Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 82 , Issue 11
Showing 1-23 articles out of 23 articles from the selected issue
  • Akira AOIKE
    1985 Volume 82 Issue 11 Pages 2723-2732
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Natural killer (NK) activity of the peripheral blood lymphocytes (PBL) and interferon (IFN) titers in the serum of 13 healthy donors and 60 gastric cancer patients were evaluated at the same time. There was no correlation between natural killer activities and interferon titers in the serum of healthy donors and stage I groups of gastric cancer patients, but natural killer activities were correlative to interferon titers among stage II, stage III and stage IV groups of gastric cancer patients.
    Then we tried to concentrate the natural killer cells by the technic of adsorption-elution to K-562 cells in order to find the main producing cells of serum interferon. The lymphocytes adsorbed to K-562 cells were considered to be the NK cells because of the morphology of large granular lymphocytes and high natural cytotoxicity. Those K-562 adsorbed lymphocytes produced more interferon in the culture supernatants than eluted lymphocytes when they were culture with Kato-II of gastric cancer cell line.
    From the above findings we suppose that the main producing cells of serum interferon in the gastric cancer patients are NK cells.
    Download PDF (1137K)
  • Tadashi SHIRAI
    1985 Volume 82 Issue 11 Pages 2733-2741
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to investigate the natural history of the colonic adenoma, 57 colonic adenomas in 31 patients were followed up by barium enema and colonoscopic examination for mean duration of 36 months. The histology of these adenomas was examined on the specimens obtained by biopsy or polypectomy, and their histologic atypia was graded according to the Morson's criteria. The adenomas beyond 5.1mm in initial size of maximal diameter were found to be enlarged more markedly than those under 5.0mm in size, with statistical significance(p<0.05). As regards to the relation of the location to the changes in size of the adenomas, the right sided colonic ones tended to be enlarged more markedly than those in the left sided ones during the follow-up periods. Especially the adenomas in the ascending colon were enlarged much more than those in the rectum, with statistical significance(p<0.05). The increase of the size of the colonic adenomas was found to be proportional to the grade of the atypia on final histological findings of the specimens(p<0.005).
    These results indicate that the size and location of the colonic adenoma, and also the grade of the histological atypia of the colonic adenoma are postulated to be the essential factors for their evolutional history.
    Download PDF (1140K)
  • Yasutoshi KONNO, Nobuo HIWATASHI, Yuji KUMAGAI, Kiyoshi AZUMI, Hidetos ...
    1985 Volume 82 Issue 11 Pages 2742-2751
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to clarify the influence of ileal lesions or ileal resections in Crohn's disease on bile acid metabolism, we investigated bile acid composition of bile and feces in 14 patients with non-resected Crohn's disease (NCD), 2 ileitis and 12 ileocolitis, and 5 patients with ileal resection more than 100cm (RCD). Bile acids in bile and feces were analyzed by high-performance liquid chromatography and enzymatic method using 3α-hydroxysteroid dehydrogenase, respectively.
    The following results were obtained; 1) Both NCD and RCD patients had decreased concentration of biliary bile acids and increased amount of fecal bile acid excretion, and 2) NCD patients had normal or slightly increased amount of fecal fat excretion and increased bile acid concentration in fecal water, while RCD patients had markedly increased fecal fat and a decreasing tendency to fecal bile acid concentration. Even considering dilution of bile acid concentration with increased fecal volume in both groups, these results suggest bile acid diarrhea is dominant in NCD and fatty acid diarrhea is dominant in RCD.
    The ratio of glycine-to taurine-conjugated bile acids (G/T) in bile had positive correlation with the amount of fecal bile acid excretion. NCD with extensive ileal lesions and RCD had increased G/T in bile while NCD with localized ileal lesions had normal to slightly increased G/T.
    Download PDF (1296K)
  • Hiroko TSUTSUI, Yasuhiro MIZOGUCHI, Keiji MIYAJIMA, Shuichi SEKI, Suke ...
