巻号一覧
27 巻, 7 号
選択された号の論文の17件中1～17を表示しています
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Iwao TAKESHITA, Tosuke TAKAKI, Masaharu KURAMITSU, Susumu NAGASAKA, Ta ...1987 年 27 巻 7 号 p. 581-587
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーWe established a human glioma cell line derived from a malignant glioma and evaluated it by immunochemical techniques and antibodies to astroglial (glial fibrillary acidic protein: GFAP, S-100 protein), oligodendroglial (myelin basic protein, galactocerebroside), neuronal (neuron-specific enolase: NSE, neurofilament triplet proteins), and mesenchymal (vimentin, fibronectin) antigens. The cell line was epithelial in sparse culture and glial in dense culture. GFAP was expressed by most cells in sparse culture and primarily by overlying cells in dense culture. The amount of GFAP depended on the cell density and ranged from 530 to 990 ng/mg of protein. The cells contained much more vimentin than GFAP. Neurofilament proteins, S-100 protein, myelin basic protein, and galactocerebroside were undetectable. The cells synthesized a small amount of fibronectin and released it into the medium. The amount of NSE was unrelated to cell density, ranged from 13 to 19 ng/mg of protein, and was present in greater quantity in cells cultured in a medium containing 1 μl/ml of sodium lactate.
We conclude that KNS-42 is a permanent astrocytic glioma cell line; it expresses GFAP, NSE, vimentin, and fibronectin, and is morphologically and functionally dependent on its environment.抄録全体を表示PDF形式でダウンロード (648K) -
—Cytocidal Effect and Pathohistological Analysis—Yasuhiro OKUDA, Shizuo OI, Satoshi MATSUMOTO1987 年 27 巻 7 号 p. 588-593
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーThe effect of photodynamic therapy (PDT) with a hematoporphyrin derivative (HPD) on tumor cell survival was studied in 9L gliosarcoma rat tumor systems, both in vitro and in vivo. In vitro, the cytocidal effect was dependent on HPD concentration and length of exposure to light. The cell death rate was 100% with 30 minutes of light exposure following 6 hours of culturing in a medium containing 50 μg/ml of HPD. Male Fischer 344 rats were inoculated with 9L gliosarcoma cells to produce frontoparietal surface brain tumors. An argon laser with a wave length of 514.5 nm was used as the light source. The rats were divided into several groups and received either no treatment (controls) or one of various combinations of treatment: HPD without light irradiation, placebo plus light irradiation, or HPD plus light irradiation. No degenerative changes were observed histopathologically in the control rats or those not given HPD. Necrotic foci were prominent in the groups given HPD, regardless of whether the light was delivered directly to the tumor surface or to the skin just above the tumor. The necrotic change of the tumor cells comprised nuclear pyknosis, homogenation of chromatin, and vascular collapse associated with extravasation, venous congestion, hyalinization of endothelium, and massive hemorrhage. These results demonstrate the cytocidal effect of PDT on experimental glioma and suggest that this approach will have important clinical application in neurooncology.抄録全体を表示PDF形式でダウンロード (452K) -
—Nociceptive Activity in Response to Tooth Pulp Stimulation—Takashi TSUBOKAWA, Yoichi KATAYAMA, Teruyasu HIRAYAMA1987 年 27 巻 7 号 p. 594-600
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーWe investigated the effects of electrical stimulation of the thalamic sensory relay nucleus (TSRN) on the nociceptive neural activity within the trigeminal subnucleus caudalis in the cat. We found that the nociceptive activity of the trigeminal subnucleus caudalis neurons in response to tooth pulp or facial skin stimulation was inhibited by both single-pulse and repetitive TSRN stimulation. However, the period of inhibition induced by single-pulse TSRN stimulation was clearly shorter than that induced by periaqueductal gray (PAG) or nucleus raphe magnus (NRM) stimulation. Furthermore, the nociceptive neurons inhibited by PAG stimulation were not always inhibited by TSRN stimulation. The opioid antagonist naloxone (2.0 mg/kg, i.v.) significantly antagonized the inhibition induced by PAG or NRM stimulation but failed to antagonize that produced by TSRN stimulation. These results are discussed in relation to the differences in clinical effects produced by TSRN and PAG stimulation.抄録全体を表示PDF形式でダウンロード (509K) -
—Abnormal Bursting Hyperactivity after Trigeminal Rhizotomy—Takashi TSUBOKAWA, Yoichi KATAYAMA, Teruyasu HIRAYAMA1987 年 27 巻 7 号 p. 601-606
