Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 81 , Issue 12
Showing 1-23 articles out of 23 articles from the selected issue
  • Takashi YAMAUCHI
    1984 Volume 81 Issue 12 Pages 2905-2913
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Gastric mucosal histamine and histidinedecarboxylase activitiy stimulated by tetragastrin was studied biochemically in rats in order to determine the direct pathway from gastrin to histaminocyte, in cases of gastric acid secretion in vivo. Gastric mucosal histamine was decreased by injection of tetragastrin while histidinedecarboxylase activity was significantly increased, and secretin suppressed the histidinedecarboxylase activity stimulated by tetragastrin. These results suggest that gastrin acts directly and specifically on histaminocytes.
    The levels of serum gastrin, mucosal histamine and histidinedecarboxylase activity showed significant increases in the presense of cimetidine and these increments were not suppressed after abolishment of secondary increases in endogenous gastrin secretion by intragastric perfusin with hydrochloric acid. Therefore, cimetidine acts indirectly on histaminocytes through gastrin producing cells.
    Gastric acid secretion stimulated by tetragastrin was also inhibited by cimetidine, and was completely inhibited by cimetidine plus α-Fluoromethylhistidine, a specific inhibitor of histidinedecarboxylase. These results suggest that increments in histidinedecarboxylase activity induced by cimetidine relate to gastric acid secretion.
    The important role of histamine in the mechanism of gastric acid secretion was thus elucidated.
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  • Shozo OKAMURA, Saburo NAKAZAWA, Junji YOSHINO
    1984 Volume 81 Issue 12 Pages 2914-2924
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to investigate the fine abnormal mucosal changes of microcancer and type IIb early cancer of the stomach, we induced gastric lesions in six mongrel dogs by oral administration of ENNG solution. As a result of macroscopic and histological examination, canine cancers were similar to those of human ones in major part.
    As a consequence of stereomicroscopic observation in 54 lesions, type I, type IIb and shallow type IIc early cancers were considered as the most benefical objects of stereomicroscopic examination. Especially, the latter two types of early cancers showed characteristic findings according to the histological types of them. In differentiated adenocarcinomas, the irregular foveolar pattern, which was differed from that of intact mucosa, was observed. In undifferentiated adenocarcinomas, the mucosal pattern was similar to that of the surrounding intact mucosa, but various sizes of enlarged and extended areola were demonstrated. It was considered that these stereomicroscopic findings reflected the histological cancerous invasion respectively.
    These results are considered to be valuable for the progress of clinical diagnosis of gastric cancer by means of magnifing examinations.
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  • As Compared with H2-Inhalation Method
    Hideki NISHIWAKI, Ichikun KO, Michio SOWA, Kaoru UMEYAMA
    1984 Volume 81 Issue 12 Pages 2925-2929
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The endoscopic measurements of regional gastric mucosal blood flows by using hydrogen gas generated by electrolysis and by H2 inhalation method were investigated in five anesthetized dogs. The mean blood flow were 63.3±13.6ml/min/100g following hydrogen gas generated by electrolysis and 54.2±11.2ml/min/100g after H2 inhalation method. It was observed a slightly high value of regional mucosal blood flow by gas generated by electrolysis as compared with H2 inhalation method. However, a significant correlation between both measurements was found in this experiment.
    In clinical studies of gastric mucosal blood flow by using hydrogen gas generated by electrolysis in eighteen patients with gastritis and gastro-duodenal ulcer, the mean gastric mucosal blood flow in antrum and corpus were 67.2±8.8ml/min/100g and 74.8±13.3ml/min/100g, respectively in patients with gastritis, 59.5±13.8ml/min/100g and 60.0±12.4ml/min/100g, respectively in patients with gastroduodenal ulcer.
    It is concluded that this method can be applied clinically and experimentally to determine the regional gastric mucosal blood flow under endoscopic observation.
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  • Eizo KANEKO, Junichi KUMAGAI, Hiroyuki HANAI, Nishio HONDA, Shozo BABA ...