    1985 Volume 82 Issue 11 Pages 2752-2760
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    When a small dose of lipopolysaccharide (LPS) endotoxin was injected intraveneously in mice which had been treated with heat-killed Propionibacterium acnes (P. acnes), most of them died within 24 hours from massive liver necrosis.
    We have reported that the lymphocytes from mice which was injected with P. acnes 7 days before can not enough respond to mitogen stimulation and that those from acute hepatic failure mice can little respond to the same mitogen or not.
    In the present study, we tried to detect the mechanism by which this immunosuppression was taken place. The spleen adherent cells from mice injected with P. acnes partialy inhibited the proliferative response of normal murine spleen cells to mitogen, but supernatant fluid of these cells could not suppress the normal murine spleen cells proliferation at all. However, both spleen adherent cells and thier culture fluid from liver injury mice could strongly inhibit normal murine spleen cells response to mitogen. Although the suppressive effect of adherent cells from P. acnes treated mice was counteracted by indomethacin, the suppressive activity of those from liver injury mice could not be reduced by indomethacin. These results suggest that adherent cells from P. acnes injected mice produce prostaglandin to inhibit the lymphocyte proliferation and that those from acute hepatic failure mice lead to immunosuppression by producing and secteting of chemical mediators other than prostaglandin.
    Download PDF (1138K)
  • Yasuo YOSHIKAWA
    1985 Volume 82 Issue 11 Pages 2761-2768
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to study the hepatic regeneration under the portacaval shunt, changes of various parameters, especially plasma cyclic AMP levels after glucagon administration following major hepatic resection under the portacaval shunt in rats were investigated.
    The results were as follows;
    1) Death due to hepatic failure was encountered in 16 of 40 rats during 4 days after hepatectomy.
    2) Ratios of liver to body weight were recovered to 60% of preoperative ones 4 weeks after hepatectomy.
    3) Remarkable hypoglycemia and hyperglucagonemia were found one day and 3 days after operation. Hyperglucagonemia was remained during postoperative course.
    4) Plasma cyclic AMP levels induced after glucagon administration did not significantly increase until 3 days after operation and were only 50% of preoperative ones 4 weeks after operation.
    From these results, liver regeneration under portacaval shunt was remarkably delayed and was not achieved completely. Plasma cyclic AMP response to glucagon administration seemed to be useful as a parameter of liver regeneration.
    Download PDF (956K)
  • Haruhiko SUGIMURA, Junji SHIGA, Yoshinori URANO, Wataru MORI
    1985 Volume 82 Issue 11 Pages 2769-2774
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The distribution of HBsAg in the liver tissue of autopsied liver cirrhosis and/or hepatocellular carcinoma cases was investigated. The study was performed on the comparable basis between the positivity of serum HBsAg and detectability of tissue HBsAg by Victoria blue stain using numerous liver tissue sections, up to 300 in each case. The distribution pattern of HBsAg was found to be more various than expected, which was classified into three types; sparse, localized, and diffuse. No HBsAg was recognized in the liver of sero-negative cases, even after examining all through the organ.
    Download PDF (1563K)
  • Fuminori MORIYASU, Nobuyuki BAN, Osamu NISHIDA, Takefumi NAKAMURA, Yas ...
    1985 Volume 82 Issue 11 Pages 2775-2781
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In sixteen patients with hepatocellular carcinoma (HCC), the changes of portal hemodynamics were tested after treatment using transcatheter arterial embolization (TAE). The portal venous pressure was measured by percutaneous transhepatic catheterization and the portal blood flow was measured percutaneously using an ultrasonic duplex system. Neither the portal venous pressure nor the portal blood flow increased immediately after TAE. The portal blood flow increased an average of 21% one week after TAE and returned to the previous level after a further 2-3 weeks. In patients whose prognosis became poor as a result of hepatic failure caused by the TAE, the portal blood flow decreased significantly. It is suggested that the portal blood flow in patients with HCC after TAE is used as an index in predicting the patient's response to the treatment.
    Download PDF (736K)
  • Takato UENO, Eisuke NAGATA, Shotaro SAKISAKA, Ryukichi KUMASHIRO, Tuto ...
