Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 90, Issue 1
Displaying 1-12 of 12 articles from this issue
  • [in Japanese]
    1993 Volume 90 Issue 1 Pages 1-2
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hideo MIYAMOTO, Wataru ADACHI, Shoichiro KOIKE, Naohiko KOIDE, Futoshi ...
    1993 Volume 90 Issue 1 Pages 3-8
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    For evaluating the endoscopic staining of the esophageal carcinoma with lugol solution, 50 patients who underwent esophagectomy for carcinoma were subjected to this study. Among the 50 patients, 21 were radiated before surgery and 29 were not radiated. The findings of the lugol staining were compared between endoscopic staining and staining on removed specimens. Non-staining area demonstrated by endoscopic procedure almost agreed with that by the procedure on removed specimen in non-radiation group, but both areas of 28.6% cases disagreed in radiation group.
    On the second step, the extent of non-staining area demonstrated by the procedure of removed specimen was compared with histological extent of carcinoma. The non-staining area on the removed specimen was more extended than histological extent of carcinoma; 10.3% in the non-radiation group and 71.4% in the radiation group. As one of the causes of the large non-corresponding rate in the radiation group, radiation esophagitis was demonstrated.
    It can be finally concluded that the reliability of endoscopic lugol staining is reduced by preoperative irradiation.
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  • Osamu NAKANO, Choitsu SAKAMOTO, Yoshitaka KONDA, Kohei MATSUDA, Takash ...
    1993 Volume 90 Issue 1 Pages 9-15
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    To understand the mechanism by which prostaglandins (PGs) preserve gastric mucosal integrity, we established a primary cultured monolayer of guinea pig gastric mucous cells, and by using this culture system, we studied whether endogenously released PGE2 could influence the proliferation of the mucous cells. By the histochemical and morphological analysis at 24h of the culture periods, the cells were recognized to contain PAS-positive mucous granules with only 3% of them being parietal cells. Although the cells which were simultaneously labeled with [3H] arachidonic acid in 0.5% serum-containing medium synthesized and released radiolabeled PGE2, PGI2 and PGA2, the release of PGE2 was more markedly observed and was partially dependent upon arachidonic acid added to the ulture medium. By radioimmunoassay of the culture media, the mucous cells were found to release PGE2 in a time-dependent manner in response to 10% serum.
    Pretreatment of the cells with 10-4M indomethacin not only inhibited PGE2 release but also inhibited increase in cell number. However, the addition of PGE2 dose-dependently restored the indomethacin-induced inhibition of cell growth with the maximal increase almost to the control level at 10-6M PGE2. These results suggest that PGE2 endogenously released from the cells may exert a proliferative effect on gastric mucous cells.
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  • Nobuo OMURA
    1993 Volume 90 Issue 1 Pages 16-23
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The effects of 4-week indomethacin administration (1mg/kg/day, orally) on gastrin cell (G-cell), somatostatin cell (D-cell) and prostaglandin E2 (PGE2) of gastric mucosa were examined in pyloric stenosis rats.
    As a result, pyloric stenosis rats showed hypergastrinemia, G-cell hyperplasia and D-cell hyperplasia with normal PGE2 concentration of gastric mucosa compared with sham operated rats. However, indomethacin administration completely abolished these endocrinic changes of pyloric stenosis by reducing PGE2 concentration of gastric mucosa in both fundic and pyloric regions.
    These results underline the importance of gastric mucosal PGE2 concentration on the proliferation of G-cells and D-cells in pyloric stenosis.
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  • Atsuo KITANO, Takayuki MATSUMOTO, Akihiro TABATA, Makoto OBAYASHI, Mak ...
    1993 Volume 90 Issue 1 Pages 24-32
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    The effect of the betamethasone sodium phosphate (BSP) enema on the colonic mucosal lesions in the carrageenan induced colitis (rabbit) was examined laboratory and histologically. The effect of drugs were evaluated by the changes of body weight, fecal occult blood, blood analysis, and histological examinations. Fecal occult blood were highly positive in the physiololgical saline treated but less positive in the BSP groups. In the blood analysis, anemia was not detected in both groups.
