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Fumi ISHII, Bun-ei IIZUKA, Toshimi NAKANISHI, Kou NAGASAKO, Naoaki HAY ...
1997 Volume 94 Issue 6 Pages
389-397
Published: June 05, 1997
Released on J-STAGE: February 26, 2008
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Vitamin K deficiency caused by antituberculous agents was examined in clinical patients and in experimental rats. When antituberculous agents were given to the patients who had only total elental diet because of small intestinal dysfunction, a marked increase in plasma PIVKA-II and a decrease in thrombo-test value were observed. These changes were quickly normalized by administration of vitamin K, despite of succeeding or stopping of antituberculous agents. In rat experiments, effects of four agents (ethambutol, isoniazid, para-aminosalicylate, and rifampicin) on prothrombin time were studied. Among these agents, only rifampicin prolonged prothrombin time. This prolongation depended on drug doses and duration of administration. In addition to this hypoprothrombinemia, an increase in plasma PIVKA-II was also observed, and these changes were normalized within 24 hours of vitamin K administration. These data suggest that rifampicin inhibits vitamin K epoxide reductase interfering re-use of vitamin K and caused vitamin K deficiency in patients with total elental diet.
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Masakazu IKENAGA, Kenji KOBAYASHI, Yasunori HASUIKE, Masahiro IKEDA, N ...
1997 Volume 94 Issue 6 Pages
398-401
Published: June 05, 1997
Released on J-STAGE: February 26, 2008
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Daisuke SHIRASAKA, Munehiko NAGAO, Takahiro IKEMURA, Koichi SHIRAKATA, ...
1997 Volume 94 Issue 6 Pages
402-406
Published: June 05, 1997
Released on J-STAGE: February 26, 2008
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Kazuyuki NAKAZAWA, Yukinori NAKAE, Machiko ICHIKAWA, Kimiyuki YANAOKA, ...
1997 Volume 94 Issue 6 Pages
407-412
Published: June 05, 1997
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Tsunehiro ENDO, Kazuaki YASUHARA, Masaharu YOSHIKAWA, Hiroshi NAKAMURA ...
1997 Volume 94 Issue 6 Pages
413-418
Published: June 05, 1997
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Masayo ASAWA, Fumihiko KOMINE, Seiji FUKAMIZU, Kazuhiko NAKAI, Mitsuhi ...
1997 Volume 94 Issue 6 Pages
419-423
Published: June 05, 1997
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Hiroaki SATOH, Masayuki ITOH, Yasushi AMADA, Kazue MURATA, Shigeru WAT ...
1997 Volume 94 Issue 6 Pages
424-428
Published: June 05, 1997
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Toshiaki SAKURAZAWA, Toshifumi OHKUSA, Hideaki FUJIMOTO, Hironoshin KU ...
1997 Volume 94 Issue 6 Pages
429-433
Published: June 05, 1997
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Kazuhiko BAN, Yutaka MAEDA, Ryuichi MIZUBAYASHI, Jiro KANIE, Hitoshi F ...
1997 Volume 94 Issue 6 Pages
434-439
Published: June 05, 1997
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Kazuyuki YAZAWA, Yoshiaki TSUGE, Chiharu TAKAHASHI, Masayoshi ICHIJO, ...
1997 Volume 94 Issue 6 Pages
440-444
Published: June 05, 1997
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Gen TOHDA, Teruyuki KANE, Shotaro KOSAKA, Toshiaki TAKAHASHI, Toshio O ...
1997 Volume 94 Issue 6 Pages
445-449
Published: June 05, 1997
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[in Japanese], [in Japanese]
1997 Volume 94 Issue 6 Pages
450
Published: June 05, 1997
Released on J-STAGE: February 26, 2008
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