    1984 Volume 81 Issue 12 Pages 2930-2934
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Immunochemical method employing anti-human hemoglobin (rabbit r-globulin) is considered to be very specific in detecting fecal occult blood due to gastrointestinal bleeding. The clinical evaluation, however, has not been established. Our method is single radial immunodiffusion (SRID). Its sensitivity to human hemoglobin is 1-2mg/dl hemoglobin concentration, which is almost same as guaiac method. Feces in 20 cases with upper gastrointestinal bleeding, which showed strongly positive reaction in guaiac method, revealed negative in all except one in SRID. On the otherhand 15 cases with bleeding due to colonic diseases are all positive in both method, but 5 in 11 cases with ulcerative colitis in remission, feces of which are negative in guaiac method, showed positive reaction in SRID. To confirm the different reaction in different sites of gastrointestinal tract, we instilled 10ml whole blood to the stomach, upper jejunum and lower jejunum in three healthy volunteers. The results also showed strong positive reaction in guaiac method and negative in SRID in any cases. These results suggest that SRID has specific reaction in the bleeding of lower digestive tract and this method, when combined with guaiac method, may differentiate the bleeding site of the digestive tract.
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  • Comparison in Sensitivity to Detect Hemoglobin and Positive Reactions in Colorectal Cancer Cases with Single Radial Immunodiffusion and Hemoccult Test
    Hiroshi SAITO, Shigeki TSUCHIDA, Michio FUKUSHI, Ryosuke KAKIZAKI, Tad ...
    1984 Volume 81 Issue 12 Pages 2935-2939
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We have developed a new immunological fecal occult blood test employing counter immunoelectrophoresis (CIEP), which has shown to detect human hemoglobin in stool specifically and to give no false positive reactions in 35 control specimens.
    The minimum level of hemoglobin for positive reaction was 0.5mg/g stool and 7μg/ml hemolysate by this method, while 1.0 and 3.0 mg/g stool, 9 and 7ug/ml hemolysate by single radial immunodiffusion (SRID) and Hemoccult test (HO), respectively. CIEP was most sensitive among the three tests to detect hemoglobin both in feces and in hemolysate.
    Of 21 cases with colorectal cancer, 19 (73%), 14 (54%) (p<0.05), and 12 (46%) (p<0.02) gave positive reactions by CIEP, SRID and Hemoccult test, respectively. CIEP gave the highest positive values both in all stages of the cancer according to Dukes' classification and in all sites of the cancer.
    In addition to a potential of our method for screening of colorectal cancer, the clinical usefulness of CIEP was shown by presenting a case. CIEP is a more specific, sensitive and clinically useful occult blood test than the previously known methods.
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  • Kentaro TAKEUCHI
    1984 Volume 81 Issue 12 Pages 2940-2950
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to clarify the relationship between the hepatic and exocrine pancreatic injuries in patients with chronic pancreatitis, liver function tests in 74 cases with chronic alcoholic pancreatitis (CAP) and 40 cases with chronic idiopathic pancreatitis (CIP) were analysed and histologic findings of biopsied liver in 33 cases with CAP were studied.
    The incidence of abnormal liver function tests was higher in CAP than in CIP. However, on the histologic findings of biopsied liver in patients with CAP, hepatic fibrosis was the lesion most often observed, followed by minimal changes, and liver cirrhosis was rather rarely found. The histologic findings of the liver in patients with CAP bore no relation to the presence of pancreatic calcification, the X-ray findings of pancreatic and bile ducts or to the pancreatic exocrine function, but bore a close relation to the total amount of the ethanol consumption.
    These observations indicate that the grade of alcoholic liver injury does not necessarily paralell the severity of alcoholic pancreatic injury and that the hepatic lesions in CAP are principally of alcohol-induced ones with minor share of secondary liver injury associated with pancreatitis.
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  • Preliminary Report
    Osamu YAMAZAKI, Katsuji SAKAI, Hiroaki KINOSHITA, Kazuhiro HIROHASHI, ...
    1984 Volume 81 Issue 12 Pages 2951-2959
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Ganz's thermistor catheter was originally developed to determine human coronary sinus blood flow, which is low compared with that of the portal vein. To use this device determining portal blood flow, we prepared a model circuit with high flow, and examined its appropriateness and reproducibility.
    There was a significant regression between calculated (X) and measured (Y) blood flow rate while the thermal indicator was being injected at a constant rate of 48ml/min with blood flow rates of 240 to 1, 148ml/min in this circuit. The regression equation was Y=1.15X-22.6 (r=0.9949, p<0.001). Reproducibility was satisfactory.
    We used this catheter inserted in the portal trunk by percutaneous transhepatic portal catheterization to determine portal blood flow. The circuit was the same as before. Fifty-five such measurements in 26 cases showed portal blood flow ranging from 315 to 1, 513ml/min, with a mean of 713.5±277.8ml/min Reproducibility was excellent, with a random error of 3.9±2.9%. The portal blood flow in the 19 cases complicated with cirrhosis, 441.0±192.6ml/min/m2 was not significantly lower than in cases without cirrhosis, in which the mean was 509.2±187.5ml/min/m2.
