巻号一覧
23 巻, 7 号
選択された号の論文の11件中1～11を表示しています
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Toshio MASUZAWA, Hiroshi SHIMABUKURO, Fumiaki SATO1983 年 23 巻 7 号 p. 511-514
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーIntracortical microvessels of the rat frontal lobe were examined by light and electron microscopy with special reference to the relationship between the localization of alkaline phosphatase activity on the walls and the luminal diameters of the vessels.
The lead citrate method of Mayahara et al.2) was used to histochemically demonstrate alkaline phosphatase.
At the electron microscopic level, electron dense reaction products of alkaline phosphatase activity were found on the walls of arterioles with one medial layer and in those of metarterioles with single-layered and incomplete media. However, no reaction was encountered on the walls of arterioles with 2-3 medial layers. On the walls of capillaries 6-9 μm in luminal diameter, the reaction products of alkaline phosphatase were distributed discontinuously on the abluminal surfaces of endothelial cells and on the surfaces of pericytes. Intense reaction products were distributed evenly on the surfaces of astrocytic processes in contact with the thick basal lamina. On the other hand, capillaries less than 5 μm in luminal diameter showed no reaction at all. The walls of venules and veins also displayed no activity for this enzyme.
In view of increasing interest in the physiology of cerebral microcirculation and the blood-brain barrier, the ultrastructural localization of alkaline phosphatase would cbntribute to the understanding of this system.抄録全体を表示PDF形式でダウンロード (367K) -
Hiroki NAMBA, Masaru AKIMOTO, Akira YAMAURA, Yashiro HAGIHARA, Hiroyas ...1983 年 23 巻 7 号 p. 515-520
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーThe main cause of sudden death in patients with intracranial hypertension is respiratory failure. This study was a search for a clue to respiratory treatment which could be used at the scene of an accident. For this purpose, intravenous administration of respiratory stimulants was thought to be the most simple measure.
Doxapram hydrochloride (Doxapram) was used to stimulate respiration impaired by balloon-induced intracranial hypertension in cats. Intravenous administration of Doxapram resulted in sufficient respiratory stimulation at the dose of 1.0 mg/kg, but could not decrease PaCO2 lower than 25 torr. In 4 out of 10 cats, administration of Doxapram improved the respiratory condition and increased cerebral perfusion pressure and regional cerebral blood flow. Further investigation was required to find the best timing of Doxapram administration to maximize life preservation.抄録全体を表示PDF形式でダウンロード (350K) -
Hirofumi HAMADA, Heiko TAUBER, Stanislaw KRAJEWSKI, Beatrix EBERHARDT, ...1983 年 23 巻 7 号 p. 521-528
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーTo study the sequential growth patterns of hematogenous cerebral metastatic tumors, syngenetic RG2 glioma cells were injected into the right common carotid artery of 61 adult CDF rats.
Electron microscopic study 1 hr and 24 hrs after injection revealed arrested tumor cells in the capillaries, some with faint glial filaments in their cytoplasm. Perivascular edema of the right hemisphere which developed following occlusion of the right common carotid artery during injection was noteworthy concerning the attachment of the tumor cells to the capillary walls and their penetration into the perivascular spaces. Luminescence microscopic observation with acridine orange 1 hr and 24 hrs after injection showed circulating or embolized tumor cells in the capillaries, and about 5 days after injection, the cells began to penetrate the perivascular space. For light microscopic examination, 51 rats were sacrificed from 1 hour to 20 days after injection. From 9 days after injection on, microtumors began to appear and metastatic tumors developed in 76% of the right hemispheres, and in 57% of the left hemispheres. Considering all sections of the 21 rat brains from 9 to 20 days, the difference of tumor frequency between the right (42%) and left (19%) hemispheres became even more significant. Morphometrical evaluation using a planimeter showed the growth curve of the tumor area to have a low pitch from 12 to 18 days which became steeper from 18 to 20 days.
