Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
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Volume 89, Issue 10
Displaying 1-13 of 13 articles from this issue
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  • Effect of long-term administration of antisecretary drugs on rat gastric histamine synthesis and acid secretion
    Compare with omeprazole and cimetidine
    Rikako MORITA, Shigeru HARASAWA, Takeshi MIWA, Masahiko MATSUMOTO
    1992 Volume 89 Issue 10 Pages 2551-2558
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2551
    JOURNAL FREE ACCESS
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    To investigate the effect of 6 weeks administration of proton pump inhibitor (omeprazole) and H2-receptor antagonist (cimetidine) on gastric histamine synthesis and acid secretion, we studied experimentally in the rat stomach. Then gastric mucosal histamine concentration, histidine dcarboxylase (HDC) activity and serum gastrin concentration, and HDC posotive cell number were examined in time-course. The 6 weeks administration of omeprazole caused more increase of HDC positive cells than cimetidine.
    After cessation of administration with omeprazole, high plasma gastrin level immediately reduced. However the increase of gastric mucosal HDC activity and histamine concentration were prolonged, compared with cimetidine. These findings suggest to affect differently between omeprazole and cimetidine on gastric acid secretion after cessation of long-term treatment.
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  • Evaluation of plasma thrombomodulin (TM) levels in patients with liver disease
    Kenzi AKIYAMA, Kimihide NAKAMURA, Isao MAKINO
    1992 Volume 89 Issue 10 Pages 2559-2567
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2559
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    Plasma TM levels in patients with various liver diseases were determined by using ETA. In normal subject (n=58), it's concentration was 15.9±3.5ng/ml (mean±SD). In liver diseases, the level increased: Acute hepatitis (n=16), 23.0±6.5, chronic active hepatitis (n=21) 22.2±6.6, compensated liver cirrhosis (n=20) 27.8±10.1, decompensated liver cirrhosis (n=14) 47.6±17.5, compensated liver cirrhosis with hepatocellular carcinoma (n=7) 26.3±7.9, decompenstated liver cirrhosis with hepatocellular carcinoma (n=4) 46.0±11.8, and fulminant hepatitis (n=9) 42.0±20.4.
    The percentages of abnormal values higher than 22.9ng/ml, which is mean+2SD in control subject was 38-100% in liver diseases, especially 100% in patients with liver cirrhosis or with fluminant hepatitis. There was little correlation between plasma TM levels and conventional liver function tests in various liver diseases.
    Immunohistochemical study of liver tissue showed that an increase of plasma TM level was partially caused by damage and regeneration of endothelial cell.
    Based on these results the measurement of plasma TM concentration could be an useful marker for detection of hepatic failure.
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  • Delayed CT
    A technique for the detection of hepatic metastases
    Yuko TANIGUCHI
    1992 Volume 89 Issue 10 Pages 2568-2576
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2568
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    Plain CT and subsequent dynamic (or enhanced) CT demonstrated liver tumors in 43 patients: hepatocellular carcinoma in 24 patients, metastatic liver tumors in 15 patients and hemangioma of the liver in 4 patients. Delayed CT was furthermore performed 4 hours later to investigate its significance in the diagnosis of hepatic metastases by primarily comparing it with plain CT. The difference in CT numbers between the lesion and the normal hepatic parenchyma at delayed-type scanning 31.48±7.41 HU in metastatic liver tumors, which was significantly higher than 17.37±11.32 HU in hepatocellular carcinoma (p<0.001). TDI after delayed CT was -0.43±0.13 in metastatic liver tumors and -0.26± 0.15 in hepatocellular carcinoma, between which a significant difference was noted (p<0.01). Delayed CT presented similar images to those obtained from plain CT in 14 of the 24 patients with hepatocellular carcinoma (58.3%) and a less clear tumor boundary in the remaining 10 patients (41.7%). On the other hand, the tumor boundary became clearer in 12 of the 15 patients with metastatic liver tumors (80.0%) at delayed-type scanning, than after plain CT, although the images remained almost unchanged in the remaining 3 patients (20.0%). The findings obtained from delayed CT in hemangioma of the liver were little different from those obtained from plain CT. This study suggested that delayed CT might better detect metastatic liver tumors than could plain CT. Delayed CT is recommended when metastases from other organs to the liver are suspected, and particularly when such metastatic liver tumors are small in size and multiple.
