Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 84 , Issue 11
Showing 1-21 articles out of 21 articles from the selected issue
  • Hiroaki UJIIE, Michio HONGO, Yih-Fong LIN, Kenzo SATAKE, Shigeru ASAKI ...
    1987 Volume 84 Issue 11 Pages 2479-2485
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The therapeutic effect of pneumatic dilatation was evaluated quantitatively by radionuclide transit study in 11 achalasia patients.
    Before pneumatic dilatation, marked retention with more than 80% of isotope in the esophagus at 15 minutes after ingestion was noted in all patients. Marked improvement in emptying was shown after pneumatic dilatation.
    Pneumatic dilatation is a safe and effective therapeutic aid for chalasia treatment, and radionuclide transit study is not only noninvasive and physiologic but also its procedure is easily performed.
    We conclude that radionuclide transit study is a good method to evaluate the result of the treatment quantitatively in achalasia patients.
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  • Takeshi OKUBO
    1987 Volume 84 Issue 11 Pages 2486-2493
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The role of the pituitary-adrenal system in the development of stress ulcer induced by water immersion was evaluated in hypophysectomized rats. Changes with time after stress loading were studied with respect to the Ulcer Index (U.I.) along with the gastric pH and serum gastrin level as aggressive factors and the amount of gastric mucus glycoprotein (hexose) and gastric mucosal blood flow as defensive factors. In controls, the gastric pH decreased immediately after the stress loading, and the U.I. and gastrin level began to increase after 4 hours. The amount of hexose significantly decreased with time, and gastric mucosal blood flow decreased by about 50% in the eraly stage. In the hypophysectomized rats, increases in the U.I. was inhibited, but the effects of stress on the gastric pH, gastrin level, amount of hexose, and gastric mucosal blood flow were negligible. These results show that the pituitary-adrenal system plays an important role in the development of stress ulcer.
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  • Takahiko TOKUMARU, Junichi SAKAMOTO, Tadashi WATANABE, Nasaji YAMAUCHI ...
    1987 Volume 84 Issue 11 Pages 2494-2503
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The expression of blood group antigens and blood group related cancer-associated antigen (CA19-9, sialylated Lea) in gastric cancers and normal gastric tissues from 46 patients was analysed using an immunohistological method and a series of mouse monoclonal antibodies. Secretory status was determined by ELISA test on glycoproteins extracted from saliva of a selected number of the patients.
    In normal gastric tissues, type 1 (lea, Leb) was expressed in the surface epithelium, whereas type 2 (X, Y) was mainly detected in the deep glands.
    In gasric cancers, experssion and production of Lea and CA19-9 were greatly increased, especilly in secretors, and consistent distribution of Lea and CA19-9 were observed. X, Y as well as Leb were almost similar to normal tissues, but staining pattern of these antigens in cancers was classified as stromal type. High concentration of CA19-9 were found in sera from patients with advanced cancers.
    Study of those antigens in normal and malignant tissues from the same patient may provide us a clue to understand the anomalous expression in neoplasia.
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  • Shinichi YAMADA
    1987 Volume 84 Issue 11 Pages 2504-2512
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The study was conducted with the aim of examining motility disturbance in the upper gastrointestinal tract of patients with chronic cervical spinal cord injury. The function to drain gastric content was tested using a test meal (400ml of milk) containing 99mTc-DTPA, while the serum gastrin levels were investigated during this test meal loading.
    The mean gastric emptying time (T1/2) was 44 minutes and 34 seconds ±4 minutes and 2 seconds in the control group, while it was markedly prolonged in the cervical spinal cord injury group taking more than 60 minutes in 56% of them. Concerning fasting serum gastrin levels, the cervical spinal cord injury group tended to show higher levels (p<0.01) than the control group. There were more cases in the control group which showed two peaks on the serum gastrin concentration curve at the 30 and 90min fractions following the test meal loading. On the other hand, almost all of the cervical spinal cord injury group showed the gastrin reaction of different types from the control group.
