The effect of prostaglandin E
1 on bile excretion was investigated using the
ex vivo perfused rat liver.
In the control group (normal liver), the perfusion system was stabilized 60 minutes after the induction of the perfusion and the effect of administered prostaglandin E
1 was most markedly observed at the concentration of 2.5μg/
l.
The effects of prostaglandin E
1 on the liver with biliary obstruction was investigated on 14 days after the induction of biliary obstruction when the obstruction was spontaneously resolved by recanalization of the obstructed bile duct. Both portal blood flow and bile excretion increased significantly in the PGE
1 (+) group, perfused with perfusate containing 2.5μg/
l of prostaglandin E
1, compared to the PGE
1 (-) group. However, there was no significant difference between the PGE
1 (+) and the PGE
1 (-) in excretion of total bile acid. The c-AMP level of perfusate increased by the administration of prostaglandin E
1.
It was concluded that prostaglandin E
1 increased portal blood flow and bile acid-independent bile flow in the liver after relief of biliary obstruction.
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