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Volume 81, Issue 8
Displaying 1-23 of 23 articles from this issue
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Keiko SHIRATORI, Shin-ichiro WATANABE, Tadashi TAKEUCHI1984 Volume 81 Issue 8 Pages 1737-1741
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe have regarded a physiological dose of secretin as GIH-secretin 0.02-0.05CU/kg-hr in the amount that can achieve plasma concentrations of immunoreactive secretin comparable with those after a meal. The physiological significance of secretin on gastric secretion was determined in 5 healthy volunteers.
The gastric secretion was stimulated by intravenous infusion of tetragastrin in a dose of 0.05μg/kg-hr for 3hrs, and GIH-secretin was given intravenously at a rate of 0.05CU/kg-hr for the 2nd hr and 0.1CU/kg-hr for the 3rd hr. Gastric acid output decreased statistically significantly in 63.3% with 0.05CU/kg-hr and in 36.3% with 0.1CU/kg-hr. On the other hand, pepsin output was not affected by intravenous infusion of secretin. Plasma secretin concentration increased statistically significantly to about 5 times during the infusion of 0.05CU/kg-hr, and to about 10 times during the infusion of 0.1CU/kg-hr, compared with the basal concentration (4.1±0.3pg/ml).
The studies indicate that the secretin in a physiological dose can inhibit gastric secretion of acid in such low plasma secretin concentration.View full abstractDownload PDF (642K) -
Shugo AKAZAWA, Akio HARADA, Yuzo KANDA, Toshio FUJIKI, Hirofumi KITAGA ...1984 Volume 81 Issue 8 Pages 1742-1749
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSSince increased synthesis of collagen has been demonstrated in human cancer tissues, we attempted to detect the amino-terminal peptide of the bovine type III procollagen (type III-N-peptide) in the serum of gastric cancer patients with radioimmunoassay.
The results showed that: (1) the mean levels and positive ratios of the type III-N-peptide increased as the clinical stage of the patients with gastric cancer advanced; (2) the mean serum levels were highest in the patients with liver, lung or bone metastasis; (3) the mean serum levels in the patients with type IV gastric cancer in Borrmann's gross classification were higher than those in the patients with type I, II, III; (4) the mean serum levels in the patients with undifferentiated adenocarcinoma were also higher than those in the patients with differentiated type; (5) the serum levels of type III-N-peptide in the patients with gastric cancer decreased after total resection of stomack and also decreased in the case that entered into partial response with chemotherapy; (6) the serum levels of the type III-N-peptide in the patients with gastric cancer were not correlated either with those of carcinoembryonic antigen (CEA), or with carbohydrate antigen (CA 19-9).
These results suggest that the assay of type III-N-peptide in sera may have diagnostic value in gastric cancer, and may be available for the detection of the liver, lung or bone metastasis and for the monitering in the therapy.View full abstractDownload PDF (983K) -
Yoshihito UCHIDA1984 Volume 81 Issue 8 Pages 1750-1758
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSVarious classes of immunoglobulin (Ig) containing cells and secretory component (SC) were investigated using immunofluorescence technique in 90 specimens of colonic adenoma. The percentage proportions of IgM and IgD containing cells in colonic adenoma revealed a statistically significant rise as compared with normal mucosa. This rise was remarkable in samples showed severe dysplasia. The stainability of SC was deteriorated in about a quarter of specimens. Then, as the grade of dysplasia showed more severe, the samples with less amount of SC were observed more frequently. In regard to the relationship between Ig containing cells and SC, IgM and IgD containing cells were significantly increased in adenoma with less amount of SC, comparing in adenoma with sufficient amount of SC. It was suggested that the increase of both IgM and IgD containing cells was one of the most characteristic feature in local immune response occurring inside of adenoma tissue, and that dysplastic change and SC might play the important part of this phenomenon.View full abstractDownload PDF (1198K) -
Hitoshi ASAKURA, Masahiro YOSHIOKA, Tetsuo MORISHITA, Koichi SUZUKI, T ...1984 Volume 81 Issue 8 Pages 1759-1766
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn order to assess protein-energy malnutrition from the viewpoint of rapid turnover transport proteins and elemental diet therapy, twenty-four patients with Crohn's disease, digestive cancers and miscellaneous diseases received elemental diet ED-AC (Elental) and rapid turnover transport proteins in plasma such as transferrin, retinol-binding protein and prealbumin were measured before and after the elemental diet therapy as compared with serum total proteins and albumin.
