Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 81 , Issue 1
Showing 1-20 articles out of 20 articles from the selected issue
  • Tohru TAKESHIMA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1984 Volume 81 Issue 1 Pages 1-6
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    239 cases of esophageal hiatus hernia were classified into sliding, short esophagus, mixed, and paraesophageal type according to their "form". Sliding type was further divided into grade I, II and III from a standpoint of "size", which was examined from the maximal horizontal width of the sac of herniated stomach. It was found that there was a close relationship between the size of hernias and the severity on the clinical course. In sliding type, the symptoms of heart burn and/or dysphagia and the incidence of esophagitis increase as the size of hernia becomes larger. The patients of grade I and II in sliding type have not much complaints. However the incidence of complaints and esophagitis increases in the following order: sliding type grade III, mixed type, and short esophagus. Espescially short esophagus was the most severe and intractable in the clinical course.
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  • Koichi MIWA, Tadashi SASAKI, Hideo KITAMURA, Itsuo MIYAZAKI
    1984 Volume 81 Issue 1 Pages 7-15
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Development of gastric cancer was experimentally investigated in conditions of anacidity and hyperacidity of gastric juice. By method of injesting drinking water containing MNNG (N-methyl-N'-nitro-N-nitrosoguanidine) in concentration of 50mg/l for 20 weeks, gastric cancer whose invasion was limited to the mucosa of glandular stomach in wistar male rats had been established. The animals were divided into two groups; one was fundectomized and showed anacidity of gastric juice and the other was simply laparatomized, showing normoacidity. At the 50th week after beginning to intake MNNG, the incidence of further development of gastric cancer which was defined as being a tumor invading the deeper layer beyond the submucosal layer, was 67% (20/30) in the group of rats with anacidity and 20% (9/44) in that with normoacidity.
    Other rats with mucosal cancer of glandular stomach prepared by the same method were grouped into two. One group rats which were injected 2000γ/kg b.w. of AOC-tetragastrin in depot form subcutaneously once daily for 10 weeks. The other rats were injected with oil using the same technique mentioned above. The incidence of occurrence of gastric cancer at the 50th week after the beginning of the experiment was 29% (7/24) in the group with AOC-tetragastrin injection and 25% (8/32) in that with oil injection. The size of tumors were 5±3mm in maximum diameter in the group with AOC-tetragastrin injection and 19±10mm in the group with oil injection. The depth of the tumor invasion was shallower in the group with AOC-tetragastrin injection than in the group with oil injection.
    And so, it is concluded that anacidity of gastric juice promotes development of gastric cancer and hyperacidity inhibits it.
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  • Hiroshi SAITA, Motonobu MURAKAMI, Makoto SEKI, Takeo MIYAKE
    1984 Volume 81 Issue 1 Pages 16-21
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The application of the gastric mucosal blood flow measurement by the laser-Doppler velocimetry (LDV) was examined in rats by comparison with that by the hydrogen gas clearance technique (contact electrode method).
    The laser-Doppler flow signal and the absolute gastric mucosal blood flow by the hydrogen gas clearance technique were significantly correlated (p<0.01). And the flow measurement by the LDV was reproducible in the same rat as long as the probe was pressed lightly against the same mucosa.
    The LDV had the advantages that it yielded a continuous measurement in a small localized gastric mucosa, responding instantaneously to the delicated change of the mucosal flow, and that the LDV was able to measure the low blood flow which could not be recorded by the hydrogen gas clearance technique.
    Therefore, the LDV has a good possibility of the application of the gastric mucosal blood flow measurement, and is very useful in the studies of the pathophysiology of the gastric mucosal blood flow that is one of the gastric mucosal defensive factors.
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  • Kiyoaki KITAMURA, Hiroo FURUKAWA, Takeo MIYAKE, Haruto UCHINO, Etsuko ...
    1984 Volume 81 Issue 1 Pages 22-27
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We have obtained the phenol water extract of the human colon according to the method of Broberger and Perlmann. This extract was reported by them to be antigenic as for circulating autoantibody in patients with ulcerative colitis. Moreovere we have already confirmed that this extract was an inducer of delayed reactivity in man and guinea pig. In this paper, antigenicity of this extract was examined.
    This extract was treated with gel filtration technique using Sephadex G-200 and divided into polysaccharide (PS) fraction and OD280nm fraction.
    Fifteen randombred guinea pigs were divided into three groups. The first group was immunized with PS fraction in Freunds Complete Adjuvant (FAC), the second group with OD280nm fraction in FCA, and the third group with saline in FCA.
