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Volume 87, Issue 6
Displaying 1-23 of 23 articles from this issue
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Akio MATSUMOTO, Hirofumi MIYOSHI, Ko TAKADA, Katsuyoshi HAYASHI, Shuji ...1990 Volume 87 Issue 6 Pages 1343-1349
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe effect of heptoglobin (Hp) used on endoscopic injection sclerotherapy (EIS) was evaluated by examining the increase of serum free hemoglobin (FHb) and the changes of renal function. In control group, the increase of serum FHb (ΔFHb) was paralleled with the volume of 5% Ehanolamine Oleate (EO) injected intravariceally, and free Hp (FHp) was disappered in this group soon after EIS. On the contrary, in the group treated with Hp, neither the increase of FHb nor decrease of FHp were recognized. The significant increase of urine β2 microglobulin and NAG was recognized in control group.
Therefore, if Hp is used at initial EIS, it would be prevented that serum FHb due to intravascular hemolysis increases, consequently the possibility of renal dysfunction.View full abstractDownload PDF (738K) -
Yoshitaka KONDA, Choitsu SAKAMOTO, Hogara NISHISAKI, Osamu NAKANO, Koh ...1990 Volume 87 Issue 6 Pages 1350-1356
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe effects of ethanol on pepsinogen release from isolated guinea pig gastric chief cells were investigated. Ethanol, at concentrations of 300mM to 900mM, dose-dependently stimulated increases in pepsinogen release, initial Ca influx rate and intracellular free Ca concentration ([Ca2+]i) without affecting chief cells' viability. The increases in all parameters were inhibited by La3+ or EGTA, but not by nifedipine or verapamil.
COOH-terminal octapeptide of cholecystokinin (CCK8) also stimulated increases in pepsinogen release, initial Ca influx rate and [Ca2+]i. However, the increases were dependent on not only extracellular Ca2+ but also intracellular Ca2+ mobilization. These results suggest that ethanol stimulates Ca2+ influx via the mechanism different from that of CCK8 and thereby stimulates pepsinogen release from isolated ginea pig gastric chief cells.View full abstractDownload PDF (831K) -
Hiroshi NAGATA, Tetsuo MORISHITA, Haruyuki MINAMITANI, Masayuki SUZUKI ...1990 Volume 87 Issue 6 Pages 1357-1363
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSAcute gastric mucosal lesions in the rats were produced by intermittent electrical stimuli to a main trunk of the left gastric artery (LGA), right gastroepiploic artery (RGEA) or a posterior branch of the left gastric artery (PLGA). The image processing analysis was applied to determine the relation between distribution of the lesions and perfusion area of the supplying artery to which electrical stimuli were given. Electrical stimuli of 50Hz, 5msec, 100μA was applied to the artery for 30 sc three times with 10sec interval. A series of these stimuli was repeated three times. The mucosal blood flow measured with the laser doppler method in each perfusion area was reduced to less than 35% of the control value during the electrical stimuli for 30sec. After the repeated electrical stimuli to LGA, 85.8 and 95.4% of the mucosal lesions were found in the mean and maximum perfusion area of LGA, respectively. Electrical stimuli to PLGA caused 84.5% and 95.3 of the lesions in the mean and maximum area of PLGA, respectively. Stimuli to RGEA caused 53.4% and 74.1% of the lesions in the mean and maximum perfusion area of RGEA. In the antrum, electrical stimuli to LGA, PLGA or RGEA produced 0%, 5.4% or 5.0% of the mucosal lesions. It is concluded that the corpus mucosal lesions induced by regional ischemia are distributed in the ischemic area.View full abstractDownload PDF (1335K) -
Masumi AKIMOTO, Mutsuo SHIGEMOTO, Masae ISHIKAWA, Hideharu YAMAGATA, T ...1990 Volume 87 Issue 6 Pages 1364-1370
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSGastric mucosal blood flow and gastric mucosal prostaglandin E2(PGE2) and prostacyclin (PGI2) were investigated in male Wistar rats intraarterially injected with endothelin (ET), an endothelium-derived vasoconstrictor peptide.
