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from a choleretic to an immunomodulator, and at present time
Isao MAKINO
2002 Volume 99 Issue 10 Pages
1163-1172
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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Makoto OTSUKI
2002 Volume 99 Issue 10 Pages
1173-1185
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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Hiromitsu SAISHO, Taketo YAMAGUCHI, Takeshi ISHIHARA
2002 Volume 99 Issue 10 Pages
1186-1190
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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Hiroyuki INABA, Takashi TSUDA, Aya MIYAZAKI, Yoshiyuki WATANABE, Shini ...
2002 Volume 99 Issue 10 Pages
1191-1196
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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Recently chemoradiotherapy for esophageal cancer has been drawing public attention to the issue of quality of life maintenance for patients. Although the standard method of chemoradiotherapy is CDDP/5FU, it has been claimed that CDGP (a derivative of CDDP) alone is more effective than CDDP for the treatment of esophageal cancer due to its low nephro-and digestive toxicity. We used a small amount of CDGP/5-FU in combination with radiation instead of CDDP, for the treatment of esophageal cancer and performed clinical examination of patients. The partial response rate was 80% and the complete response rate was 50%. Major side-effects were leukopenia, neutropenia, thrombocytopenia and anemia. Further study of dosage and schedule is necessary, however, CDGP/5-FU combined with radiation therapy could be used as choices of chemoradiotherapy for esophageal cancer in the future.
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with special reference to the presence of Helicobacter pylori infection and rate of recurrence
Masahiro SAKAGUCHI, Hiroshi OKA, Kanji AMEMOTO, Masahiko HONDA, Fumita ...
2002 Volume 99 Issue 10 Pages
1197-1204
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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Perforated duodenal ulcer was clinically evaluated with respect to
Helicobacter pylori infection and rate of reccurence in 38 ulcer patients perforated and 154 patients with non-perforaed duodenal ulcer who visited our hospital in past 5 years and 6 months. The frequency of occurrence of
H. pylori-positivity was 42.1% in patients with perforated duodenal ulcer, significantly lower than that of 92.9% in patients with non-perforaed lesions. This result suggests that
H. pylori is hardly involved in the development of perforated duodenal ulcer. The rate of recurrence was significantly lower for perforated duodenal ulcer than for non-perforated ulcer. In particular, perforated duodenal ulcer did not recur in the group on maintenance therapy with H
2-recepter antagonists. Maintenance therapy using inhibitors of gastric acid secretion seems effective for the prevention of recurrence of perforated duodenal ulcer.
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Importance of co-operation between physicians of internal medicine and transplantation surgery
Yoshiyuki YAMAGISHI, Hidetsugu SAITO, Motohide SHIMADU, Ken HOSHINO, H ...
2002 Volume 99 Issue 10 Pages
1205-1212
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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We followed up the patients with fulminant hepatic failure who admitted in our hospital and investigated clinical problems raised in the patients who underwent living-related liver transplantation (LRLT). Among 15 patients with fulminant hepatic failure 6 were managed without LRLT and 3 patients survived, and the survival rate was 50%. Other 9 patients received LRLT, and 2 of these 9 died with their complications after the transplantation. Thus the survival rate by LRLT in fulminant hepatic failure was 77.8%. Brain CT scan examination showed severe brain edema in a patient and the edema did not improve after LRLT. Another patient suffered from development of fungal infection in her lungs after LRLT. We suspected the presence of subclinical infection in the preoperation period. The recovery from brain edema and the existence of subclinical infection are mostly difficult to evaluate but are very important for obtaining a good output. These results suggest that LRLT is a promising procedure for treatment of fulminant hepatic failure but a close cooperation between physicians of internal medicine and transplantation surgery from preoperative management until postoperative period is necessary.
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Yoshikazu HONDA, Shigetoshi FUJIYAMA, Hideto CHIKAZAWAI
2002 Volume 99 Issue 10 Pages
1213-1219
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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Twenty-four weeks administration of interferon-a has been performed to 23 patientsof chronic hepatitis B. As the result, complete or partial responders reached to 47.8%, so that it was considered to be effective therapy for chronic hepatitis B. By the investigation of behaviors of HBV-DNA, thereduction of HBV-DNA below 4×10
2 copy/ml during the administration of interferon was considered to beone essential factor for inducing the effectiveness of interferon. Though lamivudine, which has a strong anti-viral effect, has been permitted, interferon is still considered as the good indication for relative young patients who do not have advanced hepatic fibrosis. As a newly strategy for the patients with high titer of HBV-DNA or breakthrough hepatitis, the combination therapy of interferon and lamivudine will be expected.
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Jo TOYOTA, Kenji SUGIMOTO, Tetsuya SHIMOMURA, Kiyoshi ASHIDA, Takumi F ...
2002 Volume 99 Issue 10 Pages
1220-1225
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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Ayako NISHIZAWA, Youichiro TOKUMITSU, Shuichi TANIGUCHI, Takashi MATSU ...
2002 Volume 99 Issue 10 Pages
1226-1230
Published: October 05, 2002
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Kaori WADA, Masahiko SHIROTANI, Tomoko OKAMOTO, Akira HASHIMOTO, Tetsu ...
2002 Volume 99 Issue 10 Pages
1231-1235
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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Toshifumi TADA, Kazuo TAKIMOTO, Kazunari TOMITA, Kiyoshi MORI, Jun WAK ...
2002 Volume 99 Issue 10 Pages
1236-1239
Published: October 05, 2002
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Kazuhisa GONDOH, Ryukichi KUMASHIRO, Keigo EMORI, Yukihiro MATSUYAMA, ...
2002 Volume 99 Issue 10 Pages
1240-1242
Published: October 05, 2002
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Jin Kan SAI, Masafumi SUYAMA, Yoshihiro KUBOKAWA, Hiroyuki TADOKORO, N ...
2002 Volume 99 Issue 10 Pages
1243-1246
Published: October 05, 2002
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Tatsuhiro TSUJIMOTO, Hiroi IIOKA, Tadashi NAMISAKI, Yasunori TOYOKAWA, ...
2002 Volume 99 Issue 10 Pages
1247-1253
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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Naoki KUMASHIRO, Shin SAKURABAYASHI, Hidekazu TAKAHASHI, Shuji NISHIMU ...
2002 Volume 99 Issue 10 Pages
1254-1257
Published: October 05, 2002
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Ryosaku TOMIYAMA, Fukunori KINJO, Mariko KAWANE, Akira HOKAMA, Ryoji M ...
2002 Volume 99 Issue 10 Pages
1258-1260
Published: October 05, 2002
Released on J-STAGE: June 17, 2011
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