Synthesizing the results sequentially, the following five stages could be defined: 1) a silent period; 2) a penetrating and mitotic period; 3) a microtumor period; 4) a multiple proliferating period; and 5) an expanding period.抄録全体を表示PDF形式でダウンロード (850K) -
Shin-ichi OTSUKA, Kinya SUDA, Junkoh YAMASHITA, Juji TAKEUCHI, Hajime ...1983 年 23 巻 7 号 p. 529-533
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーThe induction of killer activity following radiotherapy was studied in intracranial tumor-bearing mice. When local 60Co irradiation was administered to intracranial tumor-bearing mice, tumor growth was suppressed and the survival time of the mice was prolonged. The killer activity for 203-glioma target cells gradually increased following the regression of the tumors after irradiation. The maximum killer activity for 203-glioma target cells was observed 11 days after irradiation and natural killer activity also increased after irradiation. The killer activity for 203-glioma target cells decreased after treatment with anti-Thy 1.2 and complement. Therefore, killer T-cells may play an important role in this cell-mediated immunity. The relation between the regression of the tumors following radiotherapy and the increase of killer activity may indicate that the effects of radiotherapy are related to the immunological activity of the hosts in addition to the direct cell-killing effects of radiation. These results indicate that the immunological response of patients with brain tumors should be examined both during and after the course of radiotherapy.抄録全体を表示PDF形式でダウンロード (351K) -
—Clinico-anatomic Study—Noboru GOTO, Tomoyuki HOSHINO, Mitsuo KANEKO, Hiroshi ISHIKAWA1983 年 23 巻 7 号 p. 534-540
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーThe authors dealt with three cases of central positional vertigo each caused by a different pathogenesis and presented precise autopsy findings in two of the cases after making serial sections of the brainstem and cerebellum. A definite correlation between lesions of the juxta-restiform body and central positional vertigo is suggested, with discussion on the mechanism of central positional vertigo from the clinicoanatomic point of view.抄録全体を表示PDF形式でダウンロード (559K) -
Shinya MANAKA, Keiji SANO1983 年 23 巻 7 号 p. 541-550
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーA new computer system to detect stationary potential (SP) changes of the brain and to display an isopotential chart of SP was developed. The system was named computerized stationary potential encephalography (C-SPEG).
The advantage of this new technique is that it can be operated as easily as routine EEG recording, and it is possible not only to ascertain the distribution of SP, but also to display a topographical map of each spectral band of EEG, namely, delta, theta, alpha and beta.
The device consists of 18 Ag/AgCl electrodes, an input box, a SP detector, an electroencephalograph, a data recorder controller, a mini-computer (Nihon Kohden ATAC-2300), a magnetic disc and a serial printer for display.
One hundred and forty cases were evaluated by C-SPEG. The technique allowed topographical diagnosis in 80 out of 95 cases (84%), whereas EEG did so only in 45 out of 95 (47%). The difference is statistically significant (P<0.001). The operation of this system was similar to the formerly developed SPEG, which had 90 calomel half-cell electrodes.
Four cases are presented to illustrate the advantages of C-SPEG.
The most unique point of C-SPEG is that it elucidates the relationship between the lesion and the cerebral cortex on the basis of polarity of SP change: “negative” corresponds to cortical damage, “positive” to subcortical damage, and “crateriform” to expanding mass to the cortex. Thus, C-SPEG potentiates the diagnostic ability of computerized tomography (CT).抄録全体を表示PDF形式でダウンロード (663K) -
—A Clinical Investigation of the Mechanism of Cancer Pain Relief—Fumikazu TAKEDA, Takashi FUJII, Jiro UKI, Ryuji TOZAWA, Yoshiaki FUSE, ...1983 年 23 巻 7 号 p. 551-560
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーClinical investigations were carried out to elucidate the mechanism through which pituitary neuroadenolysis (NALP) relieved intractable cancer pain. When investigating hypothalamopituitary interaction, continuous elevation of TRH and arginine vasopressin were observed in the cerebrospinal fluid (CSF) following NALP. ACTH1-39 in the CSF abruptly increased after NALP in cases with complete pain relief, in contrast with the far less elevation in cases without complete relief. There was no significant increase of endorphins in the CSF. The sufficient inactivation of the anterior and posterior pituitary functions indicated the success of the procedure, but had no exact correlation with the obtainability of complete relief of cancer pain, though cancer pain was more frequently alleviated in hormone-dependent carcinomas than in non-dependent.
