日本消化機病學會雜誌
Online ISSN : 1349-7693
Print ISSN : 0446-6586
57 巻, 9 号
選択された号の論文の7件中1~7を表示しています
  • 千葉 郁樹
    1960 年 57 巻 9 号 p. 1103-1116
    発行日: 1960/09/30
    公開日: 2011/06/17
    ジャーナル フリー
    Though the distribution of tender points on the front abdominal wall is complicated, Prof. Kudo has closely analyzed these points according to each of diseases and Kudo's tender point of duodenal ulcer (D-point) which always being existed at the front abdominal wall of the patients in the case of duodenal ulcer. The position of D-point is explained as follows: Taking the center at the navel, draw a median line over the abdominal wall and then draw a lateral line crossing it, thus divide the front abdominal wall into four angles. The position will be found on a bisector of the right upper angle by 1.5 to 2 cm distance from the navel and is easily examined in abdominal palpation. The author has examined 125 cases of thn patients and recognized 76.0% positive of it, thus the results were considered that it was not inferior to the test of Onodera's point. D-point will be found in high rate at relatively earlier stage of duodenal ulcer or the disease which has hemorrhagic focus, and it will be ceased within average 3.5 weeks by proper internal treatment. It is presumed that the position is located within a fixed sphere, but it does not conform with D-point at the lying position and it comes from the viscerosensory reflex. It also is presumed that the point is under the charge of 8 th, 9 th, 10 th, and 11 th thoracic nerves, especially of 9 th and 10 th of them. Of course the clinical value of Onodera's point will be highly evaluated for the diagnosis of the stomach-duodenal ulcer, however, it sometimes recognized in other than the cases of the stomach-duodenal ulcer.
    In diagnosing those, it is considerable to add a further efficacy if taking both into continual consideration and examine with proper manupulation.
  • 笹川 庄三
    1960 年 57 巻 9 号 p. 1117-1154
    発行日: 1960/09/30
    公開日: 2011/06/17
    ジャーナル フリー
    A number of research has been carried out on biliary tract physiology. A considerable amount of unsolved problems, however, have been left at the present time.
    Experimental studies on these problems have been attempted in various aspects in our department. Fundamental studies were mainly performed by the author and the following results were obtained.
  • 堀越 弥太郎
    1960 年 57 巻 9 号 p. 1155-1171
    発行日: 1960/09/30
    公開日: 2011/06/17
    ジャーナル フリー
    1. With applying flexiblly mounted urtramicroelectrodes, the intracellular electric potentials in ginea-pig's tenia coli and haustra coli in situ were successfully recorded and the following results were obtained.
    2. The resting potentials of the tenia coli are ranging in 30 mV to 60 mV and the action potentials are recorded up to 30 mV without overshoot usually 4 mV to 10 mV (average 7.9±0.7 mV). The spike duration is 241±29 msec. repeating 0.5-2.5 sec in periods. Haustra coli presents a grouping of the spikes 1-8 pieces with 2 to 30 sec. intervals.
    3. Two kinds of slow potentials are observed. The formar type of them is local potentials which are resulted from spontaneous excitation of its cell or of the adjacent cells, then behave as generator prior to the spike activity. The second type of the slow potentials is consisted with slow movoments of the resting level appearing in about 5 seconds periods, which are corresponding to fluctuation on the electromechanogram. Usually the spike potentials are appeared in equal intervals on the slow potentials II, and are predominant on their rising phase and are disminished on the declining phase as if having a closed relation between the spike potentiall and the slow potentials II.
    4. There are some distinguishable differences of the results obtaining in situ from those in isolated tenia coli as follow;
    1) In situ the periods of the spike potentials are distributed in 0.5 sec. up to 2.5 sec. with variable.
    2) Spontaneous alteration of the spike configulation and arresting of the spike activity are observed not infrequently.
    3) The slow potentials II is prominent.
    5. With administration af Acetylcholine or Neostigmine i. m. or i. v., it appeares a decreasing of the resting potentials and a prolongation of the repolarizing phase. These facts seem to due to accentuation of nonspecific ion permiability of the protoplasmic membrane.
    6. With Adrenaline i. m. a rising resting potentials decreasing of the spike frequency, a steeping of the spike configuration, and isolation of the prepotentials are observed. These phenomena seem to be caused by a rising threshold of the spike depolarization and due to vascular effects as well as to neurogenic effects directly by Adrenaline in some extends.
