Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 83 , Issue 7
Showing 1-25 articles out of 25 articles from the selected issue
  • Yoshi NAGAHATA, Tomoaki URAKAWA
    1986 Volume 83 Issue 7 Pages 1289-1297
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Dopamine has been recognized not only as a precursor of norepinephrine but also as a neurotransmitter playing a part of the role itself. Inorder to explore the mechanism of stress ulcer from the viewpoint of dopamine, the authors inflicted restrained and water-immersion stress on control rats and measured gastric mucosal norepinephrine and dopamine content. The latter increased about 2 fold 8hr after stress, although the former decreased. Exogenous dopamine administration of 10μg/kg/min brought about increased gastric mucosal blood flow, depressed gastric motility, decreased gastric acid output, and depression of ulcer formation after stress. As a result, it was concluded that dopamine has a significant role in the mechanism by which stress ulcer is formed.
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  • Yih-Fong LIN, Michio HONGO, Kenzo SATAKE, Takayoshi TOYOTA, Yoshio GOT ...
    1986 Volume 83 Issue 7 Pages 1298-1303
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    For the evaluation of solid meal emptying, radioisotope scanning of labeled solid meal is widely accepted. We have developed a labeled solid meal which can be prepared easily and is stable in gastric juice. This test meal is consisted of 99mTc Sn-colloid labeled omelet, served with toast and milk, with total calorie of 590 kcal. Tagged omelet in human gastric juice showed 12% of isotope liberation into liquid phase in 2 hours.
    Gastric emptying study was performed in 10 healthy male volunteers. Gastric emptying curve showed initial plateau phase followed by linear regression. This is typical pattern for solid emptying. The starting index was 31±9 minutes (mean±SD) and the retention rate of isotope in stomach after 150 minutes was 37±19% (mean±SD).
    We conclude that 99mTc-labeled omelet is useful in gastric emptying study.
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  • Shoichiro HIROSE, Keiichi SHIMAZAKI, Nobu HATTORI
    1986 Volume 83 Issue 7 Pages 1304-1310
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    An attempt was made to study the effect of secretin, pancreozymin and caerulein on the absorption of water, electrolytes and glucose from the jejunum of the dog. During intravenous (iv) infusion of secretin (Eisai) 2 or 4u/kg/hr the glucose absorption decreased significantly compared to control. Adding iv infusion of pancreozymin (Boots) 4u/kg/hr over the infusion of the secretin 4u/kg/hr the jejunal absorption of water, sodium and glucose was increased significantly compared to the absorption of the period with infusion of secretin alone. During iv infusion of secretin (GIH) 1cu/kg/hr the jejunal absorption of water, sodium and glucose decreased significantly compared to control. When iv infusion of caerulen 0.4μg/kg/hr was added over the infusion of secretin, the absorption of water, sodium and glucose was increased significantly compared to the absorption of the period with infusion of the secretin alone. From the foregoings and that caerulein is known to closely mimic the action of CCK it is considered that secretin reduces the absorption of water, sodium and glucose from the jejunum of the dog and the addition of CCK over the secretin reverses the effect of secrein.
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  • Takefumi NAKAMURA, Fuminori MORIYASU, Nobuyuki BAN, Osamu NISHIDA, Ken ...
    1986 Volume 83 Issue 7 Pages 1311-1317
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We measured the blood flow of the splenic artery (SPA) using an ultrasonic duplex system, and the splenic volume using an X-ray CT scanner in patients with various liver diseases and normal controls.
    Each of the blood flow volumes of the SPA of patients with liver cirrhosis (LC; 842±483ml/min, mean±S.D.) and idiopathic portal hypertension (IPH; 1456±630 ml/min) was larger than that of normal controls (NC; 381±168 ml/min). The volume of the IPH group was larger than that of the LC group.
    The pulsatility index of the IPH group (0.650±0.019) was lower than that of the LC group (0.710±0.075) and markedly lower than that of the NC group (0.737±0.079).
