Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 85, Issue 6
Displaying 1-19 of 19 articles from this issue
  • Shigenobu NAMBA
    1988 Volume 85 Issue 6 Pages 1223-1232
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The effects of pretreatments with omeprazole and cimetidine on gastric mucosal pH, gasrtic transumcosal potential difference (PD) and ulcer index in rats which were subjected to water-immersion stress after experimental induction of obstructive jaundice or acute renal failure were examined. The gastric mucosal pH was significantly higher in omeprazole-treated rats than in cimetidine-treated rats both in obstructive jaundice and acute renal failure. PD was remarkably elevated by omeprazole treatment but not significantly affected by cimetidine treatment in obstrucitve jaundice. In rats with acute renal failure, either drug showed no significant effect on PD. Ulcer index was markedly decreased by treatment with both drugs in rats with obstrucitve jaundice. However, in acute renal failure, only omeprazole strongly inhibited ulcer formation and the effect of cimetidine was much less.
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  • Shigekazu HAYASHI, Tsuneya NAKAMURA, Yasumitsu KURITA, Takeshi TSUCHID ...
    1988 Volume 85 Issue 6 Pages 1233-1239
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    A clinical study on 70 nonpseudomembranous cases of drug associated colitis was conducted after classifying them into the following 4 types according to the endoscopic findings. Type I (diffuse lesion) showed the highest incidence, seen in 40 cases. The features were; predilection for young people, high occurrence of bloody diarrhea and abdominal pain, high frequency of common cold as underlying disease, and many of the cases were given single administration of synthetized penicillins orally. Type II (longitudinal ulcer) seen in 7 cases was similar to Type I, except that a considerable number of the cases were administered cefems. Type III (aphthoid lesion) seen in 15 cases was similar to pseudomembranous colitis in many respects, such as the age of patients, symptoms, type of antibiotics, route of their administration, predilection place, and existence of C. difficile D1 toxin-positive case. Type IV (nonspecific lesion) seen in 8 cases was considered as the mild case of Type I or II according to the endoscopic examination, however, clinically there was no similarity. As mentioned above, the respective different onset mechanisms of Type I, II, III and IV were indicated.
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  • Katsuyoshi HAYASHI, Ichiro HIRATA, Shinya ORINO, Osamu SAITOH, Tooru F ...
    1988 Volume 85 Issue 6 Pages 1240-1244
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The peripheral blood NK activity and the NK subsets profile were studied in 27 patients with ulcerative colitis and Crohn's disease, 5 patients with non IBD colitis and 12 healthy control subjects.
    The NK acitivity was assessed by a 3-hr 51Cr release cytotoxicity assay using K-562 target cells. The NK subsets profile was assessed by a fluorescence activated cell sortor using Leu 7 and Leu 11c monoclonal antibodies.
    In IBD patients, the NK activity was significantly decreased, as compared with normal controls. In UC patients, the decreasing of NK activity was independant of the disease activity and was more remarkable in the patients with the steroid therapy. The population of mature NK subset (Leu 7-11+) was decreased in the lymphocyte from patients with IBD, whereas the population of immature NK subset (Leu 7+11-) was increased.
    These results suggest that there may be a maturational defect of the NK cell in patients with IBD. Moreover, it is thought that our results of NK subsets profile comfirm decreasing of NK activity in IBD.
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  • Saburo KAMOI
    1988 Volume 85 Issue 6 Pages 1245-1251
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Serum antibody levels to lipid A in 11 patients with Crohn's disease (CD) and 8 patients with ulcerative colitis (UC), were analysed by ELISA for detection of lipid A antibody activity in IgA, IgM and IgG classes.
    IgG anti-lipid A levels increased in CD (73.5±18.2%) compared with UC (52.2±14.3%) and normal controls (54.5±23.8%). IgA anti-lipid A levels increased in both CD (56.7±22%) and UC (35.8±6.7%). But especially in the CD group, IgA anti-lipid A levels were higher than those in the UC group.
    There were no differences in IgM anti-lipid A levels among three groups. In the CD group, the amount of dimeric IgA increased, compared with those in UC and NC groups by HPLC analysis and IgA anti-lipid A levels in dimeric IgA fraction markedly increased.
