Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 91 , Issue 1
Showing 1-20 articles out of 20 articles from the selected issue
  • [in Japanese]
    1994 Volume 91 Issue 1 Pages 3-9
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Hiroyuki KISHIMOTO, Masahiko SAKAI, Toru KAJIYAMA, Ayao TORII, Masaya ...
    1994 Volume 91 Issue 1 Pages 10-19
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    From August 1992 through February 1993, we treated 21 patients with endoscopic variceal ligation (EVL). Two patients had a history of the esophageal variceal bleeding, but 19 patients did not have bleeding episodes. To evaluate preventive effect of bleeding, we selected the patients who had grade F2 or red color sign positive varices. We repeated EVL until varices improved into grade F0 or F1 and red color sign negative. The therapeutic goal was sometimes changed according to patient's general condition. No additional therapy was performed to eradicate varices, such as endoscopic injection sclerotherapy. As a result of our therapy, eradication rate was 73.7% and period of hospitalization were 25± 11 days. No major complications were found during and after EVL. EVL affected neither liver function test nor size of gastric varices. Recurrent varices with red color sign were found in 4 patients, but easily controlled by retreatment with EVL. EVL seems to be convenient and effective therapy in our short-term study, and useful for preventive therapy of the esophageal variceal bleeding.
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  • Toshiaki WATANABE, Norichika NARIMIYA, Mari JOKI, Masahiko IWASAKI, Iz ...
    1994 Volume 91 Issue 1 Pages 20-26
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Thein vivomorphology of scierosants, n-butyl-2-cyanoacrylate (Histoacryl; referred hereinafter to briefly as HA) polymer formed within the gastric wall was investigated in an animal experiment. The results indicate that HA polymer formed after local injection of HA into the stomach wall with deliberate avoidance of contact with blood got scattered in an arboroid pattern, suggesting thus that when HA is injected into the gastric mucosa at an extravascular site, the resulting polymer is likely to get scattered and miss the target site. Polymerization products that were formed after injection of HA alone were deep purple, dense, firm, rounded in shape and lesser in adverse histologic influence upon the walls of stomach. On the other hand, those formed by injection of HA with Lipiodol were large-sized, light brown and oval-shaped ones with more irregular margins and less distinct boundaries as compared to those seen after injection of HA alone. These results of the study led us to conclude that at the present time it would seem wise to limit the use of HA for this particular therapeutic purpose only to those cases of bleeding gastric varices.
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  • Naoya KATOH, Makoto ITOH, Yoshifumi YOKOYAMA, Takashi JOH
    1994 Volume 91 Issue 1 Pages 27-35
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    There are several reports on the gastric mucotoxic effect of endothelin (ET). The mechanism of this effect, however, remains largely unknown. To evaluate this, we assessed the gastric injury and changes in gastric mucosal blood flow induced by ET using ONO-1078, a sulfide peptide leukotriene (LT) antagonist, CV-3988, a platelet-activating factor (PAF) antagonist, and diltiazem, a Ca2+ channel blocker. In fasted and anesthetized rats, 2 nmol/kg of ET was infused for 30 min into splenic artery to deliver the drug as much as selectively to the stomach. Ninety minutes after beginning the drug infusion rats were killed and gastric mucosal damage in the removed stomachs was assessed. Gastric mucosal blood flow (GMBF) was measured for 90 min with a 30 min-interval by the laser Doppler flowmetry method. ET induced severe gastric mucosal damage, which was characterized by congestion of mucosal capillary and accompanied by significant reduction of GMBF, as compared with control. However, these mucotoxic effect of ET was significantly inhibited by 20 mg/kg of ONO-1078 given i. g. 60 min before ET infusion and i. v. administration of 10 mg/kg of CV-3988 and 1 mg/kg of diltiazem 30 min prior to ET. From these results, we conclude that PAF, LT and Ca2+ may play important pathogenetic roles as chemical mediators in the mechanism of the formation of ET-induced gastric mucosal lesions.
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  • Yoshirou TAMAKI, Yoko ARAI, Tadayoshi KAKEMURA, Takashi OHISHI, Toshif ...
    1994 Volume 91 Issue 1 Pages 36-41
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Generally two types of ultrasonic colon examination method are carried out. One is extracorporeal ultrasonographic examination (US). And another is endoscopic ultrasonographic examination (EUS).
    US is technically easy but is difficult to take good image of colon diseases. EUS can give us good and sufficient informations. But it is technically difficult and gives much trouble to patients.
    During usual endoscopy, we have tried extracorporeal ultrasonic examination by filling de-aired water around the diseased colon area.
    With this new method, we could easily identify the disease and got much better picture than usual US. And this new method gave almost no trouble and pain to examinees in comparison with EUS.
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  • Yuji MIZUKAMI, Syogo YAMASHITA, Yasushi HOSOKAWA, Akihiko USAMI, Kimit ...
    1994 Volume 91 Issue 1 Pages 42-47
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Motor activity of the sphincter of Oddi has been evaluated in 26 patients who underwent ERCP examination. Manometric recordings from the common bile duct and the sphincter of Oddi were performed with a single end-lumen perfused catheter. The number of successive 3 mm spaced black marks, observed during the pull-through from the first appearance of the proximal sphincter activity to that of duodenal pressure, was used to measure the length of the sphincter zone. In 14 of 26 patients, the length of phasic activity zone of the sphincter of Oddi was 9mm. However, the narrow distal segment of the common bile duct was 15.1±3.6mm in length. In same patients, the length of phasic activity zone was shorter than the anatomical one. The mean sphincter of Oddi pressure(SOP)at the distance of 6 mm from the papillary pore(77.8±22.1mmHg)was greater than that of 9 mm(58.4±27.0mmHg)and 12mm (51.0±16.9mmHg).