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーWe studied in the cat the effects of thalamic sensory relay nucleus (TSRN) stimulation on abnormal hyperactivity following trigeminal rhizotomy within the contralateral trigeminal subnucleus caudalis, a trigeminal equivalent of the dorsal horn. The animals were subjected to unilateral retrogasserian rhizotomy 2-6 weeks prior to the experiments. Following the rhizotomy, abnormal bursting and continuous nonbursting hyperactivities were recorded from laminae IV-V of the trigeminal subnucleus caudalis on the rhizotomized side. Some of these neurons responded to peripheral stimuli applied to rostral cervical dermatomes in a manner resembling the nociceptive, wide dynamic range (WDR) neurons of the intact side. However, periaqueductal gray (PAG) stimulation inhibited the hyperactive neurons on the rhizotomized side less frequently than the WDR neurons on the intact side. In contrast to PAG stimulation, TSRN stimulation inhibited the hyperactive neurons on the rhizotomized side as frequently as the WDR neurons on the intact side.
These results are apparently consistent with our clinical observation that neurogenic pain due to deafferentation can be relieved by TSRN stimulation but not by PAG stimulation. This in turn suggests that the pain relief obtained with TSRN stimulation may result at least in part from inhibition of the nociceptive activity or abnormal hyperactivity of dorsal horn neurons.抄録全体を表示PDF形式でダウンロード (444K) -
Akira TANAKA, Masamichi TOMONAGA1987 年 27 巻 7 号 p. 607-612
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーChanges in microcirculation during and after 3 hours of middle cerebral artery (MCA) occlusion in cats were studied with the carbon black perfusion technique. The effect of mannitol on these changes was also studied. The impairment of carbon black filling extended to the entire MCA region when transient hypotension was induced during occlusion. The filling defect was reversed with restoration of blood flow following recirculation, but the animals deteriorated with subsequent elevation of epidural pressure. Preocclusional administration of mannitol protected the microcirculation during occlusion and prevented the development of acute brain swelling associated with reperfusion. On the other hand, postocclusional administration of mannitol had an adverse effect. The pathogenesis of dynamic microcirculatory changes in relation to the development of acute brain swelling and the mechanisms of both the beneficial and adverse effects of mannitol are discussed.抄録全体を表示PDF形式でダウンロード (523K) -
W. LUYENDIJK, G.Th.A.M. BOTS, M.Vegter-vander VLIS, L.N. WENT1987 年 27 巻 7 号 p. 613-616
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーPDF形式でダウンロード (276K) -
Kazuyo NISHIHARA, Yukinao KOHDA, Haruhiko TSUTSUMI, Masaru SASAKI, Toh ...1987 年 27 巻 7 号 p. 617-622
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーWe attempted to determine the optimum dosage regimen for pentobarbital (PTB) in patients with head injury by using the pharmacokinetic profile obtained by measuring the serum concentration over time after a single intravenous administration of PTB. The optimum loading dose of PTB (0-10 hours) was calculated at 125.2-250.4 mg/hour and the maintenance dose at 24.3-48.6 mg/hour. Therefore, we used loading and maintenance doses of 200 and 50 mg/hour, respectively. Eight of nine patients were intravenously infused for 10 hours at a constant rate with the loading dose of sodium PTB. They were then given the maintenance dose to sustain the optimal serum PTB concentration (15-30 μg/ml) for about 2 days. The serum PTB concentrations gradually decreased despite the constantrate infusion. In one patient of low body weight, however, the serum PTB concentration was as high as 40-55 μg/ml from 10 to 56 hours after the start of infusion, although the dosage was the same as that of the other patients. The elimination half-life of PTB after cessation of constant-rate infusion was 13.1 ± 2.9 hours, whereas following a single dose it was 39.5 ± 14.9 hours. These results indicate that PTB metabolism is accelerated with long-term infusion and that the dosage regimen we tested is useful for only 2 days in patients weighing 50-75 kg.抄録全体を表示PDF形式でダウンロード (344K) -
Kenro SUNAMI, Akimasa UOZUMI, Akio SEMBA, Akira YAMAURA, Hiroyasu MAKI ...1987 年 27 巻 7 号 p. 623-627
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーThirteen children, aged 6 months to 14 years, underwent surgery for medulloblastoma at Chiba University Hospital from 1971 to 1985. The nine patients treated prior to 1980 received postoperative irradiation therapy with or without chemotherapy. Since 1980, four patients have been treated postoperatively with interferon (IFN) plus radiation therapy. The IFN was administered intramuscularly once or twice a week throughout the period of radiation therapy.