Immediately following ET (4nmol/kg) administration, gastric mucosal blood flow decreased. Then 30min later, the blood flow reached the minimum, but PGE2 and PGI2 showed the highest value. PGE2 showed a tendency to decrease 90min later, while PGI2 continued to show high value. There were redness and hemorrhagic damage in the gastric mucosa.
Endogenous PGs were presumed to be relate to the regulation of the development of the mucosal damage owing to decrease in the blood flow after ET administration.View full abstractDownload PDF (2245K) -
Toshikatsu OKUMURA, Kiyoshi OKAMURA, Akira UEHARA, Shigeru KITAMORI, H ...1990 Volume 87 Issue 6 Pages 1371-1375
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe role of the lateral hypothalamic area (LHA) in the development of gastric mucosal damages induced by water immersion restraint stress was evaluated in bilateral LHA-lesioned rats. The ulcer index of lesions (M±SEM, mm) was significantly higher in LHA-lesioned rats (21.6±2.8) than in both thalamus-lesioned rats (9.8±2.0) and non-treated rats (10.2±1.5). The gastric acid and pepsin outputs during water immersion for 5 hours were significantly lower in the LHA-lesioned rats than in both the control rats. In the LHA-lesioned rats, PAS-positive mucus content of gastric corpus without lesions was significantly decreased after water immersion restraint stress for 5 hours. All these results suggest that lateral hypothalamic area plays an important role in the process of stress ulcer formation mainly through the disturbance of mucosal defensive mechanism such as changes in gastric mucus contents.View full abstractDownload PDF (714K) -
Yoshi NAGAHATA, Tomoaki URAKAWA, Hitoshi MORITOMO, Takao ICHIHARA, Ats ...1990 Volume 87 Issue 6 Pages 1376-1382
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSPreventive effect of dopamine on stress ulcer formation was investigated in rats. Dopamine 1-10 μg/kg/min suppressed the elevation of ulcer index significantly after water immersion and restraint stress in a dose-dependent fashion, however ulcer indices of 25μg/kg/min of dopamine were higher than 10μg/kg/min. Dopamine 1-10μg/kg/min suppressed the decrease of gastric mucosal blood flow, gastric mucosal prostaglandin E2 content and gastric transmucosal potential difference during stress loading in a dose-dependent manner, although the supression of them in25μg/kg/min of dopamine was smaller than in 10μg/kg/min also. Dopamine suppressed the increase of gastric acid secretion and gastric motility during stress loading in a dose-dependent fashion up to 25μg/kg/min.
These results indicates that dopamine suppresses the formation of stress ulcer by increasing defensive factors and decreasing aggresive factors.View full abstractDownload PDF (937K) -
Haruo MURAOKA1990 Volume 87 Issue 6 Pages 1383-1391
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn order to investigate the factors that make viral hepatitis type A serious, clinical pictures were analized in 269 patients with viral hepatitis type A broken out during the past 8 years. In 1986 incidence of patients with severe hepatic dysfunction was higher and the average age of them was as high as 36.8±12.8 years old. The percentage of patients over 40 years of age was increasing from 1979 to 1986. Moreover in 6 patients with fulminant hepatitis type A, 4 of them (66.7%) were older than 50 years. Analysis of the clinical courses of 9 patients associated with underlying chronic liver disease disclosed serious hepatic dysfunctions in 7 out of 9. And the prolonged course of abnormal transaminase levels was observed in one of them. Therefore, aging and underlying chronic liver disease were considered as main factors that make viral hepatitis type A severe.View full abstractDownload PDF (1101K) -
Hiroyuki HASHIMOTO1990 Volume 87 Issue 6 Pages 1392-1400
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSTo assess the metabolic characteristics of cirrhotic hepatocytes, a primary culture of hepatocytes was established using rat liver induced cirrhosis by CCl4 administration. Using this system, cell responsiveness to different metabolic and excretory stimuli was investigated and compared with a primary culture of normal healthy rat hepatocytes.
