Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 84 , Issue 9
Showing 1-25 articles out of 25 articles from the selected issue
  • [in Japanese]
    1987 Volume 84 Issue 9 Pages 1735-1736
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tsugio EBIHARA, Shohei KOYAMA, Toshiaki OSUGA
    1987 Volume 84 Issue 9 Pages 1737-1739
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Immunohistochemical reactivity of antibody against a synthetic peptide corresponding to positions 160-179 of the Ha-ras gene product was studied in 67 (78 lesions) surgically resected stomach cancers of humans. The cytoplasma of cancer cells in 31 of 78 lesions (39.7%) was positively stained. Staining positivity of advanced type carcinoma was accentuated than that of early type carcinoma. However, there was no correlation between depth of gastric carcinoma invasion and ras p21 expression. Immunoperoxidase staining pattern of these tumors was shown by the strong expression of ras p21 in more superficial glands versus the lesser amount of ras p21 expression in deeply invasive glands. Cancer cells of well differentiated type showed to react more frequently to antibody. In nontumorous gastric mucosa, some portions of regenerating epithelial cells and intestinal metaplasia were stained with antibody.
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  • Kiyotaka YABUKI
    1987 Volume 84 Issue 9 Pages 1740-1748
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    To clarify the role of the sympathoadrenal system in gastric acid secretion, the author evaluated the effects of epinephrine on gastric acid secretion during stimulation with tetragastrin, betazole hydrochloride, bethanechol, and bombesion in dogs with a total gastric fistula. Epinephrine administration reduced gastric acid secretion dose-dependently during stimulation with these agents except betazole hydrochloride. Blood flow in the gastric mucosa did not show direct effects on inhibition of secretion induced by epinephrine. The serum gastrin value markedly increased, but gastric acid secretion decreased following epinephrine administration (2.0μg/kg/min) during stimulation with bombesin. These results suggest that epinephrine secreted from the adrenal medulla directly acts on parietal cells, inhibiting gastric acid secretion.
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  • Tamotsu SUKO
    1987 Volume 84 Issue 9 Pages 1749-1754
    Published: 1987
    Released: December 26, 2007
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    PPD and PHA skin tests were carried out on 73 patients with hepatocellular carcinoma (HCC) for the index of cellular immunity at the time of diagnosis established. Studies were mode on the relationship between clinical data and these tests. Clinical data included space occupying rate of HCC, survival time, symptoms and laboratory evaluations. PPD skin test showed an increased negativity along with increasing of tumor size. The positive PPD test had a tendency of positive correlation to the survival time and body mass index, however, inverse correlation with log (AFP), GOT and LDH was obserbed.
    The survival rate in group of positive PPD tests more than 20mm skin reaction was significantly greater than that in those less than 20mm (p<0.001).
    In patients with hypoalbuminemia, PPD and PHA tests showed lower reaction compared to the patients with normoalbuminemia.
    Consequently it is suggested that PPD skin test is useful for prediction of prognosis in the patients with HCC.
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  • Hitoshi NAKANO
    1987 Volume 84 Issue 9 Pages 1755-1763
    Published: 1987
    Released: December 26, 2007
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    Remarkable elevation of total serum immunoglobulin M (IgM) is a characteristic feature of acute hepatitis A. The cause of this elevation was investigated and the results were obtained as follows; (1) In examination of fecal microflora in patients with acute hepatitis, no significant difference was found between type A and B hepatitis. (2) In patients with acute hepatitis A, serum level of IgM class anti-lipid A antibody activity during acute pahse was significantly higher than that of acute hepatitis B, however, it decreased uniformly during convalescent phase in all cases of hepatitis A. This change was most remarkable in a hepatitis A patient with endotoxemia. The change of serum level of IgM class anti-lipid A antibody activity was parallel with change of total serum IgM.
    These results suggest that the reticuloendotherial system (RES) of the liver is markedly damaged in acute hepatitis A. If IgM antibody is producted against many gut derived bacterial antigens spilled over to the peripheral blood because of damaged liver RES, the elevation of total serum IgM in acute hepatitis A could be mostly understood.
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  • Norio HORIIKE, Morikazu ONJI, Yasushi OGAWA, Kojiro MICHITAKA, Toshiko ...
    1987 Volume 84 Issue 9 Pages 1764-1771
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The change in HBV markers of 118 patients with chronic hepatitis type B were studied with special reference to their clinical courses. The patients were divided into 3 groups (HBeAg positive group: 85 cases. anti-HBe positive and abnormal GPT group: 16 cases. anti-HBe positive and normal GPT group: 17 cases)
    Serum HBV-DNA was detected in 99%, 91%, 0%, respectively. Likewise HBV-DNA-P was in 95%, 94%, 0%, and HBcAg in livers was detected in 51%, 20%, 0%, respectively. An increase of HBV-DNA and DNA-P preceeding exacerbation of hepatitis was detected in 94% of the HBeAg positive group and in 82% of the anti-HBe positive and abnormal GPT group.
