Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 87 , Issue 2
Showing 1-21 articles out of 21 articles from the selected issue
  • Yoshihiko KAWASHIMA
    1990 Volume 87 Issue 2 Pages 163-172
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Changes in blood coagulation and fibrinolysis were investigated in twenty seven patients with esophageal varices, who underwent endoscopic injection sclerotherapy (EIS) with 5% ethanolamine oleate with meglumine amidotrioate (EOMA), 1% Aethoxyskererol (AS) and pure ethanol. Changes in platelet aggregation between before and just after EIS were also investigated. Results obtained were as follows.
    1) Remarkable changes in blood coagulation and fibrinolysis were observed in twenty patients, who underwent EIS by intravariceal injection combined with paravariceal injection. The patients showed significant change in factor XIa-α1 antitrypsin complex as a result of destruction of the endothelium of varices, caused by the sclerosants. On the other hand, no significant changes were observed in seven patients, treated by paravariceal injection alone.
    2) These changes were different from those observed in DIC because they were transient without bleeding tendency or multiple organ failures.
    3) Paravariceal injection was suitable for EIS in the patients with very poor liver function.
    4) Platelet aggregation was not elevated by EIS.
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  • Toshio TANI, Yasunari TSUCHIHASHI, Syozo YORIOKA, Kyohei MARUYAMA, Syo ...
    1990 Volume 87 Issue 2 Pages 173-180
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We have experimentally studied whether or not repeated episodes of acute gastric mucosal lesions can induce chronic gastritic changes. Rats received pyloromyotomy and repeated per os administration of acetic acid-glycerin. Gastric mucosal lesions thus induced were studied histopathologically in cardiac glandular areas using morphometric analysis. It was found that pyloromyotomy induced fibrosis between the bottom of the gland and muscularis mucosa. On the other hand, the per os administration of acetic acid-glycerin induced hyperplastic change of mucous neck cells. They were increased in number and in size. Distribution of mucous neck cells were distended vertically to the mucosal surface and towards the bottom of the gland. Greater the amount of acetic acid-glycerin administration, stronger the changes of mucous neck cells, i.e., the distended zone of mucous neck cells spreaded more and more anally from the cardiac area. Parietal and chief cells were decreased in number in the course of the mucous neck cell hyperplasia. Branching of glands was occasionally seen in rats receiving greater amount of acetic acid-glycerin.
    It was concluded that there are basic structural similarity between the gastric mucosal changes induced by repeated episods of acute gastric mucosal lesions and the change seen in human chronic gastritis. Thus acute gastric mucosal lesions can be one of the cause of chronic gastritis.
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  • Junichi OKUZUMI, Takashi YOKOTA, Kiyoshi SAWAI, Sinji KONDOH, Katsuya ...
    1990 Volume 87 Issue 2 Pages 181-186
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Surgical specimens from 2 patients with chronic ulcerative colitis accompanied with colon cancer were evaluated by immunoperoxidative staining using monoclonal antibodies A7 (against human colon cancer), S202 (against human gastric cancer), and anti-carcinoembryonic antigen (CEA). The three monoclonal antibodies were reactive with cancerous tissue, anti-CEA antibody and monoclonal antibody S202 reacted with dysplasia tissues, whereas monoclonal antibody A7 did not.
    Using high-iron diamine technique for mucosubstances (sialomucin and sulfomucin), cancer and dysplasia showed no secretory elements. Surrounding mucosa showed both sialomucin and sulfomucin secretion.
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  • Masayuki KIMURA, Kimitomo MORISE
    1990 Volume 87 Issue 2 Pages 187-194
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In 27 patients withulcerative colitis the colonic mucosa was analyzed by an immunohistochemical technique. A quantitative evaluation for lymphocyte subsets shows significantly-increased numbers of CD3+ cells, CD4+ cells, CD8+ cells and Leu7+ cells in ulcerative colitis cases of histological grades 4 and 5 by Matts's classification comparing to controls. However, CD4/CD8 ratio in each histological grade of ulcerative colitis was simillar to that in normal controls. The HLA-DR antigen on the colonic epithelium was frequently expressed in patients with grades 3 to 5 (84.2%), and in active patients (88.9%). The antigens were also expressed on the lamina propria mononuclear cells, which coincided with the ditribution of S-100+ dendritic cells. Moreover double staining for S-100 antigen and IL-2R antigen revealed that most of the S-100+ dendritic cells were also IL-2R positive. These findings seem to provide of idence for the important role of lamina propria dendritic cells in the immunological pathogenesis of ulcerative colitis.
