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Koji TAKEUCHI, Akiko TANAKA, Tohru MIYAZAWA
2002 Volume 99 Issue 7 Pages
751-759
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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Hideyuki HIRAISHI, Shin-ichi OTA, Akira TERANO
2002 Volume 99 Issue 7 Pages
760-768
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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Masataka NISHI, Fuminori MORIYASU
2002 Volume 99 Issue 7 Pages
769-778
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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The following studies were undertaken using specimens of submucosal invasive colorectal cancer surgically or endoscopically resected from 104 patients: 1) measurement of the depth of submucosal invasion ; 2a) histological reevaluation of colon sm cancer by scoring of the degree of histological differentiation using a modified Gleason's grading system proposed for prostatic cancer ; and 2-b) immunohistological evaluation of E-cadherin, a cell adhesion factor. Lymphatic node metastasis occurred in no case with the depth of submucosal invasion of less than 1, 000 μm. In the histological reevaluation, high incidence of lymphatic metastasis was noted in the high-score group, while lymphatic node metastasis was not seen in any patients in the lowscore group. Immunohistological evaluation of E-cadherin showed that the destructive pattern is correlated with lymphatic metastasis, suggesting that weakening of the cell adhesive factor was related to a decline in the degree of differentiation of the tumor. Findings obstained in the present study suggest that endoscopic therapy is indicated for colon cancer measuring less than 1, 000 μm and that its indication can be expanded to colorectal cancer with the depth of submucosal invasion of more than 1, 000 μm by adding histological reevaluation.
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Mikiko OHTA, Aiji NODA, Eri IBUKI, Junko IZUMI, Mariko YAMAMOTO, Madok ...
2002 Volume 99 Issue 7 Pages
779-788
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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We conducted the statistical analysis of both initial symptoms and clinical symptoms and signs of different etiologies of chronic pancreatitis by using odds ratios which was one of the techniques of evidence-based medicine. The official report published by The Research Group of Intractable Pancreatic Diseases sponsored by the Welfare Ministry of Japan in 1986 was available as the data source of the present study. Nine items of initial symptoms and 25 items of 28 clinical symptoms and signs were compared in 4 differnt etiologies of the disaese which were alcoholic, biliary, idiopatic and nonalcoholic (both biliary and idopatic). In initial symptoms, 1.5 items were significantly more observed in alcoholic pancreatitis than in nonalcoholic, biliary and idioatic pancreatitis, 4 of which (abdominal pain, back pain, poor appetite and loss of body weight) were common items as might be related closely to the alcohol intake, 2. only one item of jaundice was significantly more observed in biliary pancreatitis than in alcoholic and idiopatic pancreatitis, 3.3 items of poor appetite, diarrhea and abdominal mass were more frequently observed in idiopatic pancreatitis than in biliary pancreatitis. In clinical symptoms and signs, 1. almost all items (21 to 24) were significantly more observed in alcoholic pancreatitis than in the other etiologies of the disease, and seemed to be related directly or indirectly to alcohol intake, 2.3 or 4 items which were related closely to gallstone and acute cholecystitis were significantly more observed in biliary pancreatitis than the other two etiologies of the disease, and 3.4 items consisting of diarrhea, loss of body weight, and pancreatic swelling were more frequently observed in idiopathic pancreatitis than in biliary pancreatitis.
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Minoru NAKAI, Junko SHIROKO, Takashi SHIROKO, Naoe GOTO, Nobuo HASHIYA ...
2002 Volume 99 Issue 7 Pages
789-797
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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Hidetaka TAKASHIMA, Hiroyuki KIMURA, Hideki NAKAMURA, Satoshi MYOJO, Y ...
2002 Volume 99 Issue 7 Pages
798-802
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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Katsuyuki KOICHI, Shuzou TUGAWA, Hiroaki IWANE, Tomoko NAKATUMI, Toshi ...
2002 Volume 99 Issue 7 Pages
803-807
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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Tomoyoshi MURAMATSU, Masahito MARUTAKA, Akira MATSUMI, Naomi WATANABE, ...
2002 Volume 99 Issue 7 Pages
808-813
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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Nobuo TOMIYASU, Keiichi MITSUYAMA, Kenji MIYAKODA, Asuka SUZUKI, Kousu ...
2002 Volume 99 Issue 7 Pages
814-819
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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Naoto MAEDA, Akeri MITSUDA, Masaharu KODA, Masahiko KODA, Akihide HOSO ...
2002 Volume 99 Issue 7 Pages
820-827
Published: July 05, 2002
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Katsumasa SUZUKI, Takanobu YOSHIMOTO, Shinya WAKI, Akira NAKAMURA, Shi ...
2002 Volume 99 Issue 7 Pages
828-832
Published: July 05, 2002
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Kazuo YAMAFUJI, Tadao TSUJI, Zenichi MORISE, Noritaka HAYASHI, Tomomi ...
2002 Volume 99 Issue 7 Pages
833-837
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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Yoko NARIBAYASHI, Shigeru TAI, Yasuo NAKATA, Syusaku YOKOGAWA
2002 Volume 99 Issue 7 Pages
838-842
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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Hiroshi KISHIKAWA, Jiro NISHIDA, Masaru NAKANO, Nobuo HOSOE, Toyotaka ...
2002 Volume 99 Issue 7 Pages
843-847
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
2002 Volume 99 Issue 7 Pages
850-852
Published: July 05, 2002
Released on J-STAGE: February 26, 2008
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