Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 85, Issue 1
Displaying 1-20 of 20 articles from this issue
  • Yasuaki HARAGUCHI, Atsuo SAKAMOTO, Akihiko HIGA, Hidenori SAKAMOTO, Yo ...
    1988 Volume 85 Issue 1 Pages 1-5
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The initial study was directed toward examining the effect of gastrin-releasing peptide (GRP) on gastric blood flow of anesthetized rats, measured by hydrogen gas clearance technique. The GRP injected intravenously decreased gastric blood low in a dose related manner. But GRP in combination with atropine did not inhibit the response of gastric blood flow to GRP. This result indicates that GRP is an intramural neural regulator and GRP nerve is of noncholinergic neuron.
    The next study was aimed to clearify the change of gastric tissue GRP in water immersed stress rats and to investigate whether GRP stimulates to stress ulcer formation or gastrin release. The concentration of GRP was progressively increased up to 4-6 hours and returned to basal level afterwards. This response was not related to gastrin secretion, but the peak of GRP concentration was synchronous to ulcer formation.
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  • With special reference to endoscopic findings
    Masahiko TAKAMASU, Yoshinobu FUSE, Tatsuyuki SATOH, Hiroshi NISHIDA, K ...
    1988 Volume 85 Issue 1 Pages 6-13
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Endoscopically, we deviled mucosal findings of duodenal bulb into six types as follows; erosive, hyperemic, nodular, rough surfaced, granular and appearance of blood vessels type. Biopsied or resected specimens from these types and from endoscopically normal duodenal bulb (88 cases) were evaluated with histological grading of duodenitis proposed by Whitehead. Histological findings were in higher degree (Grade 2 or Grade 3) in erosive, hyperemic, nodular and rough surfaced type than in others. So these four types were considered to be adequate as doodenitis, and it was concluded that endoscopic findings of duodenitis should be classified into four types, erosive, hyperemic, nodular and rough surfaced type. In addition, there were some morphological changes of Brunner's glands in erosive type. We considered that Brunner's glands probably had an important role in the healing process of erosion, since these glands were continous with the surface covering regenerated epithelium in some areas. Evaluations of the resected specimens obtained from nodular and appearance of blood vessels type disclosed that the former type had thick and nodular layer of Brunner's glands and the latter had thin layer of the glands.
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  • Hiroshi SUZUKI, Michiro SATA, Yohichi YANO, Saburo KAMOI, Hideo IKEDA, ...
    1988 Volume 85 Issue 1 Pages 14-19
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    2-5oligoadenylate synthetase activity was mearsued in the serum of the patients with Crohn's disease (CD) and ulcerative colitis (UC). NK cell activity was also measured in the patients with CD. Furthermore, we tried to administrate of IFN-α to a patient with CD. The results of this study were as described below.
    1) 2-5AS activity in the active stage of CD increased compared with normal control and returned to normal in the remission.
    2) In the UC, 2-5AS activity also increased, but it's degree is lesser than active CD and it fell under normal value in the remission.
    3) NK activity was low in the active stage of CD and returned to normal in the remission.
    4) This study sugests the effectiveness of IFN-α administration to the patient with CD.
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  • Masahiro NAKAO, Hideaki YAMADA, Tokio ONO, Tetsuo KUROKI, Kenzo KOBAYA ...
    1988 Volume 85 Issue 1 Pages 20-27
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The immunogenic effect of inactivated hepatitis B vaccine was evaluated in 80 healthy volunteers working at medical institutions who were negative with both HBsAg and HBsAb. Antibody was induced in 51 (69.9%) out of 73 subjects at 4th week after the third vaccination.
    At three years after the first vaccination, the reverse seroconversion to HBsAg-negative was found in 5 (18.5%) out of 27 responders to HB vaccine. All of these 5 cases were of those whose HBsAb titers were less than 50 in cut off index (RIA) after the third vaccination.
