Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 82 , Issue 2
Showing 1-22 articles out of 22 articles from the selected issue
  • Study on the Gastric Secretory Responses to Tetragastrin in Patients with Gastric Ulcer Near the Angle
    Akinori YANAKA, Hiroshi MUTOH, Hiromi SHIBATA, Hisayuki FUKUTOMI, Tosh ...
    1985 Volume 82 Issue 2 Pages 217-222
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Twenty-six patients with gastric ulcer near the angle were divided into two groups with endoscopic follow up study. One is the recurrent group (14 cases), and the other is the non-recurrent group (12 cases).
    Graded doses of tetragastrin [0.25, 1, 4 (γ/kg/h)] were administrated, and the gastric secretory responses to tetragastrin were investigated in all the patients.
    The results were as follows.
    1) There were no significant differences in basal and maximal secretion between the two groups.
    2) Recurrent group showed more increased sensitivity to tetragastrin than non-recurrent group.
    These results strongly suggest that the increased sensitivity to tetragastrin causes the recurrence of gastric ulcer.
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  • Tohru HOSHI, Fumio KITAME, Morio HOMMA, Makoto ISHIKAWA
    1985 Volume 82 Issue 2 Pages 223-231
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Bacteriological studies of the feces from 4 methane-producers and 11 nonproducers in the expired air were made.
    In all methane-producers, methane was detectable after incubation of the fecal specimens and methanogenic bacteria were present in their feces.
    In 7 of the 11 methane-nonproducers, methane was not detectable after incubation of the fecal specimens and methanogenic bacteria were absent in the feces. In the remaining 4 cases, however, positive results were obtained in both tests. The latter cases may not excrete methane in the colon.
    A methanogenic bacterium was isolated for the first time from the feces of a Japanese methan-eproducer. It was classified to the genus Methanobrevibacter since it was an anaerobic, gram-positive and short rod bacterium.
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  • Akira FUKAO
    1985 Volume 82 Issue 2 Pages 232-238
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to elucidate the association between hepatitis B virus and hepatocellular carcinoma (HCC), geographic correlation between HBsAg positive rates among blood donors (1980-81) and mortality rates for liver cancer (1980) was examined in 44 prefectures in Japan, and also in 74 districts in Miyagi prefecture (1979-81). Correlation coefficient were 0.388 and 0.270 respectively, and both were statistically significant. Furthermore, a cohort sudy was conducted by using the records of blood donors (over 30 year old, male) in Miyagi prefecture. One thousand HBsAg-positive males were assembled from 1971 to 1977 (HBsAg-positive group). Ten HBsAg-negative male donors, matched by age, district of residence and month of blood donation, were selected for each male in HBsAg-positive group (control group, 10, 000 males). These two cohorts were linked to the records of cancer registry (Miyagi Prefectural Cancer Registry) from 1971 to 1980. Three HCC cases were detected in HBsAg-positive group and one in control group. Relative risk of HCC among HBsAg-positive males was estimated to be 30.0, and population attributable risk percent of HBsAg to HCC was estimated to be 36.7%.
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  • Hiroiku KAWAKAMI, Masaya KIKKAWA, Toshiziro MATSUURA, Hiroo KAWAMOTO, ...
    1985 Volume 82 Issue 2 Pages 239-246
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The method for assay of HBV-specific DNA polymerase (DNA-P) activity was studied and the DNA-P activity in HBsAg positive hemodialysis patients, asymptomatic HBsAg carriers and patients with HBsAg positive chronic liver disease were measured to investigate the relation between HBV replication and occurrence of liver injuries.
    The normal level (negative) of the DNA-P activity as measured by our method was 18±5cpm. The level below 30cpm was defined as negative. In 81 (89%) of 91 HBeAg positive patients (MO or RIA method), the DNA-P activity was positive, but there was no significant correlation (r=0.329) between the DNA-P activity and HBe ratio in RIA. The severity of liver diseases were inversely correlated with the levels of DNA-P activity. The DNA-P activity rose early to the maximum level, preceding the elevation of transaminase activity. This indicates the time lag between the HBV replication and the onset of liver injuries.
    The above results confirmed the absence of a direct relationship between the viral replication in the liver or release of HBV from liver cell and liver damege in chronic HBV carriers, suggesting the importance of host immune response to HBV released to the liver cell membrane and the changes of the liver cell membrane related to HBV.
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  • On the Diagnostic Problems and the Limits of Detectability
    Narito KURIOKA, Toru KANNO, Koshun KIM, Susum TODA, Kenji SO, Shinya N ...
    1985 Volume 82 Issue 2 Pages 247-254
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Problems associated with the ultrasonic (US) diagnosis of small hepatocellular carcinoma (HCC) was studied on 119 cases, especially on 31 cases with small lesions under 3cm in diameter. Ultrasonography was useful for the screening of small HCC, but there were not a few undetectable cases. It is difficult to make a qualitative diagnosis of small lesions under 2cm in diameter. And echogenic nodules accounted for 32% of the nodules of hepatoma, so care should be taken with the US method to differentiate echogenic small HCC, from other echogenic lesions.