Cirrhotic hepatocytes showed reduced protein synthesis in response to insulin and reduced urea synthesis in response to glucagon.
However, DNA synthesis stimulated by insulin and EGF was significantly enhanced in cirrhotic hepatocytes.
No significant difference was obserbed in the fluorescein diacetate excretion rate.
Cirrhotic hepatocytes showed impairment of antipyrine metabolism and conjugation and excretion of unconjugated bilirubin.
These results suggest indirectly that cirrhotic hepatocytes may be less functionally mature than normal healthy hepatocytes.View full abstractDownload PDF (1065K) -
Ryousuke YAMAMOTO1990 Volume 87 Issue 6 Pages 1401-1409
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSArterial ketone body ratio (AKBR) were examined in 114 cases of hepato-biliary tract diseases. AKBR of the normal control was 1.47±0.38, while it remained less than 0.7 in liver cirrhosis, hepatocellular carcinoma (HCC), alcoholic liver diseases and malignant biliary tract obstruction. AKBR correlated well with serum albumin and cholinesterase. Thirty five cases of HCC were treated with transcatheter arterial embolization (TAE), 20 cases with gelatin sponge and 15 cases without gelatin sponge. In cases with gelatin sponge AKBR decreased significantly immediately after TAE and recovered gradually during 24 hours. Without gelatin sponge AKBR decreased slightly and remained unchanged until 24 hours later. Concerning the prognosis after TAE, AKBR recovered well in cases with good prognosis, while in poor prognosis AKBR progressively decreased to below 0.3. In experimental TAE with gelatin sponge using rabbit VX2-induced liver tumor, AKBR decreased significantly. In fatal rabbit group after TAE, AKBR decreased progressively. Plasma endotoxin was also measured in TAE with experimental rabbit, AKBR and endotoxin showed reverse correlation. From these results it was suggested that the measurement of AKBR is very useful for the evaluation of efficacy and prognosis of TAE in primary liver cancer.View full abstractDownload PDF (1117K) -
Masae KOKUBUN, Masahito KURODA, Tohru TAKAGI, Koichi SAITO, Tomoe NISH ...1990 Volume 87 Issue 6 Pages 1410-1416
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe numbers and the percents of eosinocytes in peripheral blood of thirty patients with primary biliary cirrhosis were serially measured and were compaired with their clinical data.
Eosinocytes of 22 patients at non icteric stage (total bilirubin less than 2.0mg/dl) were significantly higher (P<0.05) than those of 8 patients at icteric stage (total bilirubin more than 2.0mg/dl). Seven patients (23.3%) showed eosinophila with value of 6% or more and in which four patients (13.3%) showed eosinophilia more than 8%. These eosinophilia was found in non icteric patients alone but not in icteric. In two patients who have shown eosinopilia at their non icteric stage, numbers of their eosinocytes decreased gradually following the increment of their total bilirubin levels.
These results would indicate that eosinocytes in the periferal bloods of PBC patients could reflect some clinical conditions at their non icteric stage.View full abstractDownload PDF (828K) -
Effect of posture changeHidemasa OKUMURA, Takumi ARAMAKI, Yasumi KATSUTA, Hideto TERADA, Tatsu ...1990 Volume 87 Issue 6 Pages 1417-1422
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe effect of changes in body posture on estimated hepatic blood flow (EHBF) and various hemodynamic parameters was examined in 15 patients with compensated cirrhosis. EHBF and various hemodynamic parameters were first measured with the patients in the supine position, and then again 10min after tilting to 45 degrees. EHBF was 1089±315ml/min at supine and 1065±328 after tilting; the difference was not significant. However, the patients were then divided into two groups according to the magnitude of the decrease in EHBF after tilting, with those showing a decrease of 10% of more assigned to group B, and those showing a decrease of less than 10% assigned to group A. It was found that ICG (R15) and BSP (R45) were significantly higher in group A. Meanwhile, among hepatic and systemic hemodynamics, wedged hepatic venous pressure, hepatic venous pressure gradient, free hepatic venous pressure, cardiac index, systolic blood pressure, systemic vascular resistance, and stroke volume were found to have changed significantly after tiliting. These reuslts suggest that posture change has no effect on EHBF in compensated cirrhotic patients.View full abstractDownload PDF (767K) -
Koji ISHII, Wataru YAMAMURO, Masahiro FUSE, Hideo MIZUYOSHI1990 Volume 87 Issue 6 Pages 1423-1429
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe observed previously in humans that loading with BSP in obstructive jaundice resulted in elevated blood levels, of cysteine-conjugated BSP (Cyst-BSP).