Six of the nine patients not treated with IFN died within 1 year. In this group, the 3 and 5-year survival rates were 33% and 22%, respectively. One of the four patients treated with IFN died within 10 months of surgery, and another is disabled. The remaining two patients are in good condition. The 3and 5-year survival rates in the IFN group were both 75% as of the last follow-up in January of 1986.抄録全体を表示PDF形式でダウンロード (366K) -
—Report of Four Cases—Akira UCHINO, Kanehiro HASUO, Masashi FUKUI, Toshio MATSUSHIMA, Shozo ...1987 年 27 巻 7 号 p. 628-632
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーFour jugular foramen neurinomas studied by computed tomography and verified by surgery originated from the glossopharyngeal nerve. Characteristic CT findings were a mixed low and isodense extraaxial mass with ring-like enhancement in the cerebellopontine angle; enlargement of the jugular foramen, with smooth margins and a normal internal auditory canal; and an extracranial soft tissue mass extending through the jugular foramen.抄録全体を表示PDF形式でダウンロード (494K) -
—Report of Three Cases—Susumu WAKAI, Yasuichi UEDA, Masakatsu NAGAI1987 年 27 巻 7 号 p. 633-636
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーThree cases of primitive trigeminal artery (PTA), one associated with arteriovenous malformation and two with cerebral aneurysm, are described. All three patients presented with intracranial hemorrhage. One patient had multiple vascular anomalies, including bilateral PTAs, an unpaired pericallosal artery with a large aneurysm on its bifurcation, and a lobar hematoma. The clinical significance of PTA in patients with intracranial hemorrhage is discussed.抄録全体を表示PDF形式でダウンロード (338K) -
—Report of Two Cases and Review of the Literature—Toshihiko KUBOTA, Masahiro KITABAYASHI, Minoru HAYASHI, Tetsumori YAMA ...1987 年 27 巻 7 号 p. 637-642
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーTwo cases of nontraumatic cerebrospinal fluid rhinorrhea were presumed to be an indirect manifestation of brain tumor. One patient had a parietal convexity meningioma and the other a cerebellopontine angle neurinoma. Following excision of the tumors these patients spontaneously developed cerebrospinal fluid rhinorrhea, which disappeared after the repair of fistulas at the base of the frontal fossa. In such cases the rhinorrhea may be caused by fragility of certain structures as a consequence of long-standing increased intracranial pressure due to brain tumor.抄録全体を表示PDF形式でダウンロード (404K) -
—Report of Two Cases—Norihiko TAMAKI, Tohru SUYAMA, Takayuki SHIRAKUNI, Satoshi MATSUMOTO1987 年 27 巻 7 号 p. 643-646
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーTwo patients developed acute subdural hematomas of arterial origin following ventriculoperitoneal shunting for normal-pressure hydrocephalus. The causative factors appeared to be low intracranial pressure, a consequence of the shunting, and rupture of small arterial branches due to movement of the brain within the intradural cavity. These cases are described and the importance of this rare complication is discussed.抄録全体を表示PDF形式でダウンロード (303K) -
—Report of Two Cases—Michio YABUMOTO, Kazuyoshi FUNAHASHI, Ichiro KAMEI, Seiji HAYASHI, Nor ...1987 年 27 巻 7 号 p. 647-650