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  • Morphological changes of extrahepatic bile ductal epithelia in hamsters feeded with lithogenic diet
    Ryuichiro SAKATA
    1992 Volume 89 Issue 10 Pages 2577-2585
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2577
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    Experimental cholelithiasis was established by feeding hamsters with lithogenic diet. Morphological changes of extrahepatic bile ductal epithelia were observed under light and electron microscopes at weeks 1, 2, 4 and 6 after the treatment. Moreover, the changes of mucus composition in goblet cells, which were located among the epithelia, were particularly evaluated using High iron diamin-Alcian blue pH 2.5 (HID-AB) stain. Compared with the controls, goblet cells of both superior bile duct (S-BD) and inferior bile duct (I-BD) increased in number, but more prominently in I-BD than in S-BD. Furthermore, goblet cells of the controls mainly contained sulfomucin positive for the HID in their cytoplasm. On the other hand, goblet cells of the lithogenic diet group mainly contained sialomucin negative for the HID in their cytoplasm. Electrom microscopy demonstrated the extensive accumulation of secretory granules in the cytoplasm of the epithelial cells of both S-BD and I-BD. These results suggest that cholelithiasis may enhance the mucus secretion from extrahepatic bile ductal epithelia, and that the mucus oversecretion results in the protective effect on biliary epithelia. On the other hand, it is suggested that the mucus oversecretion may cause the bile retention in extrahepatic bile ducts, and also may have relation to the choledochitis or pancreatitis associated with cholelithiasis.
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  • Effects of urso-deoxycholic acid (UDCA) on α-naphthyl-isothiocyanate (ANIT) induced intrahepatic cholestasis in rats
    Masaya ANDO
    1992 Volume 89 Issue 10 Pages 2586-2593
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2586
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    Using the ANIT induced model of cholestasis in rats, the therapeutic effects of UDCA to the intrahepatic cholestasis were evaluated by changes of serum chemistry and liver histology. ANIT was administered once at a dosage of 40mg/kg b.w. per os and UDCA was given ad libitum for 7 days by a drinking water containing UDCA at 0.5 and 5.0% solution. In the period of bile duct epithelial degeneration and necrosis, effects of UDCA for jaundice was not detected, but hepato-cellular disturbances were appeared histologically. Moreover, the elevation of serum levels of chenodeoxy cholic acid, deoxycholic acid and lithocholic acid was accompanied. On the other hand, in the recovery stage of the bile duct epithelium, serum bilirubin was decreased significantly in the UDCA group which seemed to be related with the potent choleretic effect of UDCA. These results may indicate that UDCA is effective for the intrahepatic cholestasis in the case with no bile duct epithelial damage but in the presence of it hepato-cellular injury is introduced by the accumulated toxic bile acids in the blood.
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  • Changes on hosts' immunological response in HCC patients treated with transcatheter arterial embolization (TAE)
    Kenji KOMIYAMA
    1992 Volume 89 Issue 10 Pages 2594-2603
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2594
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    In order to investigate the changes of hosts' immunological response against cancer treated with transcatheter arterial embolization (TAE), percent change of surface antigens of peripheral lymphocites using two color analysis with flow cytometry and NK activity were measured before TAE and 1, 2 and 3 weeks after TAE in 41 cases with hepatocellular carcinoma. CD4+2H4+ subset (suppressor inducer cell) significantly increased 1 week after TAE and the increase significantly continued for 3 weeks.