    In 5 cases of the anti-HBe positive and abnormal GPT group, GPT was normalized in the successive peroid. However, in continuous abnormal GPT cases, 3 of 4 progressed to liver cirrhosis and 2 cases resulted in hepatic failure. These data suggest that patients with anti-HBe positive chronic hepatitis showing GPT fluctuation were related to HBV replication and that these cases should be observed carefuly.
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  • Hiroaki WATANABE
    1987 Volume 84 Issue 9 Pages 1772-1777
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Urinary neopterin excretion levels were determined in 7 esophageal, 36 gastric, 10 colonic, 8 pancreatic and 18 hepatocellular carcinomas, and in 20 normal controls.
    Urinary neopterin excretion increased significantly in gastric, colonic, pancreatic and hepatocellular carcinoma more than normal controls.
    Percent abnormality of urinary neopterin in gastric cancer was 42% and urinary excretion increased in proportion as the stage advanced.
    Urinary neopterin excretion in seven patients with gastric cancer decreased significantly after gastrectomy.
    Urinary neopterin excretion level in patients with hepatocellular carcinoma was correlated positively with their size.
    From these results, it may be suggested that urinary neopterin excretion level reflects both the clinical status of the patient and tumor size, and is useful for observing clinical course and judging effects of the treatment.
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  • Yoshinobu SHIODA, Akira TOKUNAGA, Noritake TANAKA, Masahiko ONDA, Goro ...
    1987 Volume 84 Issue 9 Pages 1778-1786
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The distribution of Ulex europaeus agglutinin-1 (UEA1) binding sites was investigated in normal and 1, 2-dimethylhydrazine (DMH) treated F344 rat bowel.
    In normal rat small intestine, UEA1 binding was distributed in the mucus of goblet cells, on the granules of Paneth cells and along the microvillous surface of epithelial cells of both crypt and villi. A faint staining was also detected along the latero-basal membrane.
    The staining intensity of the lectin was rather greater in the ileum than in the jejunum. In the normal proximal colon, UEA1 binding was observed in the mucus of columnar epithelial cells in the half lower crypt, whereas little or no staining was seen in normal distal colon.
    In adenoma and cancer induced by DMH, UEA1 was frequently and intensely positive along the apical surface of the tumors, and sometimes it also was bound to cytoplasmic site.
    In the distal colon of DMH treated animals, UEA positivity of biopsies from normal appearing mucosa increased progressively with time, although UEA1 was seldom observed at the begining of the experiment. At least one or two biopsies containing increased amount of UEA1 binding sites were obtained from every animal before appearance of tumor. Thus the UEA1 binding appeared to be a useful marker of the neoplasms and the high risk mucosa for cancer in DMH treated F344 rat distal colon.
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  • Significance of Intestinal Metaplasia, Adenoma, and Dysplasia
    Joji ISEKI
    1987 Volume 84 Issue 9 Pages 1787-1796
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Thity-eight gallbladder carcinomas were classified into four types on the basis of gross appearances, that is, type A: pedunculated polyp type, type B: sessile polypoid type, type C: superficially spreading type, type D: diffuse infiltrating type.
    The significance of intestinal metaplasia, adenoma, and dysplasia for the evolution of gallbladder carcinoma was investiaged in each type. As a result, three modes of histogenesis of gallbladder carcinomas were suggested. In the first mode, carcinomas showing the gross appearence of type A, arise from areas of adenoma, where intestinal metaplastic changes are unusually observed. In the second mode, islands of intestinal metaplasia, or dysplastic areas accompanied with intestinal metaplasia make a considerable role in the histogenesis of carcinomas of type B and C. In the third mode, dysplastic areas which originate in the mucosa with severe chronic cholecystitis may contribute to the inception of carcinomas of type D.
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  • Hisami ANDO, Takahiro ITO, Tetuyuki SUGITO
    1987 Volume 84 Issue 9 Pages 1797-1801
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Most literature states that choledochal cysts lack muscles and mucosa and dose not mention the presence of a muscles in the wall of the lower portion of the choledochal cyst and in the narrow portion which lies in the pancreatic tissue. The present studies were made in order to determine whether or not smooth muscle may exist as a structural component of the wall.
    Specimens were obtained at laparotomy from 9 patients with choledochal cyst. These specimens were examined microscopically and the thickness of the smooth muscle bundles and mucosal layer was measured with a micrometer.
    Numerous smooth muscle bundles were found in the lower part of the choledochal cyst wall. Longitudinal and circular muscles formed a layer around the wall of the duct. Longitudinal muscle bundles had 3 to 8 layers and were 10 to 50μ thick. Circular muscle bundles had 1 to 9 layers and were 60 to 250μ thick. Muscle layers were 0.7 to 1.6mm in thickness and were localized 6 to 25mm in length. In 7 patients, the lower protion of the choledochal cyst wall exibited tall columnar epithelium 0.2 to 0.7mm in height and 2 to 20mm in length. On the other hand, there was no distinct muscle layer and short columnar epithelium was present in the narrow portion.