    These findings demonstrated that the evaluation of HBsAb titers at 4th week after three vaccinations is useful in understanding the changes of HBsAb titers after vaccinations so as to decide on the timing for additional vaccination.
    In high responders with HBsAb titers of 50 or more, additional vaccinations are not needed at least for three years.
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  • The effect of hyperdynamic systemic circulation
    Toshiyuki KATO, Toshiaki NONAMI, Yasushi KASAI, Akio HARADA, Akimasa N ...
    1988 Volume 85 Issue 1 Pages 28-34
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    To elucidate the effect of hyperdynamic systemic circulation in cirrhotics, systemic hemodynamics and oxygen transport and consumption were investiaged in 127 cirrhotic patients.
    Oxygen transport and consumption were maintained in patients with mildly deteriorated liver function. In patients with severely deteriorated liver function and hyperdynamic systemic circulation, oxygen consumption was also maintained by increased oxygen delivery. On the other hand, in patients with severely deteriorated liver function and normodynamic systemic circulation, oxygen consumption was significantly decreased comparing with that in control (p<0.02).
    These results suggest that hyperdynamic systemic circulation in cirrhotic patients has a compensative effect on oxygen trnsport and consumption.
    We concluded that hyperdynamic systemic circulation in cirrhotic patients was followed by maintaining oxygen consumption, and seemed to have a compensative effect on the deterioration of oxygen transport and consumption.
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  • Nobuyuki BAN, Fuminori MORIYASU, Takashi TAMADA, Toshihiko KAWASAKI, Y ...
    1988 Volume 85 Issue 1 Pages 35-41
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The effects of ischemia and reperfusion on hepatic energy metabolism were studied in four white rabbits (about 2.0kg) using P-31 magnetic resonance spectroscopy (MRS). The hepatic ischemia was induced by clamping the portal vein and hepatic artery. Hepatic ischemia was continued for 19 minutes in three rabbits and 32 minutes in one. P-31 MRS was carried out using a 2.0-T whole-body MR imager and a solneoid RF coil fitted around the liver.
    A rapid reduction of the β-ATP peak and a rapid increase in that of inorganic phosphate (Pi) can be seen after the onset of ischemia. After 19 minutes the β-ATP peak dropped to 20% of its original value, and the Pi peak rose to 347%. Twenty-five minutes after reperfusion, the β-ATP peak returned to 77% and the Pi peak dropped back to 155%. Neither peak showed a complete recovery.
    The PME peak also showed a rapid increase after the onset of ischemia, reaching 224% after 19 minutes. In contrast to the β-ATP and Pi peaks, however, it showed almost complete recovery (109%) after 25 minutes of reperfusion.
    The PDE peak showed no remarkable change during ischemia and reperfusion.
    The rabbit subjected to 30-minutes of ischemia died during reperfusion. The β-ATP peak had dropped to 27% when reperfusion was started, but failed to rise again. The Pi peak began to drop at the start of reperfusion, but the PEM peak continued to rise.
    The reduction in the ATP peak almost equaled result of biochemical assay of freeze-clamped tissue, indicating that P-13 MRS using a whole-body MR imager is useful in studying the effects of hepatic ischemia on hepatic energy metabolism. The ATP level did not recover completely even after only 19 minutes of ischemia, showing that irreversible deterioration of hepatic energy metabolism can easily be caused by even short periods of hepatic ischemia. The increase in PMR peak after the onset of ischemia was thought to reflect an accelerated glycolysis in the liver during ischemia.
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  • Susumu ITO, Akiharu IWASAKI, Jyoji SYUNDO, [in Japanese], Yasuhiro TSU ...
