Neurologia medico-chirurgica
Online ISSN : 1349-8029
Print ISSN : 0470-8105
ISSN-L : 0470-8105
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Volume 31, Issue 8
Displaying 1-10 of 10 articles from this issue
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  • Superinduction of Cytotoxic Interferon-β in Glioma Cells
    Itaru INOUE, Jun YOSHIDA, Masaaki NAGATA, Masaaki MIZUNO, Hisao SEO, N ...
    1991 Volume 31 Issue 8 Pages 485-489
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.485
    JOURNAL FREE ACCESS
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    The possibility for new interferon therapy was investigated using the effect of endogenous human interferon-β (HuIFN-β) on various culture cell lines. Cell lines were exposed to superinduction agents (poly I: poly C, cycloheximide, and actinomycin D) and the production of endogenous interferon analyzed. Quantitative determination of HuIFN-β and messenger ribonucleic acid (mRNA) showed HuIFN-β was induced in all of five glioma cell lines, one of two melanoma cell lines, and all of three lung carcinoma cell lines as well as fibroblasts. Northern blot analysis showed HuIFN-β mRNA induced in glioma cells was identical to that from fibroblasts. Endogenous HuIFN-β induced from glioma cells had a cytostatic or cytocidal effect against various human glioma cell lines, even those resistant to fibroblast-derived HuIFN-β. These results show it may be possible to use the induction of excess endogenous cytotoxic HuIFN-β in human glioma tissue itself.
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  • Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture
    —Investigation Before and After Ventriculoperitoneal Shunt—
    Naoshi YAMADA, Hideaki IWASA, Shigeo MORI, Norikazu KUROKAWA, Kazuko F ...
    1991 Volume 31 Issue 8 Pages 490-497
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.490
    JOURNAL FREE ACCESS
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    Melatonin (MLT) secretion was examined in six normal pressure hydrocephalus (NPH) patients before and after ventriculoperitoneal (VP) shunt surgery. Ten healthy subjects were used as controls. Venous blood samples were taken daily at 2 p.m., 8 p.m., 2 a.m., and 8 a.m. Radioimmunoassay of MLT used a new specific antiserum and separation method achieving low cross-reactivity and high-efficiency MLT separation. Plasma levels in the control group at 2 p.m. and 2 a.m. were significantly different, showing diurnal rhythm (DR). The patients' MLT levels before VP shunt were significantly lower than control levels and the DR was absent. Postoperatively, the values were significantly different from preoperative values only at 2 a.m., but the DR reappeared. Thus, in NPH, VP shunt surgery improved the melatonin DR, probably through normalization of the dilated third ventricle.
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  • Spontaneous Intracerebral Hemorrhage in Cases of Severe Angiospasm Following Ruptured Aneurysm
    —A Pathological Study—
    Toshisuke SAKAKI, Shigeru TSUNODA, Tetsuya MORIMOTO, Toru HOSHIDA, Hir ...
    1991 Volume 31 Issue 8 Pages 498-502
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.498
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    Eleven patients with a history of moderate or severe angiospasm following ruptured cerebral aneurysm developed spontaneous intracerebral hemorrhage between 31 and 111 months after aneurysm surgery. In all cases, hemorrhage occurred in the ipsilateral hemisphere to the original aneurysm. In nine patients, the hematoma was surgically evacuated and bleeding perforating arteries were resected for histological examination. Computed tomographic scans showed the hematomas to be unusually extended compared to those after hypertensive intracerebral hemorrhage. The histological examination showed various degenerative changes in the elastic lamina and media of the perforating arteries, even though most patients were young and normotensive. These findings suggest that patients who have suffered severe cerebral angiospasm may have a higher risk for subsequent development of intracerebral hemorrhage than those without prior angiospasm.
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  • Investigation of Normal Pressure Hydrocephalus by 123I-IMP SPECT
    Ken KAMIYA, Nobuko YAMASHITA, Hajime NAGAI, Ikuo MIZAWA
    1991 Volume 31 Issue 8 Pages 503-507
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.503
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    We evaluated N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) as a method for identifying normal pressure hydrocephalic (NPH) patients eligible for shunting procedures. 123I-IMP SPECT scans were taken before and after cerebrospinal fluid (CSF) taps in NPH cases. Post-subarachnoid hemorrhagic (SAH) patients showed apparent frontal blood flow reduction but non-SAH cases did not. The frontal blood flow increased in comparison with the temporal flow after CSF tapping in SAH cases who benefited most from shunting. Cerebral blood flow study before and after CSF removal is a potential method for classifying NPH patients likely to benefit from the shunting operation.
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  • Clinicopathological Study of Bacterial Intracranial Aneurysms
    Mikihiko TAKESHITA, Mizuo KAGAWA, Osami KUBO, Seiji YATO, Kazuei SATOH ...