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  • An Clinical Evaluation as Supporting Therapy for Hepatocellular Carcinoma and Liver Cirrhosis
    Kenji HIRAI, Yoshiharu KAWAZOE, Masanobu KUMAGAI, Yasuo MAJIMA, Masahi ...
    1984 Volume 81 Issue 12 Pages 2960-2966
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Transcatheter splenic arterial embolization (TSAE) was successfully carried out in one case of liver cirrhosis and six cases of hepatocellular carcinoma with liver cirrhosis for treatment of hypersplenism. A mean value of infarcted area of the spleen by TSAE was 62.5%. Leukocyte and platelet counts of the peripheral blood increased significantly after TSAE and its effects continued over 10 months after the treatment. There were transient adverse effects such as high fever, abdominal pain and pleural effusion.
    This study suggests that TSAE is an effective supporting therapy for patients of cirrhosis or hepatocellular carcinoma with hypersplenism, who need further treatment such as chemotherapy, injection sclerotherapy and others.
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  • Toshio MURAKI
    1984 Volume 81 Issue 12 Pages 2967-2977
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Biliary scintigraphy is one of the most useful examination for the evaluation of pathophysiology of the biliary system among various techniques for imaging the biliary tract. Qualitative and quantitative analysis of bile flow dynamics and contraction of the gallbladder was performed in normal controls and in the patients with disease of gallbladder and/or bile duct, chronic liver disease, and malignancy. Results disclosed the dysfunction of the gallbladder and biliary tract in patients with biliary disease as well as in chronic liver disease and cancer of digestive tracts. Function of the gallbladder (vesica fellae) and sphincter of Oddi was well shown as sequential images based on tracer movement through the biliary tract and intestine. Abnormality of the system might be understood as vesicosphincter dysfunction.
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  • Kazumori KARAKI, Yoshio MATSUBARA
    1984 Volume 81 Issue 12 Pages 2978-2985
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Ninety-two chronic biliary typhoid and paratyphoid carriers were operated on at Tokyo Metropolitan Toshima Hospital from January 1964 to December 1980. Out of these carriers, 90 had gallstones, and 2 were suspected of having gallstones. Carcinoma of the gallbladder was found in 5 carriers (5.4%). The carriers whose stool and bile cultures became negative by surgery alone were followed up for 4 months, while the carriers whose stool and bile cultures became negative by additional antibiotic treatment after surgery were followed up for 1 year. Out of 74 carriers who were followed up for the above perods, 70 (94.6%) were proved to be cured. The cure rate of 98.5% in 66 carriers with gallbladder stones was higher than that of 62.5% in 8 carriers with bile duct stones (p<0.005). Four failures had dilatation of the common bile duct. Furthermore, 1 of 4 failures had numerous intrahepatic duct stones.
    Since existence of gallstones is considered to be a major factor in the pathogenesis of the typhoid and paratyphoid carrier states, gallstones in these carriers must be completely removed by surgery. Chronic biliary carriers with gallstones should have a cholecytsectomy. A choledochotomy is indicated for the carriers with dilatation of the bile ducts or bile duct stones. We recommend to select a papilloplasty in the carriers who may have small bile duct stones. A long-term antibiotic treatment should be added in the carriers who have positive stool and bile cultures after surgery.
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  • Determined in the Model of Pancreatic Insufficiency in the Rat
    Kyoko MIYASAKA
    1984 Volume 81 Issue 12 Pages 2986-2991
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The pancreatic insufficiency was simulated in terms of intestinal enzyme activities by excluding 90% of pancreatic juice from the intestine, since we have reported that the basal secretion of pancreas could be maintained by the returning of as little as 10% of pancreatic juice to the intestine. Then, the pancreatic secretory response to the elemental diet was determined in pancreatic insufficiency model and in controls. The intraduodenal infusion of elemental diet produced the greater responses of pancreas in terms protein an volume secretions in rats with pancreatic insufficiency than the infusion of isotonic saline did in these animals. However, the increase in pancreatic secretion was not statistically significant in rats receiving 100% pancreatic juice return. These enhanced responses were abolished by the administration of pancreatin. These results indicate the possibility that the administration of pancreatic enzyme might be useful to relieve the pain produced by food intake and to keep pancereas at rest in patients with chronic pancreatitis.