    1988 Volume 85 Issue 1 Pages 42-47
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Ganine deaminase (EC 3.5.4.3.) was purified using the method reported previously. Anti human liver guanase rabbit serum formed a single precipitin line with the pertial purified enzyme. The antiserum also completely inhibited the guanase activity of the extract. We prepared the Fab'-horseradishperoxidase (HRP) conjugates in order to establish immunohistochemical stain of guanase. DAB (3.3'-diaminobenzidine tetrahydrochloride) reaction was negative in the control, and was positive at the same site in the where the histochemical guanase reaction was positive, indicating that DAB reaction is demonstration the guanase itself. The immunohistochemical procedure we present here overcomes the disadvantages inherent in the histochemical method for guanase demonstration and should become a valuable tool in the clinical study.
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  • Shizou SATO
    1988 Volume 85 Issue 1 Pages 48-54
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    By combining use of planar dynamic scintigraphy and single photon emission computed tomography, author devised the method to measure organ uptake rate and hepatic Kupffer cells's degradation rate of 99mTc-millimicrosphered albumin (HSA-MM). By this method the function of hepatic Kupffer cell in patients with liver cirrhosis and without cirrhosis were measured.
    Uptake rate of HSA-MM in liver was decreased but increased in spleen in patients with liver cirrhosis, which proved decreased phagocytic activity of hepatic Kupffer cells.
    Hepatic excretion rate and degradation rate of HSA-MM in the first 60 minutes in patients with liver cirrhosis were decreased, which meant decreased metabolic activity of hepatic Kupffer cells.
    This new method to measure organ uptake rate and degradation rate of HSA-MM is useful clinically to evaluate the function of reticuloendothelial system in liver.
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  • Its histopathological peculiarities
    Yoshinobu HATA, Junichi UCHINO, Fumiaki SASAKI, Hiroshi KAMEDA, Yoshie ...
    1988 Volume 85 Issue 1 Pages 55-61
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Undifferentiated sarcoma of the liver is a new entity proposed by Stocker and Ishak and only a few cases have been reported in Japan. Nonepithelial liver tumors were seen in a 5 year old girl and in a 5 year old boy. Close similarity in the clinical and pathological features was found between our cases and Stocker and Ishak's cases. However the postmortem histopathological examinations disclosed that most part of the tumor in both cases were occupied with the components of undifferentiated sarcoma. Furthermore, the component of rhabdomyosarcoma in the girl case and the component of hepatocellular carcinoma in the boy case were observed. According to these findings, undifferentiated sarcoma of the liver has a potentiality to be differentiated into rhabdomyosarcoma or hepatocellular carcinoma. These findings were not seen in the collected Japanese cases.
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  • Hidetoshi YODA
    1988 Volume 85 Issue 1 Pages 62-72
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    30 cases with HBeAg positive, chronic hepatitis type B were treated with interferon (IFN) for 4 weeks (total dose 1.5-5.0×108U) and followed up for 18 to 68 months.
    After completion of IFN treatment, 14 cases became sero-negative for HBeAg within 18 months and 6 cases seroconverted to anti-HBe, but 10 cases remained positive for HBeAg. Remaining 6 cases became seronegative for HBeAg within 18 months, but HBeAg reappeared at a later time. In most cases, these changes of HBeAg/anti-HBe status had happened almost within 18 months after completion of IFN treatment.
    14 cases who became sero-negative for HBeAg revealed high biochemical and histological activity before treatment. But after lose of HBeAg, their biochemical activity decreased, histology of follow up liver biopsy improved and their intrahepatic HBcAg disappeared.
    In 30 IFN treated cases, HBeAg sero-negative rate was significantly higher and histological-prognosis was distinctly better than in 70 non-treated cases.
    It was suggested that IFN treatment yielded benefit effects on long term prognosis of chronic hepatitis type B in serological and histological aspects, and the judgement for these effects can be made at 1-1.5 year after complesion of IFN treatment.
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  • Fumiaki HINO
    1988 Volume 85 Issue 1 Pages 73-80
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The method for calculating lithogenic index using simultaneous determination of biliary lipids by gas-liquid chromatography was improved adopting methyl acetylation of bile acids and silicone OV-1 capillary column.