    The splenic arterial blood flow volume per unit of splenic volume was slightly less in the IPH group (2.37±0.48ml/min/cm3) than in the NC group (3.29±0.96ml/min/cm3), while it was markedly less in the LC group (1.79±0.78ml/min/cm3).
    These findings indicate that:
    i) The splenic circulation contributes to the portal circulation more in the IPH group than in the LC group.
    ii) In the LC spleen, vascular resistance is slightly decreased, while in the IPH spleen, vascular resistance is markedly decreased.
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  • Yoshihide SAKAGAMI, Yasuhiro MIZOGUCHI, Keiji MIYAJIMA, Hiroko TSUTSUI ...
    1986 Volume 83 Issue 7 Pages 1318-1323
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    A marked decrease in bile flow and bile acid excretion was induced in the tuberculin-sensitized guinea pigs by intravenous injections of heat-killed Propionibacterium acnes and PPD at a week interval. In sera of these animals, total bile acid content some enzyme activities derived from bile duct and cholesterol content were shown to be elevated.
    Histological changes such as dilation of bile canaliculi and decrease in microvill of bile canaliculi were also observed.
    These results suggested that the sensitized lymphocytes infiltrated into the live tissues by Propionibacterium acnes injection were activated by PPD and produce the cholestatic factor resulting in the induction of intrahepatic cholestasis.
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  • Hiroko TSUTSUI, Yasuhiro MIZOGUCHI, Keiji MIYAJIMA, Yoshihide SAKAGAMI ...
    1986 Volume 83 Issue 7 Pages 1324-1329
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    When heat-killed Propionibacterium acnes (P. acnes) and a small amount of endotoxin lipopolysaccharide (LPS) were intravenously injected into mice at a week's interval, most animals were died of massive liver necrosis within 24 hours. Our previous studies suggested that adherent cells accumulated in liver and primed by P. acnes could produced cytotoxic factor(s) once activated by LPS.
    Since tumor necrosis factor (TNF) is also produced from activated macrophages, we designed our experiment to clarify the difference between the cytotoxic factor and TNF. Some TNF activity was detected in mouse sera 2 hours after injecting of LPS in our experimental system. However, such TNF-contained sera did not exhibit any cytotoxicity for the isolated normal liver cells. In the culture supernatants containing a remarkable cytotoxic activity for liver cells, little TNF activity was detectable. The chelating agent, o-phenanthroline which is known to block TNF production did not exhibit any reduction in cytotoxic activity. Taking together with our previous physio-chemical observations of the cytotoxic factor(s), it is much likely that our cytotoxic factor may be different from TNF.
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  • Masaru ITAKURA
    1986 Volume 83 Issue 7 Pages 1330-1337
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Portal blood flow was measured by a ultrasonic pulsed Doppler flowmeter in liver cirrhosis, and the results were compared with KICG with and without glucagon. Relative portal blood flow measured at the portal trunk was significantly decreased in liver cirrhosis without collateral circulation than in liver cirrhosis with collateral circulation (15.4±6.6cm3/sec vs. 21.9±9.2cm3/sec, p<0.05). The KICG, however, is significantly impaired in the latter (0.099±0.051 vs. 0.073±0.040, p<0.05). By loading glucagon intraveneously, portal blood flow was found to be increased, and KICG was improved significantly in patients without collateral circulation, but not in those with collateral circulation. The measurement of portal blood flow and glucagon-loaded ICG can be important tools for the diagnosis of derranged hemodynamic state in the hepatic circulation in liver cirrhosis.
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  • Keiichiro YUASA, Shoji YAMADA, Takeaki NAGAMINE, Masahiro UEHARA, Ken ...
    1986 Volume 83 Issue 7 Pages 1338-1343
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Clinical and morphological features were investigated in 81 patients with fatty liver. Liver biopsy specimens revealed that more than 30% of hepatic lobules were infiltrated by fat. These patients were devided into two groups, Group I (GPT_??_130U) and Group II (GPT<130U).
    In Group I, fatty infiltration was caused by obesity or acute weight gain in 9 patients (60%).
