1) The purpose was to determine which kind of hexoses might be better absorbed from the intestinal mucosa and reserved most effectively in the liver, by analysis of blood specimens drawn from the portal vein anal the ear lobe, after injecting hexose solutions (galactose, glucose and fructose) into the jejunum of patients during laparotomia.
Secondly, arterial-venous differences in blood sugar level were determined after injection of concentrated hexose solutions (glucose and fructose) into the cubital and portal veins of patients in the course of laparotomia, and these differences were compared with those obtained in non-operative condition.
Further, effects upon sugar metabolism of operative procedure were observed.
2) Generally speaking, both the reduction of liver glycogen and the increment of peripheral blood sugar caused by mere operative procedure were observed, and the degree of such increment ran parallel to the extensiveness of the surgical procedure involved.
3) Fructose was absorbed most rapidly from the intestinal mucosa and reserved most effectively in the liver.
Galactose was also rapidly absorbed and seemed to be reserved considerably well in the liver-in the early stage of absorption.
The absorption of glucose was steady and protracted with a gradual increase, but the total amount absorbed in the first one hour exceeded that of fructose.
4) It, was demonstrated that the blood sugar level of the ear lobe was equal to that of the finger tip, when glucose solution (20%, 40 c.c.) was administered into the cubital vein in the course of one minute so long as these blood specimens were drawn simultaneously one minute or more after the completion of the administration.
5) It was also demonstrated that the glucose solution intravenously injected was reserved in normal peripheral tissues in proportion to the concentration of such solution reaching the tissues.
Similar result was observed in adminstration of fructose.
6) Concentrated glucose solution, injected into portal vein, was reserved directly in the liver better than in the case of fructose, while its reservation in the peripheral tissues was inferior to fructose solution.
7) Arterio-venous differences of blood sugar after administration of concentrated glucose solution into the cubital vein in the course of laparotomia, were evidently reduced in spite of remarkable hyperglycemia which exceeded hyperglycemia to be observed after its administration in normal conditions, while, in the case of similar administration of concentrated fructose, the differences were not reduced but rather tended to increase parallel to the progress of hyperglycemia.
Namely, operative procedure seems to produce in peripheral tissues a condition of relative deficiency of insulin, antagonistic to the hormons of adrenal cortex and anterior pituitary system.

View full abstract