In order to clarify the mechanism of this phenomenon, an investigation was made into the origin of Cyst-BSP in rats with experimentally produced obstruction of bile duct (O-J).
Using untreated rats as controls, the animals were determined for glutathione content and glutathione S transferase activity (GST) in liver cytosol.
The influence of nephrectomy upon and the role of liver cell menbrane in biodisposition of BSP were also investigated.
The results are summarized as follows:
1) In the O-J group, the excretion in bile of glutathione-conjugated BSP (GSH-BSP) was markedly decreased.
2) O-J livers were found to have higher glutathione content and GST activity as compared to control livers.
3) Nephrectomy in O-J rats was followed by no gross change in the proportion of Cyst-BSP in blood and liver cytosol.
4) Following administration of individual liver cell membrane components change from GSH- BSP to Cyst-BSP was noted to occur only in O-J rats.
These results led us to surmise that GSH-BSP accumulated in the liver in O-J is hydrolyzed to Cyst-BSP in the liver cell membrane.View full abstractDownload PDF (797K) -
Effects on hepatitis C virus (HCV)Masao OMATA, Minoru TADA, Kazuhiko HOSODA, Susumu TAKANO, Masami TAGAW ...1990 Volume 87 Issue 6 Pages 1430-1435
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe have treated 16 patients with chronic non-A, non-B hepatitis with short term (7-13 weeks) and long term (1 year) interferon. Sustained effect (normalization) of treatment was noted in all by long term treatment, where 7 of 8 with short term treatment showed flare-ups of transaminase after the therapy. In addition, negative turn of anti-HCV antibody was noted in 2 of 5 patients with long term treatment, whereas such change was noted in none of 6 anti-HCV antibody positive patients treated with short term treatment. These data suggest that long term interferon therapy may change natural course of chronic non-A, non-B hepatitis caused by HCV.View full abstractDownload PDF (658K) -
Pancreatic damage experimentaly induced by diethyldithiocarbamateToshiyuki SASAKI1990 Volume 87 Issue 6 Pages 1436-1443
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn order to investigate the role of the oxygen-derived free radicals in the pathogenesis of acute pancreatitis, an experimentaly induced pancreatic damage was prepared in rats by the injection of diethyldithiocarbamate (DDC), which was known to be an inhibitor of Cu, Zn-superoxide disumutase (SOD).
Male Wistar rats weighing 200-250g received a single subcutaneous injection of DDC at a dose of 1000mg/kg. Serum activities of amylase were significantly increased at 3 and 5 hours after the injection of DDC. Thiobarbituric acid reactants (TBA reactants) concentrations in the pancretic tissue were increased at 30 minutes after the injection of DDC. At 7 hours after the injection of DDC, focal necrosis and degeneration of pancreatic acinar cells were observed. Peroral administration of allopurinol, an inhibitor of xanthine oxidase, before the injection of DDC suppressed the increase of TBA reactants concentration in the pancreatic tissue, but did not suppress the increase of serum activities of amylase.