    Severe fatty infiltration (p<0.01), acidophilic bodies (p<0.01) and lipogranulomas (p<0.05) were significantly more often found in Group I than in Group II.
    Serum-GPT levels after therapy significantly (p<0.05) more often improved in patients without lipogranulomas(71%)than in patients with lipogranulomas(24%).
    This study suggests that lipogranulomas seem to be useful indexes of serum-GPT improvement after therapy in patients with fatty liver.
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  • Nobuaki GOTO, Hirotaka MUSHA, Hidetaka TERABAYASHI, Kunihiko ONISHI, K ...
    1986 Volume 83 Issue 7 Pages 1344-1349
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The relation between the plasma molar ratio of valine, leucine and isoleucine to phenylalanine and tyrosine and portal systemic shunt was examined by three kinds of studies in clinically stable cirrhosis.
    1) Using the method of percutaneous transhepatic portal vein injection of two different laveled macroaggregated albumins, total, intrahepatic and extrahepatic shunt index were measured in 14 cirrhosis. The good correlation existed between lowering of the ratio and increasing of each of total shunt index (r=-0.76, p<0.005) and intrahepatic shunt index (r=-0.76, p<0.005)
    2) Oral ammonia tolerance test was carried out in 15 cirrhosis. Increment of arterial blood ammonia level 30min after administration of ammonium chloride of 50mg/kg was correlated with the ratio significantly (r=-0.72, p<0.005).
    3) Changes of the ratio between encephalopathic and non-encephalopathic states were examined in 5 cirrhosis with chronic recurrrent hepatic encephalopathy who were demonstrated to have large portal collateral pathyway by the portography. The mean ratio was 0.79±0.09 on encephalopathic state and 0.82±0.12 on non-encephalopathic state, and no significant difference was existed between them.
    The results revealed the ratio is a good marker of the degree of portal-systemic shunt in stable cirrhosis. Marked lowering of the ratio suggests the presence of large portal-systemic shunt and easy development of encephalopathy.
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  • Michiyasu YOSHITSUGU, Yushi SEKIYA, Masashi IHORI
    1986 Volume 83 Issue 7 Pages 1350-1354
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Plasma somatomedin C/insulinlike growth factor I (Sm-C/IGF I) was estimated by radioimmunoassay in 9 patients with chronic hepatitis, 17 with liver cirrhosis, 3 with acute hepatitis and 7 control subjects.
    In the patients with chronic liver diseases a negative correlation was found between plasma Sm-C/IGF I levels and ICG R15 values, and then there was a positive correlation between plasma Sm-C/IGF I levels and serum ChE activity, albumin and HPT values.
    In the patients with acute hepatitis plasma Sm-C/IGF I levels decreased during acute illness and returned to normal with recovery. No correlation was found between plasma Sm-C/IGF I levels and serum GH values in the patients either chronic liver diseases or acute hepatitis.
    These findings suggest that plasma Sm-C/IGF I levels are reduced in proportion to the degree of hepatic damage and that they are not dependent on serum GH values.
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  • Masatoshi FUJII, Makoto OTSUKI, Takahiko NAKAMURA, Toru OKA, Shigeaki ...
    1986 Volume 83 Issue 7 Pages 1355-1359
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We have studied the effect of neuromedin C, a novel decapeptide isolated from porcine spinal cord, on amylase secretion from isolated rat pancreatic acini. The effect of neuromedin C was detectable at concentration of 3pM, and the amylase release was increased in a dose-related manner. The maximal effect of neuromedin C was found at concentration of 1nM.
    The concentration that produced half maximal effect (EC50) was 45.3±4.5pM for neuromedin C. Atropine, muscarinic receptor antagonist, and proglumide, cholecystokinin receptor antagonist, did not affect on the response to neuromedin C.
    These results suggest that neuromedin C acts directly on the rat pancreatic acinar cells, and the neuromedin C-induced pancreatic secretion is mediated via neither muscarinic nor cholecystokinin receptors.
