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Junichi SUZUKI, Kaori SASAKI, Tomoaki ADACHI, Kuniaki SADAOKA, Tetsuno ...
1997 Volume 94 Issue 8 Pages
519-525
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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To evaluate the incidence of abnormal gastroesophageal reflux in patients with bronchial asthma and the influence of drug therapy on the gastroesophageal reflux, we investigated the gastroesophageal reflux patterns using an ambulatory 24-hour esophageal monitoring in 25 healthy volunteers and 58 asthmatics. All the patients were stable conditions at the time of the study. Bronchodilator therapy was continued, if necessary along with steroid inhalation and xanthines. Compared with healthy volunteers, the asthmatics had significantly greater esophageal acid exposure time, more frequent reflux episode, and longer single reflux time. About 70% of asthmatics had abnormal gastroesophageal reflux. Asthma medications were not associated with the incidence of abnormal gastroesophageal reflux. However, asthmatics receiving β
2-stimulants therapy (
n=27) had significantly greater esophageal reflux exposure time than those not receiving (
n=31). Our study suggested that most asthmatics have abnormal gastroesophageal reflux unrelated to asthma attack or asthma medications and that β
2-stimulants used in asthmatics may worsen gastroesophageal reflux.
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Satoshi NUMATA, Kimihiro AKAGI, Ikuo SAKINO, Hisami OGATA, Toshiharu K ...
1997 Volume 94 Issue 8 Pages
526-531
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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We have evaluated the efficasy of partial splenic embolization (SE) in the treatment in 10 cirrhotic patients with marked hypersplenism. The mean infarction rate of the spleen was 84%. The change of spleen size, peripheral blood cell counts and liver function tests after SE were investigated during 3 years, and also 10 cirrhotic patients without SE were followed as control. The residual spleens after SE did not enlarged except 1 case with 65% infarction rate of the spleen. In these cases, the SE led not only to a sustained increase in both platelet and white blood cell counts but also to a significant improvement of hepatic function tests (hepaplastin test, total cholesterol and albumin) during observation period. On the other hand, these parameters tended to decrease in control patients without SE. This study suggests that SE performed with a high infarction rate of spleen is an useful therapy for hypersplenism in cirrhosis.
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Takahumi YAMAMOTO, Jun MATSUMOTO, Ken SHIOTA, Kazuaki NAKASHIO, Teruka ...
1997 Volume 94 Issue 8 Pages
532-537
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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Yasushi KITO, Hiroshi KANDA, Tomohito WATANABE, Takao TERAMOTO, Osamu ...
1997 Volume 94 Issue 8 Pages
538-542
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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Masako FUKAZAWA, Hiroshi INOUE, Hideyasu KAWAMURA, Yasuhiro KIHARA, Na ...
1997 Volume 94 Issue 8 Pages
543-548
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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Toshio INADA, Hiroaki YOSHINAGA, Katsuhiko SHIOMI, Makoto ISHIDA, Hiro ...
1997 Volume 94 Issue 8 Pages
549-551
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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Noriaki KOBAYASHI, Masaharu OHTA, Misa KONDO, Motonari SAKAI, Takashi ...
1997 Volume 94 Issue 8 Pages
552-557
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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Takashi NAKAMURA, Katsuhisa OMAGARI, Hideki KINOSHITA, Isao MATSUO, Ke ...
1997 Volume 94 Issue 8 Pages
558-563
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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Seishi YOSHIKUBO, Keishi KIMURA, Kensuke MIZUTARI, Shojiro KAMO, Kazuh ...
1997 Volume 94 Issue 8 Pages
564-568
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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Norio MATSUKURA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
1997 Volume 94 Issue 8 Pages
569
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
1997 Volume 94 Issue 8 Pages
570-571
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
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[in Japanese], [in Japanese]
1997 Volume 94 Issue 8 Pages
572
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
JOURNAL
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
1997 Volume 94 Issue 8 Pages
573
Published: August 05, 1997
Released on J-STAGE: February 26, 2008
JOURNAL
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