1. Pharmacological experiment: the dogs and rabbits were selected for the experimental animals. The nodular ganglion of these animals were exposed to and suffused or injected with TEAB. The preganglionic fiber was then stimulated by the electric stimulator. At that time, the gastric movement was recorded by a kymograph which was connected to the gastric tube with a top of the inflated rubber balloon. As a result, the preganglionic stimulation of Nodular ganglion was inhibited by TEAB and it was ascertained that in Nodular ganglion, there were some ganglion cells which junct the pre and postganglionic fiber of the centrifugal vagal fiber to the stomach.
The presence of some ganglion cells in the stomach wall which can be blocked by TEAB was also estimated. To make the estimation, the following experiment was done: the vessels of the stomach were discontinued from the total circulation, and then TEAB and saline water were injected into those vessels.
As a result, the motility of the stomach was inhibited by TEAB. Namely, it was ascertained that there must be some ganglion-cells in the wall of the stomach.
2. Pharmacologic experiment A guinea pig was used for the experimental animal. The abdomen was opened and the stomach was removed. The muscle of the stomach was settled to the Magnus' Apparatus, into which various kinds of drugs were dropped-i. e., Ach, Nicotine, TEAB, C
6, Ba and K.
The action of nicotine, used as a ganglionic stimulator, was inhibited by both TEAB and C
6. The action of Ach was blocked by TEAB, but not by C
6. The direct stimulative action of Ba and K to the muscle was not inhibited by TEAB.
As a result, the following fact was observed; TEAB acted upon both the ganglion cells and the neuromuscular junction in approximately the same concentration.
The blocking agents of the autonomic nerve in the past did not have such a double action. Such an action of TEAB is considered to be unusual.
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