Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 84 , Issue 1
Showing 1-25 articles out of 25 articles from the selected issue
  • Yih-Fong LIN, Michio HONGO, Kenzo SATAKE, Takayoshi TOYOTA, Yoshio GOT ...
    1987 Volume 84 Issue 1 Pages 1-5
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The aim of this study was to investigate the relationship between the gastric emptying of solid meal and the severity of autonomic neuropathy in diabetic patients.
    The degrees of autonomic neuropathy (AN) were classified into mild AN and severe AN by heart rate variation with deep breathing.
    Gastric emptying was normal in mild AN patients, whereas marked delay was noted in severe AN patients. Patients with gastroparesis with gastric retention more than 80% at 150 minutes after ingestion of meal were noted only in severe AN patients. Patients with starting index slower than 60 minutes were seen in 8 among 13 severe AN patients, whereas 2/7 in mild AN patients and 1/14 in AN (-) patients had delayed starting index. Blood glucose level variations after ingestion of solid meal were small in severe AN patients.
    We conclude that the pathogenesis of diabetic gastroparesis is correlated with the impaired autonomic nerve function.
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  • Osamu SAITOH
    1987 Volume 84 Issue 1 Pages 6-12
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Qualitative and quantitative analysis of fatty acids in fecal fat was performed in healthy controls and five disease groups: subtotal gastrectomy (Billroth I), subtotal gastrectomy (Billroth II), total gastrectomy, Crohn's disease and ileal resection. The composition of eight different fatty acids including 10-hydroxystearic acid (10-OHSA), which is produced predominantly from dietary oleic acid by intestinal bacteria, was measured with high-performance liquid chromatography (HPLC).
    All five disease groups had significantly higher fecal fat excretion than the control population. Fecal fatty acids concentration was increased in Billroth II and total gastrectomy. The percentage of 10-OHSA in fecal fatty acids was increased significantly in Billroth I, Billroth II, total gastrectomy and Crohn's disease. The ratio of 10-OHSA to oleic acid in fecal fat, which may represent the degree of bacterial conversion of oleic acid to 10-OHSA, was increased significantly in all disease groups. There was a linear relationship between the percentage of 10-OHSA and fecal fat excretion. These findings suggest there is a close relationship between bacterial overgrowth and fat malabsorption.
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  • Shih Che HUANG, Kazumasa MIKI, Akihiro SHIMIZU, Masao ICHINOSE, Hirosh ...
    1987 Volume 84 Issue 1 Pages 13-19
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    A monoclonal antibody against group I pepsinogen (PG I) was used to develop an enzyme-liked immunosorbent assay for PG I in serum. The enzyme-linked immunosorbent assay for serum pepsinogen I correlated positively with radioimmunoassay. The intra- and interassay coefficients of variation were 7.6% and 13.0%, respectively. The normal range was 15-100μg/m.
    Pepsinogen I levels in serum were significantly higher in the subjects who developed active duodenal ulcer (n=38) or active gastric ulcer (n=21) than in 354 control subjects. In contrast, PG I levels in serum were significantly lower in the subjects who developed gastric cancer (n=26) than in control subjects.
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  • Toshio TANI, Yasunari TSUCHIHASHI, Shozo YORIOKA, Kyouhei MARUYAMA, Ta ...
    1987 Volume 84 Issue 1 Pages 20-26
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Gastric mucosal changes were pathologically studied in rats after surgical insertion of the stainlesssteel spring into the pyloric sphincter. The gastric contents obtained 5 weeks after the spring insertion showed decreased acidity by pH measurement, indicating the regurgitation of the duodenal content. After the spring insertion, the pyloric canal was strongly distended and the pyloric mucosa was thickened at both the sites oral to as well as of direct contact with the spring. Such pyloric mucosa demonstrated histologically hyperplasia of both the foveolar and glandular epithelial cells, mild goblet cell metaplasia, diffuse inflammatory cell infiltration and lymph follicle formations. The fundic mucosa displayed both slight elongation and widening of the gastric pits. Furthermore, in the fundic region after 5 weeks, there occasionally observed a few, focal elevated lesions, which consisted of the foveolar lining cell hyperplasia.