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  • Hisashi TAKAYAMA, Hitoshi TAKAGI, Shuuichi SAITO, Toru OJIMA, Harutaro ...
    1990 Volume 87 Issue 2 Pages 195-198
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to investigate the effect of tumor necrosis factor (recombinant TNF-α) on hepatoma, we assessed the antitumor activity of TNF-α on hepatoma cell line, PLC/PRF/5 in vitro, and combined effects of interferon-γ (IFN-γ), that is thought to increase TNF-receptors. TNF-receptors. TNF-α for itself, had no significant effect on DNA synthesis and viability, and Lipopolysaccharidethe production of HBsAg from PLC/PRF/5.
    On the other hand, treatment of IFN-γ- combined with TNF-α inhibited DNA synthesis and production of HBsAg. The decrease of viability of PLC/PRF/5 was also found in this combination treatment.
    According to these findings, antitumor activity of TNF-α had no effect on PLC/PRF/5 in itself, but was significantly enhanced when treated with IFN-γ at the same time.
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  • Toshikazu YOSHIKAWA, Hirokazu OYAMADA, Hiroshi ICHIKAWA, Yuji NAITO, K ...
    1990 Volume 87 Issue 2 Pages 199-205
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The role of superoxide and lipid peroxidation in liver injury induced by ischemia-reperfusion was investigated in rats.
    Ischemic condition of the liver was created by applying small clamps to the right brunch of portal vein and the right hepatic artery for 15min. Clamping of hepatic artery and portal vein could decreased the hepatic blood flow to about 30% of that measured before the clamping. Levels of serum GPT and thiobarbituric acid (TBA) reactive substances in the liver tissue were significantly increased 30min after the reperfusion following 15min of ischemia. The increase in serum GPT and TBA reactants in the liver tissue was significantly inhibited by the treatment with superoxide dismutase combined with catalase. The treatment with allopurinol significantly inhibited the elevation of serum GPT levels and showed a tendency to inhibit the increase in TBA reactants in liver tissue.
    These results suggest that active oxygen species and lipid peroxidation may play an important role in the pathogenesis of ischemia-reperfusion injury in the liver, and hypoxanthine-xanthine oxidase system may be one of the main sources of active oxygen species.
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  • Koichi SAITOU, Masahito KURODA, Toru TAKAGI, Tomoe NISHIMAKI, Takao MO ...
    1990 Volume 87 Issue 2 Pages 206-210
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We studied the clinical significance of serum Gc levels in the sera of patients with acute hepatic necrosis. Gc concentration were measured using an EIA in double sandwich technique with purified Gc as standard. Mean levels of serum Gc were 6.0±7.4mg/dl in fluminant hepatitis, 20.8±13.6mg/dl in acute hepatitis and 39.4±13.8mg/dl in nomal subjects respectively. There was slight correlation between Gc and PTT (P<0.05). In the observation of sequential study in patients with fulminant hepatitis, serum Gc levels of live cases elevated but those of dead cases slightly elevated, thereafter decreased.
    These results suggested that serum Gc levels was the useful marker as a grade of liver cell demage and a parameter of regeneration in liver cells.
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  • Hiroshi KUBOI, Yasuhiro MIZOGUCHI, Norifumi KAWADA, Hiroki SAKAGUCHI, ...
    1990 Volume 87 Issue 2 Pages 211-217
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    When heat-killed Propionibacterium acnes was intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide (LPS) was also intravenously injected, most of them died of massive hepatic cell necrosis. However, then glucagon (0.5mg/kg body weight) and insulin (0.5 units/kg body weight) or glucagon (0.5mg/kg body weight) individually were administered during this experimental induction of massive hepatic cell necrosis, the survival rate of mice increased and serum transaminase levels improved. Also, the histological changes of the liver improved remarkably. But, insulin (0.5units/kg body weight) individually was not effective in an experimental massive cell necrosis model.
    These results suggested that glucagon and insulin was effective in our experimental massive hepatic cell necrosis model.
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  • Shuichi OKADA, Kunio KIMURA, Hiromitsu SAISHO, Yukihiro TSUCHIYA, Taku ...