    CD8+CD11b+ bright subset (suppressor cell), CD8+CD11b- subset (cytotoxic T cell) and CD4+2H4-subset (helper/helper inducer cell) did not change significantly for 3 weeks after TAE. Total of CD16+Leu7-, CD16+Leu7+ and CD16-Leu7+ subsets (NK cell subsets) significantly decreased 1 week after TAE and the decrease significantly continued for 3 weeks. NK activity was significantly suppressed 1 week after TAE, and the suppression of NK activity significantly continued for 3 weeks. It was identified that decrease of NK cell subsets was significantly related to increase of suppressor inducer cell by statistical multivariate analysis. In NK cell subsets composited ratio of CD16-Leu7+significantly increased 1 week after TAE, of CD16+Leu7+ significantly decreased 1 week after TAE, and of CD16+Leu7- significantly decreased 2 week after TAE. Therefore it is suggested that patients' immunity against cancer is weakened by TAE, and that TAE should not be rashly done in order to preserve the immunological response when it is previously expected that patients might have residual cancer; metastasis or invasion into vessels after TAE.
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  • Usefulness of selective endoscopic retrograde pancreatography (Selective ERP) and Endoscopic Pancreatic Biopsy (EPB) in the diagnosis of mucin-producing tumor of the pancreas
    Hiroyuki MAGUCHI, Takeshi OBARA, Yuji KOIKE, Yusuke SAITOH, Hitoshi UR ...
    1992 Volume 89 Issue 10 Pages 2604-2613
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2604
    JOURNAL FREE ACCESS
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    Selective ERP and EPB were employed in the diagnosis of mucin-producing tumor (MPT) of the pancreas and their usefulness was evaluated. Thirty five cases of MPTs were subdivided into three subtypes, i.e., 1) main duct type, 2) branch duct type and 3) peripheral type (mucinous cystadenoma/cystadenocarcinoma). Selective ERP was proved to be useful in demonstrating precise and whole pancreatograms, especially in revealing multiple lesions, when compared with standard ERP. Selective ERP could demonstrate communication between cystic tumors of the peripheral type and the pancreatic duct in seven (88%) of eight cases of the peripheral type, which suggests high frequency of the communication in the peripheral type. For preoperative tissue diagnosis, EPB was shown to be a useful method to yield sufficient tissue materials for histopathological evaluation and may be used as an adjunction method to diganose the intraductal extent of the tumorous lesion.
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  • A case of early esophageal adenocarcinoma arising in Barrett's epithelium
    Yasushi KITO, Haruhiko CHIGIRA, Takehito KATOH, Tsuyoshi SANO, Masahik ...
    1992 Volume 89 Issue 10 Pages 2614-2618
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2614
    JOURNAL FREE ACCESS
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  • A case of recurrent ischemic colitis associated with barium enema study
    Masao HONDA, Manabu YONEJIMA, Rieko SAIKI, Taisei SAWADA, Yoshirou KIT ...
    1992 Volume 89 Issue 10 Pages 2619-2622
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2619
    JOURNAL FREE ACCESS
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  • A case of smoldering adult T-cell leukemia associated with duodenal dilatation due to Strongyloidiasis
    Norifumi KUDEKEN, Keizo KITSUKAWA, Asanori HOKAMA, Atsushi SAITO, Masa ...
    1992 Volume 89 Issue 10 Pages 2623-2628
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2623
    JOURNAL FREE ACCESS
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  • A case of Sweet's syndrome with intrahepatic cholestasis
    Mitsuhiro TERADA, Yasutsugu MIZUNO, Hideyuki RYOURIN, Mikio KUMAGAI, T ...
    1992 Volume 89 Issue 10 Pages 2629-2633
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2629
    JOURNAL FREE ACCESS
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  • A case of gastric aberrant pancreas with stone in it
    Hiroyuki SUZUKI, Akihiko MORIYA, Zyuniti NAKAGAWA, Kiyosi MATUMARU, Ka ...
    1992 Volume 89 Issue 10 Pages 2634-2637
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2634
    JOURNAL FREE ACCESS
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  • An experience of chemoembolization, effective for recurrence after opperation of renal cell carcinoma
    Youichi KATO, Masaya SASAKI, Ryouta FUJIWARA, Yoshiaki OKUMURA, Katsuh ...
    1992 Volume 89 Issue 10 Pages 2638-2642
    Published: 1992
    Released on J-STAGE: December 26, 2007
    DOIhttps://doi.org/10.11405/nisshoshi1964.89.2638
    JOURNAL FREE ACCESS
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