Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 82 , Issue 10
Showing 1-21 articles out of 21 articles from the selected issue
  • Shuichi IWAI, Shigeru ASAKI, Toshiaki NISHIMURA, Akira SATOH, Shuichi ...
    1985 Volume 82 Issue 10 Pages 2529-2537
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The temperature of the mucosal surface of the stomach was measured using a gastrothermometer consisting of a thermistor and using a semiconductor.
    The results of this study revealed:
    1) In healthy subjects, the temperature of various portions of the mucosal surface varied greatly. Furthermore, in many patients the temperature of the posterior wall was higher than in the anterior wall. In many of the patients the temperature was higher in the corpus than the antrum.
    2) In both experimental dogs and in patients of gastric ulcer, the differences between the temperatures of the mucosal membrane surrounding the ulcer and the regenerating membrane decreased progressively with the healing process.
    3) In many cases of recurrent gastric ulcer, the center of the scar had a lower temperature than that of the surrounding mucosa.
    Furthermore, in cases, when the mean duration time of ulcer scar was shorter, the temperature was lower.
    The measurement of gastric mucosal temperature, therefore, is considered valuable for clinical evaluations of gastric ulcer especially in the prediction of protracted healing and/or recurrence cases.
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  • Shinji OKA, Ken-ichi NODA, Makoto MURATA, Yasushi SHINGAI, Hajime HARA ...
    1985 Volume 82 Issue 10 Pages 2538-2543
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to study γ-glutamyl transpeptidase (GGT) in gastric cancer and intestinal metaplasia, amount of GGT in each tissue (gastric cancer, intestinal metaplasia, and fundic gland mucosa) and the localization of GGT were determined.
    The resected tissues were homogenized with Tris-HCL buffer (3mM, pH7.4). After centrifugation (700×g, 10min), GGT activity was measured in supernate of each tissue. The value of GGT was 24.9± 15.2(U/g. protein) in the cases of differentiated carcinoma, 6.0±2.4(U/g. protein) in the cases of undifferentiated carcinoma, 8.2±1.3 (U/g. protein) in fudic gland mucosa. In intestinal metaplasia, the localization of GGT activity was observed in all cases, which coincided with alkaline phosphatase.
    In gastric cancer, the frequency of GGY localization increased statistically in differentiated carcinoma, compared with undifferentiated carcinoma. The localization was observed at luminal border and mucus in the cases of differentiated carcinoma, while at cytoplasma in undifferentiated carcinoma.
    Although the GGT localization was various, many tissues of gastric cancer showed positive for GGT. It is therefore considered that GGT is an important marker protein for studying on phenotypes of gastric cancer and intestinal metaplasia.
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  • Tadashi NISHIMAKI, Hidenobu WATANABE, Terukazu MUTO
    1985 Volume 82 Issue 10 Pages 2544-2553
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Of 759 gastric carcinomas found in 679 surgically resected stomachs, 131 lesions (17.3%) were accompanied with peptic ulcer. The associated peptic ulcer was significantly common in the gastric carcinoma which was grossly depressed typed early gastric carcinoma or depressed typed early carcinoma-like advanced carcinoma, histologically undifferentiated type, and located in an intermediate area. Peptic ulceration tended to occur at the invasive portion of submucosal or more advanced gastric carcinomas, and it is supposed as one of the reasons why the gastric carcinoma showing malignant cycle grows slowly. A contiguous type peptic ulcer showing F1 or F2 phase fibrosis is suggested to be a peptic ulcer occurring secondarily at the invasive portion of gastric carcinoma.
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  • Yutaka SHIMIZU, Saburo NAKAZAWA
    1985 Volume 82 Issue 10 Pages 2554-2561
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In an attempt to evaluate the effects of dietary factors and fecal bile acids on colon carcinogenesis, Donryu rats were maintained on one of the diets containing high fat, 1.5% of colestipol, high fiber, high fat plus high fiber or control and were given subcutaneous injection of DMH, and fecal bile acids were measured with high performance liquid chromatography.
    The number of colon tumors was increased in rats fed high fat diet and colestipol diet compared with control diet, and in these groups fecal bile acids were increased, too.
    However, in high fiber diet group the number of colon tumors was decreased, though fecal bile acids were not decreased.
    The number of colon tumors in high fat plus high fiber diet was decreased significantly compared with that in high fat diet.
    These results indicate that high fiber diet is more important than high fat diet on colon carcinogenesis in rat.
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  • With Reference to Cyclooxygenase Products
    Hideo YAMAZAKI, Nobuo HIWATASHI, Yoshio GOTO
    1985 Volume 82 Issue 10 Pages 2562-2568
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Prostaglandin (PG) E2, thromboxane (TX) B2 and 6-keto-PGF in the culture media of the colonic mucosa specimens obtained from patients with inflammatory bowel disease were measured by radioimmunoassays.
    In active stage of ulcerative colitis, PGE2, TXB2 and 6-keto-PGF production were significantly higher than those in remission. The ratio of 6-keto-PGF to TXB2 in active stage was significantly reduced than that in remission. Furthermore, similar tendencies were recognized in the patients whose courses were observed from active stage to remission.