    These gastric mucosal changes observed after the spring insertion into the rat pyloric canal seem to be similar in several respects to those of chronic gastritis in human.
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  • Koji WAKIYAMA
    1987 Volume 84 Issue 1 Pages 27-35
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Changes of trace metals during the process of liver fibrosis up to the development of liver cirrhosis were determined using an ICP emission analyzer in the serum and the organs from rats with CCl4 treatment. Zn levels in hepatic tissue showed significant decrease sucessively with high collagenase activity during the development of liver cirrhosis, together with low Zn levels and high Cu level in the serum. And then the bepatic fibrosis were completed, the isolation of Zn and Cu binding fractions in the liver cytoplasma from cirrhosic rats showed on a Sephadex G-75 Gelchromatography that the contents of 65Zn and Zn-binding substance were decreased and that the content of Cu-binding substance were increased. Zn and Cu are co-enzymes of the enzymes functioning cytokinesis and fibrosis, and no metal in the organs of pancreas, kidney and heart were shown neither sucessive increase nor decrease, may suggest a relation to the process of experimental liver fibrosis.
    The difference of the organ uptake of orally and intravenousely administered 65Zn gave an suggestion of the possibility that Zn deficiency of cirrhosic rats would be due to decreased gastrointestinal absorption of Zn.
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  • Shuhei NISHIGUCHI, Tetsuo KUROKI, [in Japanese], Shigeyoshi HARIHARA, ...
    1987 Volume 84 Issue 1 Pages 36-44
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The effects of interferon (IFN) on DNA synthesis, cAMP levels, and induction of ornithine decarboxylase activity (ODC) were examined in the regenerating mouse liver after partial hepatectomy. IFN administration suppresed [3H] thymidine incorporation into DNA to 30% of that of the control mice after patial hepatectomy. To find why IFN suppresed DNA synthesis in the regenerating liver, we tested the effects of IFN on the intracellular levels of cAMP and polyamines, which were both important in cell growth. IFN inhibited adenylate cyclase activity, resulting in the suppresion of cAMP levels. IFN also suppressed the induction of ODC and elevation of polyamine levels. The inhibitions by IFN of ODC induction and DNA synthesis were reversed by db-cAMP and putrescine, respectively. These results suggest that IFN suppresses accumulation of cAMP and polyamine levels, and thus inhibits DNA synthesis in the regenerating liver.
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  • Its Clinical Significance in Chronic HBsAg Carriers
    Makoto NAKAMURA
    1987 Volume 84 Issue 1 Pages 45-51
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Sera and biopsied liver specimens from 45 hepatitis B surface antigen (HBsAg) carriers with or without liver diseases were examined for markers of hepatitis B virus (HBV): hepatitis B e antigen (HBeAg) and its corresponding antibody (anti-HBe), HBV deoxyribonucleic acid (HBV-DNA) in serum and hepatitis B core antigen (HBcAg) in the liver. Their clinical features were analyzed in terms of these virological markers.
    HBV-DNA in serum and HBcAg in the liver were positive in all of asymptomatic HBsAg carriers positive for HBeAg in serum, but none of those positive for serum anti-HBe. Whereas in patients with chronic liver diseases, such a concordant presence or absence of serum HBV-DNA and HBcAg in the liver according to the HBeAg/anti-HBe status was found in only 22 of 37 cases (59.6%). Of these three HBV markers, the presence of serum HBV-DNA was found to reflect most closely the serum transaminase levels in chronic liver diseases.
    These results indicate that detection of serum HBV-DNA is the most sensitive parameter for HBV replication and also reflects the inflammatory activity in the liver of patients with chronic liver diseases.
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  • A FOLLOW-UP STUDY
    Susumu IMOTO, Hidetoshi MATSUMOTO, Kang-yi WANG, Toshiaki KOHRIYAMA, M ...