    After immunization, these guinea pigs were injected intradermally at their flanks with this phenol water extract, PS fraction, OD280nm fraction, E. coli 014 LPS, and saline, then intradermal reactions were examined timely.
    In the first group, these reactions were positive with this extract and PS fraction, but were negative with OD280nm fraction. The same results were also found in the second group. In the third group, all these reactions were negative.
    From this study, we confirmed that antigenicity of this extract was present in the polysaccharide fraction of this extract. Reactions against E. coli 014 LPS were positive in all these three groups.
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  • Kenichi SUGIHARA
    1984 Volume 81 Issue 1 Pages 28-36
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    It is widely known that in Western countries left-sided diverticular disease is common, whereas in Japan right-sided diverticular disease is more frequent. Intraluminal pressure in the ascending colon of thirteen patients with right-sided diverticular disease and of ten normal subjects was studied with Mikro-Tip pressure transducer inserted through a colonoscope in order to investigate the pathogenesis of right-sided diverticular disease. In the resting state the colonic motility index of patients with rightsided diverticular disease was greater than that of controls. After intravenous injection of neostigmine methylsulfate higher pressure waves were more frequently observed in patients with diverticular disease than in controls and the colonic motility index of patients with diverticular disease was much greater than that of controls with statistical significance. There was no difference in colonic motility between asymptomatic and symptomatic patients with right-sided diverticular disease, whereas the colonic motility index of asymptomatic patients with diverticular disease was significantly greater than that of controls both in the resting state and in the neostigmine stimulated state. These intraluminal pressure waves were generated by segmental contractions which did not transfer barium in the ascending colon distally. From these observations it is suggested that high intraluminal pressure and the abnormal motility in the ascending colon play an important role in the pathogenesis of right-sided diverticular disease.
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  • Yoshiko SAMESHIMA, Yasuko SHIOZAKI, Takako MIZUNO, Mineko SASAKAWA
    1984 Volume 81 Issue 1 Pages 37-45
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Drug-induced hepatic injury is one of the important problems in medical practice in recent years in Japan.
    We collected 8156 cases of drug-induced hepatic injury reported in Japanese articles published over a period of 70 years from 1911 to 1980.
    The greatest number of cases of drug-induced hepatic injury was due to antibiotics 2729, followed by drugs acting on the central nervous system 1223, chemotherapeutic drugs 1174, cardiovascular drugs 879, carcinostatic agents 604, hormones and hormone antagonists 452, diagnostic aids 370, and other drugs 725.
    Ten of the most common drugs which caused hepatic injury were chephalosporins, penicillins, thorium dioxide, arsphenamine, aminoglycosides, ethionamide, refampicine, macrolides, 4, 4'-diethylaminoethoxy hexestrol, cholrpromazine in descending order of frequency.
    The common clinical symptoms were gastrointestinal complaints, jaundice, fever, hepatomegaly and less frequently skin eruption.
    Approximately 93% of all cases were diagnosed on the basis of clinical history and laboratory tests. Readministration test, skin test, lymphocyte stimulation test and macrophage migration inhibitory test of suspected drugs were also performed as a diagnostic aid in nearly 7% of all cases. The positive rate of macrophage migration inhibitory test was 92.62%, that of readministration test 92.33%, lymphocyte stimulation test 88.83% and skin test 66.52%.
    The total 8156 cases included 395 fatal cases. The highest fatality rate was shown by thorium dioxide (153 cases), followed by halothane (28 cases), pyrazinamide (22 cases), arsphenamine (21 cases), 4, 4'-diethylaminoethoxy hexestrol (20 cases) in descending order.
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  • Tomoyuki SUGIYAMA, Hiroshi NAKANO, Hiroo IMURA, Kenichi ITO
    1984 Volume 81 Issue 1 Pages 46-55
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To examine a possible role of "fibrogenic factor", a kind of lymphokines, that enhances the collagen production by fibroblasts in the mechanism of hepatic fibrosis in chronic hepatitis, we devised a simplified 1-step method instead of the previously reported, standard 2-step method.
    The activity of the fibrogenic factor (fibrogenic activity, FA) was assayed by adding both peripheral lymphocytes and liver specific lipoprotein (Meyer zum Büschenfelde's LSP) at the same time to L929 fibroblast culture system.