    1991 Volume 31 Issue 8 Pages 508-513
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.508
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    The authors report the clinicopathological findings in six cases of bacterial intracranial aneurysms. All patients received appropriate high-dose antibiotics, and four were treated surgically. One patient with multiple aneurysms of the main trunks died of disseminated intravascular coagulation. Autopsy disclosed no apparent aneurysm or inflammatory cell infiltration, but a partially interrupted internal elastic lamina and thickened intima were disclosed at the angiographical aneurysm sites. These findings suggest that 1) appropriate high-dose antibiotics are effective against inoperable bacterial aneurysms in the main trunks, 2) new aneurysms may be formed in patients with cyanotic congenital heart disease, because bacterial emboli can directly reach the cerebral circulation and reimplant on the fragile arterial walls after vasculitis. Histological examination of aneurysmal walls revealed inflammatory cell infiltration after resolution of clinical endocarditis. This suggests that both appropriate high-dose antibiotic therapy and surgery should be considered in patients with distal bacterial aneurysms.
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  • Ruptured Distal Anterior Cerebral Artery Aneurysms Presenting as Acute Subdural Hematoma
    —Report of Three Cases—
    Kunihiko WATANABE, Susumu WAKAI, Soushi OKUHATA, Masakatsu NAGAI
    1991 Volume 31 Issue 8 Pages 514-517
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.514
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    The authors report three cases of distal anterior cerebral artery aneurysm presenting as acute subdural hematoma (SDH). Two patients were comatose on admission and died of massive SDH. One patient underwent aneurysmal neck clipping in the chronic stage and returned to normal daily life. A convexity SDH continuous with a wedge-shaped interhemispheric SDH was the characteristic computed tomographic appearance in all cases. There was no accompanying subarachnoid or intracerebral hemorrhage in one case (pure SDH). These cases are 9.4% of 32 ruptured distal ACA aneurysms treated in our institute in the last 14 years, a higher incidence than reported previously.
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  • Treatment of Metastatic Brain Tumor from Esophageal Carcinoma
    —Report of Four Cases—
    Hisashi KOGA, Jiro MUKAWA, Koichi MIYAGI, Susumu NAKASONE, Toshihiko K ...
    1991 Volume 31 Issue 8 Pages 518-522
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.518
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    Metastasis to the brain from esophageal carcinoma is rare. Recently we had four cases, all treated by tumor removal. Three received postoperative whole or local brain irradiation. Anticancer pellets were implanted in two. The postoperative 1-year survival rate was 37.5%, which suggests the prognosis is not worse than for other metastatic brain tumors.
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  • Cerebral Arteriovenous Malformation Causing Benign Intracranial Hypertension
    —Case Report—
    Jeffrey V. ROSENFELD, Henry A. WIDAA, Christopher B.T. ADAMS
    1991 Volume 31 Issue 8 Pages 523-525
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.523
    JOURNAL FREE ACCESS
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    A 32-year-old male with a large arteriovenous malformation (AVM) in the right temporoparietal area presented with features of benign intracranial hypertension. This association is rare. The pathogenesis is believed to be due to cerebral venous hypertension. The excision of the AVM eliminated the intracranial hypertension.
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  • Peduncular Hallucinosis Associated with Ruptured Basilar-Superior Cerebellar Artery Aneurysm
    —Case Report—
    Yasuhiro HARADA, Hiroshi ISHIMITSU, Ichiro MIYATA, Chiho HONDA, Ken NI ...
    1991 Volume 31 Issue 8 Pages 526-528
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.526
    JOURNAL FREE ACCESS
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    A 65-year-old female developed peduncular hallucinosis 3 days after rupture of a basilar-superior cerebellar artery aneurysm. There were no neurological deficits except slight anisocoria when she first complained of hallucinations. Vasospasm of the perforating arteries to the upper brainstem, rather than direct brainstem damage caused by the bleeding, was probably the cause. Peduncular hallucinosis is possibly the only localizing sign of ruptured upper posterior circulation aneurysm.
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  • Hypothalamic Histiocytosis X with Diabetes Insipidus and Korsakoff's Syndrome
    —Case Report—
    Masami YOSHIKAWA, Mitsuo YAMAMOTO, Shinji OHBA, Keiji OHTA, Kenji SHIB ...
    1991 Volume 31 Issue 8 Pages 529-534
    Published: August 15, 1991
    Released on J-STAGE: July 19, 2006
    DOIhttps://doi.org/10.2176/nmc.31.529
    JOURNAL FREE ACCESS
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    A 54-year-old female presented with apparent isolated hypothalamic histiocytosis X associated with diabetes insipidus and Korsakoff's syndrome. Computed tomographic and magnetic resonance imaging demonstrated a single hypothalamic mass. A craniotomy for biopsy found granulation tissue of unknown cause. Further investigation discovered genital bleeding before admission. Biopsy of the cervix uteri revealed histiocytosis X. Further studies showed the disease was restricted to the hypothalamus and the endometrium of the cervix uteri. Low-dose irradiation led to partial regression of the hypothalamic mass and improvement of Korsakoff's syndrome. Even when a diagnosis of isolated hypothalamic histiocytosis X is confirmed, the possibility of another histiocytosis X lesion in an unexpected region must be considered.
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