Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 82 , Issue 7
Showing 1-25 articles out of 25 articles from the selected issue
  • Masami SHIRATO
    1985 Volume 82 Issue 7 Pages 1665-1674
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to study the defence mechanism against cancer cells in patients with malignancy, tumor-infiltrated lymphocytes (TIL) and macrophages isolated from 18 operated stomachs with gastric cancer were tested for natural killing (NK) or natural cytotoxic (NC) activity and antibody dependent cellmediated cytotoxic (ADCC) activity against two target cells: K562 cells and antibody coated-P815 cells. The resected stomachs were deviled into 3 parts: cancerous, surrounding and normal area, and lymphocytes and macrophages were isolated. The obtained results were as follows: (1) TIL showed higher NK activity in the surrounding area than in other areas. There was no significant difference in the ADCC activities of TIL in each areas. (2) T cells were predominant over B cells in TIL, and null cells and Tγ cells showed higher percent. Especially, Tγ cell percent was higher in the surrounding area. (3) Tumor infiltrated macrophages showed relatively high NC and ADCC ativities, but there was no significant difference among the areas. (4) NK activity of TIL in patients with favorable prognosis was significantly higher than that in patients with unfavorable prognosis. NC activity of the tumor infiltrated macrophages showed the similar tendency.
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  • Masayo WADA
    1985 Volume 82 Issue 7 Pages 1675-1683
    Published: 1985
    Released: December 26, 2007
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    γ-Glutamyl transpeptidase (GGT), which has been reported as a tumor marker, was studied biochemically and histochemically in the proper gastric mucosa, intestinal metaplasia and carcinoma of the stomach. Histochemical localization of GGT activities in those tissues was compared with those of alkaline phosphatase (ALP) and CEA.
    Quantitative measurement revealed that GGT activities in the tissues of carcinoma, intestinal metaplasia and pyloric glands with intestinal metaplasia were higher than those of proper fundic and pyloric glands. Histochemically, GGT activity localized in the pyloric glands with intestinal metaplasia and in the pseudopyloric gands but not in the fundic glands. GGT activity was also found in the striated borders of all of the complete type of metaplastic glands and those one half of the incomplete type of metaplastic glands. These localization of GGT in the metaplastic glands were more extensive than those of ALP. GGT activity was found in the cancerous tissues in a high incidence and showed similar localization as CEA.
    Thus, GGT may be a useful marker for the studies of the relation between gastric carcinoma and precursory lesions.
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  • Kazuhiko MIZUTA, Motoyuki MORIGA, Hiroaki NARUSAWA, Haruto UCHINO, Mit ...
    1985 Volume 82 Issue 7 Pages 1684-1692
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The inhibitory effects of intravenously and intragastrically administered prostaglandin E2 analogues, 15(R)-15 methyl PGE2 and 15(S)-15 methyl PGE2, on basal and 6μg/kg/hr of pentagastrin-stimulated gastric secretion were examined in Ghosh-Schild's rats. The inhibition of gastric acid secretion and the duration of activity were dose-dependent. 15(S)-15 methyl PGE2 was more active than 15(R)-15 methyl PGE2, and both analogues were more effective when given intragastrically than when given intravenously. Much of 15(R)-15 methyl PGE2, given intragastrically, appears to be transformed into 15(S)-15 methyl PGE2 which is more active. Although the intracellular pathyways of their inhibition are not understood, both methyl analougues appear to inhibit gastric secretion both by local (mucosal contact) and systemic mechanisms.
    The effect is limited mainly to parietal cells; the chief cells seem unaffected because pepsin output is not appreciably reduced. It is concluded that these methylated PGE2 analogues are very potent inhibitors of basal and pentagastrin-stimulated gastric acid secretion and may have clinical potential in the treatment of peptic ulcer.