    In CD patients, it is suggested that antibody formation is increased in the local intestinal mucosa.
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  • Atushi YAMAGATA
    1988 Volume 85 Issue 6 Pages 1252-1259
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The volume and percent uptake of the liver and spleen were estimated with single photon emission computed tomography (SPECT) using 99mTc-phytate.
    Clinical usefulness of these parameters was evaluated by comparison with other liver function tests in 87 patients including 25 normal controls, 24 liver cirrhosis and 16 other chronic liver diseases. SPECT images were obtained by Maxi Camera 400T. Cut-off level for reconstruction of images and relationship between counts and activity (mCi) were obtained from phantom studies. Volumes estimated using SPECT and computed tomography were compared in 16 patients. Results obtained were as follows.
    1) Optimal cut-off level for measurement of volumes for the liver was 37% and for the spleen was 42%.
    2) Correlation between organ volumes estimated with CT and SPECT was good (r=0.92 for the liver and r=0.96 for the spleen), although volumes measured with SPECT were larger than those with CT.
    3) Significant differences of percent uptake were observed between normal controls and liver cirrhosis.
    4) Better correlation between spleen volumes and uptake was recognized in cases without liver cirrhosis than in cases with liver cirrhosis.
    The spleen uptake in liver cirrhosis was higher than those in others in comparison with the volume.
    5) The liver/spleen ratio of 99mTc-phytae uptake could most clearly differentiate liver cirrhosis from others.
    6) Negative correlation was observed between liver volume or uptake and ICG (R15).
    Estimation of volume and uptake of the liver and spleen could be a useful procedure to assess liver function, probably related with effective hepatic blood flow in liver cirrhosis.
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  • its distribution in relation to other HBV markers
    Kojiro MICHITAKA
    1988 Volume 85 Issue 6 Pages 1260-1268
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Hepatitis B virus (HBV) DNA in hepatocytes was visualized by an in situ hybridization method using 3H-labelled probe. HBV DNA was visualized as silver grains on 47 of 63 liver specimens from patients with chronic hepatitis B. The distribution of HBV DNA positive hepatocytes was classified into three patterns: diffuse (HBV DNA distributed diffusely within the section), lobular (HBV DAN was present in 1/3-2/3 of the section) and spotty. Nineteen of 47 specimens showed diffuse, 17 showed lobular and 11 showed spotty pattern. Most cases of diffuse and lobular pattern were serum HBeAg-positive and HBV DNA polymerase activity-positive. Immunohistochemical study of HBsAg and HBcAg in serial sections revealed that HBcAg positive hepatocytes were usually HBV DNA rich, although HBsAg positive hepatocytes were not always HBV DNA rich. These data indicate that HBV DNA detected by in situ hybridization is a useful marker for HBV replication.
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  • Yoshihide SAKAGAMI, Yasuhiro MIZOGUCHI, Norihumi KAWADA, Hiroshi KUBOI ...
    1988 Volume 85 Issue 6 Pages 1269-1272
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The peptide leukotriene C4 D4, and E4 (LTC4, LTD4, and LTE4) are derived from arachidonic acid via a lipoxigenase pathway and are potent mediators of inflammation and allergy. It is also reported that Kupffer cells may have the capacity to influnece imflammatory events in chronic liver diseases. In this study, to clarify the relation of leukotrienes to liver injury, we have examined the release of LTC4, LTD4 and LTE4 from rat Kupffer cells in vitro.
    Kupffer cell suspensions (5×105cells/ml) in modified Tyrode's solution incubated with the calcium ionophore A23187 (1μg/ml). The incubation proceeded for 0, 5, 10, 15, 30, 60min at 37°C and was stopped with 4-fold of ice-cold ethanol. Leukotrienes were assayed using combined technique of reverse-phase high-performance liquid chromatography and radioimmunoassay.
    When activated in vitro with the calcium ionophore A23187, Kupffer cells generated LTC4, LTD4, and LTE4. Thus, our studies indicate that Kupffer cells also could generate LTC4 LTD4, and LTE4 as well as polymorphonuclear leukocytes or monocytes. In addition, it is suggested that Kupffer cells maybe able to modify inflammatory and immunologic events in liver tissue by the release of LTC4 LTD4, and LTE4.