    1985 Volume 82 Issue 11 Pages 2782-2789
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The biochemical and histological features were investigated in 22 patients with fatty liver accompanied with obesity. In biochemical studies, Serum-GOT, GPT, Cholinesterase, Albumin, Triglyceride and ICG R15 were frequently abnormal before therapy for obesity. These parameters, however, recovered after the therapy and were thought to be good markers for following these fatty liver patients. In light microscopic examination, there were two subgroups showing different histological abnormalities: one with only steatosis and the other with hepatic fibrosis in addition to steatosis. There was no difference in period for recovery of biochemical values between two groups, however, histological abnormalities lasted longer in those patients with fibrotic changes other than steatosis alone even after normalization of biochemical tests. In electron microscopic observation, dilatation of the endoplasmic reticulum and Golgi apparatus, swelling of the mitochondria were found in the hepatocyte.
    These findings disappeared in response to the therapy. In addition to these hepatocytic changes, fibroblast-like Fat-storing cells (FSC) appeared to be increased around collagen bundles in patients with hepatic fibrosis, which may suggest a close relationship between FSC and collagen synthesis.
    Download PDF (2235K)
  • Hisataka OGASAWARA, Tomio SUDA, Makoto MIKAMI, Haruo NISHINO, Tsuneo M ...
    1985 Volume 82 Issue 11 Pages 2790-2798
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In 125 patients with liver diseases comfirmed by histological diagnosis, it was studied whether glutamic dehydrogenase (GLDH)/GPT ratio and GLDH/ornithine carbamyl transferase (OCT) ratio in sera were useful parameters for diagnosis of liver diseases with histological alcoholic liver injury. Serum samples in drinkers were obtained wihtin seven days after abstinence. Each serum enzyme was expressed with international units (I.U./l), and was compared each other. Since GLDH and OCT activities were increased in some cases without histological alcoholic liver injury, it was difficult to differentiate liver diseases with histological alcoholic liver injury from other liver diseases by only values of serum GLDH or OCT activities. In these cases, useful parameter was indicated by GLDH/GPT ratio in sera. GLDH/GPT ratios in sera were over 0.4 in most of patients with histological alcoholic liver injury, and were under 0.4 in most of patients without histological alcoholic liver injury. GLDH/GPT ratio in sera was suggested to be more useful than GOT/GPT ratio in sera as a parameter for diagnosis of liver diseases with histological alcoholic liver injury.
    Download PDF (1652K)
  • Masatoshi SUMIDA, Masao OHTO, Takumi KAJIKAWA, Toshio KOBAYASHI, Shoic ...
    1985 Volume 82 Issue 11 Pages 2799-2808
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Angiographic findings of hepatocellular carcinoma (HCC) less than 50mm in diameter were evaluated. In angiographic diagnosis of small HCC, abnormal findings were rare in the arterial phase, and tumor stains in the capillary to venous phase were the only findings, especially in HCC smaller than 20mm. Tumor stains consisted of staining and non-staining areas. There was no interrelationship between the degree of tumor stains and the width of histological blood sinusoids of the tumor. The non-staining area of the tumor stains had pathological backgrounds of necrosis, fibrosis and fatty degeneration. Slow growing HCC demonstrated round and homogeneous tumor stains. Tumor stains in angiography clearly delineated the tumor growth and extension in cases of hepatocellular carcinoma, and also proved to be important in the angiographic diagnosis of small HCC. Tumor stains were obtained in 42 cases out of 51(82.4%) cases of hepatocellular carcinoma, and in blind evaluation of tumor stains of HCC, metastatic liver carcinoma and hemangioma, an overall accuracy of 92.1% was obtained. In order to obtain consistent tumor stains, it is necessary to perform infusion hepatic angiography super-selectively. However infusion angiography induced tumor-like stains in all 7 cases of liver cirrhosis without HCC. Therefore careful deferentiation between HCC and cirrhotic nodules is mandatory.
    Download PDF (2967K)
  • Tetsuo HAYAKAWA, Aiji NODA, Takaharu KONDO, Tokimune SHIBATA, Toshiyuk ...
