Neurologia medico-chirurgica

Analysis of Tumor Necrosis Factor and Lymphotoxin Secreted by Incubation of Lymph okine-activated Killer Cells with Tumor Cells

Hirofumi NAGANUMA, Ryoichi KIMURA, Atsushi SASAKI, Hideaki NUKUI, Kach ...

1992 Volume 32 Issue 4 Pages 189-195
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.189

JOURNAL FREE ACCESS

Show abstractHide abstract

This study investigated the secretion of a tumor necrosis factor (TNF) and lymphotoxin (LT) from lymphokine-activated killer (LAK) cells during co-culture with glioblastoma cell lines, autologous glioma cells, and other non-gliomatous tumor cell lines (K562 and Daudi). Cytokine secretion from peripheral blood mononuclear cells (PBMC) was also examined. The TNF activity of culture supernatants was measured by L cell cytotoxic assay, and a neutralization test using anti-TNF and/or anti-LT antibodies determined whether the cytotoxic activity was due to TNF or LT. The results show that LAK cells secrete both TNF and LT during monoculture and release increased amounts of TNF and LT with non-gliomatous tumor cell stimulation, but PBMC secrete only TNF with tumor cell stimulation. Glioblastoma or anaplastic astrocytoma cells, however, did not stimulate cytokine secretion from either LAK cells or PBMC. This indicates a discrepancy between the capability of LAK cells to lyse malignant glioma cells and cytokine secretion from LAK cells, and suggests that malignant glioma cells may produce some factors which inhibit cytokine secretion from LAK cells.

View full abstract

Download PDF (454K)
Cortical and Subcortical Cavernous Angioma: A Comparison of Patients with and without Hemorrhage as the Initial Symptom

Hiroyuki NAKASE, Tetsuya MORIMOTO, Shigeru TSUNODA, Toshisuke SAKAKI, ...

1992 Volume 32 Issue 4 Pages 196-200
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.196

JOURNAL FREE ACCESS

Show abstractHide abstract

Cavernous angioma is a benign vascular hamartoma with an obscure etiology. Clinical, radiological, and histological features of 24 cases of cortical and subcortical cavernous angiomas were analyzed to investigate the etiology. The lesions were classified as hemorrhaging (8 cases) or non-hemorrhaging (16 cases) according to the initial symptom. Age, sex, location, calcification and postcontrast enhancement by computed tomography (CT), tumor staining by angiography, and calcification and hemosiderin by histological examination were analyzed. Multivariate analysis showed that calcification by CT and histological examination correlated with non-hemorrhaging cases. Histological examination showed that calcification occurred inside and outside the blood vessels, within the vessel walls and in the adjacent brain tissue. Hemosiderin was also seen in most cases. These findings suggest that cavernous angiomas without hemorrhage have a poor circulation, resulting in minor recurrent bleeding and thrombosis, as well as calcification.

View full abstract

Download PDF (417K)
Choroid Plexus Arteriovenous Malformations

Yoshio MIYASAKA, Kenzoh YADA, Takashi OHWADA, Seiji MORII, Takao KITAH ...

1992 Volume 32 Issue 4 Pages 201-206
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.201

JOURNAL FREE ACCESS

Show abstractHide abstract

Among 24 arteriovenous malformations (AVMs) involving the choroid plexus, 11 were plexal type AVMs predominantly located in the choroid plexus of the lateral ventricle, and 13 were parenchymal type AVMs mainly situated in the paraventricular cerebral parenchyma. 83% of all AVMs involved both the choroid plexus and the paraventricular cerebral parenchyma. Most cases presented with intracranial hemorrhage, particularly intraventricular hemorrhage. The most serious surgical problem was a small residual nidus unrecognized at the initial operation causing postoperative hemorrhage. Five parenchymal type AVMs presented residual niduses in the choroid plexus, causing death in two cases. Two plexal type AVMs resulted in residual AVMs supplied by the cisternal segment of the anterior choroidal artery, situated in the medial temporal lobe. To prevent postoperative hemorrhage from a small residual nidus, immediate postoperative angiography while the patient is still under general anesthesia should be performed to identify any residual nidus.

View full abstract

Download PDF (517K)
Chronic Subdural Hematoma in Elderly People: Present Status on Awaji Island and Epidemiological Prospect

Hiroshi KUDO, Keiichi KUWAMURA, Ichirou IZAWA, Hideki SAWA, Norihiko T ...

1992 Volume 32 Issue 4 Pages 207-209
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.207

JOURNAL FREE ACCESS

Show abstractHide abstract

The epidemiological aspect of chronic subdural hematoma (CSH) in the elderly who are 65 years old or elder was evaluated on Awaji Island with about 170, 000 inhabitants. The overall incidence of CSH was 13.1 per 100, 000/year, 3.4 in people under 65 years old, and 58.1 in the elderly. The elderly were 17.7% of all inhabitants. If these incidences of CSH are extrapolated to all of Japan in the year 2020, the incidence will be 16.3 per 100, 000/year. This suggests that CSH may become the most common neurosurgical condition.