    FA was assayed in 9 patients with chronic active hepatitis (CAH), 7 patients with chronic inactive hepatitis (CIH) and 8 healthy persons by both this simplified 1-step method and the standard 2-step method to ascertain the reliability of the 1-step method. The findings matched well in 22 out of 24 (92%) of these cases.
    Next, FA was assayed by the 1-step method in a larger number of subjects. FA was detected in 8 of 12 (67%) patients with CAH, in 4 of 16 (25%) patients with CIH and in none of the 8 healthy persons. The positive frequency of FA in each group assayed by the 1-step method was similar to that by the 2-step method. The positive frequency of FA in CAH was significantly higher (p<0.01) as compared with healthy persons by the 1-step method as well as the 2-step method.
    The above data suggest that "fibrogenic factor" may have a significant role in the mechanism of hepatic fibrosis in chronic active hepatitis, and that the relative simplicity of the 1-step method has proved to be clinically useful in detecting the fibrogenic factor.
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  • Kenichi TAKAYASU, Noriyuki MORIYAMA, Yukio MURAMATSU, Yasuo SHIMA, Tsu ...
    1984 Volume 81 Issue 1 Pages 56-65
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The radiological architecture of the intrahepatic portal vein branches in living man was evaluated in detail, based on the clearly opacified portograms by the lateral view and on superselective portograms made by percutaneous transhepatic portography in 27 patients with various liver and pancreatic diseases. Attaching importance to the changes of the portal vein, especially tumor invasion and thrombosis in hepatocellular carcinoma, a clinical and practical new nomenclature is proposed. 1) In the new nomenclature for the branching order, the right anterior and posterior segmental branches, the left umbilical portion and the caudate branches originating from the 1st order branches are called the 2nd order branches. More peripheral portal vein branches (subsegmental) are named the 3rd order branches, and more proximal portal vein branches are called the 1st order branches. 2) In the new nomenclature for the 3rd order branches, each branch is named from ventral to dorsal based on the frequency of occurrence and degree of utility for surgical resection and ultrasonographical findings.
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  • Shoji YAMADA, Kunio ICHIKAWA, Takayuki ARAI, Hitoshi TAKAGI, Jiro TAKE ...
    1984 Volume 81 Issue 1 Pages 66-71
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Among 21 liver biopsy specimens from acute viral hepatitis featured with zonal necrosis, 11 specimens (52.4%) exhibited morphological changes of interlobular bile ducts.
    The inflammatory cell infiltration into the ductal epithelium was usually seen in the altered bile ducts. Swollen and/or flattened epithelial cells, vacuolated cytoplasm, karyopyknosis and eosinophilic degeneration were often observed. Some alterations were similar to those of the hepatocytes in viral hepatitis. Ruptured wall of the bile duct was not found. Inflammatory infiltration, ductular proliferation and diffuse immature fibrosis were usually noticed in the portal tracts with changed interlobular ducts. Granuloma formation was not found.
    In the patients with altered interlobular bile ducts, cases of non A non B viral hepatitis seemed to be more frequent than in those without the changes.
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  • Shigeyuki TSUNETOMI, Masao ONTO, Yasuo IINO, Takashi SHINAGAWA, Kunio ...
    1984 Volume 81 Issue 1 Pages 72-81
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The capability of CT in detecting small hepatocellular carcinoma less than 5cm in size was studied in 48 patients. Changes in the density of the tumors were analized in comparison with the pathologic and angiographic findings.
    Iso-density was the main cause that made the tumors undetectable in either precontrast or postcontrast scan. By combination of precontrast and postcontrast scans, the majority of the tumors larger than 2cm were detected.
    In precontrast scan, the density of the tumors was related to bleeding, necrosis and fatty degeneration in the cancer tissue, and fatty degeneration in the non-cancer tissue.
    In postcontrast scan, it was related to bleeding, necrosis, fatty degeneration and blood spaces in the cancer tissue.
    Thus, CT can demonstrate accurately the pathological changes of the tumors as images, and it may be useful not only in the diagnosis of small hepatocellular carcinoma, but also in the assessment of the therapeutic effects.
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  • Keizo KAGAWA, Takeshi DEGUCHI, Hiroo TOMIMASU, Takeshi OKANOUE, Kenji ...
    1984 Volume 81 Issue 1 Pages 82-91
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To investigate cell biological characteristics of the liver cell dysplasia (LCD), the differences in the ploidy pattern of the nuclear DNA content were cytofluorometrically analyzed between LCD and other hepatic lesions such as cirrhotic nodules and hepatomas.