Valuation of pain responsiveness showed the duration of tourniquet tolerance in cases with complete relief of cancer pain following NALP was twice as long as before NALP, while it was unchanged in cases without complete pain relief. Radiant heat dolorimetry revealed no significant differences between cases with complete pain relief and those without. Sensory decision theory analysis denoted increased pain threshold and improved discriminability in cases with complete relief. Pain threshold determination thus indicated increased C-fiber thresholds, which mainly mediate cancer pain, and excluded the placebo effect of NALP. Observations indicated that the increase of peptides in the CSF, which are mainly synthesized in the hypothalamopituitary axis, would exert a suppressive effect on the mediation and perception of cancer pain through the C-fibers and the central nervous system.抄録全体を表示PDF形式でダウンロード (645K) -
Márta HAJDA, Emil PÁSZTOR1983 年 23 巻 7 号 p. 561-565
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーDeterioration of visual function occured in 60% of 117 patients with pituitary adenoma. After transsphenoidal operation, both eyes regained normal visual acuity and visual fields in 28.2% of 64 patients, improvement was noted in 50%, no change was found in 15.6%, and a slight progression was observed in 6.2%.
In those cases with unimpaired optic disc before the operation, visual functions became normal in more than 50%. No full ophthalmological recovery was found when the pallor of the disc was severe.
In the authors' opinion, ophthalmological prognosis depends in the first place not on the visual acuity, but on the preoperative condition of the optic disc. Full ophthalmological recovery or improvement sufficient to resume working can be expected when the optic disc is normal or shows only temporal pallor, even when visual function is severely impaired.抄録全体を表示PDF形式でダウンロード (273K) -
—Report of Three Autopsy Cases—Shunji NISHIO, Masashi FUKUI, Michiya OHTA, Jun TATEISHI, Katsutoshi K ...1983 年 23 巻 7 号 p. 566-570
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーThree children with glioblastoma multiforme of the brain stem were autopsied and all were found to have spinal subarachnoid seeding. The clinical courses of these patients were all rapid. Brain stem gliomas are rarely reported to seed along the spinal subarachnoid spaces, but the incidence of spinal subarachnoid seeding may actually be somewhat higher than is generally accepted. In the treatment of rapidly progressing brain stem gliomas, consideration should be given to possibly accompanying subarachnoid seeding.抄録全体を表示PDF形式でダウンロード (506K) -
Shoji BITOH, Hiroshi HASEGAWA, Masaaki FUJIWARA, Hideo OHTSUKI, Yutaka ...1983 年 23 巻 7 号 p. 571-576
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーFour patients with nasopharyngeal malignancies were reported. The main symptom was diplopia due to abducens palsy in all patients; it was unilateral in three patients and bilateral in one. Skull tomographic evaluation was valuable for detecting nasopharyngeal malignancies. Histological examination of biopsy specimens from the nasopharynx confirmed these lesions to be squamous cell carcinoma in three patients and poorly differentiated carcinoma in the fourth. Radiation therapy (5, 225-7, 250 rads) was employed in combination with chemotherapy consisting of cyclophosphamide or 5-fluorouracil. In three patients, the survival time from the onset of diplopia to death ranged from seven months to three years and three months. One patient is still alive and in good condition, four years and 10 months after the onset of diplopia.抄録全体を表示PDF形式でダウンロード (803K) -
—Case Report—Susumu WAKAI1983 年 23 巻 7 号 p. 577-579
発行日: 1983年
公開日: 2006/11/10
ジャーナル フリーAn unusual case of intradiploic epidermoid tumor of the lateral orbital wall is presented. Findings of the skull X-ray were typical for this type of tumor. However, computed tomography disclosed that the mass had an isodense appearance (+35 to +40 Hounsfield units), which did not correspond to that of epidermoid tumor.抄録全体を表示PDF形式でダウンロード (254K)
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