Among various plasma proteins, lower levels below the normal ranges for plasma retinol-binding protein were found in 74% of the patients, for serum total proteins in 62%, for plasma transferrin in 58% and for serum albumin in 50% respectively. The rapid turnover transport proteins such as transferrin, retinol-binding protein and prealbumin have the highest and rapid response to the elemental diet therapy.
Therefore, rapid turnover transport proteins were found to be the useful indicators for an assessment of PEM and elemental diet was clarified to be effective against PEM.View full abstractDownload PDF (1005K) -
Yasuo UEHARA, Osamu KOJIMA, Takashi MAJIMA, Eito IKEDA, Bunzo NISHIOKA ...1984 Volume 81 Issue 8 Pages 1767-1772
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSSerum tissue polypeptide antigen (TPA) level was measured in 44 colorectal cancer patients. Then, the colorectal cancer specimens from some of these patients were stained for TPA by the unlabelled antibody enzyme method. Serum TPA levels in colorectal cancer patients (112±12U/L: Mean±SE) were significantly higher than those in normal subjects (77±3U/L), especially high in patients with stage V cancer. The cytoplasm was stained by tissue TPA staining. Tissue TPA concentrations in colorectal cancer tissues were significantly higher than those in non-cancerous colorectal mucosa. Eighteen out of 44 colorectal cancer patients (41%) showed an elevated serum TPA level. This incidence of an elevated serum TPA level was as high as that of an elevated serum CEA level, which was investigated simultaneously. These results suggest that TPA is also a useful tumor marker in colorectal cancer.View full abstractDownload PDF (794K) -
Kan TSUDA, Kiyokazu FURUYA, Yoshio KONDO1984 Volume 81 Issue 8 Pages 1773-1780
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSTo study the effect of taurocholate on sulfobromophthalein (BSP) excretion in the rats with relieved biliary obstruction, 42 Wistar rats were divided into two groups; 30 jaundiced rats were prepared ligating the common bile duct and relieving the obstruction 48 hours prior to the study, 12 control rats were prepared with a biliary fistula formation.
The hepatic uptake and biliary transport of BSP was studied in 6 ras of each groups by determining the BSP transfer rate constants (a-value, hepatic BSP uptake; b-value, reflux from liver to plasma; h-value, elimination of BSP into bile), the transport maximum and the relative storage capacity. Similar studies were carried out in 6 rats of each groups by simultaneous injection of sodium taurocholate with BSP to evaluate the influence of bile salt on BSP transport into bile.
The results were as follows:
a) Subsequent increase in bile acid excretion after biliary decompression was significantly suppressed in the jaundiced rats as compared to the control rats.
b) Biliary transport of BSP was significantly suppressed shortly after biliary decompression indicating either the secondary intrahepatic cholestasis or the insufficiency of organic anion excretion.
c) Administration of sodium taurocholate markedly increased BSP transport into bile, whereas equal amounts of sodium taurocholate injection produced cholestatic effect on the control rats.
In conclusion, effective elimination of plasma bilirubin after biliary decompression might be achieved by supplemental administration of bile salts whereby facilitating canalicular organic anion transport, provided that bile acid clearance remains intact.View full abstractDownload PDF (905K) -
Takayuki ARAI, Yasuhiro MIZOGUCHI, Yoshihiro IKEMOTO, Hiroko KATOH, Hi ...1984 Volume 81 Issue 8 Pages 1781-1787
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWhen human peripheral blood mononuclear cells were stimulated with pokeweed mitogen (PWM) and culture supernatant from lipopolysaccharide (LPS)-treated Kupffer cells, polyclonal antibody production was enhanced significantly in comparison with production in lymphocytes stimulated with PWM alone. These increases in antibody formation were attributed at least partially to interleukin-1, because the active material contained in the culture supernatant of the LPS-treated Kupffer cells caused an increase in DNA synthesis in PHA-stimulated thymocytes. However, DNA synthesis in the human peripheral blood mononuclear cells, as induced by stimulation with PWM, was diminished by the culture supernatant from LPS-stimulated Kupffer cells. This response was not presumed attributable to prostaglandin, because the diminishment of DNA synthesis was not affected by indomethacin-treated Kupffer cells.
