...
    1983 Volume 80 Issue 8 Pages 1646-1650
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Shoji MAEDA, Yuji NIMURA, Naokazu HAYAKAWA, Hiroshi HASEGAWA, Junichi ...
    1983 Volume 80 Issue 8 Pages 1651-1654
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hiroshi TAKAHASHI, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1983 Volume 80 Issue 8 Pages 1655
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hideki NISHIWAKI, [in Japanese], [in Japanese]
    1983 Volume 80 Issue 8 Pages 1656
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Sachiaki YUSA, [in Japanese], [in Japanese]
    1983 Volume 80 Issue 8 Pages 1657
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hiroyuki IGARI, [in Japanese], [in Japanese], [in Japanese], [in Japan ...
    1983 Volume 80 Issue 8 Pages 1658
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Kotaro YAMAGUCHI, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1983 Volume 80 Issue 8 Pages 1659
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Kenji TAKARA, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1983 Volume 80 Issue 8 Pages 1660
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Kenichi IDO, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1983 Volume 80 Issue 8 Pages 1661
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Nozomi YAMAGUCHI, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1983 Volume 80 Issue 8 Pages 1662
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Osamu ISHIKAWA, [in Japanese], [in Japanese], [in Japanese], [in Japan ...
    1983 Volume 80 Issue 8 Pages 1663
    Published: 1983
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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