    Detectability was compared between the US method and angiography on 25 cases with lesions of less than 3cm, diameter, in 64 nodules. It seems to be difficult to detect small lesions under 1cm in diameter by the US equipment available presently. Cases were rendered undetectable by the dead zone cused by the portion of the dome of the right hemidiaphragm, and also due to distorted intrahepatic echograms, liver atrophy and liver deformity arising from hepatic cirrhosis.
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  • Masaru MIYAZAKI, Shigeru FUJIMOTO, Hirotake SUGASAWA, Fumio ENDOH, Tak ...
    1985 Volume 82 Issue 2 Pages 255-260
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The effect of isolated liver perfusion wit high doses of chemotherapeutic agents and hyperthermia on hepatic metabolizing capacity of [14C]-aminopyrine was assessed in the rat. The in vivo isolated liver, by itself, depressed the metabolizing capacity of aminopyrine significantly (p<0.05) even at 8 days after perfusion. The perfusion with 5-FU, Mit-c or hyperthermia (37°C-43°C) induced more remarkable suppression and these suppressive effects was dose- and temperature-dependent. Following the perfusion with higher doses of 5-FU and Mit-C or higher temperature (43°C) the metabolizing capacity was decreasing as days after perfusion go on. Serum GOT and GPT values following perfusion elevated considerably on 1 day post perfusion, but returned to normal by 5 days post perfusion.
    The surgical removal of 2/3 of the liver decreased the metabolizng capacity to 55%. In fact, the aminopyrine breath test is closely associated with the liver mass. The pretreatment of the liver perfusion with 5-FU, Mit-C and hyperthermia before partial hepatectomy depressed the metabolizing capacity of aminopyrine more remarkably, 38%, 45% (p<0.01) and 34% (p<0.05). The recovery of depressed metabolizing capacity after partial hepatectomy was returned in the liver perfused with 5-FU, Mit-C and hyperthermia in comparison with sham perfusion. These results show that isolated liver perfusion with hyperthermochemotherapy should be performed with the special notice and some hepatoprotective or hepatotrophic agents for the treatment of extensive liver cancer and as adjuvant therapy prior to hepatic resection.
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  • A Fundamental Study of Porphyrin Photodynamic Therapy
    Chiaki KAWAMOTO, Kenichi IDO, Tomohiko TERADA, Masahiko HORIGUCHI, Ken ...
    1985 Volume 82 Issue 2 Pages 261-269
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Photodynamic effects of various types of porphyrins on cultured hepatocellular carcinoma cells (JTC-16) were studied, using an argon and dye laser. The porphyrins examined were hematoporphyrin derivative (HpD), hematoporphyrin, protoporphyrin, coproporphyrin and uroporphyrin. The photodynamic effects on the cells were evaluated by a phase contrast microscope at 24 hours after laser irradiation. The cell degeneration was observed most strongly in protoporphyrin and then HpD and hematoporphyrin in order. Coproporphyrin and uroporphyrin, however, did not affect on the cells.
    We conclude that photodynamic effects of porphyrins on the cultured cells would be due to photochemical response, since laser irradiation did not elevate the temperature of culture medium.
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  • Yoshiro MATSUMOTO, Hideki FUJII, Yasuoki KIJIMA, Toshisue WADA, Hidehi ...
    1985 Volume 82 Issue 2 Pages 270-276
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to clarify the morphological criteria of anomalous arrangement of the pancreatico-biliary duct system, ninety-three patients whose junction of the pancreatic duct and common bile duct located in the extramural portion of the duodenum were investigated. The present study suggested that this anomaly results either from embryonic failure of the confluence of both ducts before 4 week gestation or from arrest of the migration of the choledocho-pancreatic junction inward the duodenal lumen after 8 week gestation. In 91 of the 93 patients their characteristic cholangiographic appearance implicated the former etiology. In 26 of the 91 patients the terminal bile duct joined with the secondary or more peripheral branches of the pancreatic duct and in the others it entered directly to the duct of Wirsung. Seventy-seven of the 91 were accompanied with congenital dilatation of the common bile duct and all of the remaining had normal bile duct. Only two patients had congenital biliary atresia, development of which might be based on the latter hypothesis.
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  • Plasma Cholecytokinin Responses after a Meal and Intraduodenal Ingestion of MgSO4 in Humans
    Keiko SHIRATORI, Shin-ichiro WATANABE, Tadashi TAKEUCHI
    1985 Volume 82 Issue 2 Pages 277-287
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    A sensitive and specific radioimmunoassay of cholecystokinin (CCK) has been achieved by method of Chang and Chey. Natural porcine CCK33 was iodinated by a modification of chloramine-T method. Purification and separation of labelled CCK was carried out by two-step procedure incorporating gel filtration and ion-exchange chromatography. The labelled preparation has a specific radioactivity of 709mCi/μM. Nonspecific plasma interference was eliminated by a XAD-2 resin column extraction technique. High recovery of CCK has resulted from this procedure for extraction.