    1990 Volume 87 Issue 2 Pages 218-224
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    In order to clarify therapeutic principles of hepatolithiasis associated with a variety of pathological conditions, we studied follow-up results in a term of 5 years after diagnosis in 29 nonoperated patients with intrahepatic gallstones. The patients including 14 males and 15 females underwent direct cholangiography for making diagnosis of the disease consisting of the intrahepatic type (I) and the predominant intrahepatic (IE). Out of the patients, 21 had good results in the follow-up and no one died from the disease or cholangiocarcinoma incidentally occurred. The follow-up results were closely related with the distribution and the location of gallstones in the liver and the grade of severity in clinical symptoms at the diagnosis. The unilateral lober type of the stone distribution had better follow-up results than the bilateral (P<0.01), and the peripheral intrahepatic bile duct type of the stone location did better follow-up results than the major (P<0.01). The pathological state of mild clinical symptoms showed better follow-up results than that of severe ones (P<0.05). The removal of coexisted extrahepatic bile duct stones by endoscopic papillotomy was effective for improving clinical symptoms. The conservative treatment in hepatolithiasis with the type I or IE was generally good in the follow-up results. The follow-up results were various, depending on the pathological conditions at the diagnosis. Accordingly, the treatment of hepatolithiasis must be selected in consideration of pathological conditions.
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  • Masaharu YOSHIKAWA, Masaaki EBARA, Masao OHTO, Takeyoshi MIYOSHI
    1990 Volume 87 Issue 2 Pages 225-234
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Therapeutic effects of a combination therapy (TAE and irradiation) and a radiation therapy alone were evaluated comparatively in 54 patietns with HCCs. Twenty eight patients of them underwent external X-irradiation with a linear accelerator after TAE and the remaining twenty six did irradiation alone. The incidence of partial response was 82.1% in the combination therapy and 69.2% in the radiation therapy. The cumulative rates of survival in the combination therapy were 70.8% (1-year), 37.1% (3-year), and 27.9% (5-year), which were higher than those in the radiation therapy. The cumulative rates of recurrence in the former were lower than those in the latter. The prognoses after the both treatments were poor in the patients with advanced liver cirrhosis (Child C). In the patients with HCCs smaller than 5cm in diameter or accompanied by portal vein thrombi, the combination therapy was superior to TAE alone in the cumulative rates of survival. It is considered from the above reults that the combination therapy is useful in the patients with HCCs when properly selected.
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  • Go KOBAYASHI, Naotaka FUJITA, Shigeki LEE, Katsumi KIMURA, [in Japanes ...
    1990 Volume 87 Issue 2 Pages 235-242
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We reviewed 19 cases of so-called mucin producing tumor of the pancreas ultrasonographically and histopathologically. Conventional ultrasonography could detect 16 cases out of 19 (84%). But its detectability of localized cystic lesion or papillary projection in the cystic lesion was 68%. On the contrary, endoscopic ultrasonography could visualize such changes in 93% of the cases. In the case which have neoplastic change, it is considered that the portion showing papillary proliferation is correspondent to the ultrasonographic findings of irregularity of the wall of the pancreatic duct or thickened septum-like structure. In the cases which are diagnosed as hyperplasia, the cystic lesions are delineated as having smooth and thin septum-like structure.
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  • Ken-ichi SEGAWA, Eio ATARI, Masahiko OKUDAIRA, Tomoe KATSUMATA, Yoshim ...
    1990 Volume 87 Issue 2 Pages 243-247
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Noriyoshi TAKEUCHI, Akikuni YAGITA, Isao TATEKAWA
    1990 Volume 87 Issue 2 Pages 248-251
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Souichi YAMASAKI, Masatoshi OKAZAKI, Hideyuki HIGASHIHARA, Yuzou AKITA ...
    1990 Volume 87 Issue 2 Pages 252-255
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yoshimichi CHUGANJI, Yasushi MATSUZAKI, Tsugio EBIHARA, Junichi SHODA, ...
    1990 Volume 87 Issue 2 Pages 256-262
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Isao NISHIMORI, Kazuichi OKAZAKI, Masanori MORITA, Masako MIYAZAKI, Yo ...
    1990 Volume 87 Issue 2 Pages 263-267
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1990 Volume 87 Issue 2 Pages 268-272
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Kenji OHMOTO, Shinichiro YAMAMOTO, Seiji IDEGUCHI, Ryosuke YAMAMOTO, K ...
    1990 Volume 87 Issue 2 Pages 273-277
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Masayoshi SAKANE, Makoto USAMI, Seiji HAJI, Yutaka HAMABE, Harumasa OH ...
    1990 Volume 87 Issue 2 Pages 278-282
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Tadahiko MASAKI, [in Japanese], [in Japanese], [in Japanese]
    1990 Volume 87 Issue 2 Pages 283
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Masahiko TAKAMASU, [in Japanese], [in Japanese], [in Japanese], [in Ja ...
    1990 Volume 87 Issue 2 Pages 284
    Published: 1990
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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