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  • Kazuo KATSUMATA, Yoshinao KATSUMATA, Takeo NAKAGAWA, Sadayuki SAKUMA
    1984 Volume 81 Issue 12 Pages 2992-2995
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We have clarified that computed tomography of pancreas can be divided into three types each in margin and content, namely 1) smooth type 2) fine-granule type 3) rough-granule type. In rough-granule type, rough granules are surrounded by low density area whose CT value is around -80. This CT value suggests that in rough-granule type, large amount of lipid may be present in pacreas.
    In this report, pancreatic CT scan of 406 persons without gall stone, diabetes mellitus, liver cirrhosis, pancreatitis and malignant tumor were studied. Incidence of the rough-granule type was very low in lean persons, while that of the rough-granule type was high in obese persons.
    Present results indicate that these types of pancreas in CT scan has intimate relation to body constitution. We discussed the clinical significance of this classification of pancreatic CT scan in relation to lipid deposition in pancreas.
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  • Hiroyuki ODA, Etsuko FURUSAKA, Yutaka SASAGAWA, Kyoko NISHII, Ryuichi ...
    1984 Volume 81 Issue 12 Pages 2996-3002
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Rapid molecular sieve chromatography using HPLC was employed in the present study to demonstrate macroamylase complexes in ten patients. In this technique, the proportions of macroamylase in total amylase activities were almost identical with those which were obtained by Sephadex G-200 column chromatography method.
    All macroamylase complexes which were bound with immunoglobulin were dissociated at lower pH condition.
    HPLC method needs small sample and is not time consuming, so, this seems to be useful on detecting macroamylase and on following the course of macroamylasemic patients.
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  • Using Bradykinin Depletor Cellulose Sulphate
    Kazuo CHIBA
    1984 Volume 81 Issue 12 Pages 3003-3012
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To elucidate the role of kinins in the mechanisms of lethal toxicity of endotoxin, the effects of bradykinin depletor cellulose sulphate on endotoxin-shocked rat were investigated biochemically and morphologically.
    Initial hypotension of endotoxin was inhibited had also beneficial effect on the lethal rate was observed significantly by the pretreatment of cellulose sulphate which promote the complete release of bradykinin and cause extensive plasma kininogen depletion. Pretreatment of cellulose sulphate reduced the lethal rate of endotoxin from 100% to 40% in 12 hours and 60% in 24 hours.
    For the more detailed clarification of the beneficial effects of cellulose sulphate on endotoxin- shocked rats, hepatic carbohydrate intermediates, hepatic ATP and blood glucose were measured biochemically and the results showed a remarkable improvement of impaired carbohydrate metabolism of endotoxin by the pretreatment. Comparative studies of the hepatic morphology using electronmicroscope also revealed the marked improvement of the endotoxic changes by the pretreatment.
    From these results, it could be suggested that the close relation of bradykinin to the mechanisms of lethal toxicity of endotoxin.
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  • a case report and review
    Shingo SHIMA, Yoshiaki SUGIURA, Hajime YONEKAWA, Yutaka YOSHIZUMI, Tos ...
    1984 Volume 81 Issue 12 Pages 3013-3018
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kazuo KOMAI, Kazuo WADA, Masaomi OKAWA, Daisuke SASAKI, Yutaka YOSHIDA ...
    1984 Volume 81 Issue 12 Pages 3019-3022
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tsuyoshi ONO, Masafumi KOMATSU, Shigeki INOMATA, Masanori INOUE, Fumio ...
    1984 Volume 81 Issue 12 Pages 3023-3027
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Osamu NISHIDA, Fuminori MORIYASU, Takefumi NAKAMURA, Nobuyuki BAN, Ken ...
    1984 Volume 81 Issue 12 Pages 3028-3032
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Toshihiko SUMII, Toshinari KIMURA, Akihiro FUNAKOSHI, Hirotsugu SHINOZ ...
    1984 Volume 81 Issue 12 Pages 3033-3038
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Akiharu WATANABE, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1984 Volume 81 Issue 12 Pages 3039
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Izumi KUMON, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1984 Volume 81 Issue 12 Pages 3040
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kanji TSUCHIMOTO, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1984 Volume 81 Issue 12 Pages 3041
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Masatoshi SUMIDA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1984 Volume 81 Issue 12 Pages 3042
    Published: 1984
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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