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  • Ichiro TANABE, Hiroshi FUJIMURA, Yukinori OKAZAKI, Tadayoshi TAKEMOTO
    1987 Volume 84 Issue 11 Pages 2513-2521
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    For the method of quantitative analysis about the healing process of peptic ulcer, we employed the matrix analysis of Markov process regarding the transition of ulcer stage; A, H and S which are classified by Sakita & Miwa depending on the endoscopic findings.
    The equation P2n=P0[aij]n was concluded according to this method. [a ij] is the matrix of (3, 3)-type and stands for the transitional probability. P2n is the matrix of (3, 1)-type and indicates the ratio of each ulcer's stage (A, H and S) at 2n week.
    Then we applied this equation to several drug studies of H2-receptor antagonists. There were very good coincidence between observed and theoretical ratio in each ulcer stage. And there was significant difference at H→S process depending on the kind of drug about the cumulative healing ratio of ulcer.
    We also concluded that our method is more universal theory than methods up to this time included them of Gonoi & Kimura.
    It is possible to estimate the healing process of peptic ulcer from the viewpoint of multivariate analysis by using the matrix expression.
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  • Norito MATSUKUMA
    1987 Volume 84 Issue 11 Pages 2522-2530
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To investigate possible mechanisms of elevation of serum secretory immunoglobulin A (sIgA) level in active Crohn's disease, colonic specimens were obtained from 7 patients with active Crohn's disease and were applied to immunohistochemical study of immunoglobulin A (IgA) and secretory component (SC). Serum level of sIgA and the number of IgA containing cells in the lamina propria were significantly increased in Crohn's disease than in control subjects. Light microscopic immunohistochemistry showed that staining intensity of SC was increased in the whole mucosal epithelium, particularly at the luminal surface of the mucosa in Crohn's disease compared with the mucosal epithelium of control subjects. Electoron microscopic immunohistochemistry demonstrated that reaction products of SC were observed in the interstitium of lamina propria in Crohn's disease, possibly released from the basal plasma membrane of the epithelial cells. These findings were frequently recognized in Crohn's disease, but rarely in control subjects. These results suggested the mecanisms of elevated serum sIgA in active Crohn's disease might be derived from excessively produced sIgA in the colonic mucosa.
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  • Shuzo NODA, Sumio KAWATA, Nobuyuki ITO, Shio MIYOSHI, Yasuharu IMAI, R ...
    1987 Volume 84 Issue 11 Pages 2531-2536
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Urinary metabolites of antipyrine, 3-hydroxymethylantipyrine (HMA), norantipyrine (NORA) and 4-hydroxyantipyrine (OHA) were determined with high performance liquid chromatography (HPLC) system in 13 patients with cirrhosis of the liver (including 8 with cirrhosis bearing hepatocellular carcinoma) and in 5 control subjects with oral administration of antipyrine (600mg per unit body surface area). Total antipyrine metabolites excreted in urine for 24 hours were significantly different between the controls (31.6±2.3%) and cirrhotics without hepatoma (4.7±1.6%) and cirrhotics with hepatoma (8.6±3.0%) (p<0.001 and p<0.001, respectively).
    Excretion of each metabolite was also significantly reduced in the cirrhotics without and hepatoma (p<0.001 and p<0.01, respectively). Mean values for % total conjugation of antipyrine was significantly reduced in the cirrhotics without and with hepatoma (p<0.001 and p<0.001, respectively). These results indicate that capacity for conjugation of antipyrine metabolites as well as that for antipyrine oxidation reduce in the patients with cirrhosis than in the control subjects.
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  • Morikazu ONJI, Kenji DANJO, Hiroaki MIYAOKA, Yoshiyasu TANIGUCHI, Yasu ...
    1987 Volume 84 Issue 11 Pages 2537-2541
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In serum TPA, a mean value of 313±297 (mean±SD) U/l in hepatocellular carcinoma (HCC) was not significantly higher than that of 148±78 U/l in patients with liver cirrhosis (LC). The value of TPA was significantly correlated to those of alkaline phosphatase in HCC (p<0.005).
    Immuno-histological visualization of TPA was studied on a Bouin-fixed paraffine embedded section, using the indirect immunoperoxidase method. The TPA staining was positive in the biliary ductal and ductular epitheium of a normal liver.