    7. Atropine, Chloropromazine and Buscopan make the resting potential increased, also result in sharp gradient in the spike configuration, distinuished multiple spikes, grouping of the spikes. So that these drugs seem to be responsible to lowering of the electric activity of the cells and disjunction of the cells.
    8. In experimental ileus, the spike discharge is observed in group corresponding to the phasic contraction. The both depolarizing and repolarizing phase are prolomged and are associated by various spike configuration, also the arresting intervals are prominent. The above facts are resulted from direct effects of an obstructive toxin as well as edema and circulatory disturbance of the local area.
    9. Experimentally interrupted blood circulation result in both depolarizing and repolarizing phases prolonged marKedly as time is passed on. These phenomena are recovered with recirculation of the blood, local response to A. T. P., or rising local temperature in some extends. In these facts, temporal anoxia cause a disturbance of ionic pump mechanism accompanied by an impairment of intracellular oxygeration and ATP mechanism. It is very interested in clinical aspects.
    10. The above esperimental evidences are concluded as the action potentials are myogenic and each cells have a syncytial continuity in their function.
  • 特に胆石及び胆嚢炎発生と腸内細菌巣との関連性について
    山田 竹勝
    1960 年 57 巻 9 号 p. 1173-1207
    発行日: 1960/09/30
    公開日: 2011/06/17
    ジャーナル フリー
  • 斎藤 邦男
    1960 年 57 巻 9 号 p. 1209-1223
    発行日: 1960/09/30
    公開日: 2011/06/17
    ジャーナル フリー
    In order to examine the absorption function of colon, the author invented the absorption-test of colon by mans of enema-method containing P32 and he obtained the following results.
    1) P32 appeared into general circulating blood in about two-thirds of 26 cases within 5 minutes, and it was excreted into urine in about five-sixths of 59 cese within 30 minutes after the enema with P32.
    2) The concentration of P32 in blood of normal colon-group increased gradually in the course of time until 24 hours after the enema with P32. But in the group with severe ulcerative colitis, rapid increase of P32 occurred during from about 30 minutes to 1 hour, and then the concentration increased gradually until 24 hours.
    3) There were correlations between the concentration of P32 in blood and cumulative excretion-rate of P32 in urine during one, four and tweenty-four-hours period after pouring the enema with P32.
    4) During the first 4-hours' period after the enema with P32, the average of the excretionrate of P32 in the group with severe ulcerative colitis was the highest value of all other cases, and there were significant differences between this disease and normal colon-group, the group with slight ulcerative colitis and the other coloic diseases except chronic non-ulcerative colitis, respectively.
    But during the 24-hours' period he did not recognize the differences between this group and normal colon-group.
    On the other hand, the averages of the group with cancer or tuberculosis and the group with coloptosis or elongation of sigmoid colon were both exceedingly lower than that of normal colon-group and the group with severe ulcerative colitis.
    5) Next, he investigated the P32 excretion-rate in urine per an hour during the first 2 houre, from 2 to 4 hours and from 4 to 24 hours after the enema with P32.
    In normal colon-group, the excretion-rate seemed to increase in the course of time until 24 hours, and in the group with mild ulcerative colitis and the group with cancer or tuberculosis of colon, the excretion-rate appeared to decrease contrary to normal colon-group. In the group with severe ulcerative colitis, however, this rate was the highest value during from 2 to 4 hours after the enema of P32 and the significant differences were recognized between this group and the other groups, then the rate decreased significantly.
    In the group with coloptosis or elongation of sigmoid colon, the excretion-rate seemed to keep the low value throughout all in test.
    Consequently, this absorption-test of colon is useful to distinguish the degree of ulcerative colitis and available in differential diagnosis of the severe ulcerative colitis from other diseases of colon, especially carcinoma or tuberculosis of colon.
  • 近藤 利満
    1960 年 57 巻 9 号 p. 1225-1240
    発行日: 1960/09/30
    公開日: 2011/06/17
    ジャーナル フリー
    The author studied on the “airpocket phenomenon” using the so-called Dermatothermograph which had been previously devised and named by professor F. Matsunaga. The airpocket phenomenon is defined by the professor as a temperature drop of the skin at the paravertebral part of the various visceral diseases. This phenomenon in one of the viscero-vegetative nerve reflexes occurring from the interrelation between the interoceptive fibres exsisting in the visceral nerves and sympathetic nerves in the spinal cord itself.