    1985 Volume 82 Issue 11 Pages 2809-2815
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To evaluate the diagnostic usefulness of serum immunoreactive lipase (IRL), serum lipase was determined in 41 controls and 79 patients with various disease using an enzyme immunoassay kit. Serum level of IRL well correlated with turbidimetric values and precision, sensitivity and specificity in the assay were sufficiently high. The normal range of serum IRL was from 7 to 59μg/L (M±2SD, median 20.5). Serum IRL was elevated in 7 of 8 patients with acute pancreatitis, 8 of 24 with chronic pancreatitis and 12 of 18 with pancreatic cancer. The IRL was low in 8 of 24 patients with chronic pancreatitis, which coincided with advanced exocrine insufficiency. Elevated serum IRL was rare in nonpancreatic diseases (gallstone 2/7, liver cirrhosis 1/8, peptic ulcer 0/7), except chronic renal failure (6/7). Serum IRL determination is useful for diagnosis in pancreatic diseases.
    Download PDF (791K)
  • Kazuhide URA
    1985 Volume 82 Issue 11 Pages 2816-2823
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Quantitative and qualitative examinations of serum transferrin (Tf) were carried out clinically in various diseases of the digestive tract, and experimentally in rat hepatoma induced by 3'Me-DAB and hamster pancreatic cancer induced by DHPN.
    Quantitatively, serum Tf decreased in almost all malignant diseases. Qualitative examination by isoelectric focusing revealed that the Tf in healthy adults was divided into 3 bands, and these were named from the anodal side as Fast, Main, and Slow, respectively.
    In malignant disease the number of Main band separations significantly decreased, and in cases of pancreatic cancer the Slow/Fast bands decreased. Moreover, it was suggested that these qualitative changes were induced by changes of sialic acid. With regards to the cancer-developing period in rats and hamsters, qualitative changes were observed in Tf and Tf-like protein.
    The qualitative examination of Tf seems to be useful not only in the clarification of illness but also as a screening test for cancer of the digestive organs.
    Download PDF (1248K)
  • Yuji NARITOMI, Kazuhiro HAYASHIDA, Minoru NAKAMURA, Nobuaki HIGUCHI, K ...
    1985 Volume 82 Issue 11 Pages 2824-2828
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (1008K)
  • Yukihisa MIYAZAWA, Yoshio KITAMURA, Nobuaki WADA, Kota OKINAGA
    1985 Volume 82 Issue 11 Pages 2829-2833
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (1133K)
  • Nobuo NISHIMURA, Hisao WAKABAYASHI, Kouich AKAMATSU, Miwa TANAKA, Hiro ...
    1985 Volume 82 Issue 11 Pages 2834-2839
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (1880K)
  • Kozo NAGAI, Makoto KAKO, Satsuki KANAZAWA, Fumio HIROTA, Toru TAKAHASH ...
    1985 Volume 82 Issue 11 Pages 2840-2844
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (2484K)
  • Shozo IWAMOTO, Yoshio MIDOH, Kozi HANMYO, Seiziro HARAKAWA, Kazuhiro D ...
    1985 Volume 82 Issue 11 Pages 2845-2849
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (1091K)
  • Toshihiko YAMADA, Kunihiko IIZUKA, Keiichiro YUASA, Shun-ichi SAEKI, T ...
    1985 Volume 82 Issue 11 Pages 2850-2854
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (1200K)
  • Hiroaki YAMADA, [in Japanese], [in Japanese], [in Japanese], [in Japan ...
    1985 Volume 82 Issue 11 Pages 2855
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (277K)
  • Yasuyuki ARAKAWA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1985 Volume 82 Issue 11 Pages 2856
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (177K)
  • Hiroyuki NAKAYAMA, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1985 Volume 82 Issue 11 Pages 2857
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (184K)
  • Kazuichi OKAZAKI, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1985 Volume 82 Issue 11 Pages 2858
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (164K)
  • Tetsuo TAKAYAMA, [in Japanese], [in Japanese], [in Japanese]
    1985 Volume 82 Issue 11 Pages 2859
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Download PDF (272K)
feedback
Top