    These results suggest that the location of the orifice of catheter should be taken into consideration when comparing the SOP.
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  • Noriyoshi TAKAHASHI
    1994 Volume 91 Issue 1 Pages 48-56
    Published: January 05, 1994
    Released: June 17, 2011
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    The relationship between cholecystectomy and colonic cancer has been suggested. The effect of cholecystectomy on cell proliferation of colonic mucosa in mice was studied immunohistochemically using bromodeoxyuridine (BrdU) and anti-BrdU monoclonal antibody after sham operation and cholecystectomy. In addition, the effect of carcinogen 1, 2-dimethylhydrazine (DMH), on cellular proliferation of colonic mucosa was following. The results were obtained, (1) Cellular proliferation of colonic mucosa was increased after cholecystectomy. It was suggested that cholecystectomy influenced to the cellular proliferation of colonic mucosa in the study without carcinogen.(2) In the study using DMH, cell proliferation of colonic mucosa was increased after cholecystectomy.(3) At the time for the increased effect of DMH, cholecystectomy group tended to induce earlier proliferative effect than sham operation group.
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  • association with separate openings of the pancreatic and biliary ducts
    Tomoyuki NAKANO, Ikuo YABUTA, Hideaki SHIMOMURA
    1994 Volume 91 Issue 1 Pages 57-65
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    A total of 1293 patients who underwent ERCP between 1980 and 1990 were reviewed. A parapapillary choledochoduodenal fistula (PCDF) was noted in 42 patiants (3.2%). In order to study the frequency of PCDF, the patients were divided into groups of age of ten years. As a result, PCDF was formed to increase with advance in age. Thus the dispose is regarded as a “later on” disease. Thirty-one of these patiants were included in the definite PCDF group, in which the distance between the papillar and fistulous opening was confirmed by cannulation or choledochography, and 11 in the questionable PCDF group, in which the distance was not confirmed, and thus the opening might be the separate openings of the pancreatic and biliary ducts (Mehnen's type I). The frequency of pneumobilia, biliary stone, history of cholecystectomy, biliary inflammation and obstruction were similar in the two groups. Only one patient suspected of having separate openings of the pancreatic and biliary ducts except the questionable PCDF was seen over the same period. This suggests that majority of the cases of separate openings of the pancreatic and biliary ducts, whose prevalence is estimated to be 2-4% in Japan, may be PCDF.
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  • Surgery or follow-up
    Takeshi OBARA, Hiroyuki MAGUCHI, Yusuke SAITOH, Satoshi ARISATO, Akino ...
    1994 Volume 91 Issue 1 Pages 66-74
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
    Clinicopathological studies were carried out in 35 cases of mucin-producing tumor of the pancreas. In addition, natural history and serial pancreatogram changes were studied in 12 long-term follw-up cases. 83% of the main duct type and branch duct type greater than 4 cm were malignant, whereas hyperplasia cases were found in the branch duct type of 3 cm or less in size without marked dilation of the main duct and excrescent nodules. 33% of carcinoma cases were accompanied by parenchymal invasion and all those cases were of polypoid type of 2.5 cm or more in size. In long-term follow-up cases, all 3 cases of the main duct type showed progression of pancreatograms. In contrast, 8 of 9 cases of the branch duct type remained unchanged. These results suggest that surgical resection is mandatory in the main duct type and that the branch duct type where hyperplasia is highly suspected can be followed up.
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  • Kunihiro MIYAUCHI, Yasuo TAKANO, Yukihiko OHSHIMA, Masao SHIMIZU, Tats ...
    1994 Volume 91 Issue 1 Pages 75-79
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Hideyuki KOJIMA, Yoshikazu SAKAGUCHI, Hiroshi FUKUI, Tadasu TSUJII, Ta ...
    1994 Volume 91 Issue 1 Pages 80-83
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Toru INOUE, Toshiyuki TAKADA, Masafumi TAKADA, Megumi SHODA, Yasuhiro ...
    1994 Volume 91 Issue 1 Pages 84-88
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Fumika ORII, Masaki TARUISHI, Takanori FUJIKI, Masafumi NOMURA, Tokiyo ...
    1994 Volume 91 Issue 1 Pages 89-94
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Kiyotaka OKAWA, Kenji WATANABE, Kiyohide KIOKA, Yoshikazu SHINDO, Kenj ...
    1994 Volume 91 Issue 1 Pages 95-99
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Yutaka UEDA, Yoshito ITO, Kazuhiko TOKITA, Syoji MITSUFUJI, Syohei YOK ...
    1994 Volume 91 Issue 1 Pages 100-104
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Hiromi TAKAGI, Masuo AIZAWA, Eikan SON, Hitoshi KITANO, Katsujiro YOSH ...
    1994 Volume 91 Issue 1 Pages 105-108
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Toshihisa NOSAKA, Narihide GOSEKI, Togo AOI, Tokichi GEN, Syoichi KATO ...
    1994 Volume 91 Issue 1 Pages 109-114
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Kouji UNO, Masatsugu NAKAJIMA, Kenjiro YASUDA, Eisai CHO, Hidekazu MUK ...
    1994 Volume 91 Issue 1 Pages 115-118
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Yutaka OZEKI, Makoto OGI, Takashi MURATA
    1994 Volume 91 Issue 1 Pages 119-123
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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  • Kenji OOKUMA, Yutaka YAMADA, Mitsuo OKADA, Setsuo MADOKORO, Sadamitsu ...
    1994 Volume 91 Issue 1 Pages 124-128
    Published: January 05, 1994
    Released: June 17, 2011
    JOURNALS FREE ACCESS
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