    TPA was demonstrated in hepatocytes in of patients with chronic hepatitis and in that of the peripheral area of a regenerative nodule in LC. TPA was present in cancer cells of HCC and in also non-cancerous cell next to hepatoma cells.
    From these observations, the origin of serum TPA may be cancer cells, damaged hepatocytes and biliary duct epithelium.
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  • Katsunori AIKAWA
    1987 Volume 84 Issue 11 Pages 2542-2550
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to know the function as ligandin of the human hepatic glutathione S-transferases (GST), rose bengal (RB) binding affinities of purified hepatic isozymes of GST and hepatic cytosolic proteins including GST obtained from various liver diseases were investigated using fluorospectrophotometric method.
    Purified isozymes such as cationic (C1 and C2), neutral (N1) and anionic (A1) showed not much differences in the affinity (Kd: 0.020-0.068μM) for RB binding. Moreover, binding stoichiometry revealed a single RB binding site on one molecule of all species of GST isozyme.
    From the evaluation of 17 samples of hepatic cytosol, the GST activity, assayed with 1-chloro-2, 4-dinitrobenzene as substrate, the GST content measured by SDS-polyacrylamide gel electrophoresis and subsequent densitometry, and the number of RB binding site calculated from the binding kinetics showed significantly positive correlations each other. The result suggested that the GST enzyme function might be consistent with the function as ligandin at least in the human liver.
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  • Nobuyuki BAN, Fuminori MORIYASU, Takashi TAMADA, Toshihiko KAWASAKI, Y ...
    1987 Volume 84 Issue 11 Pages 2551-2557
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In vivo P-31 MR spectroscopic liver studies of ten normal adults and ten cirrhotic patients were carried out using a whole body MR imager with a static magnetic field strength of 2.0 Tesla. A butterfly shaped surface coil was attached to the right side of the chest to obtain a "liver" spectrum.
    The spectrum from leg muscle was scaled to that of the "liver"(so that the Pcr peak in each spectrum was the same height). The leg spectrum was then subtracted from the "liver" spectrum, leaving a spectrum of the liver without the surface tissue component.
    Peak values relative to β-ATP in the liver spectra of normal adults and cirrhotic patients were calculated. The Pi/β-ATP ratio in cirrhotic patients was the same as that in normal adults, but the PME/β-ATP ratio in cirrhotic patients was higher than that in normal adults. P-31 MR spectroscopy may be useful in estimating hepatic metabolic abnormalities in chronic liver disease.
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  • Yasuhiro MIZOGUCHI, Chie KODAMA, Tetsuo ARAKAWA, Yoshihide SAKAGAMI, S ...
    1987 Volume 84 Issue 11 Pages 2558-2562
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    When heat-killed Propionibacterium acnes is intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide is also intravenously injected, most of the mice die of massive necrosis. However, when prostaglandin (PG) was administered during this experimental induction of acute hepatic ailure, the viability of the mice increased and the histological changes of the liver remarkably improved.
    These results suggested that PG was effective in our experimental acute hepatic failure model. Since there is no definite treatment method for fulminant hepatitis at present, PG may be useful as a clinical treatment in future.
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  • Takao MANABE, Haruki NAKATSUKA, Mitsuo TSUBAKIMOTO, Toshio KAMINOU, Te ...
    1987 Volume 84 Issue 11 Pages 2563-2571
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    One hundred and ten patients with hepatocellular carcinoma (HCC) that occluded a main portal vein branch (first or second order branch) were treated by transcatheter arterial embolization (TAE).
    The therapeutic effects, outcome, and side effects were examined in these cases. When the disappearance of tumor vessels was complete at the end of TAE, tumor necrosis seen by CT was usually extensive; long-term survivors were all in this category. Outcome was worse when the right first-order branch was occluded or stenosed. The one year survival rate was 5.5% for patients with occlusions in this branch, and 16.7% for patients with the left first-order branch occluded. The mortality rate from side effects of TAE was four times higher with occlusion of a main portal vein branch than in HCC patients without occlusion; the mortality rate was highest when the right first-order branch was occluded. The location of the occlusion of the portal vein branch, tumor size, shape seen by angiography, and liver function (for example, seum total bilirubin level) were all important factors to determine the indication of TAE treatment for the patients with HCC occluding a main protal vein branch.
