日本消化機病學會雜誌
Online ISSN : 1349-7693
Print ISSN : 0446-6586
55 巻, 9 号
選択された号の論文の3件中1~3を表示しています
  • 原田 尚
    1958 年 55 巻 9 号 p. 591-604
    発行日: 1958年
    公開日: 2011/06/17
    ジャーナル フリー
    SGO-T and SGP-T activity were measured spectrophotometrically.
    The average value of SGO-T for normal young adults was 13.9±3.8, ranging from 6 to 23 units, and that of SGP-T was 5.6±1.8, ranging from 3 to 9 units.
    The activity of enzymes was found to be remarkably increased in hepatitis, especially in its earlier stage.
    In acute hepatitis, the average value of SGO-T was 771 units and that of SGP-T was 717 units, gradually decreasing to normal range within about 1 month, though BSP test, serum bilirubin and serum iron still remained abnormal.
    The average value of SGO-T was 59.1 units in patients with liver cirrhosis, and 84.8 units in obstructive jaundice, and 84.8 units in hepatic carcinoma.
    On the other hand, that of SGP-T was 56.1 units in liver cirrhosis, and 71.9 units in obstructive jaundice, and 44.4 units in hepatic carcinoma.
    The activity of enzyme was compared with the results of usual liver function tests, especially BSP test, serum bilirubin and serum iron etc., but the correlation between them was not significant.
    The measurement of transaminase alteration was found to be a useful tool in the diagnosis and study of acute liver disease and was considered to be a reliable indicater reflecting acute hepatocellular damage.
    The value of SGP-T activity was higher than that of SGO-T in experimentally produced toxic hepatitis and obstructive jaundice, however, such a definite finding was not observed in clinical cases with these conditions.
    In order to clarify the mechanism of the elevation of enzyme activity in peripheral blood, a series of experimentations was attempted.
    In experimental CCl4 toxic hepatits, the height and duration of increased enzyme activity was found be proportional to the extent of hepatocellular damage, and the release of GO-T from damaged liver was proved in hepatic venous blood using hepatic vein catheterisation.
    And in experimental ligation of biliary tract the stagnation of bile was seemed to attribute to the elevation of enzyme activity.
    As to the SGP-T elevation, the same mechanism was suggested, but in this case, the stagnation of bile seemed to play more important role than in elevation of SGO-T.
  • 村主 巖
    1958 年 55 巻 9 号 p. 605-627
    発行日: 1958年
    公開日: 2011/06/17
    ジャーナル フリー
    We have never seen any practical method to examine the peritoneal function.
    But the new method using phenolsulfonphthalein (i. e. Matsunaga-Matsuda's method) made it (peritoneal function) possible clinically by measuring absorption capacity of peritoneum.
    The author researched for the promoting factors upon the absorption capacity using rabbit, judging from the experimental data by means of Matsunaga-Matsuda's method.
    (1) When “Strong Neo-Minophagen C” was injected to the experimental animals either intravenously or intramuscularly, the absorption capacity was remarkably increased and by repeating same injections this capacity was more increased and the effect of its accumulation was manifest.
    In order to research the true nature being contained in this drug, he examined each element which composes “Strong Neo-Minophagen C”, i. e. glycyrrhizin, glycine and cysteine. From these experiments he resolved that glycyrrhizin showed no effect but glycine and cysteine, especially the latter showed the remarkable absorptional capacity.
    (2) In the experiment using “polytamin”, a combined amino acid drug, it provedthe same increased function as glycine indicated. He thought this increased function using these drugs was chiefly based upon the hypermetabolism caused by the specific dynamic action of amino acid. For this reason, cysteine had activating factor for proteolytic enzyme and had a anticoagulating activity and had a activating factor for pro teolytic enzyme and had a anticoagulating activity, thus resulting the increase of peritoneal function and circulating blood volume in the peritoneum, therefore cysteine showed, the author concluded, especially high activating factor for the peritoneal function.
    (3) In the experiment on patient using the blocking agent for autonomous nerve, the author observed in case of T. E. A. B., slightly increased function, but almost uneffected in case of hexamethonium bromide. And in case of chlorpromazin, decreased function. Concerning the result of T. E. A. B., the author thought this increased function might be due to the dilatation of arteriole caused by the blocking of sympathic nerve. And in order to certify this slightly increasing function, he resected the splanchnic nerve per peritoneally in animal and he was able to explain hat the decreased function in case of using chlorplomazine was due to the inhibitance of intestinal peristalsis and paretic function of colonic cell.
    (4) Purine derivate had more effective to increase the peritoneal function than saline and mercurial diuretics did.
    (5) Cortison had remarkably decreased this function and DOCA slightly. These two experimental facts were thought to be resulted from the inhibiting function from the saline metabolism and from the diffusion by these steroid hormones.
    (6) Expecting to increase the absorbed function, by spreading factor, “Hyaluronidase” injected into the peritoneal cavity, the author observed slightly decreased value against his anticipation.
  • 1958 年 55 巻 9 号 p. 628-690
    発行日: 1958年
    公開日: 2011/06/17
    ジャーナル フリー
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