    The liver tissues from 30 autopsy cases of liver cirrhosis (including 20 cases of hepatoma) were examined by Feulgen-DNA cytofluorometry (NIKON SPM-RFl-D) using paraffin-embedded materials. The methods employed for single cell separation from the paraffin materials and also for cytofluorometry were according to the ones previously developed by us.
    The results showed an increase in the fraction of polyploid cells in the cirrhotic nodules compared with that in the normal age-matched controls. In the LCD areas, the polyploid cells were increased in the fraction showing nuclear atypism. Furthermore, cells with intermediate DNA values between each ploidy calss (i.e., S phase cells) were not detected in the LCD areas studied. On the other hand, the hepatoma cells showed unimodal, wide DNA-content distributions with many S phase cells extending continuously from the diploid levels to various, higher ploidy levels. Thus, the LCD appears to be a non-neoplastic, hyperplastic cell population with both nuclear atypism and more increased polyploidization formed as the result of repeated cell proliferation in the course of chronic liver injuries. Finally, the possibility that LCD may be a precancerous lesion was discussed based on these findings and the literature reported so far.
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  • Keiho SHIM, Ichikun KO, Euichol KIM, Katsusuke SATAKE, Kaoru UMEYAMA
    1984 Volume 81 Issue 1 Pages 92-100
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The present examination has been attempted to investigate morphological changes of pancreatic acinar and islet cells after complete ligation of common bile duct in rats using electron microscope.
    At the early stage of the ligation of the common bile duct (2nd weeks after the ligation), the most of acinar cells and B cells of the Langerhans islands showed hyperfunctional appearance, but no remarkable changes were observed in the A cells. At the late stage (4th weeks after the ligation), acinar cells became atrophied and B cells were degenerative changes, however many of A cells showed hyperfunctional appearance.
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  • Aiji NODA, Tetsuo HAYAKAWA, Takaharu KONDO, Kenji NAGAI, Ribun MIZUNO, ...
    1984 Volume 81 Issue 1 Pages 101-107
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The effect of Dimethadione (DMO) on pancreatic stones dissolution and calcium carbonate (CaCO3) solubility was studied in vitro experiments. The principal composition of human pancreatic stones was found to be a calcite of CaCO3 by means of the elemental analysis, the infrared absorption spectrum, and the powder X-ray diffraction.
    Pancreatic stones, when kept at 37°C in DMO-M/20 NaHCO3 aqueous solution which was refreshed once a week, were completely dissolved in 1.0 (10mg/ml), 0.5 (5mg/ml) and 0.2% (2mg/ml) of DMO aqueous solution in 5, 11, and 58 weeks, respectively. The stones in 0.1(1mg/ml) and 0.05% (0.5mg/ml) of DMO aqueous solution were partially dissolved during the observed 96-week period; 33.1 and 40.1mg decrease in their dry weights, respectively. Only 3mg decrease in the stone weight was observed in NaHCO3 aqueous solution.
    DMO, when dissolved in the distilled water, induced a concentration-dependent increase in solubility of CaCO3 associated with a concentration-dependent fall of the solution pH. Solubility of CaCO3 reached a plateau at 10 to 15min in 100 and 1000μg/ml of DMO aqueous solution. A concentration-dependent increase in solubility of CaCO3 was also found in the higher concentration of DMO aqueous solution with a high pH ajusted by a NaOH solution.
    No significant difference was observed in solubility of CaCO3 in the low concentration aqueous solution of three organic acids; DMO, tartaric and citric acids.
    The results obtained indicate that DMO has the potential usefulness for pancreatic stones dissolution.
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  • Hiroshi HASEGAWA, Shoji MAEDA, Kazuhito NAKAGAMI, Teruo IKEZAWA, Yukif ...
    1984 Volume 81 Issue 1 Pages 108-111
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1984 Volume 81 Issue 1 Pages 112-116
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hideo MORIMOTO, Yasuhiro KATO, Youichi ISHIDA, Masashi UNOURA, Norio S ...
    1984 Volume 81 Issue 1 Pages 117-120
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tokio SANKE, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1984 Volume 81 Issue 1 Pages 121
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tomonori TAMURA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1984 Volume 81 Issue 1 Pages 122
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yutaka SASAGAWA, [in Japanese], [in Japanese], [in Japanese]
    1984 Volume 81 Issue 1 Pages 123
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Keiko SHIRATORI, [in Japanese], [in Japanese]
    1984 Volume 81 Issue 1 Pages 124
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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