    In active Crohn's disease, PGE2 production was higher than that of normal subjects. However, there were no significant differences in other products between patients with Crohn's disease and normal subjects.
    These results suggest that PGE2, TXA2 and PGI2 act respectively as one of the chemical mediators of inflammation in ulcerative colitis.
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  • Hideo MORIMOTO, Akihiko FURUSAWA, Masashi UNOURA, Nobuyoshi TANAKA, Yo ...
    1985 Volume 82 Issue 10 Pages 2569-2575
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The T cell subsets in the peripheral blood and the portal area of liver biopsy specimens of patients with eAg positive and eAb positive chronic active hepatitis were investigated using OKT and Leu series. In eAb positive chronic active hepatitis, OKT3 and OKT8 positive cells in the peripheral blood were decreased as compared with those of eAg positive chronic active hepatitis and control. Leu 2a positive cells in the portal area of liver biopsy specimens of patients with eAb positive chronic active hepatitis were decreased as compared with those of eAg positive chronic acitve hepatitis. Therefore, it possibly seems that the decrease of suppressor T cell plays an important role in the seroconversion from eAg to eAb. On the other hand, Leu2a positive cells in the area with piecemeal necrosis of patients with eAb positive chronic active hepatitis were few as compared with those of eAg positive chronic active hepatitis. From these findings, it might be possible that the suppressor T cell system may be related to the reduction of killer T cell in liver tissue.
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  • Toshiji SAIBARA, Takashi MAEDA, Masanao FUJIKAWA, Hirosi SAKAEDA, Akir ...
    1985 Volume 82 Issue 10 Pages 2576-2581
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    It is well known that the majority of patients with primary biliary cirrhosis (PBC) demonstrate low immune responses to a variety of exogeneous antigens, including purified protein derivative (PPD), keyhole limpet hemocyanin, and dinitrochlorobenzene. Such in vivo evidence is regarded as defect in cellular immunity, but the mechanism underlying these phenomena is not well known. We therefore inquired into the underlying mechanism in respect of (1) antigen presenting capacity assessed by lymphocyte transformation and Interleukin 1 productivity of monocytes in response to PPD, and (2) Interleukin 2 productivity of T cells in response to PPD. The results indicated that antigen presenting capacity and Interleukin 1 productivity of monocytes were not defective in PBC, but Interleukin 2 productivity of lymphocytes was lower in PBC than in healthy controls.
    Our findings may contribute in understanding the underlying mechanism of immunological hyporesponse to exogenous antigens in PBC.
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  • Ryoichi ENDO, Yukihisa UENO, Genichiro SATOH, Makoto ISHII, Ryogo SATO ...
    1985 Volume 82 Issue 10 Pages 2582-2593
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Serum concentrations of tyrosine were assayed by means of fluorometry (method of Wong et al.) in fasting state in normal subject (67 cases) and 202 patients with chronic liver diseases, consisting of 88 with chronic hepatitis (147 specimens), 69 liver cirrhosis (132 specimens), 6 liver cirrhosis with hepatic encephalopathy (12 specimens) and 10 liver cirrhosis with hepato-cellular carcinoma (21 specimens), respectively.
    Elevated serum concentrations of tyrosine were found in patients with chronic active hepatitis and compensated liver cirrhosis and markedly increased in patients with decompensated liver cirrhosis.
    Branched chain amino acids (Val, Ileu, Leu) were significantly reduced in severe liver disease, and the Fischer's ratio (Val+Ileu+Leu)/(Tyr+Phe) shows a significant negative correlation with serum tyrosine concentrations in chronic liver diseases (in chronic hepatitis: r=-0.429, p<0.001, in liver cirrhosis: r=-0.675, p<0.001 and in liver cirrhosis with HCC: r=-0.740, p<0.001).
    Total amino acid concentrations in plasma were also significantly correlated with serum concentrations of tyrosine in patients with chronic liver disease.
    The concentrations of tyrosine correlated with hepaplastin test (HPT) and serum cholinesterase and not with transaminase (GOT, GPT) and bilirubin.
    From these results, it is concluded that abnormalities of the serum tyrosine concentrations accurately reflect liver dysfunction in patients with severe liver disease.
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  • Osamu NISHIDA, Fuminori MORIYASU, Takefumi NAKAMURA, Nobuyuki BAN, Ken ...
    1985 Volume 82 Issue 10 Pages 2594-2600
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We studied the changes in the hemodynamics of the portal venous system induced by continuous infusion of prostaglandin E1, into the superior mesenteric artery. The superior mesenteric venous blood flow increased with a statistical significance. However, the increases in portal venous blood flow and portal venous pressure were not statistically significant. On the other hand we found that there was a statistically significant decrease in the splenic venous blood flow.
    Data of the O2 content of the blood in the superior mesenteric and splenic veins also indicated an increase in the superior mesenteric venous blood flow and a decrease in the splenic venous blood flow both induced by infusion of prostaglandin E1.