These results suggest that immunological responses are modulated by Kupffer cells.View full abstractDownload PDF (982K) -
Hirohito TSUBOUCHI1984 Volume 81 Issue 8 Pages 1788-1798
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWhen plasma from human or rats with or without hepatic injury was filtrated by columns of Bio Gel P-30, P-150 and P-300, "big plasma glucagon" (BPG), a large molecular weight form of immunoreactive glucagon (IRG), was always eluted together with glucagon degrading activity (GDA) at the void volume. The GDA in BPG fraction obtained by gel filtration from normal rats was suppressed mainly by serine and thiol proteinase inhibitors and that from carbon tetrachloride (CCl4)-treated rats was suppressed by thiol proteinase inhibitors. The IRG values in BPG fraction decreased in parallel with inhibition of the GDA. The GDA in BPG fraction obtained by a column of Bio Gel A-1.5m from plasma both normal and CCl4-treated rats was strongly inhibited by p-chloromercuriphenyl sulfonate and N-ethylmaleimide, and IRG values in BPG fraction also decreased to near zero by addition of those inhibitors to the assay system. The GDA and IRG in BPG fraction in human plasma from normal subjects and cirrhotic patients showed almost the same chromatographic profiles as those obtained from rats. These results indicate that IRG in BPG fraction in plasma from human and rats could be apparent values accounted for the degradation of 125I-labeled glucagon by plasma proteinases during the assay procedure.View full abstractDownload PDF (1277K) -
Masaaki EBARA, Masao OHTO, Takashi SHINAGAWA, Kunio KIMURA, Shoichi MA ...1984 Volume 81 Issue 8 Pages 1799-1809
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe analyzed the clinical data of 22 patients with small hepatocellular cacinoma including 19 with tumors smaller than 3cm. in size, and 3 with tumors of 3 to 5cm. who had not been treated for cancer for a minimum of 6 months to 2 years and 10 months. We focussed a particular attention on the changes in size and pattern of tumors seen on echograms and on the interrelationship between such changes and clinical data.
The results were as follows: the speed of tumor growth varied from patient to patient and also in the same patient depending upon the stage of the disease. The echographic pattern of the tumor changed in a specific order as the tumor grew in size. The echo-pattern of tumors 2 to 3cm. in size was closely related to the rate of growth. At the time of tumor detection, only 3 patients (13.7%) showed a serum AFP of more than 200ng/ml. The serum AFP level increased gradually after tumor had exceeded 3cm. in size, and rose rapidly when the echo-pattern changed from nodular to massive.
Survival rate after tumor detection was 88.6% at one year, 50.6% at two years and 0% at three years. Three patients died from massive tumor growth, two at 22 months and one at 34 months; the other three died of liver cirrhosis 3, 11 and 23 months, respectively.View full abstractDownload PDF (1252K) -
Hidemasa OKUMURA, Tatsuya SEKIYAMA, Takumi ARAMAKI, Yasumi KATSUTA, Ka ...1984 Volume 81 Issue 8 Pages 1810-1816
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe treatment with plasmapheresis was applied to four patients with intractable intrahepatic cholestasis, in whom common conservative treatments including corticosteroid were ineffective. Mean plasma volume and mean time required for exchange were 3100ml and 196 minutes, respectively. In a case of drug-induced cholestasis and a case of alcoholic hepatitis with positive HBsAg, plasma exchange led to gradual decrease in serum bilirubin at its first attempt with resultant normalization during two months. In a case of PBC with postoperative jaundice serum bilirubin decreased from 15mg/dl to 8mg/dl after the first attempt, and from 8mg/dl to 5mg/dl after the second attempt. In a case of subacute hepatitis, however, the first treatment led to decrease in serum bilirubin from 35mg/dl to 25mg/dl, though the patient died two days after the second procedure. These results suggest that the treatment with plasmapheresis may be effective for reduction of serum bilirubin in patients with intractable intrahepatic cholestasis.View full abstractDownload PDF (680K) -
Kazuo INUI, Yoshiyuki NAKAE, Junichi KANO, Taichiro SATO, Yukihiko AKI ...1984 Volume 81 Issue 8 Pages 1817-1823
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSUltrasonically-guided Percutaneous Transhepatic Cholecystography (US-PTCC) were performed on 92 cases in our hospital between 1980 and 1983.
Three cases of spontaneous internal biliary fistulas were diagnosed with US-PTCC, but other radiological examinations and ultrasonography could not reveal internal biliary fistula. All of them were old patients with gallbladder stones, a 69-year-old female with a cholecystoduodenocolic fistulas, a 77-year-old male with a cholecystoduodenal fistula and a 68-year-old female with a cholecystohepatico fistula.