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  • Masato YOSHINAKA
    1985 Volume 82 Issue 7 Pages 1693-1702
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The labeling indices of generative cell zone in the gastric mucosa and antral gastrin cells were determined in the vagotomized and non-treated control hamsters by the use of 3H-thymidine autoradiography. The labeling indices of generative cell zone and antral gastrin cells in the vagotomized hamsters showed a transient striking increase immediately after vagotomy, and then they were gradually restored with time. After 10 weeks onward, the labeling indices of generative cell zone leveled off at a slightly high value in the pyloric mucosa and a slightly low value in the fundic mucosa when compared with those in the controls. The labeling indices of antral gastrin cells showed a synchronized change with those of generative cell zone in the pyloric mucosa.
    Then, the renewal of antral gastrin cells were investigated in both the hamsters 10 weeks after vagotomy and non-treated controls. It was found that the cell cycle time of generative cells in the pyloric mucosa was shortened, and the time required for the differentiation to gastrin cells were also shortened, comparing with those in the controls, in the vagotomized hamsters. Furthermore, it was also suggested that, in the vagotomized hamsters after 10 weeks, the cell cycle time of generative cells in the fundic mucosa was prolonged and this could reduce the cell production of the superficial epithelial cells and glandular cells such as parietal cells in the fundic mucosa.
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  • THE ROLE OF FIBEROPTIC ENDOSCOPY
    Yoshiyuki FUJITA, Choichi SUGAWA
    1985 Volume 82 Issue 7 Pages 1703-1709
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    During the past four years, 14 patients have been treated for ingestion of caustic materials, including acid in three patients, lye in five, bleach in three, ammonia in one and detergent in two. Each patient underwent fiberoptic endoscopic evaluation using a small caliber panendoscope. Sulfuric acid caused extensive partial thickness injury to the esophagus, stomach and duodenal bulb in one patient who had developed pyloric stenosis requiring hemigastrectomy 30 days later. Lye ingestion caused extensive mucosal inflammation of the esophagus, stomach and duodenum in three patients and severe injury to the oral pharynx and esophagus in the other patient. One patient had emergency total gastrectomy. Bleach ingestion caused moderate esophagitis, gastritis or duodenitis, and all patients were discharged within five days. Detergent caused moderate esophagitis and esophageal ulcer. Ammonia caused extensive mucosal inflammation of the oral pharynx, esophagus, stomach and duodenum. Both groups of patients were discharged in six days. The result of treatment in these patients shows that early panendoscopy after ingestion can be performed safely and provides an accurate guide for therapy. Subsequent panendoscopy on a weekly basis allows for continued rational observation or surgical intervention according to the endoscopic findings.
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  • Kotaro YAMAGUCHI, Tadashi SHIRAI, Katsuhide SHIMAKURA, Taiji AKAMATSU, ...
    1985 Volume 82 Issue 7 Pages 1710-1716
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    A case-control study of 13 cases with pneumatosis cystoides coli (PCC) was carried out to assess the association between PCC and working conditions including occupational exposure to organic solvents. The controls consisted of 65 subjects matched by sex, age and admission year to the patients with PCC. It was found that there was a close association between the development of PCC and occupational exposure to trichloroethylene (TCE).
    Tweleve of thirteen cases of primary PCC (92.3%) each had an occupational history of exposure to TCE, and each of 2 pairs among them had been working in the same factory. The healing and recurrence of PCC in these cases substantially paralleled their occupational exposure to TCE.
    A mass survey for the detection of PCC was carried out in a company where TCE was used, and failed to find any colorectal lesion.
    These results suggested that the long-term exposure to TCE could be one of the contributing factors for the development of PCC in subjects with susceptibility, the details of which has not been yet clarified and should be further elucidated.
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  • A Mode of Initiation of DHBV Replication in Experimental Transmission Study
    Masami TAGAWA, Masao OMATA, Osamu YOKOSUKA, Fumio IMAZEKI, Katsutaro H ...