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーTwo patients developed acute, contralateral extra-axial (epidural and subdural) hematomas immediately after surgery for head trauma. One patient deteriorated rapidly following surgery. In the other case, brain swelling was noted intraoperatively following decompression. The specific pre-, intra-, and postoperative features that may indicate the formation of a contralateral hematoma are discussed.抄録全体を表示PDF形式でダウンロード (300K) -
—Report of Two Cases—Nobuhiko AOKI, Hiroshi MIZUTANI1987 年 27 巻 7 号 p. 651-653
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーWhen trauma occurs secondarily to a generalized seizure in patients with intractable epilepsy, even a simple subdural hematoma may be fatal if there is a delay in diagnosis. We encountered two such patients, both of whom suffered an acute, fatal subdural hematoma without cerebral contusion (simple subdural hematoma) as a result of falling during a generalized convulsion. In some cases, ophthalmoscopic examination is critically important in the early detection of simple subdural hematoma.抄録全体を表示PDF形式でダウンロード (209K) -
—Case Report—Shin-ichi OTSUKA, Taro FUKUMITSU, Toyoshiro YAMAMOTO, Hideshi KOMORI, ...1987 年 27 巻 7 号 p. 654-657
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーOnly a few cases of hemorrhage from metastatic foci of hepatocellular carcinoma in the brain parenchyma have been reported in the literature. We encountered a 71-year-old male who presented with intracerebral hemorrhage from a metastatic hepatocellular carcinoma. The patient was admitted with sudden onset of left hemiparesis and died about 6 weeks after hospitalization. Precontrast computed tomography (CT) on admission showed a high-density area suggestive of intracerebral hematoma. Serial CT scans revealed a ring-like enhanced mass with increased brain edema in the same region. Autopsy disclosed intraparenchymal metastasis of hepatocellular carcinoma with intratumoral and intracerebral hematoma.抄録全体を表示PDF形式でダウンロード (410K) -
—Case Report—Saburo SAKAKI, Tamotsu OHSUGI, Takahiro CHAKI, Masahiro SHIRAISHI, Ken ...1987 年 27 巻 7 号 p. 658-662
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーA 12-year-old boy had central von Recklinghausen's neurofibromatosis with multiple intracranial meningiomas and bilateral acoustic neurinomas. One of the meningiomas was found in the parenchyma of the medulla oblongata and was successfully removed. To our knowledge, this is the first reported case of surgical removal of an intramedullary meningioma of the medulla oblongata. Details of the clinical, neuroradiological, and operative findings are described.抄録全体を表示PDF形式でダウンロード (506K) -
—Case Report—Michio YABUMOTO, Kunio NAKAI, Kazuyoshi FUNAHASHI, Norihiko KOMAI, Koh ...1987 年 27 巻 7 号 p. 663-667
発行日: 1987年
公開日: 2006/09/21
ジャーナル フリーA patient with systemic lupus erythematosus (SLE) suffered, in rapid sequence, subarachnoid hemorrhage, intracerebral hemorrhage, and cerebral infarction. Small, irregular-shaped aneurysms were present on the left anterior temporal and anterior choroidal arteries. During angiography, extravasation from the second portion of the left middle cerebral artery was recognized, and a subsequent CT scan showed a massive, hyperdense lesion in the temporal lobe. A fusiform aneurysm in the posterior communicating artery was examined histologically and proved to be affected by vasculitis. The patient died of occlusion of the right internal carotid artery. We present the clinical and pathological aspects of aneurysms in SLE patients and discuss their pathogenesis and clinical management.抄録全体を表示PDF形式でダウンロード (377K)
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