    Finding the paravertevral parts where the airpocket phenomenon is observed, the examiner can determine the diseased viscera from the segementation of the spinal cord. This henomenon is therefore believed to be useful not only for diagnosis but also for therapeutic management.
    At the begining of this study, the drops of the skin tmeperature were measured with a pyrometer, a thermocouple (copper-costantan) which had been used by Dr. IGARASHI in our clinic. This procedure, however, was too complicated and the author therefore has. experimented by the Dermatothermograph, a device which employed thermister with an automatic balancing recorder by electron tube. This unit was planned by Prof. MATSU NAGA and his co-workers, and the management of this machine is much more simple. and precise than the pyrometer above-mentioned.
    Observing the Dermatothermogram (DTG) recorded by this apparatus, the examiner can compare the present condition with the previous condition in each diseases.
    This phenomenon was found to be positive 100 per cent in a cases of pleurisy, 91 per cent in cardiac diseases, ober 80 per cent in diseases of the bile ducts, stomach and. duodenum (particularly in peptic ulcer) and 78 per cent in pulmonary tuberculosis even.
    The paravertebral segments in which the airpocket phenomena are observed are determined in each viscerum as follows:
    Bile duct: (right) T2-5-7-8, (left) T2-3
    Stomach: (left) T2-5-7-8, (right) T5-7
    Heait: (left) C6-7, T2-3-4, 9-10-11-12.(right) T2-4, 9-12
    Lung: C6-7, T2-3-4, 8-11-12 (the site depending upon the site of the lesion)
    Pleura probably: C6-7, T7-8, 10-12 (the side depending upon the lesions side)
    Kidney: C6-7, T7-8-10-12 (the side depending upon the lesions side)
    (C…cervical, T. thoracic. The segment underline are the sites where the phenomenon is observed most frequently and remarkably.)
    The segment related with above-mentioned viscera may differ in some points from the previous reports described by other workers.
    The chief results from the previous reports of his work are following:
    1) In the diseases of the upper gastrointestinal tracts, the airpocket phenoemenon is. observed not only in the middle thoracic segent but also more widly from the upper to the lower parts of the thoracic segments.
    2) In the diseases of the intrathoracic organs, the airpocket phenomenon is observed not only in the upper thoracic segments but likewise also in the lower cervical segments.
    3) Airpocket phenomenon is recognized in the cases of renal diseases not only in higher thoracic segments, viz. T8-9-10, than expected from the literature previously described but also in the upper thoracic and lower cervical segments.
    In order to clarify these results different from many previous papers of other workers, it may be necessary to mind the existence of a secondary genetic mechanism which is caused by the complications.
  • 小野 不二男
    1960 年 57 巻 9 号 p. 1241-1259
    発行日: 1960/09/30
    公開日: 2011/06/17
    ジャーナル フリー
    In this report, the observations of “Airpocket Phenomenon” by DTG (Dermatothermogram), which can record the skin temperature of paravertebral region automatically by the using of thermister, was descrived. Moreover, in order to clarify the pathological physiology of the “Airpocket Phenomenon”, the influences upon this phenomenon by the administration of the various sympathomimetic and parasympathomimetic drugs and by the changes of the bodily position were studied. Then the relation between the “Airpocket Phenomenon” and the results obtained pharmacologically from the function test of autonomic nervous system was also investigated. The results obtained from these experiments were as follows:
    1) The average skin temperature of the paraverteval on the 10 normal subjects was highest in the 5 th paravertebral part on the right side and 4 th on the left.
    2) The “Airpocket Phenomenon” was found in 93 (77.5%) out of 120 cases with various visceral diseases, but this positive cases were observed at the considerable wide area of the paravertebral region.
    3) The “Airpocket Phenomenon” was relieved or disappeared by the subcutaneous injection of 2-benzyl-imidazoline or hexamethonium bromide. On the contrary, atropin sulfate strengthened “Airpocket Phenomenon” in 60 per cent of the examined cases. While adrenalin relieved or disappeared the “Airpocket Phenomenon” in 67% of the patients.
    4) By pressing the axillar part of the side at which the “Airpocket Phenomenon” was most positive, no definite changes were found, but the pressure of it at the healthy side made almost relief or disappearence of the “Airpocket Phenomenon”.
    5) According to the pharmacological function test of sympathomimetic and parasympathomimetic system, patients who showed positive “Airpocket Phenomenon” were generally in a condition of the sympatheticotonia.
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