    In this paper the relationship between these changes are discussed and we suspect the compensatory relationship between the splenic venous blood flow and the superior mesenteric venous blood flow.
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  • Fuminori MORIYASU, Osamu NISHIDA, Nobuyuki BAN, Takefumi NAKAMURA, Yas ...
    1985 Volume 82 Issue 10 Pages 2601-2607
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The blood flow volume of the portal vein was measured in patients with hepato-cellular carcinoma (in this paper referred to as liver cancer) and compared with that in patients with cirrhosis not complicated by liver cancer. The relationship between the measured blood flow and types of liver cancer, classified according to the angiographic findings, was tested. An ultrasonic duplex system was used to measure the portal blood flow. The portal blood flow in patients with liver cancer was 814±401ml/min (n=44, mean±S.D.) and was 888±331ml/min in the 81 patients with cirrhosis not complicated by liver cancer. In patients with liver cancer, the blood flow volume through the portal vein trunk does not have any correlation with the degree of portal venous invasion by liver cancer except for the total obstruction of the portal vein. However, the volume of the portal blood flow was less in the patients with a diffuse type of liver cancer than in those with other types, such as nodular or massive types.
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  • Yoshihide SAKAGAMI, Yasuhiro MIZOGUCHI, Keiji MIYAJIMA, [in Japanese], ...
    1985 Volume 82 Issue 10 Pages 2608-2612
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The effects of "Inchinko-to", a Chinese prescription frequently applied to hepatobiliary diseases, on bile flow were investigated using the erythritol clearance methods. As a result, it was found that when Inchinko-to was administered into the duodenum of normal rats, bile flow was enhanced. Moreover, it seemed to affect the bile formation mainly in the bile canaliculi but not the distal fluid transfer. Furthermore, Inchinko-to significantly blocked the reduction of bile flow induced by the cholestatic factor.
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  • Koichi SASAKI, Seiki MATSUNO, Eishi MIYASHITA, Hidemi YAMAUCHI
    1985 Volume 82 Issue 10 Pages 2613-2621
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The aim of this study was to investigate the effect of biliary diversion upon the pancreatic exocrine secretion in dogs with chronic pancreatic fistula.
    Response of pancreatic exocrine secretion to intravenous administration of various doses of pancreozymin and secretin was estimated before and after biliary diversion.
    Biliary diversion suppressed the response of pancreatic exocrine secretion to low doses of pancreozymin and secretin. On the contrary, higher response of pancreatic exocrine secretion occurred after biliary diversion than before under high doses of pancreozymin and secretin administration. Though plasma insulin and gastrin levels showed no significant changes before and after biliary diversion, plasma glucagon levels elevated significantly after biliary diversion.
    Elevation of plasma pancreatic glucagon levels after biliary diversion might contribute to the suppression of the response of pancreatic exocrine function to low doses of pancreozymin and secretin administration.
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  • Yasuyuki SASAKI
    1985 Volume 82 Issue 10 Pages 2622-2631
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Pancreatic histology and exocrine function were examined in mongrel dogs experimentally undergone blockade of pancreatic lymphatics over 50 to 100 days. Pancreatic histology revealed slight fibrosis without pancreatic parenchymal necrosis and also dilated lymph vessels with formation of oil cyst. Intraductal injection of sodium deoxycholate (DOC) resulted in loss of acini with marked fibrosis in the pancreatic head, body, and uncus, which were similar to the histology of human chronic pancreatitis. The area of those pancreatic lesions by DOC injection were extended further to the tail of the pancreas when pancreatic lymph flow was chronically blocked in addition. Experimentally produced pancreatic fibrosis was followed by the impairment of pancreatic exocrine function. These results suggest that pancreatic lymphatic blockade plays a promoting role in the progression of pancreatic lesions.
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  • Hitomi TAKAHASHI, Shoji YAMADA, Shunichi SAEKI, Masahiro UEHARA, Setsu ...
    1985 Volume 82 Issue 10 Pages 2632-2636
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Shigeru SUGIYAMA, Rikiya FUJITA, Fumio SUGATA, Michio HIGUCHI, Tadashi ...
    1985 Volume 82 Issue 10 Pages 2637-2641
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Sumio MIZUNO, Toshio UENO, Hideki SIMASAKI, Shuichiro YASUHARA, Ryoyu ...
    1985 Volume 82 Issue 10 Pages 2642-2646
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Junichi KAMIYA, Yuji NIMURA, Naokazu HAYAKAWA, Shigehiko SHIONOYA
    1985 Volume 82 Issue 10 Pages 2647-2650
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasufumi ITO, Tatsuo ISHIZUKA, Kiyoshi MIURA, Atsuko TANAKA, Masao TAN ...
    1985 Volume 82 Issue 10 Pages 2651-2656
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Ken-ichi OKANO, [in Japanese], [in Japanese], [in Japanese], [in Japan ...
    1985 Volume 82 Issue 10 Pages 2657
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kenji FUSE, [in Japanese], [in Japanese]
    1985 Volume 82 Issue 10 Pages 2658
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasuyuki ARAKAWA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1985 Volume 82 Issue 10 Pages 2659
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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