    1985 Volume 82 Issue 7 Pages 1717-1723
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Experimental DHBV infection was performed with one-day old ducklings, inoculated with 10μl and 50μl of DHBV positive serum. The presence of DHBV DNA was analysed in the serum, liver, pancreas, kidney and spleen. In the group inoculated with 10μl serum DHBV DNA was detectable in the liver on day 6 postinoculation and in the serum on day 10. When the inoculum was increased to 50μl, DHBV DNA became detectable earlier, on day 3 in the liver and on day 6 in the serum. In both groups, single stranded DHBV DNA was first observed in the liver. Replicative forms of DHBV were also demonstrated in the pancreas, kidney and spleen. The appearance of DHBV DNA in those organs was preceded by that in the liver. In the group inoculated with 10μl serum, infection appeared to occur sequentially in the liver, pancreas, kidney and spleen in this order.
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  • Seikoh SHIMAGUCHI, Joe ARIYAMA, Masabumi SUYAMA, Kaoru OGAWA, Masaki I ...
    1985 Volume 82 Issue 7 Pages 1724-1730
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Nonsurgical internal biliary drainage, percutaneous transhepatic biliary endoprosthesis, PTBE, was successfully performed in all of 60 attempts (100%). Value of PTBE was assessed in comparison with PTCD undergone in 214 patients. Efficacy of PTBE in the reducement of plasma bilirubin level and improvement of general condition were excellent and incidence of interruption of biliary drainage became infrequent by PTBE. Convalescence rate and cumulative survival rate were higher in the patients with malignant obstructive jaundice treated by PTBE. Complications such as the catheter clogging should be solved in the near future.
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  • Masahiro KAWANISHI, Susumu FUJITA, Satoko KUNITA, Yoshinari FURUKAWA, ...
    1985 Volume 82 Issue 7 Pages 1731-1741
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Although several tumor markers have been evaluated for the diagnosis of pancreatic cancer, there is no single marker that is adequate for diagnosis of pancreatic cancer. We have therefore attempted to differentiate cases of pancreatic cancer from chronic pancreatitis or normal subjects by the combined use of 13 kinds of pancreatic cancer markers determined in the same serum samples. A total of 100 samples were obtained from 50 patients with parcreatic cancer, 20 with chronic pancreatitis and 30 normal subjects. When only a single marker was employed, the best marker for the diagnosis of pancreatic cancer was CA19-9, while with combination assay the combination of CA19-9, TPA, ferritin and α1-AT, was found to be superior, but the diagnostic specificity of these markers was limited. Using discriminant analysis, CEA, α1-AT, ferritin and CA19-9 were weighted and the discriminant eqation y=-13.5+0.32ln (CEA)+0.32ln (ferritin)+1.83ln (α1-AT)+0.20ln (CA19-9) was derived. This equation was found to have 95% accuracy rate in distinguishing cases of pancreatic cancer from chronic pancreatitis or normal subjects. Furthermore, by adopting this equation in other patients with gastrointestinal cancers, we found it to have adequate organ specificity except for periampullary cancer. From this results, it may be concluded that the discriminant equation involving CEA, α1-AT, ferritin and CA19-9 is useful for the diagnosis of pancreatic cancer.
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  • Yoshinobu TAKEDA, Takashi AMATSU, [in Japanese], Hideki TADA, Junichi ...
    1985 Volume 82 Issue 7 Pages 1742-1747
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    0.5g of N-benzoyl-L-tyrosyl-PABA (BT-PABA) was orally administered to 20 patients with chronic pancreatitis and to 10 control subjects. 1 and 2 hours after the administration, serum levels of PABA were determined, and the higher value of the two, the maximal value of serum PABA (MS-PABA), was chosen as the index of the exocrine pancreatic function. In order to estimate the clinical efficiency of the above stated MS-PABA test, its results were compared with those of pancreozymin secretin test (PS test) and of conventional urinary PABA test which takes 6 hours (6HU-PABA test). MS-PABA in patients with decrease in one out of three PS test parameters (Moderate Group) and those with decrease in two or three (Severe Group) revealed statistically significant reduction compared with cortrols. As to the comparison of MS-PABA and 6HU-PABA, the positive ratio of the former was 6/7 and that of the latter was 7/7 for Severe Group, and for Moderate Group both tests produced the same positive ratio of 3/5, whereas in patients with chronic pancreatitis who showed normal PS test results, positive ratios of MS-PABA and 6HU-PABA were 2/8 and 4/8 respectively. Thus, it is concluded that MS-PABA test is particularly valid in diagnosis of moderate and severe chronic pancreatitis.