    Histological findings such as the defect of superficial epithelium, crypt abscess, inflammatory cell infiltration, atrophic changes, defect of muscularis mucosae, goblet cell depletion, goblet cell depletion, ulcer formation, and edematous change were scored to evaluate the colonic mucosal lesions. These scores (Mean±S.D.) were 4.4±1.96, 7.7±3.67 for BSP, physiological saline groups respectively. From these results, BSP enema showed an antiulcerative effect on the entire colonic lesions in the carrageenan induced colitis in the rabbit.
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  • Kimiyoshi SHIMANUKI, Wataru SUZUKI, Ikunosuke SAKURABAYASHI, Hirokazu ...
    1993 Volume 90 Issue 1 Pages 33-40
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    In order to determine whether or not the lidocaine metabolism, monoethylglycinexylidide (MEGX) formation, could be used as a liver function test, we measured the serum levels of MEGX in 38 patients. There were significant correlations between values of MEGX (MEGX15, MEGX30, AUC15-30, AUC0-180) and conventional liver function tests (ICG R15, ATIII, T. Bil). It appeared that value of MEGX 30 had maximum factor loading on conventional liver function tests by using principal component analysis. The advantage of adapting the MEGX formation as a liver function test of drug metabolism is simplicity of the method. MEGX formation could be useful index of the total liver function.
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  • Evaluation using direct hemoperfusion under hepatic venous isolation
    Yonson KU, Masahiro SAMIZO, Takumi FUKUMOTO, Hiromoto SHIKI, Yoko MAEK ...
    1993 Volume 90 Issue 1 Pages 41-48
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Hepatic extraction rates (ER) of anticancer drugs during hepatic arterial infusion were investigated with the aid of direct hemoperfusion (DHP) under hepatic venous isolation (HVI). Using mongrel dogs (n=6), adriamycin (ADR), mitomycin C (MMC) and cisplatin (CDDP) were simultaneously administered to the hepatic artery at each dosage of 1mg/kg in 10 minutes under HVI•DHP. Hepatic venous flow and plasma concentrations of each drug at the carotid artery, the inlet and outlet sides of DHP were periodically determined during HVI•DHP. Based on these data, drug adsorption and removal rates were estimated. In addition, hepatic tissue uptakes of each drug were calculated from the amounts of drug administered and leaked in the hepatic effluent. Subsequently, the percentage of tissue uptake of each drug to the amount of drug administered was determined as ER of each drug. Drug adsorption rates during the first 10 minutes after infusion showed no significant difference among three drugs. Drug removal rate of CDDP tended to be higher than those of other two drugs. ER of CDDP (54.8±18.3%) were significantly lower (p<0.01) as compared to ADR (84.4±16.2%) and MMC (83.1±15.7%).
    These results indicate that ER of each drug should be taken into consideration to determine appropriate drug for hepatic arterial chemotherapy.
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  • Go KOBAYASHI, Naotaka FUJITA, Yutaka NODA, Katsumi KIMURA, Hiromitsu W ...
    1993 Volume 90 Issue 1 Pages 49-56
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
    Thirty-six cases of pancreatic cancer including 27 cases of so-called mucin producing cancer of the pancreas, examined with endoscopic ultrasonography(EUS) and treated with surgery, were reviewed to evaluate the usefulness of EUS in the diagnosis of portal venous(PV) invasion. The detection rate of pancreatic tumors cancer by EUS was 92% in 36 cases. The detection rate of PV invasion by EUS was compared with histological results in each case. Judgement of the correlation between the tumor and the PV wall was possible in 30 cases(83%), and the overall accuracy of EUS in the diagnosis of PV invasion was 73%. It is concluded that EUS is a very useful method for diagnosis of PV invasion in cases of pancreatic cancer.
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  • Naoyuki UENO, Yasunaga SUZUKI, Sakumi SAEGUSA, Hideaki JINNAI, Takashi ...
    1993 Volume 90 Issue 1 Pages 57-61
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hiroshi TOKUYAMA, Fuyuhiko HIGASHI, Hidehito TAMAKI, Toshihiko KUNISHO ...
    1993 Volume 90 Issue 1 Pages 62-66
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Hirotaka SHIBATA, Shigenari HOUZAWA, Hiromasa ISHII, Masaharu TSUCHIYA ...
    1993 Volume 90 Issue 1 Pages 67-73
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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  • Yuko TAMURA, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...
    1993 Volume 90 Issue 1 Pages 74
    Published: 1993
    Released on J-STAGE: December 26, 2007
    JOURNAL FREE ACCESS
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