    1987 Volume 84 Issue 1 Pages 52-57
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We studied bridging necrosis (BN) of liver biopsy specimens obtained within 14 days after the onset of symptoms from patients with acute drug-induced allergic hepatitis (ADIAH), and acute viral hepatitis type A and type B. BN was observed in 13 among 53 cases of the former group and in 6 among 68 cases of the latter group. We have found that the ADIAH group is frequently associated with BN (p<0.02).
    Furthermore, we surveyed the patients having ADIAH with BN. A significant female prepon-derance was shown in patients having ADIAH with BN compared with those without BN (p<0.05). Central-central BN was most common among three forms of BN and considered to be a more characteristic form in ADIAH with BN. Serial histologic studies revealed that the long-term prognosis in patients having ADIAH with BN is excellent, provided the causative drug is withdrawn promptly.
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  • Analysis of Intrahepatic Replicative DNA
    Katsutaro HIROTA, Masao OMATA, Osamu YOKOSUKA, Fumio IMAZEKI, Katsuo U ...
    1987 Volume 84 Issue 1 Pages 58-64
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We analyzed the effects of adenine arabinoside (Ara-A) on duck hepatitis B virus (DHBV) in the serum and livers of chronically infected DHBV carrier ducks. We initially studied 9 ducks, aged 5 weeks, divided into four groups. Ducks were treated for 14 days with either Ara-A 5mg/kg (2 ducks), 10mg/kg (2 ducks) or 20mg/kg (3 ducks). Two ducks were used as a control group. DNA polymerase (DNA-P) reaction products were measured in serum and showed a decrease of approximately 50% from pretreatment values in each of the treated groups, during the course of treatment.
    The next phase of the experiment involved 9 5-month-old ducks divided into four groups. Ducks were treated with Ara-A 20mg/kg (2 ducks), 40mg/kg (2 ducks) or 80mg/kg (3 ducks). There were two control ducks. Ara-A was given intravenously daily for 2 weeks. Serial serum samples showed a doserelated decrease of DHBV DNA during the treatment period. Three serial wedge liver biopsies were performed (pretreatment, immediately post-treatment and four weeks post-treatment). Intrahepatic DNA was extracted and analysed by the Southern blot hybridization technique. In all treated ducks there was a decrease in intrahepatic DHBV DNA.
    Further analysis using the hot phenol extraction technique and densitometry showed that the decrease in DHBV DNA was predominantly due to a decrease of mature replicative forms.
    These results suggest that Ara-A exerts its effect in DHBV infection through an inhibition of DNA polymerase activity and resultant decrease in the formation of double stranded DNA that uses the minus strand DNA template according to the DHBV replicative pathway proposed by Summers et al.
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  • Hiroyoshi FURUKAWA, Munemasa RYU, Toshiyuki KIKUCHI, Minoru MUKAI, Hir ...
    1987 Volume 84 Issue 1 Pages 65-73
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Preoperative diagnosis of vascular invasion is important to improve the operative planning. We performed "Slow-injection dynamic CT scanning (SI-CT)" and compared it with conventional angiography to evaluate the detecting of vascular invasion in biliary cancers. In SI-CT, the relationships between tumors and vessels were classified into four types. We hypothesized that Type I•II had not been invaded and Type III•IV had been invaded. The diagnostic accuracy of SI-CT was 91.1% in common hepatic artery (CHA), 82.1% in proper and right/left heaptic artery (PHA), and 87.5% in portal vein (PV). On the other hand, that of angiography was 94.6% in CHA, 85.7% in PHA, and 85.7% in PV. So, the accuracy of SI-CT in detecting vascular invasion by biliary cancers was comparable to that of angiography. The major advantage of SI-CT is the visualization not only the vessels, but also the tumors and surrounding organs. The resectability of cases with portal vein invasion varied according to the CT type; Type III lesion were often resectable whereas Type IV lesion were generally unresectable.
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  • Yutaka OGAWA, Tetsuo HAYAKAWA, Takaharu KONDO, Tokimune SHIBATA, Yoshi ...