View full abstract

Download PDF (137K)
Entrapment of the Temporal Horn: A Form of Focal Non-communicating Hydrocephalus Caused by Intraventricular Block of Cerebrospinal Fluid Flow —Report of Two Cases—

Ryuichi TSUGANE, Masami SHIMODA, Tsutomu YAMAGUCHI, Isao YAMAMOTO, Osa ...

1992 Volume 32 Issue 4 Pages 210-214
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.210

JOURNAL FREE ACCESS

Show abstractHide abstract

In two cases of entrapment of the temporal horn, computed tomography demonstrated the typical appearance of a comma-shaped homogeneous area isodense with water surrounded by a periventricular low-density area. The cause was probably choroid plexitis resulting in obstruction of the cerebrospinal fluid pathway at the atrium. External drainage followed by shunt emplacement is indicated.

View full abstract

Download PDF (426K)
Effect of Long-term Treatment with Somatostatin Analogue (SMS 201-995) on Pituitary Tumor Shrinkage in Acromegaly —Report of Two Cases—

Kazutoshi MUKADA, Tohru UOZUMI, Akihiko TAKECHI, Kazunori ARITA, Takas ...

1992 Volume 32 Issue 4 Pages 215-219
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.215

JOURNAL FREE ACCESS

Show abstractHide abstract

The effect of long-term somatostatin analogue (SMS 201-995) treatment in two acromegalic patients is reported. Continuous tumor shrinkage was observed even after 129 and 139 weeks of treatment with 600μg of SMS 201-995 daily. A huge and firm adenoma underwent shrinkage during treatment with SMS 201-995. No serious side effect appeared during 160 weeks of treatment. SMS 201-995 has a longterm tumor shrinkage effect and improves endocrinopathies.

View full abstract

Download PDF (349K)
Association of Meningioma and Ependymoma —Case Report—

Kiichiro ZENKE, Saburo SAKAKI, Kou NAKAGAWA

1992 Volume 32 Issue 4 Pages 220-224
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.220

JOURNAL FREE ACCESS

Show abstractHide abstract

We report the rare association of a meningioma and an ependymoma in a young boy. A meningioma was detected in the left cerebellopontine angle at age 8 months, and an ependymoma in the left frontal lobe 2 years later. Chromosomal analysis was normal, and his family showed no signs of phacomatosis. Both tumors were totally removed, and he recovered well after both operations.

View full abstract

Download PDF (473K)
Successful Removal of Intracavernous Neurinoma Originating from the Oculomotor Nerve —Case Report—

Yasutaka KUROKAWA, Teiji UEDE, Osamu HONDA, Osamu HONMOU

1992 Volume 32 Issue 4 Pages 225-228
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.225

JOURNAL FREE ACCESS

Show abstractHide abstract

An oculomotor neurinoma was confirmed intraoperatively to be located in the lateral wall of the cavernous sinus in a 55-year-old male. By protruding into the true venous cavity, it caused obliteration of the blood flow in the cavernous sinus. The tumor was totally removed without entering the true venous cavity of the cavernous sinus. The cavernous sinus was closed by suturing the dural membrane to the thin fibrous membrane, preventing intraoperative bleeding.

View full abstract

Download PDF (281K)
Aneurysm Arising at the Triplicate Anterior Communicating Artery —Case Report—

Tatsuhito YAMAGAMI, Haruhiko KIKUCHI, Kenichiro HIGASHI, Hajime HANDA, ...

1992 Volume 32 Issue 4 Pages 229-231
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.229

JOURNAL FREE ACCESS

Show abstractHide abstract

A very rare case of triplicate anterior communicating artery associated with ruptured aneurysm in a 21-year-old female is reported. The triplicate configuration was not predicted by preoperative cerebral angiography, but found intraoperatively. The aneurysm was trapped successfully, and she recovered with no neurological deficit.

View full abstract

Download PDF (141K)
Cerebral Sinus Thrombosis in Patient with Ulcerative Colitis —Case Report—

Eiji MORIYAMA, Chie SHINOHARA, Koji TOKUNAGA, Masato KAMITANI, Hiroshi ...

1992 Volume 32 Issue 4 Pages 232-235
Published: 1992
Released on J-STAGE: June 20, 2006

DOIhttps://doi.org/10.2176/nmc.32.232

JOURNAL FREE ACCESS

Show abstractHide abstract

Left transverse sinus thrombosis developed in a 27-year-old male with ulcerative colitis. The diagnosis was based on cerebral angiography and magnetic resonance (MR) imaging, the latter of which clearly delineated the intraluminal thrombus. Serial MR images demonstrated thrombus organization. The use of this method in the diagnosis of cerebral sinus thrombosis might reduce the need for cerebral angiography.

View full abstract

Download PDF (316K)

Register with J-STAGE for free!