Neurologia medico-chirurgica
Online ISSN : 1349-8029
Print ISSN : 0470-8105
ISSN-L : 0470-8105
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Volume 31, Issue 6
Displaying 1-10 of 10 articles from this issue
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  • Antiproliferative Effect of Trapidil on PDGF-associated Growth of Human Glioma Cell Lines in Vitro
    Mitsuhiro TADA, Toshimitsu AIDA, Masuo HOSOKAWA, Hiroshi KOBAYASHI, Yu ...
    1991 Volume 31 Issue 6 Pages 313-317
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.313
    JOURNAL FREE ACCESS
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    The effects of trapidil on platelet-derived growth factor (PDGF)-associated growth of glioblastoma cells were studied. The assessment using PDGF-dependent rat lung endothelium cells revealed secretion of a PDGF-like factor from SF-126 cell line but not from SF-188. Human recombinant PDGF stimulated proliferation of both these glioblastoma cell lines. The anti-PDGF monoclonal antibody inhibited the growth of SF-126 more than SF-188. The results suggest the presence of an autocrine growth mechanism in SF-126 cells mediated by PDGF. The growth of both SF-126 and SF-188 cells was suppressed by trapidil, a specific PDGF antagonist, at 10 and 50μg/ml, respectively. The proliferative response to exogenous PDGF and the antagonistic effect of trapidil were greater in the SF126 cell line. In addition, trapidil markedly reduced production of prostaglandin E2 in both glioblastoma cell lines. This anti-proliferative effect on malignant glioma cells suggests that trapidil might be a new therapeutic agent for malignant gliomas.
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  • Intraoperative Monitoring of the Somatosensory Evoked Potentials and Cerebral Blood Flow During Aneurysm Surgery
    —Safety Evaluation for Temporary Vascular Occlusion—
    Kazuo MIZOI, Takashi YOSHIMOTO
    1991 Volume 31 Issue 6 Pages 318-325
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.318
    JOURNAL FREE ACCESS
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    Somatosensory evoked potentials (SEPs) and cerebral blood flow (CBF) were monitored during temporary vascular occlusion in 67 aneurysm operations to evaluate the usefulness of SEP as an indicator for cerebral ischemia. The SEP N20 component completely disappeared during temporary vascular occlusion in 24 cases, 23 of which demonstrated complete recovery following recirculation and had no postoperative neurological sequelae. The only one with postoperative sequelae demonstrated rapid, within 1 minute, loss of N20 followed by no recovery. Another eight cases showed prolongation of central conduction time during vascular occlusion and had no postoperative sequelae. The SEP N20 attenuation reflected the CBF reduction in the middle cerebral artery (MCA) territory during MCA occlusion. However, CBF changes in the internal carotid artery (ICA) territory during ICA occlusion greatly varied. No detectable changes in SEP were found during anterior cerebral artery occlusion for anterior communicating artery aneurysms. This study indicates that intraoperative SEP monitoring is useful to detect ischemia in the MCA territory and that rapid disappearance of the N20 component is a danger signal.
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  • Congenital Hydrocephalus Mimicking Dandy-Walker Syndrome Induced by 6-Aminonicotinamide Injection in Pregnant Rat
    Hiroshi YAMADA, Shizuo OI, Norihiko TAMAKI, Satoshi MATSUMOTO, Katsush ...
    1991 Volume 31 Issue 6 Pages 326-329
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.326
    JOURNAL FREE ACCESS
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    Fetal hydrocephalus was induced by single intraperitoneal injection of 8 mg/kg 6-aminonicotinamide (6-AN), a niacinamide antagonist, in Sprague-Dawley rat on day 13 of gestation. Materials for histological examination were obtained by uterotomy 1, 2, 4, and 8 days after injection, and untreated fetuses of the same ages were used as controls. Macrocephalus was clear at day 17 (4 days after injection), when cerebral dysgenesis was suggested by bromodeoxyuridine immunohistochemical study. The entire ventricular system was dilated, including the aqueduct and foramen of Monro, and hypoplasia of the cerebellum was also observed. On day 21, macrocephalus was remarkable, and considerable hypoplasia of the choroid plexus and cerebellum and agenesis of the corpus callosum were recognized. These results indicate that this experimental hydrocephalic model associated with various central nervous system anomalies mimics human Dandy-Walker syndrome, suggesting the pathogenesis of Dandy-Walker syndrome to be a feature of systemic metabolic deficits.
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  • Giant Intracranial Aneurysms
    —Magnetic Resonance Imaging Follow-up and Clinical Symptoms—
    Takeshi KONDOH, Katsuzo FUJITA, Haruo YAMASHITA, Masaya SHIRAKATA, Nor ...
    1991 Volume 31 Issue 6 Pages 330-335
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.330
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    Twenty-four intracranial aneurysms over 20 mm in diameter were studied with magnetic resonance (MR) imaging. MR imaging follow-up of eight cases revealed induced thrombus with homogeneous intensity and decreased size even after complete intraluminal thrombosis. Most cases demonstrated homogeneous intensity thrombus in contrast to the heterogeneous intensity of spontaneous thrombus. The clinical symptoms could not be explained retrospectively by the thrombus characteristics. Perianeurysmal high intensity, indicating cerebral edema, was detected in one case presenting with a rapid increase in size. MR imaging is useful for following these pathological intra and perianeurysmal changes.