    1987 Volume 84 Issue 1 Pages 74-83
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    An enzyme immunoassay for human cationic trypsin was set up using anti-trypsin IgG coated polystyrene balls as the solidphase antibody, peroxidase-labeled anti-trypsin IgG as the conjugate and TLCK-trypsin as the standard. The sensitivity of the assay was 18.8ng/ml. The coefficients of variation were 1.9 to 9.3% within one assay and 5.4 to 18.5% between assays. The normal range of serum immunoreactive trypsin (IRT) in 98 controls was 43 to 185ng/ml (mean±2SD). Serum IRT was elevated in all 15 patients with acute pancreatitis, 12 of 39 with chronic pancreatitis and 22 of 34 with pancreatic cancer. The rate of serum IRT elevation in chronic pancreatitis group and pancreatic cancer group was higher than that of serum amylase elevation. The IRT was low in 13 of 39 patients with chronic pancreatitis, which coincided with advanced exocrine insufficiency. Abnormally high serum IRT was rare in nonpancreatic diseases (gallstone 11/40, liver cirrhosis 11/27, peptic ulcer 10/25, irritable bowel syndrome 0/15, diabetes mellitus 5/26) except chronic renal failure (26/31). Serum IRT determination is more useful for diagnosis in pancreatic diseases than amylase.
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  • Takashi JOH, Makoto ITOH, Kei MASTUSAKO, Kazuo IKEDA, Sinpei IMAI, Tad ...
    1987 Volume 84 Issue 1 Pages 84-91
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We established a sandwich enzyme immunoassay (ETA) system for human epidermal growth factor, which has a high sensitivity (500fg/tube) and makes it possible to measure directly a minute amount of endogenous human EGF in biological fluids such as serum or urine. EGF in plasma was not detected (less than 0.05ng/ml). The concentrations of serum EGF in normal adult males and females were 0.57 and 0.46ng/ml respectively. Urinary EGF levels were 63.8ng/ml for males, and 87.2ng/ml for females. There was no correlation between serum and urinary EGF levels. It seems most likely that majority of urinary EGF is not derived from blood but from kidney itself.
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  • Motoo ISHIDA, Sanae SAKATA, Hironori MASUYAMA, Akihiko UENO, Toshio SU ...
    1987 Volume 84 Issue 1 Pages 92-97
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takao SATOH, Hideo IMATANI, Tomoteru SUGIMOTO, Hiroyuki MISAWA, Tosio ...
    1987 Volume 84 Issue 1 Pages 98-103
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hideto TSUKAMOTO, Wasaburo KOIZUMI, Eio ATARI, Masahiko OKUDAIRA, Sige ...
    1987 Volume 84 Issue 1 Pages 104-107
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Shigehiko OGAWA, Yoshikiyo YAMAZAKI, Toshihiro HABA, Kenji DOISHITA, Y ...
    1987 Volume 84 Issue 1 Pages 108-112
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hiroshi TSUJI, Shinichiro OSATO, Yuji NISHIMURA, Kensuke NOMIYAMA, Hid ...
    1987 Volume 84 Issue 1 Pages 113-117
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tadashi TERADA, Yasuni NAKANUMA, Goroku OHTA
    1987 Volume 84 Issue 1 Pages 118-122
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hiroshi NISHIDA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1987 Volume 84 Issue 1 Pages 123
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Shinji OKA, [in Japanese], [in Japanese], [in Japanese], [in Japanese] ...
    1987 Volume 84 Issue 1 Pages 124
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Motonobu MURAKAMI, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1987 Volume 84 Issue 1 Pages 125
    Published: 1987
    Released: December 26, 2007
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  • Masahiro SENJUH, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1987 Volume 84 Issue 1 Pages 126
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Mitsuo SUGA, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1987 Volume 84 Issue 1 Pages 127
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kanji HASE, [in Japanese], [in Japanese], [in Japanese], [in Japanese] ...
    1987 Volume 84 Issue 1 Pages 128
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Masashi YONEDA, [in Japanese], [in Japanese], [in Japanese]
    1987 Volume 84 Issue 1 Pages 129
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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