SGOT and SGPT (activities) were determined together with other liver function tests on patients with hepatic and biliary diseases, and the clinical significance of the data was evaluated.
It was found that, in 91% of cases with acute infectious hepatitis, SGOT and SGPT returned to the normal level within two months (SGOT: 47 & plusmn;16 days and SGPT: 53 & plusmn;15 days) from the onset of the disease, and in 9% of cases, SGOT and SGPT stayed inabnormal range. TTT and ZST showed continuously abnormal values from the early stage of the disease in latter cases. In chronic cases, chronic hepatitis and cirrhosis of the liver, SGOT and SGPT did not return to the normal level as TTT and ZST values abnormaly continued. It is said that an increase of SGPT is usually more pronounced than that of SGOT in acute hepatitis, and this relationship is reversed in chronic cases. But present data did not agree with the above-mentioned concept in certain number of chronic cases and suggested the necessity of evaluating other liver function tests results, such as colloidal reaction tests.
In cases with biliary obstruction, both SGOT and SGPT were increased moderately. These levels were also slightly elevated in some cases without biliary obstruction, such as cholecystitis and stone of gallbladder. When biliary diseases were complicated by inflammation, these values were further increased. There was no appreciable difference in SGOT and SGPT values between the cases with bile duct tumor and that with bile duct stone. Therewere some cases with biliary obstruction who showed that an increase of SGPT was more pronounced than that of SGOT which necessitated the use of serum alkaline phosphatase determination in differentiating liver disease from biliary obstruction.
Experimental studies were performed to clarify the mechanism of SGOT and SGPT elevation by cellular fractionation of the rat liver, injured by CCl₄ and islanditoxin. The GOT and GPT of supernatant was mainly transferred from the liver cells into the blood. And it was thought that an increase of SGOT and SGPT seen in biliary obstruction was partly due to the coexistent liver cell damage. The GOT and GPT in the urine, bile and ascites were determined in orderto clarify the mechanism of the disappearance of SGOT and SGPT, and it was discussed aboutthe possible roles of the kidney, liver and transferrence of the substances into the tissue fluid.

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This paper was dealt with the effects of one long-acting anticholinergics, isopropamide iodide mixture (Marygin M) on several gastric diseases.
Sixteen out of nineteen patients with peptic ulcer and four out of seven patients with gastritis got better after administration of the mixture for 13-55 days orally, accompanying with apparent improvements on X-ray and/or gastro-camera findings, and with mild normalizing effect on hypersecretory disorders. No remarkable side-effects were found during the observation besides few cases of complaining thirsty.

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