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  • Post-irradiation Vasculopathy of Intracranial Major Arteries in Children
    —Report of Two Cases—
    Shigeru NISHIZAWA, Hiroshi RYU, Tetsuo YOKOYAMA, Toshiaki NINCHOJI, Ic ...
    1991 Volume 31 Issue 6 Pages 336-341
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.336
    JOURNAL FREE ACCESS
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    We report two rare cases of post-irradiation vasculopathy of intracranial major arteries in children. A 13-year-old girl suffered from transient right hemiparesis 1 year after irradiation for suprasellar germinoma. Left carotid angiograms revealed marked stenoses of the intracranial internal carotid, middle cerebral, and anterior cerebral arteries, which were previously normal, and moyamoya vessels. A 2.5-year-old girl underwent internal irradiation with 198Au colloid for cystic craniopharyngioma. At the age of 10 years, she suddenly became unconscious after vomiting. Computed tomographic scans showed a right frontal intracerebral hematoma. Right carotid angiograms disclosed complete obstruction of the intracranial internal carotid, middle cerebral, and anterior cerebral arteries and moyamoya vessels, previously not present. The danger of radiation therapy causing occlusive vasculopathy in small and major cerebral arteries in children is emphasized. To prevent permanent ischemic neurological deficits, vasculopathy should be treated either medically or surgically as early as possible.
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  • Cerebral Alveolar Hydatid Cyst
    —Case Report—
    Tatsuo IHARA, Tomohiro IMAI, Hisatoshi SAITO, Kunio TASHIRO, Yuuta ONM ...
    1991 Volume 31 Issue 6 Pages 342-345
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.342
    JOURNAL FREE ACCESS
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    A rare case of cerebral alveolar hydatid disease in a 41-year-old female is presented. The larval mass was subtotally removed and the presence of alveolar hydatid cysts established histologically. Postoperatively, slight mental disturbance persisted but paresis did not develop.
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  • Aspergillus Mycotic Aneurysm
    —Case Report—
    Yoji KOMATSU, Kiyoshi NARUSHIMA, Eiki KOBAYASHI, Yuji TOMONO, Tadao NO ...
    1991 Volume 31 Issue 6 Pages 346-350
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.346
    JOURNAL FREE ACCESS
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    A 61-year-old female developed subarachnoid hemorrhage after trans-sphenoidal surgery for Rathke's cleft cyst. Neuroradiological examination revealed a large aneurysm at the C1 portion of the right internal carotid artery. Autopsy revealed marked proliferation of aspergillus hyphae in the wall of the aneurysm. A review of previously reported cases of fungal aneurysm proposes two developmental processes. Aneurysms secondary to fungal meningitis tend to be large in size and located in the major cerebral artery trunk, but aneurysms following fungal sepsis tend to be small and in peripheral branches. The former aneurysms are probably caused by fungus invasion into the intracranium, usually from the paranasal sinus, and the latter may be due to fungal emboli like bacterial emboli in bacterial endocarditis. Ruptured fungal aneurysms are difficult to treat, so fungal meningitis or sepsis must be eradicated before an aneurysm develops.
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  • Excision and End-to-end Anastomosis of a Fusiform Aneurysm of the Distal Posterior Inferior Cerebellar Artery Associated with Ischemia
    —Case Report—
    Akira IKEDA, Tsutomu YAMAGUCHI, Tsuyoshi YAMAGUCHI, Isao YAMAMOTO, Osa ...
    1991 Volume 31 Issue 6 Pages 351-355
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.351
    JOURNAL FREE ACCESS
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    A 35-year-old male with a sudden onset of severe vertigo and vomiting had a fusiform aneurysm of the distal portion of the left posterior inferior cerebellar artery. The symptoms were caused by cerebellar infarction probably due to an embolism from the aneurysm. The aneurysm was excised and the artery reconstructed by end-to-end anastomosis with an excellent outcome. Histological examinations showed mural thrombus but no wall dissection.
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  • Brain Metastasis of Thyroid Papillary Carcinoma
    —Case Report—
    Noritaka AIHARA, Hajime NAGAI, Mitsuhito MASE, Naoki SHIMAZU, Hideki K ...
    1991 Volume 31 Issue 6 Pages 356-358
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.356
    JOURNAL FREE ACCESS
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    A rare case of brain metastasis of thyroid papillary carcinoma is reported. The cerebral metastasis was surgically treated without irradiation despite the presence of a spinal metastasis. No recurrence was demonstrated by computed tomography 1 year postoperatively. We suggest that surgery is indicated for a brain metastasis of thyroid papillary carcinoma even if other metastatic lesions are present.
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  • Magnetic Resonance Imaging of Fat Embolism Syndrome
    —Case Report—
    Shigetaka ANEGAWA, Takashi HAYASHI, Ryuichiro TORIGOE, Tetsuzo OGASAWA ...
    1991 Volume 31 Issue 6 Pages 359-361
    Published: 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.359
    JOURNAL FREE ACCESS
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    The authors describe a case of fat embolism syndrome in a 20-year-old male. Magnetic resonance (MR) imaging demonstrated multiple small cerebral infarcts suggesting this is the cause of the associated cerebral dysfunction. He underwent chemotherapy and hyperbaric oxygen therapy and recovered rapidly. MR imaging can provide prognostic indications in fat embolism syndrome.
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