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  • Satoshi HAYASHI, Takaaki TAKEBE, Kohzoh OHYAMA, Yoshihiro ODAKE, Yoshi ...
    1986 Volume 83 Issue 7 Pages 1360-1366
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We designed a series testing for the mass examination of pancreatic cancer, in which serum CA 19-9 and elastase-1 were measured in the first screening and ultrasonography was carried out on the subjects with positive results of serum markers in the second screening. The mass examination was performed on 1, 039 persons over forty years old. The group consisted of 432 out-patients visiting the medical clinics in two hospitals and 607 persons undergoing the health examination for adults. When abnormal findings of the pancreas were found on ultrasonograms, the close examinations including abdominal computed tomography, endoscopic retrograde cholangiopancreatography and absorption cytology under ultrasonic imaging were performed. Eventually, two non-resectable pancreatic cancers, five other malignant tumors and twenty-one benign abdominal diseases were detected. On the basis of the results, some problems in reference to the mass examination for pancreatic cancer were discussed.
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  • Yoshinari FURUKAWA, Susumu FUJITA, Hiroyasu YAMADA, Takeo KANAYA, Sato ...
    1986 Volume 83 Issue 7 Pages 1367-1375
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The method for measurement of the colipase concentration in duodenal fluid using artificial substrate BALB was established. The pattern of colipase secretion in C-S test and the relation between the pancreatic secretion of enzymes and the output of colipase were investigated. The measurement using BALB permitted easy and simultaneous analysis of a large number of samples. The results well correlated with the titrimetric method. The colipase secretion in C-S test remarkably increased by stimulation with caerulein but manifested no significant reaction to stimulation with secretin. On examining the secretion of pancreatic enzymes during C-S test in patients with mild to moderate pancreatic dysfunction, the outputs of colipase, lipase and amylase amounted to 72.6%, 72.9% and 94.7% of those in normal controls, respectively. The measurement of the colipase concentration in duodenal fluid in C-S test was found useful in the diagnosis of mild pancreatic dysfunction.
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  • Youichi MORIMOTO, You NAKAO, Akimasa NAGAHARA, Jun TOMODA, Akiharu WAT ...
    1986 Volume 83 Issue 7 Pages 1376-1381
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Osamu MIYANAGA, Hiromi ISHIBASHI, Ikuo SUMITA
    1986 Volume 83 Issue 7 Pages 1382-1386
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hiroshi SUZUKI, Michio SATA, Yoichi YANO, Reiichiro HIDAKA, Ei SASAKI, ...
    1986 Volume 83 Issue 7 Pages 1387-1391
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kohichi SAITOH, Tohru TAKAGI, Sekio MOTEGI, Shu SUZUKI, Takao MORITO, ...
    1986 Volume 83 Issue 7 Pages 1392-1395
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hirotsugu SHINOZAKI, Itsuro NAKANO, Kouko SAKAI, Kouki KONOMI
    1986 Volume 83 Issue 7 Pages 1396-1400
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hideki FUJII, Kazuo MIURA, Muneaki KONISHI, Yuzuru IIMURA, Akihiro NOG ...
    1986 Volume 83 Issue 7 Pages 1401-1405
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tatsuo OGIHARA, [in Japanese], [in Japanese], [in Japanese], [in Japan ...
    1986 Volume 83 Issue 7 Pages 1406
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takeshi AZUMA, [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1986 Volume 83 Issue 7 Pages 1407
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Norimasa YOSHIDA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1986 Volume 83 Issue 7 Pages 1408
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kazuei ORIKASA, [in Japanese], [in Japanese], [in Japanese], [in Japan ...
    1986 Volume 83 Issue 7 Pages 1409
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kojiro MICHITAKA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...
    1986 Volume 83 Issue 7 Pages 1410
    Published: 1986
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Keiichi KUBOTA, [in Japanese], [in Japanese], [in Japanese], [in Japan ...
    1986 Volume 83 Issue 7 Pages 1411
    Published: 1986
    Released: December 26, 2007
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