For the purpose of clarifying the correlation between blood pyruvate level and degenerative changes of the microsomes of the liver-cells, forty-three cases diagnosed as having viral hepatitis or so-called post-hepatitic syndrome were studied, and thefollowing results were obtained:
1. No definite relationship existed between blood pyruvate level and degenerative changes of cytoplasmic ground substance (cell matrix) and endoplasmic reticulum of the liver-cells. However, an excellent correlation between blood pyruvate level and the intensity of degeneration of mitochondria was noted.
2. Those cases with elevated blood pyruvate level showed such marked degenerative changes of the mitochondria as concentration of inner matrix of mitochondria, destruction of cristae or outer membrane; clouding or destruction of the double membrane structure of the outer envelope and cristae.
3. Even for those cases of so-called post-hepatitic syndrome with elevated blood pyruvate level, an appropriate treatment for organic liver change would be necessitated since some sort of parenchymal derangements such as degenerative changes of themitochondria were almost always thought to be present.
4. In cases of viral hepatitis blood pyruvate level always remained elevated whichever they had swelling and destruction or atrophy and concentration of the mitochondria.

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Studies were made on the correlation between BSP retention and degenerative changes of the microsomes of the liver-cells in fifty-four cases of viral hepatitis including those who showed an elevated BSP retention without or with relatively mild impairment of conventional liver functions. And the following results were obtained:
1. No definite correlation was found between BSP retention and degenerative change other of cytoplasmic ground substance (cell matrix) of the liver-cells.
2. A close correlation between degenerative changes of the endoplasmic reticulum and BSP retention was noted. Therefore it was considered that the endoplasmic reticulum must play an important role for the excretion of intravenously abministered BSP dye into the bile.
3. A rough correlation between degenerative changes of the mitochondria anu BSP retention was noted.
4. Degenerative changes of the liver-cells were still remained in hepatitis cases in. whom liver function including BSP test had already returned to normal. This fact was considered as reflexions of prolonged subjective symptoms of so-called post-hepatitic syndrome and, on the other hand, difficulty in deciding of clinical cure.

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For the purpose of clarifying the correlation between blood pyruvate level and degenerative changes of the microsomes of the liver-cells, forty-three cases diagnosed as having viral hepatitis or so-called post-hepatitic syndrome were studied, and thefollowing results were obtained:
1. No definite relationship existed between blood pyruvate level and degenerative changes of cytoplasmic ground substance (cell matrix) and endoplasmic reticulum of the liver-cells. However, an excellent correlation between blood pyruvate level and the intensity of degeneration of mitochondria was noted.
2. Those cases with elevated blood pyruvate level showed such marked degenerative changes of the mitochondria as concentration of inner matrix of mitochondria, destruction of cristae or outer membrane; clouding or destruction of the double membrane structure of the outer envelope and cristae.
3. Even for those cases of so-called post-hepatitic syndrome with elevated blood pyruvate level, an appropriate treatment for organic liver change would be necessitated since some sort of parenchymal derangements such as degenerative changes of themitochondria were almost always thought to be present.
4. In cases of viral hepatitis blood pyruvate level always remained elevated whichever they had swelling and destruction or atrophy and concentration of the mitochondria.

抄録全体を表示