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  • Satoru TAMURA, Kazuichi OKAZAKI, Yasuro YAMAMOTO
    1987 Volume 84 Issue 9 Pages 1802-1812
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    A new pancreatic ductal cell antigen was identified by using a monoclonal antibody SP3-1 which was produced by hybridoma cells made by fusing mouse myeloma cells (P3U-1) with spleen cells of a BALB/c mouse immunized with pig pancreatic antigen. The homogenized pig pancreas was fractionated by gel filtration through Sephadex G-100 and the void fraction was absorbed with DEAE-Sephacel and then the 3rd eluted fraction was used for immunogen. Immunohistochemically, using the peroxidase labeled antibody-staining method, the antigen against SP3-1 was demonstrated in the pancreatic ductal cell, bile ductal cell, ductal cells of the salivary gland and the esophageal gland, and the renal tubules of the pig and human. The molecular weight of the recognized antigen was estimated at 60 kilo-daltons by polyacrylamide gel electrophoresis and Western immunoblotting. The varous enzyme treatments suggested that the antigenic determinant contained protein but not sialic acid or glucose, and that isotype of SP3-1 was IgM.
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  • Hirotake HISANO, Seiki MATSUNO, Masao KOBARI, Toshio SATO
    1987 Volume 84 Issue 9 Pages 1813-1820
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Sensitivities to anti-tumor drugs, Mytomycin C (MMC), Aclarubicin hydrochloride (ACR), Doxorubicin hydrochloride (ADR), Cisplatin and 5-fluorouracil (5FU), were examined using PK-1, PK-8, PK-9, PK-12, PK-14 and PK-16 cell lines derived from human pancreatic cancer. These cell lines showed different sensitivities to each of these anti-tumor drugs. The concentrations required for 50% growth-inhibition (IC50) after 2 hours of exposure were 0.096-0.35μg/ml for MMC, 0.0074-0.0076μg/ml for ACR, 0.033-0.23μg/ml for ADR, 0.35-1.9μg/ml for Cisplatin and 21-42μg/ml for 5FU. The IC50 of each anti-tumor drug decreased significantly after 48 hours of exposure. The combination of two out of three drugs, MMC, ACR and 5FU, resulted in a synergistic effect to inhibit the proliferation of pancreatic cancer cells.
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  • T. FURUKAWA, Y. MATSUOKA, H. TAKIZAWA, T. SAITO, H. KISHIMOTO, J. FUKU ...
    1987 Volume 84 Issue 9 Pages 1821-1824
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tatsuya KUBO, Kenichi NISHIDA, Kouichi FUJITA, Nobuo OKABE, Kazuhiko T ...
    1987 Volume 84 Issue 9 Pages 1825-1829
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tsunehisa KAWASAKI, Yoshihiro FUKUDA, Yukitoki IKEHARA, Hiroshi NAKAYA ...
    1987 Volume 84 Issue 9 Pages 1830-1834
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasushi KASAI, Masahiro SUENAGA, Akio HARADA, Toshiaki NONAMI, Akimasa ...
    1987 Volume 84 Issue 9 Pages 1835-1838
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Masakazu EGAWA, Yoshinori MORIMOTO, Hidenori NAKATA, Takeshi HARA, Kik ...
    1987 Volume 84 Issue 9 Pages 1839-1843
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Hidetomo NAKAMOTO, Yasutaka INAGAKI, Takeyuki MARUYAMA, Takashi MASUDA ...
    1987 Volume 84 Issue 9 Pages 1844-1849
    Published: 1987
    Released: December 26, 2007
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  • A CASE THAT WAS DIFFICULT TO DIAGNOSE THE ORIGINAL LESION
    Seiichiro ANDOH, Seiji YANG, Masayuki ITAKURA, Seikon KIN, Junichi ONO ...
    1987 Volume 84 Issue 9 Pages 1850-1854
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Toshiya KOJIMA, Tohko SHIROTA, Nobuyuki KAKEI, [in Japanese], Kensuke ...
    1987 Volume 84 Issue 9 Pages 1855-1858
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tatsuo JIBU, Hideo NAGAI, Daisuke SENBA, Yoshiyuki WADA, Akira KURODA, ...
    1987 Volume 84 Issue 9 Pages 1859-1862
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takashi KAWAI, [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1987 Volume 84 Issue 9 Pages 1863
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kuniyasu MATSUI, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1987 Volume 84 Issue 9 Pages 1864
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kazuhiro KATAYAMA, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1987 Volume 84 Issue 9 Pages 1865
    Published: 1987
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Susumu SHIOMI, [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1987 Volume 84 Issue 9 Pages 1866
    Published: 1987
    Released: December 26, 2007
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