These results indicate that oxygen-derived free radicals may play an important role in the pathogenesis of aucte pancreatic damage. However, since allopurinol did not suppress the increase of serum activities of amylase, further examination is needed to analyze the mechanism of DDC-induced pancreatic damage.View full abstractDownload PDF (2702K) -
Yoichiro KAKUGAWA, Kazunori TAKEDA, Makoto SUNAMURA, Shinya KAWAGUCHI, ...1990 Volume 87 Issue 6 Pages 1444-1450
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe effectiveness of continuous arterial infusion of protease inhibitor on acute experimental pancreatitis was investigated. Acute hemorrhagic pancreatitis was induced by closed duodenal loop obstruction using mongrel dogs. The obstruction was released at 16hr, and dogs were divided into three groups; Group I: non-treated control, Group II: nafamostat mesilate (FUT-175) was admitted intravenously (5μg/kg/min), Group III: FUT-175 was admitted via celiac artery.
At 24hr, the concentration of FUT-175 in the pancreatic tissues in group II and III were 905 and 4453ng/g, respectively. The trypsin like activities in the pancreatic tissues in group I, II and III were 2.1, 1.4 and 0.7nmol/min/mg protein, and the extent of necrosis of pancreatic parencyma in each group were 49.5, 25.6 and 12.4%, respectively. Serum calcium, amylase and lipase levels were significantly improved in group III.
These results suggest that continuous arterial infusion of protease inhibitor markedly decreases the extent of pancreatic necrosis in severe acute pancreatitis.View full abstractDownload PDF (1418K) -
Tamiko MATSUFUJI, Kazuo NAGAYAMA, Satoshi HIYANE, Tsutomu TAKEUCHI, Hi ...1990 Volume 87 Issue 6 Pages 1451-1455
Published: 1990
Released on J-STAGE: December 26, 2007
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Naohiko HARADA, Tadashi MISAWA, Satoru NAKATE, Teppei KABEMURA, Akira ...1990 Volume 87 Issue 6 Pages 1456-1459
Published: 1990
Released on J-STAGE: December 26, 2007
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Masayuki YANAGI, Youichi TAKAHASHI, Masao KUROSAKI, Reiji ISHIDA, Ryou ...1990 Volume 87 Issue 6 Pages 1460-1464
Published: 1990
Released on J-STAGE: December 26, 2007
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Jun FUJITA, Naoki SHIMADA, Kenji AKASHI, Kaori SASAKI, Osamu WAKABAYAS ...1990 Volume 87 Issue 6 Pages 1465-1469
Published: 1990
Released on J-STAGE: December 26, 2007
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Influence of alcohol abuse on exacerbation of chronic liver diseaseJunji SHIGA, Yumiko OHTOMO, Eiichi TOMITA, Yasutoshi MUTOU1990 Volume 87 Issue 6 Pages 1470-1478
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSCases of acute exacerbation in chronic liver disease ("acute-on-chronic") in Japan were surveyed by questionnaire method since 1986 and 220 cases were collected. 73 pathological specimens of 102 cases which were autopsied were subjected to morphological analysis. The cases were divided according to causes of acute exacerbations: namely super-imposed viral infection or drugs (Group I), unknown causes or post immunosupressant therapy (Group II), alcohol abuse (Group III), operation, digestive tract hemorrhage or post TAE etc, (Group IV). Area of hepatic necrosis was large and regeneration of hepatocytes were significantly strong in Group I and II compared with cases of Group IV.
Regeneration was also inhibited in liver of habitual alcohol drinker. Significant difference was shown in cases of Group IV. Pathologically liver of 10 cases of Group III divided to florried cirrhosis (3 cases), alcoholic liver cirrhosis (4 cases) and alcoholic hepatitis combined with post hepatitic liver cirrhosis (3 cases, all HBV carriers).View full abstractDownload PDF (3043K) -
Yoshinobu FUSE, [in Japanese], [in Japanese], [in Japanese], [in Japan ...1990 Volume 87 Issue 6 Pages 1479
Published: 1990
Released on J-STAGE: December 26, 2007
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Rika BABA, [in Japanese], [in Japanese], [in Japanese], [in Japanese], ...1990 Volume 87 Issue 6 Pages 1480
Published: 1990
Released on J-STAGE: December 26, 2007
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Yushi Taniguchi, Yukio Yoshida, Ken Kimura, Masao Mato1990 Volume 87 Issue 6 Pages 1481
Published: 1990
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (264K)
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