We investigated the effect of 4-weeks famotidine administration (15mg/kg/day) on gastrin cell (G-cell), somatostatin cell (D-cell) and prostaglandin E
2 (PGE
2) of gastric mucosa in pyloric stenosis rats.
As a result, the increase of G-cell number and serum gastrin level in pyloric stenosis rats were potentiated by famotidine administration. However, the increase of D-cell number in pyloric stenosis was remarkably abolished by famotidine administration, and G/D cell ratio was increased accordingly. Moreover, famotidine administration decreased PGE
2 concentration in fundic mucosa of the stomach without altering PGE
2 concentration in pyloric mucosa.
Our results suggested that famotidine administration in pyloric stenosis had a possibility to worsen the balance of endocrine cell kinetics in stomach, and PGE
2 in fundic mucosa would play a roll on the proliferation of D-cell in pyloric stenosis.
View full abstract