US-PTCC is to be performed in cases with non-visualized gallbladder by other radiological examinations. US-PTCC is the most reliable diagnostic procedure for spontaneous internal biliary fistulas between the gallbladder and adjacent organs.View full abstractDownload PDF (2484K) -
Kyoko MIYASAKA, Kenichi KITANI1984 Volume 81 Issue 8 Pages 1824-1829
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe effects of intraduodenal instillation of Na2 EDTA and Ca EDTA on pancreatic secretion were determined in concious rats. Rats were prepared with cannulae, draining pure pancreatic juice and bile, separately, and two duodenal cannulae. When a solution of Na2 EDTA, 25mM, was infused intraduodenally at a rate of 1ml/hr, pancreatic juice flow, bicarbonate and protein outputs were all significantly increased while bile-pancreatic juice was returned to the duodenum. After a 6-10 hour diversion of bile-pancreatic juice, Na2 EDTA still increased panceratic juice flow and bicarbonate output, but the increase of protein output was only transient. In contrast, the infusion of Ca EDTA did not cause these stimulatory effects on pancreas. It is suggested, therefore, that Ca ion in the duodenum plays an important role in regulating pancreatic secretion in rats.View full abstractDownload PDF (755K) -
Itsuo SUEHIRO, Makoto OTSUKI, Toru OKA, Yoshinori OKABAYASHI, Atsushi ...1984 Volume 81 Issue 8 Pages 1830-1836
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSPancreatic secretory trypsin inhibitor (PSTI) concentration in serum from patients with various malignant diseases was measured by radioimmunoassay and compared with the values of well-known tumor markers, such as α-fetoprotein (AFP), carcinoembryonic antigen (CEA), in the same sample. Serum PSTI concentration in 32 healthy subjects was 10.2±2.9ng/ml (mean±SD). Elevated serum PSTI concentration more than 18.9ng/ml of mean +3SD of 32 normal persons was observed not only in the patients with pancreatic diseases or renal failure, but also in patients with various malignant diseases. The incidence of elevated serum PSTI concentration in the patients with malignant diseases was 41.8%, which was similar to that of CEA and ferritin. One of four (PSTI, CEA, AFP and ferritin) was found to be increased in 87.5% of patients with malignant diseases.View full abstractDownload PDF (795K) -
Junji KASANUKI, Takayasu ISHIKAWA, Terue IMAIZUMI, Hideaki KOSEKI, Ryo ...1984 Volume 81 Issue 8 Pages 1837-1841
Published: 1984
Released on J-STAGE: December 26, 2007
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Ultrasonographic and angiographic findingsHiroshi YAMAMOTO, Yoshikazu YASUDA, Kogoro KASAHARA, Akiyoshi KASHII, ...1984 Volume 81 Issue 8 Pages 1842-1847
Published: 1984
Released on J-STAGE: December 26, 2007
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Kohichi SAITOH, Yosihisa TUKADA, Masayosi YAMASIKI, Satosi WATANAVE, M ...1984 Volume 81 Issue 8 Pages 1848-1852
Published: 1984
Released on J-STAGE: December 26, 2007
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Masami OHRUI, Masaki KAWANO, Toshio SUGITA, Misao MAEHARA, Hitoshi SUG ...1984 Volume 81 Issue 8 Pages 1853-1857
Published: 1984
Released on J-STAGE: December 26, 2007
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Mikiko KUNIEDA, Takumasa OKUYAMA, Michio KATO, Takashi MIYAMOTO, Manab ...1984 Volume 81 Issue 8 Pages 1858-1862
Published: 1984
Released on J-STAGE: December 26, 2007
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Hirohiko AKIYAMA, Tohru HIDAKA, Taneomi OKUHARA, Shigeru IWAMORI1984 Volume 81 Issue 8 Pages 1863-1866
Published: 1984
Released on J-STAGE: December 26, 2007
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S. TAKAGI, [in Japanese], [in Japanese], [in Japanese], [in Japanese], ...1984 Volume 81 Issue 8 Pages 1867
Published: 1984
Released on J-STAGE: December 26, 2007
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the significance of adherent cell activation in liverHiroko TSUTSUI, [in Japanese], [in Japanese], [in Japanese], [in Japan ...1984 Volume 81 Issue 8 Pages 1868
Published: 1984
Released on J-STAGE: December 26, 2007
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Seiji SAITO, [in Japanese], [in Japanese]1984 Volume 81 Issue 8 Pages 1869
Published: 1984
Released on J-STAGE: December 26, 2007
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Hisashi KIDANI, [in Japanese], [in Japanese], [in Japanese], [in Japan ...1984 Volume 81 Issue 8 Pages 1870
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (112K)
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