    The contribution of gastrin was relatively small in extracted samples. The detection limit was 3.2pM. Intra- and interassay precision was 27.0±2.4 (M±SD) pM(n=10) and 32.4±4.0 pM (n=10), respectively. Using this assay, plasma CCK concentrations in response to ingestion of a test meal were studied in 6 healthy subjects. After ingestion of a meal, the mean plasma CCK concentration increased significantly above the fasting concentration of 11.6±0.5 (M±SE) pM and remained elevated over a 2-hr period (p<0.01). In 6 healthy subjects, Meltzer-Lyon test was studied. As the flow of bile from duodenal tube increased markedly following intraduodenal ingestion of 25% MgSO4 40ml, significant increase in plasma CCK concentration was detected (p<0.05).
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  • Toshiyuki MATSUI, Mitsuo IIDA, Takumi NANBU, Norio KOHROGI
    1985 Volume 82 Issue 2 Pages 288-295
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The present study was undertaken to examine the minimal dose of secretin in secretin provocation test to diagnose Zollinger-Ellison syndrome (ZES). Two different dosage (3 units/kg•weight and 6 units/kg•weight) secretin provocation tests were performed in 4 patients with ZES and 20 patients with ordinary peptic ulcer disease (non-ZES). Secretin provocation tests by drip infusion and bolus injection were performed in 2 patients with ZES. Single dosage secretin provocation tests were performed in other two patients with ZES.
    In non-ZES patients serum gastrin levels increased as much by 3 units/kg secretin as by 6 units/kg secretin. Six units/kg secretin injection raised serum gastrin significantly in 4 cases with ZES whereas 3 units/kg secretin injection didn't raise it significantly in 3 of 4 case with ZES. Bolus injection of secretin raised serum gastrin levels higher than drip infusion of secretin. Other two ZES patients had positive secretin test by 3 units/kg or 6 units/kg secretin injection.
    These studies indicates that secretin provocation tests should be done with the dosage of 6 units/kg by bolus injection. In ZES patients serum ionized calcium levels increased so little after secretin injection that direct relation between serum gastrin and serum ionized calcium could not be determined.
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  • Akimasa NAKAO, Masahiko SHINOHARA
    1985 Volume 82 Issue 2 Pages 296-300
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In platelet-rich plasma of rats and mongrel dogs, added endotoxin was determined by quantitative endotoxin assay using synthetic chromogenic substrate with perchloric acid pretreatment. By this method, the quantitative assay of endotoxin was proved to be relatively accurate.
    Dynamic chages of circulating blood endotoxin were examined after intravenous administration of 0.5, 5 and 50μg/kg of endotoxin in 5 mongrel dogs. When 0.5μg/kg was administered, there was no remarkable changes. However, when 5 and 50μg/kg were administered, approximately 99.8 to 99.9% of administered endotoxin disapeared within 5 minutes, then followed a slower clearance rate with a mean half life of 21.4 and 10.3 minutes respectively. Though, when 500μg/kg was administered, also approximately 99.8 to 99.9% of administered endotoxin disappeared within 5 minutes, rapid clearance was shown till 30 minutes. Then, from 30 minutes to 3 hours, it was slowly clearanced, but after 3 hours there were no remarkable changes and approximately 50 to 500pg/ml of endotoxin was still found after 12 hours.
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  • Hideki ONODERA, Takafumi KOGAWA, Kenji ITANI, Tadasu SIBATA, Minoru YA ...
    1985 Volume 82 Issue 2 Pages 301-305
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Therapeutic effect of an elemental diet on ulcerative colitis
    Katsuhiro ENDO, Tsuneaki SATO, Akira UNOURA, Takashi OKATA, Hikaru WAT ...
    1985 Volume 82 Issue 2 Pages 306-309
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Shozo IWAMOTO, Kenichiro SHIGEMOTO
    1985 Volume 82 Issue 2 Pages 310-314
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Its hazard and reconsideration
    Kazuo NAKAMURA, Jiroichi ONO, Taketo KATSUKI, Tetsuya WADA
    1985 Volume 82 Issue 2 Pages 315-318
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yuichi NAKAMURA, Atsuhisa TAMURA, Hideaki FIJIMOTO, [in Japanese], Mas ...
    1985 Volume 82 Issue 2 Pages 319-323
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Rapid Progress in Four Months
    Hiroshi TSUJI, Ken OKAMURA, Eiji KAJIWARA, Koichiro MURAI, Kimihiro AK ...
    1985 Volume 82 Issue 2 Pages 324-329
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Jun MATSUMOTO, Noboru NOTO, Yoshio KIKUCHI, Syuya KITAZIMA, Mitsuomi K ...
    1985 Volume 82 Issue 2 Pages 330-334
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takefumi NAKAMURA, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1985 Volume 82 Issue 2 Pages 335
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yoshihiro FUKUDA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1985 Volume 82 Issue 2 Pages 336
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Susumu ITO, [in Japanese], [in Japanese], [in Japanese], [in Japanese] ...
    1985 Volume 82 Issue 2 Pages 337
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kazuhiko OKABE, [in Japanese], [in Japanese]
    1985 Volume 82 Issue 2 Pages 338
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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