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  • Harumasa OHYANAGI, Tsuneyuki ISHIDA, Kunio UESAKA, Masahiro YAMAMOTO, ...
    1985 Volume 82 Issue 7 Pages 1748-1755
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The new monoclonal antibodies, named KM01-antibody and KM02-antibody, were developed and reversed passive hemagglutination reagents (RPHA) for these antibodies were studied about its basic and clinical properties. These new antibodies had high affinity for the tissue of pancreas. The antigenic determinant of antigens, named KM01 and KM02 which were detected by these antibodies, were almost same as that of CA19-9. It was eluciated that these RPHA reagents were fit for clinical application, because these reagents had good singularity and reproducibility. The sensitivity, specificity and predictive value of these antigens for 40 cases of pancreatic cancer as contrast with 19 cases of chronic pancreatitis was in order 82.5%, 78.9% and 90% in CA19-9, 75.0%, 73.7% and 85.7% in KM01 and 80.0%, 84.2% and 91.4% in KM02. The diagnostic value of KM02 was better in specificity and predictive value than that of CA19-9. Thus, KM01 and KM02 were useful as the tumor marker for diagnosis of pancreatic cancer.
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  • Ken TAKEHARA, Michio KOGURE, Fumiaki AKASU, Teruo YOSHINAGA, Keiichiro ...
    1985 Volume 82 Issue 7 Pages 1756-1760
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Nobutaka UMEKITA, Yasuo IDEZUKI, Seiji KAWASAKI, Kenshou SANJO, Tomoe ...
    1985 Volume 82 Issue 7 Pages 1761-1764
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1985 Volume 82 Issue 7 Pages 1765-1770
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kazuya KITAMURA, Katsuya KUWATA, Yoshifumi SASAKI, Takashi ISHII, Masa ...
    1985 Volume 82 Issue 7 Pages 1771-1774
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Masaru KAWAMOTO, Tsuneo FUKUSHIMA, Akira SUGITA, Hiroshi SUWA, Yasunob ...
    1985 Volume 82 Issue 7 Pages 1775-1779
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Setsuo TAKEKAWA, Takashi HAGIWARA, Hiromasa ISHII, Yoshiki HAMADA, Ken ...
    1985 Volume 82 Issue 7 Pages 1780-1785
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hiroyoshi ARAI, Masahiro TANAKA, Masahiko HORIGUCHI, Ken KIMURA, Hirok ...
    1985 Volume 82 Issue 7 Pages 1786-1790
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kenji IKEDA, Hiromitsu KUMADA, Takashi MORI, Naoya MURASHIMA, Akira YO ...
    1985 Volume 82 Issue 7 Pages 1791-1794
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Morio SAGARA, Isao MAKINO, Hisashi NAKAHATA, Kazuo TAKEBE, Yosimasa KA ...
    1985 Volume 82 Issue 7 Pages 1795-1797
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kazuhito MISAWA, Yoh KAMIIZUMI, Manabu NISHIBE, Isao SAIKI, Shuichi WA ...
    1985 Volume 82 Issue 7 Pages 1798-1802
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Sunao KAWANO, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1985 Volume 82 Issue 7 Pages 1803
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hiroaki YOSHINO, [in Japanese], [in Japanese], [in Japanese]
    1985 Volume 82 Issue 7 Pages 1804
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Susumu ITO, [in Japanese], [in Japanese], [in Japanese], [in Japanese] ...
    1985 Volume 82 Issue 7 Pages 1805
    Published: 1985
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takashi YOSHIMURA, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1985 Volume 82 Issue 7 Pages 1806
    Published: 1985
    Released: December 26, 2007
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