日本消化機病學會雜誌
Online ISSN : 1349-7693
Print ISSN : 0446-6586
59 巻, 11 号
選択された号の論文の8件中1~8を表示しています
  • 江原 弘
    1962 年 59 巻 11 号 p. 845-854
    発行日: 1962年
    公開日: 2011/06/17
    ジャーナル フリー
    This communication will present results of the experiments undertaken in order to make clear the process of iron absorption in rabbits.
    Large doses of stable iron or small doses of radioiron was instillated into stomach by tube, and then, the blood samples were taken concomitantly from the femoral artery and pancreaticoduodenal vein at the given time intervals.The blood samples were analyzed for ferritin by employing an immunolgic technics, and for radioactivity by well-Type Scintillation Counter.
    The results obtained were as follow:
    1) An oral admininistration of large amount of iron, which could some times provoke serious clinical symptoms and signs of iron intoxication, induceed ferritinemia, most markedly in the blood sample from pancreaticoduodenal vein.The blood samples collected from the vein coming from the pouched duodenum, into which a large doses of iron had been injected, revealed consistently positive for ferritin.
    On the contrary, oral administration of a small amount of iron did not induce ferritinemia, except one case of five.
    These facts suggest to us that oral administration of a large amount of iron can induce ferritinemia, especially in the blood of the portal vein, and that the ferritin detected in the blood seems most likely to be originated in the duodenal mucosal cells.
    2) It has been generally accepted that rabbits, which were made anemic by venesection, made repeatedly hypoxic by placeing in a low pressure chamber, or injected with turpentine oil, show accelerating absorption of iron from the intestine.
    In the rabbits pretreated in such ways as stated before, a small amount of radioiron was instillated into the stomach, and then the blood samples collected in the same ways as in the previous experiment were analyzed for both ferritin and radioactivity.
    As compared with the control experiment using intact rabbits, it can be said that even a small amount of iron can provoke marked ferritinemia in rabbtis which are pretreated to accelerate iron absorption from the intestine.
    On the basis of results stated above, it can be concluded that ferritin can migrate from the intestinal mucosal cells into the portal circulation, when a large amount of iron was ingested or even a small dose of iron under such condition as iron being viggorously absorbed.
    Appearance of ferritin in the portal circulation associated with process of iron absorption through the intestine can be considered to be a tphysiological or unphysiological phenomena still needs further studies.
  • 第一編 肝硬変症における肝表面構造と内部組織との関連性について
    樋口 祥光
    1962 年 59 巻 11 号 p. 855-866_6
    発行日: 1962年
    公開日: 2011/06/17
    ジャーナル フリー
    The purpose of this study is to investigate the diagnostic value of needle liver biopsy, to compare microscopic histological and gross macroscopic findings of the cirr-hotic liver, and to attempt to classify cirrhosis from clinical point of view. 40 cases with cirrhosis were selected in this study. A peritoneoscope with gradation and also a probe with gradation were utilized.
    No significant differences in size of nodules, superficial and noted in the autopsied cases. Accurate diagnosis of cirrhosis by means of needle biopsy technique was app-roximately 70 to 85%, the larger the nodules, the lower the accuracy. 15% of difference in the diagnostic accuracy was observed when two kinds of biopsy needles, 2.0mm and 1.5mm in diameter, were used.
    Inflammatory or active process, proliferated connective tissue or necrotic areas and sublobular pseudolobules were frepuently observed in those cirrhotic livers with smaller nodules. Multilobular pseudolobules were seen rather in the cirrhotic livers with larger nodules. Clinical courses in cirrhotic patients with larger nodules were longer as compared with those with smaller ones. Such cases were frequently seen in whom the nodules grew larger with the passage of time.
    Although it was considered to be rather difficult to establish accurate diagnosis of cirrhosis only by means of needle liver biopsy technique, it would be possible when peritoneoscopy and further measurement were undertaken.
  • Dubin-Johnson症候群とGilbert病
    増田 正典
    1962 年 59 巻 11 号 p. 867-871
    発行日: 1962年
    公開日: 2011/06/17
    ジャーナル フリー
  • 高橋 晄正
    1962 年 59 巻 11 号 p. 873-879
    発行日: 1962年
    公開日: 2011/06/17
    ジャーナル フリー
  • 三輪 清三, 伊藤 進
    1962 年 59 巻 11 号 p. 881-890_2
    発行日: 1962年
    公開日: 2011/06/17
    ジャーナル フリー
  • 阿部 達夫
    1962 年 59 巻 11 号 p. 891-900
    発行日: 1962年
    公開日: 2011/06/17
    ジャーナル フリー
  • 山川 邦夫, 内藤 聖二, 岩田 竜三郎
    1962 年 59 巻 11 号 p. 901-906
    発行日: 1962年
    公開日: 2011/06/17
    ジャーナル フリー
  • 1962 年 59 巻 11 号 p. 907-959
    発行日: 1962年
    公開日: 2011/06/17
    ジャーナル フリー
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