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  • Nobuo MURATA, Tomoo KOSUGE, Tomoe BEPPU, Yasuo IDEZUKI
    1987 Volume 84 Issue 11 Pages 2572-2578
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Sulfated and nonsulfated bile acids in serum were studied in ten patients after percutaneous transhepatic cholangial drainage (PTCD) for extrahepatic bile duct obstruction. After PTCD, the concentration of nonsulfated bile acids in serum was reduced more rapidly than that of serum bilirubin. The decrease of sulfated bile acids in serum was not so rapid as nonsulfates. In patients with delayed decrease of serum bilirubin by PTCD, the serum concentraiton of nonsulfated bile acids was reduced slow compared with the patients with effective decrease of serum bilirubin. Moreover, in the former patients, the decrease of sulfated bile acid concentration in serum was extremely slow, and in some of the patients the concentraiton was increased. The C/CDC ratio varied between patients after PTCD.
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  • Shoichiro SUMI, Kazutomo INOUE, Masafumi KOGIRE, Ryuichiro DOI, Kyoich ...
    1987 Volume 84 Issue 11 Pages 2579-2586
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Both measurement of blood flows in superior mesenteric artery and portal vein by newly developed ultrasonic transit time volume flow meter and measurement of blood flow in pancreatic tissue by laser Doppler flow meter, were performed simultaneously and continuously in dogs. By this system, the effect of VIP and Neuromedin N, a newly identified neurotensin-like peptide, was investigated. VIP induced much increse of blood flow in pancreatic tissue but relatively less increase in superior mesenteric artery, whereas neuromedin N induced most remarkable increase in superior mesenteric artery. The effects of these peptides on splanchnic blood flows were clearly characterized by this measurement system. Ultrasonic volume flow meter was also useful for the measurement of splanchnic blood flow in a conscious dog. These flow meters were found to be very helpful for further gastrointestinal investigations because of their stable, continuous and real-time measurement.
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  • Masatoshi YAMAMOTO, Tatsuo HASEGAWA, Hiromichi YAMANAKA, Miyako TONAI, ...
    1987 Volume 84 Issue 11 Pages 2587-2592
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Amylase binding mechanism were studied using purified macroamylase; which was obtained from macroamylasemia complicated by esophageal cancer exhibited antinuclear factor positive traits in clinical course, and in combination with immunohistological studies.
    1) Macroamylase was the IgA, k binding-type. 2) Purified IgA-amylase complex was in virtual agreement with the IgA sedimentation constant at 6.3s. 3) The complex P/S ratio was nearly 1.0. 4) Optimum temperature and optimum pH did not vary from normal amylase values; temperature and pH stability were increased. 5) Tissues obtained at autopsy were stained by the peroxidase antiperoxidase and immunofluorescence methods; IgA and amylase were observed in splenic endothelial cells and phagocytes.
    From the above data it appears that macroamylase consists of IgA and amylase with an unique binding mechanism which dose not influence amylase activity, and the possibility of participation by an immunological role.
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  • Shin OHNISHI, Eitetsu HOH, Nobuyuki MATSUHASHI, Takashi MORIYAMA, Taka ...
    1987 Volume 84 Issue 11 Pages 2593-2596
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yukiya YOSHIDA, Kazuo TAKEUCHI, Masao NAKAJIMA, Sohtaro FUKUCHI, Masam ...
    1987 Volume 84 Issue 11 Pages 2597-2602
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hiroshi ISHII, Kazutoshi KAWAMURA, Kazushige ARAI, Yusuke TAKAMIYA, Ta ...
    1987 Volume 84 Issue 11 Pages 2603-2606
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hiroyuki SAKUMA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1987 Volume 84 Issue 11 Pages 2607
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yukio KAWAMI, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1987 Volume 84 Issue 11 Pages 2608
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takaaki SUDO, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1987 Volume 84 Issue 11 Pages 2609
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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