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  • Wataru KIMURA, Hideo NAGAI, Akira KURODA, Yasuhiko MORIOKA
    1988 Volume 85 Issue 6 Pages 1273-1281
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    We studied 3, 000 autopsy cases, mainly consisting of the aged patients. Asymptomatic gallbladder carcinomas were found in 15 cases (0.5%), and their incidence among all gallbladder carcinomas (80 cases) was 18.8%. All the cases of symptomatic gallbladder carcinoma belong to stage IV, 12 cases of asymptomatic carcinoma belong to stage I, and one case and two cases of them belong to Stage II and III, respectively. That is, 80% of asymptomatic cases were found to be in stage I. Histologically, the carcinoma was retained in the mucosal layer (m) in four cases. The cancer infiltrated the proper muscular layer (pm) in one case, the subserosal layer (ss) in as many as nine cases (ssβ:7, ssγ:2) and the serosa (se) in one case. However, cancerous invasion to the hepatoduodenal ligament or lymphatic metastasis was found in only two of them. Hematogenous metastasis was not found in any of them. Cancerous extension beyond the gallbladder wall seemed to be rare in the cases of "ss" invasion, as well as in those of "m" or "pm" invasion. For radical resection of gallbladder carcinoma, it is very important to find it in an asymptomatic stage.
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  • Masao YAGI, Hideki ONODA, Masato TAKAMORI, Toshio WATANABE, Kohji KONI ...
    1988 Volume 85 Issue 6 Pages 1282-1287
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Clinical significance of BT-PABA (PFD) test and fecal chymotrypsin test (FCT) in postoperative pancreatic exocrine insufficiency were examined.
    In cases whose D-xylose output in 5 grams D-xylose test were more than 1.2 grams, the correlation of urinary PABA excretion rate in PFD test and fecal chymotrypsin activity in FCT was significant. In cases whose D-xylose output were below 1.2 grams there was not significant. However, pancreatic maldigestive ratio (PMDR) which is a rate corrected PABA excretion rate with D-xylose output and chymotrypsin activity in FCT was significantly correlated in all cases.
    From these results we concluded that PFD test and FCT are useful in the evaluation of postoperative pancreatic exocrine function. And we propose to use D-xylose test concomitantly in PFD test to correct malabsorption of PABA.
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  • Yukiya YOSHIDA, Mituyo HASHIMOTO, Kazuo HAYAKAWA, Sohtaroh FUKUCHI, Ta ...
    1988 Volume 85 Issue 6 Pages 1288-1294
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Junichi TAZAWA, Yuuji HOSHINO, Fumie KOBAYASHI, Masakatsu UCHIHARA, Ma ...
    1988 Volume 85 Issue 6 Pages 1295-1298
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • is the administration of corticosteroid and γ-globulin effective against the thrombocytopenia?
    Hideaki FUJIMOTO, Akiyoshi YAMANAKA, Tsuyoshi TAKENAGA, Masahiro YAMAD ...
    1988 Volume 85 Issue 6 Pages 1299-1303
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Tsuyoshi YAZU, [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1988 Volume 85 Issue 6 Pages 1304-1307
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • A case report
    Kayoko ADACHI, Tadasu FUJI, Kazutaka NAKATA, Takayoshi NOGUCHI, Tsuyos ...
    1988 Volume 85 Issue 6 Pages 1308-1311
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Nobuhiko SOYAMA, Masahiro YAMAMOTO, Harumasa OHYANAGI, Yoichi SAITOH, ...
    1988 Volume 85 Issue 6 Pages 1312-1316
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Takashi OHSONE, [in Japanese], [in Japanese], [in Japanese], [in Japan ...
    1988 Volume 85 Issue 6 Pages 1317
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Keiko ICHIBA, [in Japanese], [in Japanese], [in Japanese], [in Japanes ...
    1988 Volume 85 Issue 6 Pages 1318
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Susumu ITO, [in Japanese], [in Japanese], [in Japanese], [in Japanese] ...
    1988 Volume 85 Issue 6 Pages 1319
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hiroo TERASHIMA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1988 Volume 85 Issue 6 Pages 1320
    Published: 1988
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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