    The following results were obtained by the present method. Sensitivity and reproducibility of bile acids and resolution of biliary lipids, especially between chenodeoxycholic acid and ursodeoxycholic acid and between oleate and linoleate, were imporved. Accuracy of lithogenic index was developed and elution time of all lipids was shortened. It was able not only to calculate lithogenic index but also to determine each fraction of bile acids and fatty acids in phospholipids.
    This method is, therefore, advantageous in simple and useful evaluation of clinical determination of lithogenic index.
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  • Terumi KAMISAWA, Ikuo TABATA, Tomoaki ISAWA, Naoto EGAWA, Tsuyoshi TAJ ...
    1988 Volume 85 Issue 1 Pages 81-89
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    To evaluate clinicopathological features of non-jaundiced ampullary carcinoma, ten cases were studied: four were non-jaundiced during the all clinical course, and six were macroscopically non-jaundiced (T. Bil_??_3.0mg/dl) on admission. Common symptoms were fever and abdominal pain. The levels of serum alkaline phosphatase were markedly elevated in most cases.
    Pathologically, the mechansim of non-jaundice was revealed to be determinant by the infiltrating pattern of the carcinoma to the lower portion of the bile duct as follows: 1) dominant inflitraiton to the anal side of the papilla (4 cases), 2) polypoid growth in the bile duct (2 cases), 3) papillary adenocarcinoma confined in the intraampullary common channel (2 cases), 4) superficial spreading in the mucosa of the bile duct, and 5) dominant infiltration to the bile duct via lymphatic permeation (1 case respectively).
    All cases were surgically resected, and showed relatively better prognosis than jaundiced cases: mean survival after operation was 50 months.
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  • Saburo NAKAZAWA, Kazuo INUI, Yasuo NAITO, Eizo KIMOTO, Kenji YAMAO, Ta ...
    1988 Volume 85 Issue 1 Pages 90-94
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    We studied 48 patients with primary carcinoma of the gallbladder, who were treated and resected in our hospitals, according to relationship between cancer development and gallstone. Gallstones were present in 23 (46%) of 48 cases: in an incidence of 45% of 20 patients with stage I carcinoma of the gallbladder and in an incidence of 46% of 28 patients with stage II, III and IV carcinoma of the gallbladder. Early case of gallbladder cancer must be analysed to study relationship between cancer development and gallstone, because they are not passed for long time after cancer occurrence. The incidence of gallstone was only 10% in patients with mucosal cancer, 67% in patients with involvement of muscularis and 86% in patients with involvement of subserosa. Macroscopic view of carcinoma of the patients with gallstone was protruded type, but one of carcinoma of the patients without gallstone was flat. From these result, it is suggested that gallstone may not relate to development of gallbladder cancer and mechanically change the macroscopic view of gallbladder cancer.
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  • Junichi EJIMA, Eiji MORIOKA, Kazuma FUJIMOTO, Teruhisa OOTSUKA, Takash ...
    1988 Volume 85 Issue 1 Pages 95-98
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Masayoshi AZUMA, Takashi IKAWA, Tetsuo TAKEHARA, Hiroyuki MATSUDA, Hir ...
    1988 Volume 85 Issue 1 Pages 99-102
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Masao KOBATAKE, Tsutomu SAKAI, Kazuo OGISO, Yoshihiro YANO, Makoto TAR ...
    1988 Volume 85 Issue 1 Pages 103-106
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Report of a case with review of literature
    Ikuo MURATA, Kazuya MAKIYAMA, Toshiro TANAKA, Masahiro SENJU, Masayuki ...
    1988 Volume 85 Issue 1 Pages 107-111
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Toshiaki CHIBA, Kazuyoshi ISHIKAWA, Yoshihito TAZAWA, Toshiya ENDO, Ta ...
    1988 Volume 85 Issue 1 Pages 112-116
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Kaoru MORISHITA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1988 Volume 85 Issue 1 Pages 117
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hironobu ISHIYAMA, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1988 Volume 85 Issue 1 Pages 118
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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